Publications by authors named "Meng Zhang"

2,836 Publications

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Compact Integration of Hydrogen-Resistant a-InGaZnO and Poly-Si Thin-Film Transistors.

Micromachines (Basel) 2022 May 27;13(6). Epub 2022 May 27.

School of Electronic and Computer Engineering, Peking University, Shenzhen 518055, China.

The low-temperature poly-Si oxide (LTPO) backplane is realized by monolithically integrating low-temperature poly-Si (LTPS) and amorphous oxide semiconductor (AOS) thin-film transistors (TFTs) in the same display backplane. The LTPO-enabled dynamic refreshing rate can significantly reduce the display's power consumption. However, the essential hydrogenation of LTPS would seriously deteriorate AOS TFTs by increasing the population of channel defects and carriers. Hydrogen (H) diffusion barriers were comparatively investigated to reduce the H content in amorphous indium-gallium-zinc oxide (a-IGZO). Moreover, the intrinsic H-resistance of a-IGZO was impressively enhanced by plasma treatments, such as fluorine and nitrous oxide. Enabled by the suppressed H conflict, a novel AOS/LTPS integration structure was tested by directly stacking the H-resistant a-IGZO on poly-Si TFT, dubbed metal-oxide-on-Si (MOOS). The noticeably shrunken layout footprint could support much higher resolution and pixel density for next-generation displays, especially AR and VR displays. Compared to the conventional LTPO circuits, the more compact MOOS circuits exhibited similar characteristics.
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http://dx.doi.org/10.3390/mi13060839DOI Listing
May 2022

Gray Matter Structural and Functional Alterations in Idiopathic Blepharospasm: A Multimodal Meta-Analysis of VBM and Functional Neuroimaging Studies.

Front Neurol 2022 6;13:889714. Epub 2022 Jun 6.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Background: Neuroimaging studies have shown gray matter structural and functional alterations in patients with idiopathic blepharospasm (iBSP) but with variations. Here we aimed to investigate the specific and common neurostructural/functional abnormalities in patients with iBSP.

Methods: A systematic literature search from PubMed, Web of Science and Embase was conducted to identify relevant publications. We conducted separate meta-analysis for whole-brain voxel-based morphometry (VBM) studies and for functional imaging studies, and a multimodal meta-analysis across VBM and functional studies in iBSP, using anisotropic effect size-based signed differential mapping.

Results: The structural database comprised 129 patients with iBSP and 144 healthy controls whilst the functional database included 183 patients with iBSP and 253 healthy controls. The meta-analysis of VBM studies showed increased gray matter in bilateral precentral and postcentral gyri, right supplementary motor area and bilateral paracentral lobules, while decreased gray matter in right superior and inferior parietal gyri, left inferior parietal gyrus, left inferior temporal gyrus, left fusiform gyrus and parahippocampal gyrus. The meta-analysis of functional studies revealed hyperactivity in right dorsolateral superior frontal gyrus, left thalamus and right fusiform gyrus, while hypoactivity in left temporal pole, left insula, left precentral gyrus, bilateral precuneus and paracentral lobules, right supplementary motor area and middle frontal gyrus. The multimodal meta-analysis identified conjoint anatomic and functional changes in left precentral gyrus, bilateral supplementary motor areas and paracentral lobules, right inferior occipital gyrus and fusiform gyrus.

Conclusions: The patterns of conjoint and dissociated gray matter alterations identified in the meta-analysis may enhance our understanding of the pathophysiological mechanisms underlying iBSP.
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http://dx.doi.org/10.3389/fneur.2022.889714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207395PMC
June 2022

SRS-FISH: A high-throughput platform linking microbiome metabolism to identity at the single-cell level.

Proc Natl Acad Sci U S A 2022 Jun 21;119(26):e2203519119. Epub 2022 Jun 21.

Department of Electrical & Computer Engineering, Boston University, Boston, MA 02215.

One of the biggest challenges in microbiome research in environmental and medical samples is to better understand functional properties of microbial community members at a single-cell level. Single-cell isotope probing has become a key tool for this purpose, but the current detection methods for determination of isotope incorporation into single cells do not allow high-throughput analyses. Here, we report on the development of an imaging-based approach termed stimulated Raman scattering-two-photon fluorescence in situ hybridization (SRS-FISH) for high-throughput metabolism and identity analyses of microbial communities with single-cell resolution. SRS-FISH offers an imaging speed of 10 to 100 ms per cell, which is two to three orders of magnitude faster than achievable by state-of-the-art methods. Using this technique, we delineated metabolic responses of 30,000 individual cells to various mucosal sugars in the human gut microbiome via incorporation of deuterium from heavy water as an activity marker. Application of SRS-FISH to investigate the utilization of host-derived nutrients by two major human gut microbiome taxa revealed that response to mucosal sugars tends to be dominated by Bacteroidales, with an unexpected finding that Clostridia can outperform Bacteroidales at foraging fucose. With high sensitivity and speed, SRS-FISH will enable researchers to probe the fine-scale temporal, spatial, and individual activity patterns of microbial cells in complex communities with unprecedented detail.
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http://dx.doi.org/10.1073/pnas.2203519119DOI Listing
June 2022

Effects of Selenoprotein S Knockdown on Endoplasmic Reticulum Stress in ATDC5 Cells and Gene Expression Profiles in Hypertrophic Chondrocytes.

Biol Trace Elem Res 2022 Jun 20. Epub 2022 Jun 20.

