Publications by authors named "Meng Yang"

978 Publications

3D printable, tough, magnetic hydrogels with programmed magnetization for fast actuation.

J Mater Chem B 2021 Oct 26. Epub 2021 Oct 26.

State Key Laboratory for Strength and Vibration of Mechanical Structures, Department of Engineering Mechanics, Xi'an Jiaotong University, Xi'an, 710049, China.

Magnetic hydrogels have demonstrated great potential in soft robots, drug delivery, and bioengineering, and their functions are usually determined by the deforming capability. However, most magnetic hydrogels are embedded with soft magnetic particles ( FeO), where the magnetic domains cannot be programmed and retained under external magnetic fields. Here, we present a strategy to prepare a microgel-reinforced magnetic hydrogel, embedded with hard magnetic NdFeB particles. These magnetic hydrogels show outstanding mechanical properties (ultimate stretching ratio >15 and fracture toughness >15 000 J m) and fast actuation speed under external magnetic fields. We use direct ink writing to fabricate magnetic hydrogels with sophisticated geometry and program their magnetization to achieve complex deformations. Fast, reversible, shape-changing structures have been demonstrated with printed magnetic hydrogels. It is hoped that this material system of hard magnetic hydrogels can open opportunities for wide applications.
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http://dx.doi.org/10.1039/d1tb01694fDOI Listing
October 2021

Lipid Disorders in NAFLD and Chronic Kidney Disease.

Biomedicines 2021 Oct 6;9(10). Epub 2021 Oct 6.

Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and is characterized by exaggerated lipid accumulation, inflammation and even fibrosis. It has been shown that NAFLD increases the risk of other chronic diseases, particularly chronic kidney disease (CKD). Lipid in excess could lead to liver and kidney lesions and even end-stage disease through diverse pathways. Dysregulation of lipid uptake, oxidation or de novo lipogenesis contributes to the toxic effects of ectopic lipids which promotes the development and progression of NAFLD and CKD via triggering oxidative stress, apoptosis, pro-inflammatory and profibrotic responses. Importantly, dyslipidemia and release of pro-inflammatory cytokines caused by NAFLD (specifically, nonalcoholic steatohepatitis) are considered to play important roles in the pathological progression of CKD. Growing evidence of similarities between the pathogenic mechanisms of NAFLD and those of CKD has attracted attention and urged researchers to discover their common therapeutic targets. Here, we summarize the current understanding of molecular aberrations underlying the lipid metabolism of NAFLD and CKD and clinical evidence that suggests the relevance of these pathways in humans. This review also highlights the orchestrated inter-organ cross-talk in lipid disorders, as well as therapeutic options and opportunities to counteract NAFLD and CKD.
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http://dx.doi.org/10.3390/biomedicines9101405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533451PMC
October 2021

Targeting of EIF4EBP1 by miR-99a-3p affects the functions of B lymphocytes via autophagy and aggravates SLE disease progression.

J Cell Mol Med 2021 Oct 20. Epub 2021 Oct 20.

Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Excessive activation of immune cells plays a key role in the pathogenesis of systemic lupus erythematosus (SLE). The regulation of immune cells by miRNAs is a research hotspot. In this study, second-generation high-throughput sequencing revealed a reduction in miR-99a-3p expression in patients with SLE; however, the specific mechanism underlying this phenomenon remains unclear. After transfection with an miR-99a-3p agomir, the proliferation of Ball-1 cells decreased and the levels of their apoptosis increased. The opposite effects were observed in cells transfected with the miR-99a-3p antagomir. Luciferase reporter assay indicated that miR-99a-3p directly targeted EIF4EBP1. Rescue experiments confirmed the proposed interaction between miR-99a-3p and EIF4EBP1. In vitro, in vivo and clinical investigations further confirmed that the miR-99a-3p agomir reduced the expression of EIF4EBP1, LC3B and LAMP-2A. In the in vivo experiments, serum levels of anti-nuclear antibodies, double-stranded DNA, IgE, IgM, IL-6, IL-10 and B lymphocyte stimulator were higher in mice from the antagomir group than those in mice from the MRL/lpr group. Furthermore, the protein and mRNA levels of EIF4EBP1, LC3B and LAMP-2A, the intensity of immunohistochemical staining of EIF4EBP1, LC3B and LAMP-2A, the urinary protein levels, and the C3 immunofluorescence deposition increased in mice from the antagomir group. The upregulation of miR-99a-3p expression protected B cells from EIF4EBP1-mediated autophagy, whilst the downregulation of miR-99a-3p expression induced autophagy via the EIF4EBP1-mediated regulation of the autophagy signalling pathway in B cells isolated from individuals with SLE. Based on these results, miR-99a-3p and EIF4EBP1 may be considered potential targets for SLE treatment.
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http://dx.doi.org/10.1111/jcmm.16991DOI Listing
October 2021

[A process-based model and simulation system of dynamic change and spatial variation in large-scale terrestrial ecosystems].

Ying Yong Sheng Tai Xue Bao 2021 Aug;32(8):2653-2665

Key Laboratory of Ecosystem Network Observation and Modelling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

More attention has been paid to the monitoring, assessment, prediction, early warning and sustainable management of regional ecological environment and the changes of ecosystem state in recent years. It is an important scientific and technological task to develop quantitative methods and numerical simulation techniques for ecosystem modelling, and to construct the continental scale numerical simulator with the characteristics of multi-process coupling, multi-technology integration, and multi-objective application for stimulating research on ecosystem and global change and its resources, environment and disaster effects, based on the in-depth understanding of the components, processes, functions, patterns, and their interaction mechanism of terrestrial ecosystem. Here, we reviewed the current status and future direction of terrestrial ecosystem models, and discussed the conceptual framework of developing the simulation system of dynamic change and spatial variation in large-scale terrestrial ecosystems and its resource and environment effect, as well as basic issues on the function orientation and structure design of the simulation system, which would provide reference for constructing Chinese terrestrial ecosystem numerical simulator.
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http://dx.doi.org/10.13287/j.1001-9332.202108.040DOI Listing
August 2021

[Multi-disciplinary knowledge integration and its technical approaches in the integrated ecology of macroecosystem science].

Ying Yong Sheng Tai Xue Bao 2021 Sep;32(9):3031-3044

Key Laboratory of Ecosystem Network Observation and Modelling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

The development of contemporary macroecosystem sciences requires to comprehensively understand the process mechanism and model mechanism of large-scale macroecosystem structure and function, spatial variation, and dynamic evolution, to realize quantitative simulation, scientific assessment, prediction and early warning of ecosystem change and its impacts on human well-being, and to serve the utilization, protection, regulation, and management of ecosystems. Therefore, a new research field of large-scale integrated ecology of macroecosystem science (IEMES) is emerging. Based on the systematic analysis of the basic theories, approaches and key technologies of integrated ecology of macroecosystem science, the following basic understandings have been formed: 1) IEMES takes macroecosystem at regional, continental, and global scales as the research object, and adopts the methods and technologies of multidisciplinary knowledge integration. It is aimed to solve the major resource and environmental problems during the development of human society, such as food security, resource security, ecological security, and environmental security. 2) The basic scientific and technological tasks of IEMES are to understand the basic structural and functional properties of macroecosystem, monitor the changes of ecosystem state, explain the spatiotemporal evolution of ecosystem, uncover the mechanism of ecosystem operation and maintenance process, quantitatively evaluate the functional state and service capacity of ecosystem, predict the dynamic evolution and geographical pattern of ecosystem, provide early warning of ecosystem changes and ecological environmental disasters. 3) It is needed to reconstruct the theory and methodology system of "multi-source data analysis, multi-model simulation, multi-disciplinary knowledge fusion" and develop key technology of multi-disciplinary knowledge fusion of "multi-scale observation, multi-method verification, multi-process fusion, and cross-scale simulation" for IEMES. 4) The continental scale multi-spatiotemporal ecosystem observation and experiment network is the basic scientific and technological facility to carry out deep integration of multi-disciplinary knowledge. It is necessary to develop key technology of multi-disciplinary ecological knowledge integration of multi-factor, multi-process, multi-interface, multi-medium, multi-scale, and multi-method around the regional, continental, and global scale macroecosystem science issues.
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http://dx.doi.org/10.13287/j.1001-9332.202109.040DOI Listing
September 2021

Multivariate analysis of factors associated with spinal cord area in single-door cervical laminoplasty with miniplate fixation.

BMC Musculoskelet Disord 2021 Oct 15;22(1):881. Epub 2021 Oct 15.

Department of Operation Room, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Objectives: To explore the factors associated with the increased spinal cord area in single-door cervical laminoplasty (SDCL) with miniplate fixation.

Methods: A retrospective study enrolled 83 patients underwent SDCL with miniplate fixation and the patient characteristics such as age, gender, tobacco use, alcohol use, diabetes mellitus, hypertension, diagnosis, operative level, etc., were obtained. The opening angle, door shaft position and spinal canal area of the patients were measured after surgery. The sagittal canal diameter (SCD), the C2-7 Cobb angle, the cervical curvature index (CCI), the range of motion (ROM) and the spinal canal area were measured before and after operation. The increased cervical spinal cord area was also measured before and after surgery, and the correlation between the above indicators and the increased cervical spinal cord area was studied through Pearson's correlation analysis and multivariate logistic regression analysis.

Results: There were 34 patients in small spinal cord area increment group (SAI group), 29 patients in middle spinal cord area increment group (MAI group) and 20 patients in large spinal cord area increment group (LAI group). The preoperative diagnosis(P = 0.001), door shaft position (P = 0.008), preoperative spinal canal area (P = 0.004) and postoperative spinal canal area (P = 0.015) were significant different among the 3 groups. The multivariate analysis showed that the preoperative diagnosis (OR = 2.076, P = 0.035), door shaft position (OR = 3.425, P = 0.020) and preoperative spinal canal area (OR = 10.217, P = 0.009) were related to increased spinal cord area.

Conclusions: The preoperative diagnosis, door shaft position and preoperative spinal canal area might be associated with increased spinal cord area after cervical laminoplasty with miniplate fixation. Preoperative symptoms are mostly caused by compression of the spinal cord, so spinal cord area enlargement can bring a better recovery in patients alongside long-term. Spine surgeons should pay more attention to the accuracy of the preoperative diagnosis, the preoperative measurement of spinal canal area and the door shaft position during the operation.
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http://dx.doi.org/10.1186/s12891-021-04773-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520309PMC
October 2021

Hepatitis E in 24 Chinese Cities, 2008-2018: A New Analysis Method for the Disease's Occupational Characteristics.

Front Public Health 2021 28;9:720953. Epub 2021 Sep 28.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.

The disease burden of hepatitis E remains high. We used a new method (richness, diversity, evenness, and similarity analyses) to classify cities according to the occupational classification of hepatitis E patients across regions in China and compared the results of cluster analysis. Data on reported hepatitis E cases from 2008 to 2018 were collected from 24 cities (9 in Jilin Province, 13 in Jiangsu Province, Xiamen City, and Chuxiong Yi Autonomous Prefecture). Traditional statistical methods were used to describe the epidemiological characteristics of hepatitis E patients, while the new method and cluster analysis were used to classify the cities by analyzing the occupational composition across regions. The prevalence of hepatitis E in eastern China (Jiangsu Province) was similar to that in the south (Xiamen City) and southwest of China (Chuxiong Yi Autonomous Prefecture), but higher than that in the north (Jilin Province). The age of hepatitis E patients was concentrated between 41 and 60 years, and the sex ratio ranged from 1:1.6 to 1:3.4. Farming was the most highly prevalent occupation; other sub-prevalent occupations included retirement, housework and unemployment. The incidence of occupations among migrant workers, medical staff, teachers, and students was moderate. There were several occupational types with few or no records, such as catering industry, caregivers and babysitters, diaspora children, childcare, herders, and fishing (boat) people. The occupational similarity of hepatitis E was high among economically developed cities, such as Nanjing, Wuxi, Baicheng, and Xiamen, while the similarity was small among cities with large economic disparities, such as Nanjing and Chuxiong Yi Autonomous Prefecture. A comparison of the classification results revealed more similarities and some differences when using these two methods. In China, the factors with the greatest influence on the prevalence of hepatitis E are living in the south, farming as an occupation, being middle-aged or elderly, and being male. The 24 cities we studied were highly diverse and moderately similar in terms of the occupational distribution of patients with hepatitis E. We confirmed the validity of the new method on in classifying cities according to their occupational composition by comparing it with the clustering method.
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http://dx.doi.org/10.3389/fpubh.2021.720953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506125PMC
October 2021

Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining.

Am J Transl Res 2021 15;13(9):9919-9931. Epub 2021 Sep 15.

Department of Orthopedic Surgery, West China Hospital, Sichuan University Chengdu 610041, Sichuan, China.

In this study, we attempted to further collate existing transcriptome sequencing (mRNA-Seq) data by applying data mining and screening intervertebral disc degeneration (IVDD)-related miRNAs. At the same time, combined with published articles, the miRNAs that have been screened out were further excluded, and only the miRNAs confirmed by the reported studies were retained and reviewed. We obtained 12 pro-IVDD miRNAs and ten anti-IVDD miRNAs using the above screening process, involving 33 literature sources. By reviewing and summarizing the above studies, we preliminarily constructed the regulatory network of miRNA in the pathogenesis of IVDD. This regulatory network comprises many gaps and potential miRNA interactions, and these points may be the breakthrough points for further IVDD-related research. This new review approach can also provide a reference for the mechanistic studies of other diseases.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507033PMC
September 2021

Analysis of the risk factors for central lymph node metastasis of cN0 papillary thyroid microcarcinoma: A retrospective study.

Asian J Surg 2021 Oct 9. Epub 2021 Oct 9.

Department of General Surgery, China-Japan Friendship Hospital, Beijing, 100029, China.

Objective: Cervical lymph node (CLN) metastasis (CLNM) can be found in some patients with CLN-negative (cN0) papillary thyroid microcarcinoma (PTMC), while the risk factors are still unknown. This study aimed to examine the risk factors of CLNM in patients with cN0 PTMC, contributing to screening cN0 PTMC patients with high risk in CLNM for preventive CLN dissection (CLND).

Methods: This retrospective study included consecutive patients pathologically diagnosed with cN0 PTMC and who underwent surgery at the General Surgery Department of China-Japan Friendship Hospital between 07/2016 and 01/2020. The patients were grouped according to whether CLNM was present. Factors associated with CLNM were analyzed, and a risk prediction model was established in logistic regression analysis, and their predictive power was evaluated by receiver operating characteristic curves (ROC).

Results: Finally, 171 patients were included; among them, 71 (41.5%) had CLNM. There were 32 males and 139 females. The multivariable analysis showed that males (OR = 5.619, 95%CI: 2.186-14.446; P < 0.001), age ≤45 years (OR = 2.982, 95%CI: 1.446-6.151; P = 0.003), adjacent to dorsal membrane (OR = 3.022, 95%CI: 1.430-6.387; P = 0.004), and irregular borders (OR = 4.332, 95%CI: 1.104-17.000; P = 0.036) were independent risk factors of CLNM. The risk prediction model composed of the four risk factors showed a relatively high AUC, at 0.760. When the cut-off was 0.38, the sensitivity was 67.6%, and the specificity was 73.0%.

Conclusion: Male sex, age ≤45 years, adjacent to dorsal membranes, and irregular borders are independent risk factors for CLNM in patients with cN0 PTMC. This might help identify cN0 PTMC patients needing preventive CLND.
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http://dx.doi.org/10.1016/j.asjsur.2021.09.014DOI Listing
October 2021

The Immediate and Lasting Effect of Emotion Regulation in Adolescents: An ERP Study.

Int J Environ Res Public Health 2021 09 29;18(19). Epub 2021 Sep 29.

Faculty of Psychology and Political Science, Eastern New Mexico University, Portales, NM 88130, USA.

The immediate effect is an important index of the outcomes of emotion regulation. However, in daily life, whether the effect of emotion regulation lasts and the lasting mechanism have been examined less. The present research focused on the relationships between the immediate and lasting effect of the emotion regulation of adolescents. Electroencephalogram (EEG) was recorded from 51 adolescents (31 boys and 20 girls, Mage = 12.82) during online emotion regulation using the Reactivity and Regulation-Image Task (phase 1) and re-presentation of emotional stimuli after a period of time (phase 2). Event-related potentials (ERPs) related to emotion regulation, such as N2, P3, and the late positive potential (LPP), were examined in the two phases. The results showed that: (1) In both of the two phases, in negative emotion conditions, the amplitudes of P3 and LPP 300-600 of no-regulation conditions were significantly higher than those in reappraisal conditions. However, there was no significant difference under neutral conditions; (2) The amplitudes of P3, N2, and LPP 300-600 during emotion regulation in phase 1 positively predicted the amplitudes of P3, N2, and LPP300-600 in phase 2 in different experimental conditions. Results from the regression analysis implied that the immediate effect of online emotion regulation may predict the lasting effect when adolescents face the same emotions again. In addition, our findings provide neurological evidence that the use of cognitive reappraisal could effectively help adolescents to reduce the recruitment of cognitive resources when they regulate negative emotions and when they face those negative emotions again.
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http://dx.doi.org/10.3390/ijerph181910242DOI Listing
September 2021

A novel electrochemical sensor based on TAPT-TFP-COF/COOH-MWCNT for simultaneous detection of dopamine and paracetamol.