Key Laboratory of Environment and Genes Related to Diseases in the Education Ministry and Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health, School of Public Health, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Selenoprotein S (SelS), a member of the selenoprotein family, is mainly located on the endoplasmic reticulum (ER) membrane. SelS is involved in a variety of biological processes, including oxidative stress, inflammation, glucose metabolism regulation, and ER-associated protein degradation (ERAD). This study was designed to explore the role of SelS in chondrocytes. It was confirmed that SelS is a Se-sensitive selenoprotein in low-selenium rat and cell models. ER stress was not induced in SelS knockdown ATDC5 cells. However, treatment of ATDC5 cells with tunicamycin (Tm), an ER stress inducer, increased the expression of SelS, and knockdown of SelS aggravated ER stress induced by Tm, suggesting that SelS is a regulatory molecule involved in ER stress in chondrocytes. Both osteoarthritis and Kashin-Beck disease are osteochondral diseases associated with hypertrophic chondrocyte abnormalities. Therefore, ATDC5 cells were induced to hypertrophic chondrocytes. SelS was knocked down and RNA sequencing was performed. Bioinformatics analysis of the differentially expressed genes (DEGs) revealed that SelS knockdown affected a variety of biological processes, including cell adhesion, osteoclast differentiation, and extracellular matrix homeostasis. Collectively, this study verified that SelS is sensitive to selenium levels and is an ER stress-responsive molecule. Knocking down SelS can cause abnormal expression of adhesion molecules and matrix homeostasis disorder in hypertrophic chondrocytes.
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http://dx.doi.org/10.1007/s12011-022-03313-4DOI Listing
June 2022

20()-Protopanaxadiol decreases atherosclerosis in ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9.

Food Funct 2022 Jun 20. Epub 2022 Jun 20.

Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.

Chinese medicinal and edible plants such as and ginseng are widely used for the treatment of atherosclerosis (AS). AS is the main pathological basis of cardiac-cerebral vascular disease, which seriously threatens human health and quality of life. Low-density lipoprotein (LDL) is the main pathogenic factor of AS. The LDL receptor (LDLR) is an important protein that functions to mediate the uptake and degradation of plasma LDL. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) can mediate the internalization and degradation of LDLR. So, increasing the LDLR level by inhibiting PCSK9 is an important means of prevention and treatment of AS. In this study, by combining interaction technology (surface plasmon resonance, SPR) of small molecule compounds with membrane receptor proteins, cell experiments, and experiments, it is proved for the first time that 20()-protopanaxadiol (PPD), as a hydrolytic product of saponins in the intestinal tract, can bind to the extracellular domain of LDLR and inhibit the role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in mediating LDLR degradation. The results showed that PPD significantly reduced aortic plaques and hepatic steatosis in HFD-fed ApoE KO mice. LDLR protein levels were elevated in the liver tissues isolated from PPD-treated HFD-fed ApoE KO mice and PPD-treated HepG2 cells. Our findings demonstrated that PPD significantly increased LDLR levels and reduced AS in the HFD-fed ApoE KO mice on account of LDLR degradation being inhibited by PPD inhibiting the interaction between PCSK9 and LDLR.
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http://dx.doi.org/10.1039/d2fo00392aDOI Listing
June 2022

A Novel Biomarker, FKBP10, for Poor Prognosis Prediction in Patients with Clear Cell Renal Cell Carcinoma.

Evid Based Complement Alternat Med 2022 10;2022:5490644. Epub 2022 Jun 10.

Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Objective: To screen genes associated with poor prognosis of clear cell renal cell carcinoma (CcRCC) from the public databases HPA (Human Protein Atlas), UALCAN, and GEPIA (Gene Expression Profiling Interactive Analysis) and to investigate the expression of FKBP10 in CcRCC and the effect on prognosis of the patients and the biological behavior of CcRCC cells.

Methods: The tumor tissues and adjacent noncancerous tissues of 42 patients with CcRCC diagnosed and treated in our hospital were collected, and the general information of the patients was recorded. FKBP10 expression in the tissues was determined by qRT-PCR and western blot, and its relationship with general information and prognosis of patients was analyzed. Knockdown or overexpression experiments were carried out with the human proximal tubule epithelial cell line HK-2 and CcRCC cell lines Caki-1, 786-O, ACHN, and A498 to verify the relationship between FKBP10 expression and cell proliferation and adhesion ability using MTT assay and fibronectin adhesion assay, respectively. Western blot was utilized to examine the protein expression level of c-Myc, cyclin D1, and Bcl-2 in the cells.

Results: FKBP10 was highly expressed in CcRCC tissues and cells and was correlated with poor prognosis. In addition, FKBP10 expression was positively correlated with CcRCC tumor size and staging and negatively correlated with tumor differentiation. Moreover, knockdown of FKBP10 significantly inhibited the proliferation of CcRCC cells, notably declined the protein expression of c-Myc, cyclin D1, and Bcl-2, and promoted cell adhesion.

Conclusion: FKBP10 is highly expressed in CcRCC tissues and cells and is associated with poor prognosis in patients. FKBP10 participated in the occurrence and development of CcRCC by promoting cell proliferation and inhibiting apoptosis and adhesion.
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http://dx.doi.org/10.1155/2022/5490644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205734PMC
June 2022

Bioactive prenylated phenolic compounds from the aerial parts of Glycyrrhiza uralensis.

Phytochemistry 2022 Jun 15;201:113284. Epub 2022 Jun 15.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University, 38 Xueyuan Road, Beijing, 100191, China; Peking University-Yunnan Baiyao International Medical Research Center, 38 Xueyuan Road, Beijing, 100191, China. Electronic address:

In this work, a bioassay-guided fractionation strategy was used to isolate 26 phenolic compounds from the ethyl acetate partition of an ethanol extract of the aerial parts of Glycyrrhiza uralensis Fisch. ex DC. Among them, 8 prenylated phenolic compounds (glycyuralins Q-X) were described for the first time. The two enantiomers of glycyuralin Q were purified and their absolute configurations were established by ECD spectral calculations. (1″R, 2″S)-glycyuralin Q and (1″S, 2″R)-glycyuralin Q showed significant inhibitory activities against SARS-CoV-2 virus proteases 3CL with IC values of 1.5 ± 1.0 and 4.0 ± 0.3 μM, and PL with IC values of 2.4 ± 0.2 and 1.9 ± 0.1 μM, respectively. Four compounds showed potent cytotoxic activities against A549, Huh-7, and HepG2 human cancer cells with IC values ranging from 0.5 to 2.5 μM.
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http://dx.doi.org/10.1016/j.phytochem.2022.113284DOI Listing
June 2022

Role of Rhizospheric HGS7 in Maintaining Mulberry Growth Under Extremely Abiotic Stress in Hydro-Fluctuation Belt of Three Gorges Reservoir.