Anal Methods 2021 Oct 11. Epub 2021 Oct 11.

Key Lab of Eco-Environments Related Polymer Materials of MOE, Key Lab of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Lanzhou 730070, PR China.

In this work, a covalent organic framework (COF) TAPT-TFP-COF containing a triazine ring was prepared by a typical Schiff base condensation reaction of 1,3,5-tris-(4-aminophenyl)triazine (TAPT) and 1,3,5-triformyl phloroglucinol (TFP). The TAPT-TFP-COF and carboxyl-functionalized multi-wall carbon nanotubes (COOH-MWCNTs) were drip-coated on glassy carbon electrode respectively to develop a novel and simple electrochemical sensor in order to simultaneously detect dopamine (DA) and paracetamol (PA). COOH-MWCNTs interconnected the TAPT-TFP-COF and acted as bridges between the COF particles, which had a good synergistic effect and accelerated electron transfer. Under optimal conditions, linear responses were obtained over the concentration range 1-190 μM for DA and PA with limits of detection (LOD) of 0.14 μM and 0.19 μM, respectively. Furthermore, the fabricated sensor possesses outstanding repeatability and high selectivity, and can be applied for the determination of DA and PA in dopamine injection and acetaminophen drugs with satisfactory recoveries.
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http://dx.doi.org/10.1039/d1ay01537kDOI Listing
October 2021

Fabrication, characterization and functional attributes of zein-egg white derived peptides (EWDP)-chitosan ternary nanoparticles for encapsulation of curcumin: Role of EWDP.

Food Chem 2021 Sep 30;372:131266. Epub 2021 Sep 30.

Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, People's Republic of China. Electronic address:

The food-derived peptides hydrolyzed from native food protein matrix exhibited various bioactivities and multimeric structures, which make them the promising well-defined nanoplatforms candidates to co-deliver themselves with other bioactive compounds. In this study, zein-egg white derived peptides-chitosan (Z-EWDP-CS) ternary nanoparticles (NPs) were successfully fabricated by the spontaneous assembly to enhance the stability and bioactivity of curcumin (Cur). The novel ternary NPs exhibited a typical nano-spherical structure (138.63 nm, 40.50 mV), and adorable encapsulation efficiency (EE, 93.87%) for Cur. FTIR, XRD and DSC results verified that Cur changed from a crystalline state to an amorphous state, and was successfully entrapped in the cavity of Z-EWDP-CS NPs. Furthermore, the thermal stability, photochemical stability, salt stability, and antioxidant activity were considerably improved in the NPs after the addition of EWDP. Our results demonstrate that the food-derived peptides could be an ideal affinity agent for the co-delivery of themselves with hydrophobic nutraceuticals.
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http://dx.doi.org/10.1016/j.foodchem.2021.131266DOI Listing
September 2021

The relationship between habitual use and real-time emotion regulation strategies in adolescents: Evidence from frontal EEG asymmetry.

Neuropsychologia 2021 Oct 8;162:108056. Epub 2021 Oct 8.

Department of Psychology, Eastern New Mexico University, USA.

Past research on emotion regulation has shown that cognitive reappraisal is a healthier and more effective emotion regulation strategy than expressive suppression. However, there are few studies in this field that combine real-time emotion regulation with the use of habitual emotion regulation strategies to observe the patterns of brain activity, and fewer studies focusing on adolescents. Frontal electroencephalography (EEG) asymmetry reflects the difference between brain activation in left and right frontal areas and is widely viewed as an effective biomarker of emotional reactivity and regulation. The present study investigated the asymmetry of the frontal EEG activity during adolescents' emotional regulation, and explored its relationship with adolescents' habitual use of emotional regulation strategies. Habitual use of cognitive reappraisal and expressive suppression was measured with the emotion regulation questionnaire (ERQ). EEG was recorded from 54 adolescents (24 boys & 30 girls, M = 12.59), during the Reactivity and Regulation-Image Task. Results showed that adolescents who used cognitive reappraisal strategies more habitually exhibited greater left frontal asymmetry during real-time enhancement or reduction of negative emotions. In contrast, no significant correlation was found between habitual use of suppression and frontal alpha asymmetry. The results provide neurological evidence that, for adolescents, the use of habitual emotion regulation strategies may affect real-time emotion regulation, adolescents who use cognitive reappraisal more frequently are more capable or more prone to recruit appropriate brain regions in situations that need to regulate negative emotions. This reinforces the importance of the formation and use of correct emotion regulation habits for adolescents.
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http://dx.doi.org/10.1016/j.neuropsychologia.2021.108056DOI Listing
October 2021

The neonatal PROC gene rs1799809 polymorphism modifies the association between prenatal air pollutants exposure and PROC promoter methylation.

Environ Sci Pollut Res Int 2021 Oct 6. Epub 2021 Oct 6.

Department of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.

Prenatal air pollution, protein C (PROC) gene abnormal methylation, and genetic mutation can cause a series of neonatal diseases, but the complex relationship between them remains unclear. Here, we recruited 552 mothers and their own babies during January 2010-January 2012 in Zhengzhou to explore such association. The air pollutant data was obtained from the Environmental Monitoring Stations. The rs1799809 genotype and the methylation levels at the promoter region of PROC in genomic DNA samples were detected respectively by TaqMan probe and quantitative methylation specific PCR using real-time PCR system. The results show that the levels of neonatal PROC methylation were negatively associated with concentrations of NO during the entire pregnancy, particularly during the third trimester. Of particular significance, only in newborns carrying rs1799809 AA genotype, negatively significant associations between PROC methylation levels and exposure concentrations of air pollutants were observed. Further, we observed a significant interactive effect between neonatal rs1799809 genotype and SO exposure during the entire pregnancy on neonatal PROC methylation levels. Prenatal exposure to ambient air pollutants specifically was associated with the neonatal PROC promoter methylation level of newborns carrying the rs1799809 AA genotype. Taken together, these findings suggest that neonatal PROC methylation levels are associated with prenatal exposure to ambient air pollutants, and this association can be modified by rs1799809 genotype.
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http://dx.doi.org/10.1007/s11356-021-16694-1DOI Listing
October 2021

Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis.