Front Plant Sci 2022 27;13:880125. Epub 2022 May 27.

State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding in Ministry of Agriculture, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China.

Plant growth-promoting rhizobacteria have been shown to play important roles in maintaining host fitness under periods of abiotic stress, and yet their effect on mulberry trees which regularly suffer drought after flooding in the hydro-fluctuation belt of the Three Gorges Reservoir Region in China remains largely uncharacterized. In the present study, 74 bacterial isolates were obtained from the rhizosphere soil of mulberry after drought stress, including 12 phosphate-solubilizing and 10 indole-3-acetic-acid-producing isolates. HGS7 was selected for further study due to the abundance of traits that might benefit plants. Genomic analysis revealed that strain HGS7 possessed multiple genes that contributed to plant growth promotion, stress tolerance enhancement, and antimicrobial compound production. HGS7 consistently exhibited antagonistic activity against phytopathogens and strong tolerance to abiotic stress . Moreover, this strain stimulated mulberry seed germination and seedling growth. It may also induce the production of proline and antioxidant enzymes in mulberry trees to enhance drought tolerance and accelerate growth recovery after drought stress. The knowledge of the interactions between rhizobacteria HGS7 and its host plant might provide a potential strategy to enhance the drought tolerance of mulberry trees in a hydro-fluctuation belt.
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http://dx.doi.org/10.3389/fpls.2022.880125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195505PMC
May 2022

Predictors of Persistent Participation in Youth Sport: A Systematic Review and Meta-Analysis.

Front Psychol 2022 27;13:871936. Epub 2022 May 27.

School of Physical Education and Training, Shanghai University of Sport, Shanghai, China.

There are many factors affecting decisions to persistent participation in sports and various approaches have been used to frame these antecedents. The aim of this paper was to systematically review and quantify the primary factors of persistent participation and to assess their respective strengths of association with persistent participation in youth sport. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines, a comprehensive search was implemented on 31st December 2021 in five databases and meta-analytic procedures were applied to data from studies meeting inclusion criteria. The results revealed that sports enjoyment (meta = 0.45, 95%CI [0.42, 0.49]) was highly correlated with persistent intention, while persistent intention (SMD = 1.13, 95%CI [0.70, 1.56]) was highly correlated with persistent behavior. In addition, parental support, coach support, peer support, basic psychological needs and sports competence were the primary factors associated with persistent intention and persistent behavior, respectively. This study identified the key factors related to persistent participation and provide a complete understanding of children and adolescents' decisions to continue their participation in organized sports. Referring to the key factors, it can provide information for sports clubs and policy makers to develop strategies to increase youth participation in organized sport.

Systematic Review Registration: PROSPERO, identifier: CRD42021229397.
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http://dx.doi.org/10.3389/fpsyg.2022.871936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196305PMC
May 2022

Schizophrenia Patients With Prevotella-Enterotype Have a Higher Risk of Obesity.

Front Psychiatry 2022 30;13:864951. Epub 2022 May 30.

School of Chemical Engineering and Pharmaceutics, Henan University of Science and Technology, Luoyang, China.

Recent studies have indicated the critical influence of gut microbiota on the occurrence of obesity. There is a significant risk of obesity in people with schizophrenia. This work proposed that the disorder of gut microbiota in patients with schizophrenia was based on microbial enterotypes. Ninety-seven patients with schizophrenia and 69 matched health controls were eligible. The fresh feces of all the subjects were collected and used to complete 16S rRNA sequence. Statistical analysis was performed to identify the intestinal type of gut microbiota and analyze their potential effects on metabolic function. The patients with enterotype-P had a higher BMI than that of the others. Several differences in the gut microbes of enterotype-P were found between the patients and the controls. Proteobacteria and Firmicutes had significantly higher abundance in the patients' group with enterotype-P. The Bacteroidetes had higher abundance in health controls with enterotype-P. Different metabolic pathways of the microbiota with the enterotype-P were identified in the subjects categorized in different BMI intervals. The schizophrenia patients had a significantly higher BMI than that of health controls. The patients with enterotype-P had a higher BMI. Therefore, the enterotype-P might have a critical influence on a variety of metabolic pathways to disturb the metabolism of glucose and lipid in human body.
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http://dx.doi.org/10.3389/fpsyt.2022.864951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195727PMC
May 2022

Gamma-Glutamyltransferase Activity (GGT) Is a Long-Sought Biomarker of Redox Status in Blood Circulation: A Retrospective Clinical Study of 44 Types of Human Diseases.

Oxid Med Cell Longev 2022 6;2022:8494076. Epub 2022 Jun 6.

Systems Biology & Medicine Center for Complex Diseases, Center for Clinical Research, Affiliated Hospital of Qingdao University, Qingdao 266003, China.

Methods: The clinical GGT data from 168,858 patients with 44 diseases and 132,357 healthy control in the clinical laboratory of our hospital over the past five years were retrieved. All data were analyzed with SPSS, RStudio V.1.3.1073, and python libraries 3.8.

Results: Thirty-eight out of 44 diseases had significantly increased ( < 0.001) circulating GGT activities, whereas gastric cancer, anemia, renal cyst, cervical cancer, preeclampsia, and knee-joint degenerative diseases had significantly decreased ( < 0.001) GGT activities compared to the healthy control. ROC analyses showed that GGT was an excellent biomarker for liver cancer (AUC = 0.86), pancreatitis (AUC = 0.84), or hepatic encephalopathy (AUC = 0.80). All pancreas-related diseases had more than 8-fold increases in GGT activity span than the healthy control, while pancreatic cancer had a 12-fold increase (1021 U/L vs. 82 U/L). The knee-joint degenerative disease had the lowest median and narrowest GGT activity range (63 U/L). Furthermore, most diseases' lowest to highest GGT activities were beyond the healthy control in both directions.