Drug Des Devel Ther 2021 29;15:4105-4123. Epub 2021 Sep 29.

Department of Pharmacy, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China.

Purpose: The effective treatment of ulcerative colitis (UC) poses substantial challenges, and the aetiopathogenesis of UC is closely related to infectious, immunological and environmental factors. Currently, there is a considerable need for the development of orally bioavailable dosage forms that enable the effective delivery of therapeutic drugs to local diseased lesions in the gastrointestinal tract.

Methods: Berberine (BBR) and Koidz (AM) volatile oil, derived from the Chinese herbs Franch and Koidz, have anti-inflammatory and immunomodulatory activities. In this study, we prepared colon-targeted pellets loaded with BBR and stomach-targeted pellets loaded with AM volatile oil for the synergistic treatment of UC. The Box-Behnken design and β-cyclodextrin inclusion technique were used to optimize the enteric coating formula and prepare volatile oil inclusion compounds.

Results: The two types of pellets were spherical and had satisfactory physical properties. The pharmacokinetic results showed that the AUC and MRT values of the dual-targeted (DPs) pellets were higher than those of the control pellets. In addition, in vivo animal imaging confirmed that the DPs could effectively deliver BBR to the colon. Moreover, compared with sulfasalazine and monotherapy, DPs exerted a more significant anti-inflammatory effect by inhibiting the expression of inflammatory factors including IL-1β, IL-4, IL-6, TNF-α and MPO both in serum and tissues and enhancing immunity by decreasing the production of IgA and IgG.

Conclusion: The DPs play a synergistic anti-UC effect by exerting systemic and local anti-inflammatory and provide an effective oral targeted preparation for the treatment of UC.
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http://dx.doi.org/10.2147/DDDT.S322702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489837PMC
September 2021

Atomically Dispersed Co Sites Incorporated into a Silicalite-1 Zeolite Framework as a High-Performance and Coking-Resistant Catalyst for Propane Nonoxidative Dehydrogenation to Propylene.

ACS Appl Mater Interfaces 2021 Oct 7;13(41):48934-48948. Epub 2021 Oct 7.

Institute of Molecular Catalysis and In-Situ/Operando Studies, College of Chemistry, Fuzhou University, Fuzhou 350108, P. R. China.

Propane nonoxidative dehydrogenation (PDH) is a promising route to produce propylene with the development of shale gas exploration technology. Co-based catalysts with low cost and low toxicity could activate C-H effectively, but they suffer from deactivation with coke formation. In this work, a catalyst formed by incorporating highly dispersed Co sites into a Silicalite-1 zeolite framework (Co-Silicalite-1) is synthesized by a hydrothermal protocol in the presence of ammonia, which exhibits superior propane dehydrogenation catalytic performance with 0.0946 mmol CH·s·g and propylene selectivity higher than 98.5%. It also shows outstanding catalytic stability and coking resistance in a 3560 min time-on-stream. Combined characterization results demonstrate that the tetrahedrally coordinated Co site serves as the PDH catalytic active site, which is stabilized by Si-O units of the zeolite framework. Incorporation of Co sites into the zeolite framework could avoid the reduction of Co species to metallic Co. Moreover, the catalytic performance is improved by the enhanced propane adsorption and propylene desorption.
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http://dx.doi.org/10.1021/acsami.1c15892DOI Listing
October 2021

Au Nanoclusters Exhibit Superhigh Catalytic Activity in Electrochemical Detection of As(III).

Anal Chem 2021 Oct 4;93(41):14014-14023. Epub 2021 Oct 4.

Key Laboratory of Environmental Optics and Technology, And Environmental Materials and Pollution Control Laboratory, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, China.

An atomic-level Au nanocluster, as an excellent photocatalyst, is generally not considered as an efficient electrocatalyst due to its poor stability. Herein, a method is proposed to stabilize abundant Au on FeO nanoplates (Au/OV-FeO) successfully with oxygen vacancies (OV) created. Au/OV-FeO shows superhigh catalysis in the electrochemical reduction toward As(III). The record-breaking sensitivity (161.42 μA ppb) is two orders of magnitude higher than currently reported, where an ultratrace limit of detection (9 ppt) is obtained, suggesting promising applications in the analysis of organic and bioactive substances. The stability of Au is attributed to the Au-Fe bond formed after loading Au nanoclusters on FeO nanoplates through "electron compensation" and bond length (Au-S) shortening. Moreover, the ligand S atoms in Au nanoclusters significantly contribute to the reduction of As(III). The fantastic stability and superior catalytic ability of Au/OV-FeO provide guidelines to stabilize Au nanoclusters on metal oxides, indicating their potential electroanalytical applications.
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http://dx.doi.org/10.1021/acs.analchem.1c03748DOI Listing
October 2021

Fabrication of Injectable Chitosan-Chondroitin Sulfate Hydrogel Embedding Kartogenin-Loaded Microspheres as an Ultrasound-Triggered Drug Delivery System for Cartilage Tissue Engineering.

Pharmaceutics 2021 Sep 16;13(9). Epub 2021 Sep 16.

Department of Sports Medicine, Peking University Third Hospital, Beijing 100083, China.