Conclusions: Thirty-eight out of 44 diseases were in overall oxidative states defined by the increased GGT median values. In contrast, knee-joint degenerative disease, gastric cancer, anemia, renal cyst, cervical cancer, and preeclampsia were in overall antioxidative states. Moreover, most diseases swing between oxidative and antioxidative states, evidenced by the increased lowest to highest GGT activity ranges than the healthy control. Liver- and pancreas-related abnormalities were responsible for significantly increased GGT activities. Our overall results suggested that circulating GGT was a redox status biomarker.
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http://dx.doi.org/10.1155/2022/8494076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192220PMC
June 2022

Insights into the response of anammox sludge to the combined stress of nickel and salinity.

Sci Total Environ 2022 Jun 11:156670. Epub 2022 Jun 11.

Department of Environmental Engineering, College of Environmental & Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Anaerobic ammonium oxidation (anammox) is a promising technology being applied to treat industrial wastewater, while the commonly coexistent heavy metals and salinity usually become a challenging issue to be addressed. In this study, the responses of anammox sludge in terms of performance, activity, functional enzyme and extracellular polymeric substance (EPS) to the combined stress of Ni(II) and salinity (20 ‰) were investigated holistically. It turned out that low Ni(II) concentration (0.2 mg·L) together with salinity (20 ‰) showed an insignificant effect on the anammox performance, while a decreased nitrogen removal by 46.96 % was observed with the increased Ni(II) concentration to 1 mg·L. It should be pointed out that the anammox system exhibited good robustness evidenced by rapid recovery to achieve 89.13 % of nitrogen removal efficiency and 1.21 kg·m·d of nitrogen removal rate after the elimination of stress factors within 40 days. Ni(II) concentration was revealed to play a more important role in the specific activity of anammox sludge. The functional enzymes related to nitrogen removal, e.g. nitrite reductase (NIR), hydrazine oxidase (HZO) and heme c were found to be inhibited by the combined stress of Ni(II) and salinity, with decreased activity by 49.54 %, 39.39 % and 45.88 %, respectively. However, the enzyme related to assimilation, e.g. alkaline phosphatase (AKP) and nitrate reductase (NAR) appeared to be enhanced. The EPS content was found to decrease by 55.19 % under the combined stress. Detailed analysis of 3D-EEM and FTIR spectra analysis further revealed that the combined stress of Ni(II) and salinity could change both the quantity and composition of EPS in anammox sludge. These results are expected to offer insights into the combined effect of nickel and salinity on the anammox system, and benefit the application of anammox technology for industrial metal-rich saline wastewater treatment.
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http://dx.doi.org/10.1016/j.scitotenv.2022.156670DOI Listing
June 2022

Development of a ladder-shape melting temperature isothermal amplification (LMTIA) assay for detection of African swine fever virus (ASFV).

J Vet Sci 2022 May 2. Epub 2022 May 2.

Key Laboratory of Biomarker Based Rapid-Detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang 461000, China.

Background: Due to the unavailability of an effective vaccine or antiviral drug against the African swine fever virus (ASFV), rapid diagnosis methods are needed to prevent highly contagious African swine fever.

Objectives: The objective of this study was to establish the ladder-shape melting temperature isothermal amplification (LMTIA) assay for the detection of ASFV.

Methods: LMTIA primers were designed with the p72 gene of ASFV as the target, and plasmid pUC57 was used to clone the gene. The LMTIA reaction system was optimized with the plasmid as the positive control, and the performance of the LMTIA assay was compared with that of the commercial real-time polymerase chain reaction (PCR) kit in terms of sensitivity and detection rate using 200 serum samples.

Results: Our results showed that the LMTIA assay could detect the 10 dilution of DNA extracted from the positive reference serum sample, which was the same as that of the commercial real-time PCR kit. The coincidence rate between the two assays was 100%.

Conclusions: The LMTIA assay had high sensitivity, good detection, and simple operation. Thus, it is suitable for facilitating preliminary and cost-effective surveillance for the prevention and control of ASFV.
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http://dx.doi.org/10.4142/jvs.22001DOI Listing
May 2022

Effect of wheat bran arabinoxylan on the gelatinization and long-term retrogradation behavior of wheat starch.

Carbohydr Polym 2022 Sep 7;291:119581. Epub 2022 May 7.

Beijing Key Laboratory of Functional Food From Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address:

The effect of wheat bran arabinoxylan (WBAX) with different molecular characteristics on the gelatinization and long-term retrogradation behavior of wheat starch (WS) have been evaluated. WBAXs with M of 280-754 kDa and Ara/Xyl of 0.45-0.62 were obtained through alkaline extraction with graded ethanol precipitation. WBAXs with larger M and branching degree could impede gelatinization process of wheat starch by effectively decreasing the water availability for starch gelatinization. The hydrogen-bonding interactions between WS and WBAX could enhance the gel strength of WS-WBAX mixed pastes. WBAXs with lower branching degree could inhibit the long-term retrogradation of starch through hindering the rearrangement of amylopectin and double-helical associations of amylose during long-term storage, due to hydrogen-bonding interaction between WBAX and starch. Low-field nuclear magnetic resonance (LF-NMR) relaxometry analysis confirmed that the addition of WBAXs could improve the water holding properties of retrograded starch gels.
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http://dx.doi.org/10.1016/j.carbpol.2022.119581DOI Listing
September 2022

A deep learning network based on multi-scale and attention for the diagnosis of chronic atrophic gastritis.

Z Gastroenterol 2022 Jun 13. Epub 2022 Jun 13.

Wuhan University, Wuhan City, China.

Background And Study Aim: Chronic atrophic gastritis plays an important role in the process of gastric cancer. Deep learning is gradually introduced in the medical field, and how to better apply a convolutional neural network (CNN) to the diagnosis of chronic atrophic gastritis remains a research hotspot. This study was designed to improve the performance of CNN on diagnosing chronic atrophic gastritis by constructing and evaluating a network structure based on the characteristics of gastroscopic images.

Methods: Three endoscopists reviewed the endoscopic images of the gastric antrum from the Gastroscopy Image Database of Zhongnan Hospital and labelled available images according to pathological results. Two novel modules proposed recently were introduced to construct the Multi-scale with Attention net (MWA-net) considering the characters of similar medical images. After training the network using images of training sets, the diagnostic ability of the MWA-net was evaluated by comparing it with those of other deep learning models and endoscopists with varying degrees of expertise.

Results: As a result, 5,159 images of the gastric antrum from 2,240 patients were used to train and test the MWA-net. Compared with the direct application of famous networks, the MWA-net achieved the best performance (accuracy, 92.13%) with an increase of 1.80% compared to that of ResNet. The suspicious lesions indicated by the network are consistent with the conclusion of experts. The sensitivity and specificity of the convolutional network for gastric atrophy diagnosis are 90.19% and 94.51%, respectively, which are higher than those of experts.

Conclusions: Highly similar images of chronic atrophic gastritis can be identified by the proposed MWA-net, which has a better performance than other well-known networks. This work can further reduce the workload of gastroscopists, simplify the diagnostic process and provide medical assistance to more residents.
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http://dx.doi.org/10.1055/a-1828-1441DOI Listing
June 2022

Design and evaluation of maternal early warning system to reduce preventable maternal mortality in pregnancy and puerperium for high-risk women in China.

Midwifery 2022 Jun 6;112:103392. Epub 2022 Jun 6.

Department of Obstetrics, the Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Background: The maternal early warning system is an effective tool to reduce maternal mortality and morbidity. However, there has been limited research on developing a maternal early warning system especially suitable for Chinese high-risk pregnant women.

Objective: The purpose is to develop a maternal early warning system to reduce preventable maternal mortality in pregnancy and puerperium in high-risk women in China.

Design: A cross-sectional survey design.

Setting: The study was conducted in a first-level hospital in China.

Participants: A total of 306 pregnant women were selected as the objects who were admitted to give birth from April to June 2021 in xxx.

Methods: A convenience sampling method was used to select 42 experts from 20 hospitals in more than 10 cities in east and west China, which represents the developed and undeveloped cities. The maternal early warning indicators of high-risk pregnancy during pregnancy and after birth were determined via literature research, research group discussion, and the Delphi expert consultation.

Measurements And Findings: The final maternal early warning system for high-risk women in pregnancy and puerperium included 8 first-level indicators and 30 second-level indicators. The expert authority coefficients of the two rounds of consultation were 0.92 and 0.94, respectively. The Kendall harmony coefficients were 0.252 and 0.386, respectively (P<0.001). The area under the ROC curve predicted by the early warning system for high-risk pregnancy during childbirth was higher than 0.86, and the best cut-off point was 9.97. It was statistically significant (P<0.001).

Key Conclusions: The constructed maternal early warning system for high-risk pregnancy in pregnancy and puerperium has comprehensive contents and high reliability, which will help midwives to identify high-risk pregnancies during childbirth.

Implications For Practice: The results of this study can help to detect deterioration of the patient, predict morbidity in high-risk women and enable timely intervene to prevent possible severe illness.
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http://dx.doi.org/10.1016/j.midw.2022.103392DOI Listing
June 2022

HA/CD44 Regulates the T Helper 1 Cells Differentiation by Activating Annexin A1/Akt/mTOR Signaling to Drive the Pathogenesis of EAP.

Front Immunol 2022 26;13:875412. Epub 2022 May 26.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

CD44 partcipates in multiple inflammatory reactions. Here, we aimed to investigate the role of CD44 and the ligand, hyaluronan (HA), on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) pathogenesis. We found that CD44 was universally expressed in CD4 lymphocytes in the peripheral blood of CP/CPPS patients. After silencing CD44 expression or delivering 4-methylumbelliferone (4-MU), the pain severity and prostatic inflammation were significantly relieved. assay found that HA/CD44 was able to regulate T helper 1 (Th1) cells differentiation, the deficiency of which diminished experimental autoimmune prostatitis (EAP) susceptibility. Bioinformatic analysis suggested that after HA or 4-MU treatment, mTOR signaling was significantly altered, and these results were confirmed by subsequent Western blotting assay. Besides, mass spectrometry and co-immunoprecipitation assays found that CD44 was able to interact with Annexin A1 (ANX A1), and this kind of interaction stabilized ANX A1 protein and maintained the activation of Akt/mTOR pathway. Meanwhile, HA-treatment-enhanced prostatic inflammation, Th1 cell differentiation, and Akt/mTOR pathway activation were reversed after silencing the expression of ANX A1 using shANX A1-lentivirus. The present study systematically investigates the functional role of HA/CD44 in CP/CPPS and identifies novel mechanisms for HA/CD44 promoting Th1 cell differentiation. Targeting the HA/CD44/ANX A1/Akt/mTOR signaling represents novel potential therapeutic strategies for patients with CP/CPPS.
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http://dx.doi.org/10.3389/fimmu.2022.875412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178196PMC
June 2022

Diagnosis, clustering, and immune cell infiltration analysis of m6A-related genes in patients with acute myocardial infarction-a bioinformatics analysis.

J Thorac Dis 2022 May;14(5):1607-1619

Department of Internal Medicine-Cardiovascular Disease, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Background: Accurate myocardial infarction (AMI) is one of the leading causes of mortality worldwide. N6-methyladenosine (m6A) modification plays an important role in the development of cardiac remodeling and the cardiomyocyte contractile function. The aim of this study is to analyze the m6A-related molecular biological mechanisms of AMI in terms of accurate diagnosis and prognosis.

Methods: The platform data and probe data of the GSE66360 data set were downloaded. The differential analysis was conducted by combining the m6A-related gene expression. Thereafter, a diagnostic model was established using the random-forest method. The diagnostic accuracy of the diagnostic models was assessed by using the area under the receiver operating characteristic (ROC) curve (AUC). Next, the patients with AMI were clustered by unsupervised machine learning using the R software. Finally, an immune cell clustering analysis for each cluster was conducted to determine the correlations between m6A-related gene expression and the infiltration amount of the immune cells. The case and control groups were not matched in terms of demographics.