Ultrasound-responsive microspheres (MPs) derived from natural polysaccharides and injectable hydrogels have been widely investigated as a biocompatible, biodegradable, and controllable drug delivery system and cell scaffolds for tissue engineering. In this study, kartogenin (KGN) loaded poly (lactide--glycolic acid) (PLGA) MPs ([email protected]) were fabricated by premix membrane emulsification (PME) method which were sonicated by an ultrasound transducer. Furthermore, carboxymethyl chitosan-oxidized chondroitin sulfate (CMC-OCS) hydrogel were prepared via the Schiff' base reaction-embedded MPs to produce a CMC-OCS/MPs scaffold. In the current work, morphology, mechanical property, porosity determination, swelling property, in vitro degradation, KGN release from scaffolds, cytotoxicity, and cell bioactivity were investigated. The results showed that MPs presented an obvious collapse after ultrasound treatment. The embedded PLGA MPs could enhance the compressive elastic modulus of soft CMC-OCS hydrogel. The cumulative release KGN from MPs exhibited a slow rate which would display an appropriate collapse after ultrasound, allowing KGN to maintain a continuous concentration for at least 28 days. Moreover, the composite [email protected] scaffolds exhibited faster gelation, lower swelling ratio, and lower in vitro degradation. CCK-8 and LIVE/DEAD staining showed these scaffolds did not influence rabbit bone marrow mesenchymal stem cells (rBMMSCs) proliferation. Then these scaffolds were cultured with rBMMSCs for 2 weeks, and the immunofluorescent staining of collagen II (COL-2) showed that CMC-OCS hydrogel embedded with [email protected] ([email protected]@KGN) with ultrasound had the ability to increase the COL-2 synthesis. Overall, due to the improved mechanical property and the ability of sustained KGN release, this injectable hydrogel with ultrasound-responsive property is a promising system for cartilage tissue engineering.
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http://dx.doi.org/10.3390/pharmaceutics13091487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472453PMC
September 2021

A self-assembled amphiphilic polysaccharide-based co-delivery system for egg white derived peptides and curcumin with oral bioavailability enhancement.

Food Funct 2021 Sep 27. Epub 2021 Sep 27.

Jilin Provincial Key Laboratory of Nutrition and Functional Food, College of Food Science and Engineering, Jilin University, Changchun 130062, China.

Egg white derived peptides (EWDP) and curcumin are well known for diverse biological activities, but the combinational usage of the two natural nutraceuticals is extremely limited by their low oral bioavailability and distinctly different polarities. Therefore, this study aimed to exploit a facile self-assembled amphiphilic system for oral co-delivery of hydrophilic egg white derived peptides (EWDP) and hydrophobic curcumin. The hydrophobic curcumin was first loaded into the hydrophobic cavity of β-cyclodextrin (β-CD) as a core. Then, the hydrophilic EWDP was absorbed into the region between the core and the -[(2-hydroxy-3-trimethyl ammonium) propyl] chitosan (HTCC) shell to form the amphiphilic nanoparticles (NPs) layer-by-layer self-assembly. The resulting NPs showed ideal oral applicability with excellent colloidal properties and encapsulation capacity for EWDP and curcumin at pH 2.0-7.0. X-ray Photoelectron Spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (H NMR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC) results indicated that hydrogen bonding and hydrophobic interaction were the main driving force for the formation of amphiphilic NPs. Upon combination with HTCC, EWDP (both shell material and core nutraceuticals) could facilitate curcumin loading into the deeper β-CD cavity site with admirable solubility improvement. Moreover, EWDP and curcumin after co-delivery exhibited superior bioavailability (especially for bioactivity and cellular absorption) than the simple mixture and conventional curcumin inclusion complex. Overall, these findings are enlightening for the rational peptide based oral co-delivery system formulations for a broader range of hydrophilic and hydrophobic nutraceuticals (initially synergistic or not) in the food and related health-promoting fields.
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http://dx.doi.org/10.1039/d1fo01649kDOI Listing
September 2021

Incidence and diseases burden of coal workers' pneumoconiosis worldwide, 1990-2019: evidence from the Global Burden of Disease Study 2019.

Eur Respir J 2021 Sep 24. Epub 2021 Sep 24.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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http://dx.doi.org/10.1183/13993003.01669-2021DOI Listing
September 2021

The prevalence and global burden of hearing loss in 204 countries and territories, 1990-2019.

Environ Sci Pollut Res Int 2021 Sep 23. Epub 2021 Sep 23.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.

We aimed to describe the global prevalence and temporal trends of hearing loss. We collected detailed information of hearing loss from the Global Burden of Disease study between 1990 and 2019. Average annual percentage changes (AAPCs) in hearing loss age-standardized prevalence rate (ASPR), by sex, region, and category, were calculated to quantify the temporal prevalence trends. Globally, the prevalent cases of hearing loss increased from 7514.97×10 in 1990 to 14566.62×10 in 2019, and the ASPR increased from 173.33×10 per 100,000 in 1990 to 177.56×10 per 100,000 in 2019. The years lived with disability (YLDs) increased from 220080.97×10 in 1990 to 402353.05×10 in 2019. The AAPC was 83.27 (95% CI 70.66, 95.88) ×10 in prevalence and -72.87 (95% CI -92.18, -53.56) ×10 in YLDs. Significant correlations of AAPCs with ASPR (r=-0.60, p<0.001), and age-standardized YLD rate (r=-0.43, p=0.0012 for YLD<455, r=0.32, p<0.001 for YLD≥455) were detected. The YLDs of hearing loss owing to occupational noise (HLOON) increased from 39334.39 (95% UI 26881.04, 55999.67) ×10 in 1990 to 70014.49 (98% UI 47605.62, 100593.43) ×10 in 2019, and the increasing AAPC was observed for females and aged between 15 and 49 years old in global and most regions. The age effect was under zero in 7 age groups, the period effect of hearing loss prevalence was increasing and the birth cohort effect was decreasing with the time advance. The number of cases and ASPR of hearing loss in the world is still growing. Efforts to control hearing loss, especially HLOON, are imminent.
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http://dx.doi.org/10.1007/s11356-021-16582-8DOI Listing
September 2021

Immune-Related Multiple-Organs Injuries Following ICI Treatment With Tislelizumab in an Advanced Non-Small Cell Lung Cancer Patient: A Case Report.