Results: The GSE6636 data set comprised 99 participants (49 patients with AMI and 50 without in control group). The differential analysis identified 10 m6A-related genes: 5 writers [Methyltransferase-like 3 (), Methyltransferase-like 14 (), Wilms tumor 1-associated protein (), Zinc Finger CCCH-Type Containing 13 (), and Casitas B-lineage proto-oncogene like 1 ()], 4 readers [YT521-B homology domain-containing family 3 (), Fragile X mental retardation type 1 (), YT521-B homology-domain-containing protein 1 (), and insulin-like growth factor binding protein 3 ()] and 1 eraser [fat mass and obesity associated () gene]. The Mean Decrease Gini (MDG) values of these 10 genes were greater than 2. The , and were included in the model with a C index of 0.842. , and were highly expressed in Type A, and was highly expressed in Type B.

Conclusions: A diagnostic model of AMI was established based on the genes of , , and . Additionally, 2 molecular subtypes were successfully identified from the above-mentioned gene. Our findings could provide a novel method for the accurate diagnosis of AMI.
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http://dx.doi.org/10.21037/jtd-22-569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186242PMC
May 2022

Role of environmental stresses in elevating resistance mutations in bacteria: Phenomena and mechanisms.

Environ Pollut 2022 Aug 9;307:119603. Epub 2022 Jun 9.

Guangdong Provincial Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 511443, China. Electronic address:

Mutations are an important origin of antibiotic resistance in bacteria. While there is increasing evidence showing promoted resistance mutations by environmental stresses, no retrospective research has yet been conducted on this phenomenon and its mechanisms. Herein, we summarized the phenomena of stress-elevated resistance mutations in bacteria, generalized the regulatory mechanisms and discussed the environmental and human health implications. It is shown that both chemical pollutants, such as antibiotics and other pharmaceuticals, biocides, metals, nanoparticles and disinfection byproducts, and non-chemical stressors, such as ultraviolet radiation, electrical stimulation and starvation, are capable of elevating resistance mutations in bacteria. Notably, resistance mutations are more likely to occur under sublethal or subinhibitory levels of these stresses, suggesting a considerable environmental concern. Further, mechanisms for stress-induced mutations are summarized in several points, namely oxidative stress, SOS response, DNA replication and repair systems, RpoS regulon and biofilm formation, all of which are readily provoked by common environmental stresses. Given bacteria in the environment are confronted with a variety of unfavorable conditions, we propose that the stress-elevated resistance mutations are a universal phenomenon in the environment and represent a nonnegligible risk factor for ecosystems and human health. The present review identifies a need for taking into account the pollutants' ability to elevate resistance mutations when assessing their environmental and human health risks and highlights the necessity of including resistance mutations as a target to prevent antibiotic resistance evolution.
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http://dx.doi.org/10.1016/j.envpol.2022.119603DOI Listing
August 2022

Brain Tumor Cell Membrane-Coated Lanthanide-Doped Nanoparticles for NIR-IIb Luminescence Imaging and Surgical Navigation of Glioma.

Adv Healthc Mater 2022 Jun 10:e2200521. Epub 2022 Jun 10.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.

Intraoperative visualization of the full extent of brain tumor by luminescence imaging helps to improve the degree and accuracy of brain tumor resection, thereby prolonging the survival of patients. However, the limited imaging depth and spatial resolution and the poor blood-brain barrier (BBB) permeability of most currently available luminescent probes restrict the imaging performance and surgical resection efficiency of brain tumor. Here, a brain tumor cell membrane-coated lanthanide-doped nanoparticles (CC-LnNPs) in the near-infrared-IIb window (NIR-IIb, 1500-1700 nm) is designed for brain tumor imaging and surgical navigation. The coating of brain tumor cell membrane endows CC-LnNPs with immune escape, BBB crossing, and homotypic targeting abilities, which are inherited from the source brain tumor cells. In addition, compared with clinically approved imaging agent indocyanine green, CC-LnNPs present higher temporal and spatial resolution, higher stability, and lower background signals, enabling clear visualization of the brain tumor boundary. With the guidance of NIR-IIb fluorescence, the glioma tissue (size < 3 mm, depth > 3 mm) could be clearly visualized and completely removed as a proof of concept. This study offers new insight for the future design of nanoprobe to image brain tumor and to achieve precise diagnosis and surgical navigation of brain tumor.
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http://dx.doi.org/10.1002/adhm.202200521DOI Listing
June 2022

Comparison of Omicron and Delta Variant Infection COVID-19 Cases - Guangdong Province, China, 2022.

China CDC Wkly 2022 May;4(18):385-388

Guangdong Provincial Center for Disease Control and Prevention, Guangzhou City, Guangdong Province, China.

What Is Already Known About This Topic?: The Omicron variant has been listed as a variant of concern, but the characteristics still remain unclear.

What Is Added By This Report?: The vaccinated proportion of 65 imported coronavirus disease 2019 cases that were infected with Omicron variant in this study was 89.23%, which was higher than Delta cases. Most imported cases infected with Omicron were tested positive using polymerase chain reaction after entering Guangdong within 3 days, a shorter period than Delta.

What Are The Implications For Public Health Practice?: Under this observation, the international travelers infected with Omicron variant were detected positive earlier after entry than those infected with Delta variant. Breakthrough infections occurred in most Omicron cases in this study, but vaccination was still effective to reduce the incidence of severe illness. Omicron surveillance should be strengthened.
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http://dx.doi.org/10.46234/ccdcw2022.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167612PMC
May 2022

The Health Demands of Designated Drivers - Four Cities, China, 2019.

China CDC Wkly 2022 May;4(20):426-430

Chinese Center for Disease Control and Prevention, Beijing, China.

What Is Already Known About This Topic?: The health status of designated drivers is largely associated with road safety, which is a major public health issue. However, few studies have focused on the health demands of designated drivers.