Front Oncol 2021 2;11:664809. Epub 2021 Sep 2.

Department of Medical Oncology, Integrated Traditional Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing, China.

Immune-related adverse events (irAEs) following treatment with immune checkpoint inhibitors (ICIs) can affect almost any organ systems. Multiple-organs irAEs are a rare occurrence which makes its management and treatment very challenging. This is a case report of a 71-year-old man with advanced non-small cell lung cancer (NSCLC) who developed multiple-organs irAEs (lung, muscle, myocardium, liver, and pituitary) after a single cycle (21 days) of the BGB-A317 (Tislelizumab). After more than two months of immunosuppression treatment with glucocorticoids, the tumor and inflammatory lesions in the lung were reduced. The levels of serum creatase, cardiac troponin T (TNT), and hepatic transaminase were also reduced. Four months after the termination of ICI therapy, the lung tumor reappeared in the previous site. This rare case report supplies several experiences in the management of multiple-organs irAEs, including full-scale monitoring of immunological indicators, early differential diagnosis, and prompt glucocorticoid therapy. This patient was not a candidate for the ICI re-challenge therapy due to the number and seriousness of irAEs. Multiple-organs irAEs add complexity to the management, and additional research is needed to develop optimal therapeutic guidelines.
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http://dx.doi.org/10.3389/fonc.2021.664809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443792PMC
September 2021

Activity of keloids evaluated by multimodal photoacoustic/ultrasonic imaging system.

Photoacoustics 2021 Dec 11;24:100302. Epub 2021 Sep 11.

Department of Ultrasonography, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Multiple objective assessments have been used to assess the activity of keloids to compare different therapeutic regimens and facilitate the best individual treatment choice for patients, but none of them are standardized. A multimodal photoacoustic/ultrasonic (PA/US) imaging system, including photoacoustic imaging, elastography, ultra-micro-angiography, and conventional US technologies (gray scale US, color Doppler US, and power Doppler US), was applied to evaluate keloids by a radiologist. Growing stages were defined by patients, and Vancouver Scar Scale (VSS) was assessed by a plastic surgeon. A comprehensive model based on multimodal ultrasound parameters (poor-echo pattern, high vascular density, decreased elasticity, and low SO within the keloid) and VSS might be a potential indicator of active keloids, comparing with VSS alone. The multimodal PA/US imaging system could be a promising technique for keloids assessment.
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http://dx.doi.org/10.1016/j.pacs.2021.100302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441086PMC
December 2021

Impact of interventions on the incidence of natural focal diseases during the outbreak of COVID-19 in Jiangsu Province, China.

Parasit Vectors 2021 Sep 19;14(1):483. Epub 2021 Sep 19.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, People's Republic of China.

Background: During the period of the coronavirus disease 2019 (COVID-19) outbreak, strong intervention measures, such as lockdown, travel restriction, and suspension of work and production, may have curbed the spread of other infectious diseases, including natural focal diseases. In this study, we aimed to study the impact of COVID-19 prevention and control measures on the reported incidence of natural focal diseases (brucellosis, malaria, hemorrhagic fever with renal syndrome [HFRS], dengue, severe fever with thrombocytopenia syndrome [SFTS], rabies, tsutsugamushi and Japanese encephalitis [JE]).

Methods: The data on daily COVID-19 confirmed cases and natural focal disease cases were collected from Jiangsu Provincial Center for Disease Control and Prevention (Jiangsu Provincial CDC). We described and compared the difference between the incidence in 2020 and the incidence in 2015-2019 in four aspects: trend in reported incidence, age, sex, and urban and rural distribution. An autoregressive integrated moving average (ARIMA) (p, d, q) × (P, D, Q) model was adopted for natural focal diseases, malaria and severe fever with thrombocytopenia syndrome (SFTS), and an ARIMA (p, d, q) model was adopted for dengue. Nonparametric tests were used to compare the reported and the predicted incidence in 2020, the incidence in 2020 and the previous 4 years, and the difference between the duration from illness onset date to diagnosed date (DID) in 2020 and in the previous 4 years. The determination coefficient (R) was used to evaluate the goodness of fit of the model simulation.

Results: Natural focal diseases in Jiangsu Province showed a long-term seasonal trend. The reported incidence of natural focal diseases, malaria and dengue in 2020 was lower than the predicted incidence, and the difference was statistically significant (P < 0.05). The reported incidence of brucellosis in July, August, October and November 2020, and SFTS in May to November 2020 was higher than that in the same period in the previous 4 years (P < 0.05). The reported incidence of malaria in April to December 2020, HFRS in March, May and December 2020, and dengue in July to November 2020 was lower than that in the same period in the previous 4 years (P < 0.05). In males, the reported incidence of malaria in 2020 was lower than that in the previous 4 years, and the reported incidence of dengue in 2020 was lower than that in 2017-2019. The reported incidence of malaria in the 20-60-year age group was lower than that in the previous 4 years; the reported incidence of dengue in the 40-60-year age group was lower than that in 2016-2018. The reported cases of malaria in both urban and rural areas were lower than in the previous 4 years. The DID of brucellosis and SFTS in 2020 was shorter than that in 2015-2018; the DID of tsutsugamushi in 2020 was shorter than that in the previous 4 years.

Conclusions: Interventions for COVID-19 may help control the epidemics of natural focal diseases in Jiangsu Province. The reported incidence of natural focal diseases, especially malaria and dengue, decreased during the outbreak of COVID-19 in 2020. COVID-19 prevention and control measures had the greatest impact on the reported incidence of natural focal diseases in males and people in the 20-60-year age group.
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http://dx.doi.org/10.1186/s13071-021-04986-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449989PMC
September 2021

Catalytic pyrolysis of linear low-density polyethylene using recycled coal ash: Kinetic study and environmental evaluation.

Korean J Chem Eng 2021 Sep 10:1-12. Epub 2021 Sep 10.