What Is Added By This Report?: This study investigated the health consciousness, first aid knowledge learning, acceptable ways to acquire health knowledge, and willingness to have physical examinations for designated drivers to provide suggestions for improving their health status.

What Are The Implications For Public Health Practice?: The industry and platform should provide scientific and reasonable guidance on healthy lifestyles for designated drivers and implement physical examinations to monitor their health status.
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http://dx.doi.org/10.46234/ccdcw2022.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167619PMC
May 2022

11β-HSD1 Inhibitor Alleviates Non-Alcoholic Fatty Liver Disease by Activating the AMPK/SIRT1 Signaling Pathway.

Nutrients 2022 Jun 6;14(11). Epub 2022 Jun 6.

Heilongjiang Key Laboratory of Tissue Damage and Repair, College of Life Science, Mudanjiang Medical University, Mudanjiang 157011, China.

We investigated the effect of an 11β-HSD1 inhibitor (H8) on hepatic steatosis and its mechanism of action. Although H8, a curcumin derivative, has been shown to alleviate insulin resistance, its effect on non-alcoholic fatty liver disease (NAFLD) remains unknown. Rats were fed a high-fat diet (HFD) for 8 weeks, intraperitoneally injected with streptozotocin (STZ) to induce NAFLD, and, then, treated with H8 (3 or 6 mg/kg/day) or curcumin (6 mg/kg/day) for 4 weeks, to evaluate the effects of H8 on NAFLD. H8 significantly alleviated HFD+STZ-induced lipid accumulation, fibrosis, and inflammation as well as improved liver function. Moreover, 11β-HSD1 overexpression was established by transfecting animals and HepG2 cells with lentivirus, carrying the 11β-HSD1 gene, to confirm that H8 improved NAFLD, by reducing 11β-HSD1. An AMP-activated protein kinase (AMPK) inhibitor (Compound C, 10 μM for 2 h) was used to confirm that H8 increased AMPK, by inhibiting 11β-HSD1, thereby restoring lipid metabolic homeostasis. A silencing-related enzyme 1 (SIRT1) inhibitor (EX572, 10 μM for 4 h) and a SIRT1 activator (SRT1720, 1 μM for 4 h) were used to confirm that H8 exerted anti-inflammatory effects, by elevating SIRT1 expression. Our findings demonstrate that H8 alleviates hepatic steatosis, by inhibiting 11β-HSD1, which activates the AMPK/SIRT1 signaling pathway.
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http://dx.doi.org/10.3390/nu14112358DOI Listing
June 2022

Manipulation of Elastic Instability of Viscoelastic Fluid in a Rhombus Cross Microchannel.

Polymers (Basel) 2022 May 25;14(11). Epub 2022 May 25.

School of Physics and Material Science, Guangzhou University, Guangzhou 510006, China.

This paper reports the manipulation of elastic instability of the viscoelastic fluid in a rhombus cross microchannel (RCM) structure. The bistable instability and unsteady instability of the flow is firstly demonstrated in a standard cross microchannel (SCM) for reference. We then keep the bi-stable instability over a much wider injection rate range in the RCM, which is attributed to the stabilizing effect of the rhombus structure. A semi-bistable instability was also established in the RCM at a high enough injection rate. In addition, the unsteady elastic instability is realized in the RCM through an asymmetric injection rate condition.
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http://dx.doi.org/10.3390/polym14112152DOI Listing
May 2022

Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling.

Acta Pharmacol Sin 2022 Jun 8. Epub 2022 Jun 8.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Activation of vitamin D receptor (VDR) in cancer-associated fibroblasts (CAFs) has been implicated in hesitating tumor progression and chemoresistance of several human malignancies. Yet, the role of VDR in CAF-induced chemotherapy resistance of gastric cancer (GC) cells remains elusive. In this study we first conducted immunohistochemistry analysis on tissue microarrays including 88 pairs of GC and normal mucosa samples, and provided clinical evidence that VDR was mainly expressed in gastric mucous cells but almost invisible in CAFs, and VDR expression was negatively correlated with malignant clinical phenotype and advanced stages, low VDR expression confers to poor overall survival rate of patients with GC. In a co-culture system of primary CAFs and cancer cells, we showed that treatment of HGC-27 and AGS GC cells with VDR ligand calcipotriol (Cal, 500 nM) significantly inhibited CAF-induced oxaliplatin resistance. By using RNA-sequencing and Human Cytokine Antibody Array, we demonstrated that IL-8 secretion from CAFs induced oxaliplatin resistance via activating the PI3K/AKT pathway in GC, whereas Cal treatment greatly attenuated the tumor-supportive effect of CAF-derived IL-8 on GC cells. Taken together, this study verifies the specific localization of VDR in GC tissues and demonstrates that activation of VDR abrogates CAF-derived IL-8-mediated oxaliplatin resistance in GC via blocking PI3K/Akt signaling, suggesting vitamin D supplementation as a potential strategy of enhancing the anti-tumor effect of chemotherapy in GC.
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http://dx.doi.org/10.1038/s41401-022-00927-1DOI Listing
June 2022

Dietary habits and lifestyle related to the effectiveness of low-intensity extracorporeal shock wave therapy for chronic prostatitis/chronic pelvic pain syndrome-like symptoms: Initial results.

Andrologia 2022 Jun 7:e14490. Epub 2022 Jun 7.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China.

To identify factors that could influence the treatment outcomes of low-intensity extracorporeal shock wave therapy (Li-ESWT) on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)-like symptoms and establish a predictive model based on these factors to precisely screen individuals who might be more suitable for Li-ESWT. This study enrolled 84 patients with CP/CPPS-like symptoms who received Li-ESWT. Patients were divided into an effective group and an ineffective group based on the reduction of their National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). A nomogram was established based on logistic regression analyses. Then, receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis (DCA) were used to evaluate the nomogram. Univariate and multivariate logistic regression analysis showed that a higher NIH-CPSI score, a habit of holding urine, alcohol consumption, and urination soon after intercourse were independent predictors of Li-ESWT efficacy (p < 0.05). The nomogram constructed based on these four indicators and the added age effectively predicted the probability of Li-ESWT effectiveness for CP/CPPS-like symptoms (0.809 [95% CI: 0.717-0.901]; Hosmer-Lemeshow: p = 0.936). This study established a predictive model for the efficacy of Li-ESWT in treating CP/CPPS-like symptoms patients and help improve the management of CP/CPPS-like symptoms.
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http://dx.doi.org/10.1111/and.14490DOI Listing
June 2022

Gypensapogenin H suppresses tumor growth and cell migration in triple-negative breast cancer by regulating PI3K/AKT/NF-κB/MMP-9 signaling pathway.

Bioorg Chem 2022 Sep 26;126:105913. Epub 2022 May 26.

School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Due to its aggressiveness and high metastasis rates, triple-negative breast cancer (TNBC) is a ubiquitous and deadly disease for the majority of women globally. Gypensapogenin H (GH) is a novel dammarane-type triterpene isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum. Our previous work demonstrated that GH promoted apoptosis in TNBC. In the present study, xenograft TNBC models (xenotransplantation of MDA-MB-231 cells in nude mice) were used to evaluate the efficacy of GH in vivo. We preliminarily predicted the mechanism of GH inhibiting breast cancer tumors at the gene level through transcriptome screening. Through western blot analysis of tumor tissue, we found that GH could inhibit tumor proliferation and migration by regulating the PI3K/AKT/NF-κB/MMP-9 signaling pathway in vivo. We also analyzedthe results at the cell level in vitro, which were consistent with those in vivo. In summary, GH inhibited TNBC growth in vivo and suppressed TNBC cell migration in vitro. Our findings could help understand the mechanism of action of GH and suggest that GH would be a promising agent for TNBC therapy.
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http://dx.doi.org/10.1016/j.bioorg.2022.105913DOI Listing
September 2022

A New Technique for Remodelling and Increasing the Diameter of the Legs through Lipotransfer and Vertical Subcutaneous Fasciotomy of the Posterior Tibial Aponeurosis.

Aesthetic Plast Surg 2022 Jun 7. Epub 2022 Jun 7.

The Second Department of Orthopaedic, Chengde Central Hospital, No.11 Guangren Street, Shuangqiao District, Chengde, 067000, Hebei Province, People's Republic of China.

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http://dx.doi.org/10.1007/s00266-022-02955-yDOI Listing
June 2022

Size matters: Steric hindrance of precursor molecules controlling the evolution of CdSe magic-size clusters and quantum dots.

Nano Res 2022 May 31:1-9. Epub 2022 May 31.

Institute of Atomic and Molecular Physics, Sichuan University, Chengdu, 610065 China.

Little is known about how to precisely promote the selective production of either colloidal semiconductor metal chalcogenide (ME), magic-size clusters (MSCs), or quantum dots (QDs). Recently, a two-pathway model has been proposed to comprehend their evolution; here, we reveal for the first time that the size of precursors plays a decisive role in the selected evolution pathway of MSCs and QDs. With the reaction of cadmium myristate (Cd(MA)) and tri-n-octylphosphine selenide (SeTOP) in 1-octadecene (ODE) as a model system, the size of Cd precursors was manipulated by the steric hindrance of carboxylic acid (RCOOH) additive. Without RCOOH, the reaction produced both CdSe MSCs and QDs (from 100 to 240 °C). With RCOOH, the reaction produced MSCs or QDs when R was small (such as CH-) or large (such as CH-), respectively. According to the two-pathway model, the selective evolution is attributed to the promotion and suppression of the self-assembly of Cd and Se precursors, respectively. We propose that the addition of carboxylic acid may occur ligand exchange with Cd(MA), causing the different sizes of Cd precursor. The results suggest that the size of Cd precursors regulates the self-assemble behavior of the precursors, which dictates the directed evolution of either MSCs or QDs. The present findings bring insights into the two-pathway model, as the size of M and E precursors determine the evolution pathways of MSCs or QDs, the understanding of which is of great fundamental significance toward mechanism-enabled design and predictive synthesis of functional nanomaterials.

Electronic Supplementary Material: Supplementary material (additional optical absorption spectra, TEM, NMR, FT-IR, and XRD) is available in the online version of this article at 10.1007/s12274-022-4421-4.
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http://dx.doi.org/10.1007/s12274-022-4421-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154029PMC
May 2022

Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease.

Front Neurosci 2022 20;16:852822. Epub 2022 May 20.

Department of Magnetic Resonance, First Affiliated Hospital of Xinxiang Medical University, Weihui, China.

Dynamic functional connectivity (FC) analysis can capture time-varying properties of connectivity; however, studies focusing on dynamic FC in patients with end-stage renal disease (ESRD) are very limited. This is the first study to explore the dynamic aspects of whole-brain FC and topological properties in ESRD patients. Resting-state functional magnetic resonance imaging data were acquired from 100 ESRD patients [50 hemodialysis (HD) patients and 50 non-dialysis patients] and 64 healthy controls (HCs). Independent component analysis, a sliding-window approach and graph-theory methods were used to study the dynamic FC properties. The intrinsic brain FC were clustered into four configuration states. Compared with HCs, both patient groups spent longer time in State 3, in which decreased FC between subnetworks of the default mode network (DMN) and between the dorsal DMN and language network was observed in these patients, and a further reduction in FC between the DMN subnetworks was found in HD patients compared to non-dialysis patients. The number of transitions and the variability of global and local efficiency progressively decreased from that in HCs to that of non-dialysis patients to that of HD patients. The completion time of Trail Making Test A and Trail Making Test B positively correlated with the mean dwell time of State 3 and negatively correlated with the number of transitions in ESRD patients. Our findings suggest impaired functional flexibility of network connections and state-specific FC disruptions in patients with ESRD, which may underlie their cognitive deficits. HD may have an adverse effect on time-varying FC.
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http://dx.doi.org/10.3389/fnins.2022.852822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163405PMC
May 2022
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