New Materials Institute, University of Nottingham Ningbo China, Ningbo, 315042 P. R. China.

Catalytic pyrolysis offers a sustainable route to convert plastic wastes into fuel. We investigated the catalytic performance of coal ash (fly and bottom ash) at blending ratio of 5 wt%, and 15 wt% during pyrolysis of linear low-density polyethylene (LLDPE). The influence on activation energy and oil was characterized via thermogravimetric analyzer (TGA) and gas chromatography-mass spectrometry (GC-MS). Results have shown that 15 wt% bottom ash exhibited higher catalytic activity. The activation energy estimated by Coats-Redfern method decreased from 458.7 kJ·mol to 437.8 kJ·mol, while the alicyclic hydrocarbon yield increased from 5.97% to 32.09%. This implies that CaO, which is abundant in bottom ash, could promote the conversion of LLDPE. Furthermore, a cradle-to-factory gate life cycle assessment was performed to investigate three scenarios (non-catalytic pyrolysis, 15 wt% fly ash, and 15 wt% bottom ash) of LLDPE conversion strategies via a normalization and weighting approach. It was found that LLDPE pyrolysis with 15 wt% bottom ash also showed the lowest normalized score of 2.83, implying the lowest environmental impact. This work has demonstrated that the recycling of coal ash, particularly bottom ash, as catalysts for LLDPE pyrolysis is effective.
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http://dx.doi.org/10.1007/s11814-021-0870-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432283PMC
September 2021

Partial uncinatectomy combined with anterior cervical discectomy and fusion for the treatment of one-level cervical radiculopathy: analysis of clinical efficacy and sagittal alignment.

BMC Musculoskelet Disord 2021 Sep 12;22(1):777. Epub 2021 Sep 12.

Department of Orthopedic Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Rd, Chengdu, China.

Background: Biomechanical studies have demonstrated that uncovertebral joint contributes to segment mobility and stability to a certain extent. Simultaneously, osteophytes arising from the uncinate process are a common cause of cervical spondylotic radiculopathy (CSR). For such patients, partial uncinatectomy (UT) may be required. However, the clinical efficacy and sagittal alignment of partial UT during anterior cervical discectomy and fusion (ACDF) have not been fully elucidated.

Methods: A total of 87 patients who had undergone single level ACDF using a zero-profile device from July 2014 to December 2018 were included. Based on whether the foraminal part of the uncovertebral joint was resected or preserved, the patients were divided into the ACDF with UT group (n = 37) and the ACDF without UT group (n = 50). Perioperative data, radiographic parameters, clinical outcomes, and complications were compared between the two groups.

Results: The mean follow-up was 16.86 ± 5.63 and 18.36 ± 7.51 months in the ACDF with UT group and ACDF without UT group, respectively (p > 0.05). The average preoperative VAS arm score was 5.89 ± 1.00 in the ACDF with UT group and 5.18 ± 1.21 in the ACDF without UT group (p = 0.038). However, the average VAS arm score was 4.22 ± 0.64, 4.06 ± 1.13 and 1.68 ± 0.71, 1.60 ± 0.70 at 1 week post operation and at final follow up, respectively, (p > 0.05). We also found that the C2-7 SVA and St-SVA at the last follow-up and their change (last follow-up value - preoperative value) in the ACDF with UT group were significantly higher than ACDF without UT group (p < 0.05). No marked differences in the other cervical sagittal parameters, fusion rate or complications, including dysphagia, ASD, and subsidence, were observed.

Conclusions: Our result indicates that ACDF using a zero-p implant with or without partial UT both provide satisfactory clinical efficacy and acceptable safety. However, additional partial UT may has a negative effect on cervical sagittal alignment.
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http://dx.doi.org/10.1186/s12891-021-04680-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436428PMC
September 2021

Comparative studies on the physicochemical profile and potential hypoglycemic activity of different tea extracts: Effect on sucrase-isomaltase activity and glucose transport in Caco-2 cells.

Food Res Int 2021 10 14;148:110604. Epub 2021 Jul 14.

Key Laboratory of Horticultural Plant Biology, Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Tea is one of the most popular beverages in the world and is believed to be beneficial for health. The main components in tea change greatly depending on different processes, and thus, the effects of different teas on human health may differ. In this study, we compared the effect of green, oolong, black, and dark tea extracts on sucrase-isomaltase (SI) activity and glucose transport, which are two intervention options for postprandial blood glucose control, using Caco-2 cells as a model. Theaflavin-rich black tea extracts showed the highest inhibition of SI activity and retardation of the hydrolysis of sucrose, maltose, and isomaltose, with IC values of 8.34 μg/mL, 16.10 μg/mL, and 21.63 μg/mL, respectively. All four kinds of tea extracts caused a dose-dependent inhibition of glucose transport, which were closely related to the catechin content. Green tea extracts showed the highest inhibition of glucose transport and was more effective against sodium-dependent glucose cotransporter 1 (SGLT1) than glucose transporter 2 (GLUT2) in the management of glucose transport. Black tea extracts also inhibited glucose transport despite low level of catechins. The reason could partly lie in the suppression of Na/K-ATPase, which reduced the energy needed for SGLT1 to actively transport glucose. Furthermore, the mRNA level of SI, SGLT1, GLUT2, and Na/K-ATPase in Caco-2 cells were significantly reduced after treatment with tea extracts for 2 h. These in vitro studies suggested that tea could be used as a functional food in the diet to modulate postprandial hyperglycaemia for diabetic patients.
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http://dx.doi.org/10.1016/j.foodres.2021.110604DOI Listing
October 2021

Boosting sensitive and selective detection toward Pb(II) via activation effect of Co and orbital coupling between Pb and O over [email protected] nanocatalyst.

J Hazard Mater 2021 Aug 21;416:126157. Epub 2021 May 21.

Key Laboratory of Environmental Optics and Technology, And Environmental Materials and Pollution Control Laboratory, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, China; Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address:

Fruitful achievements on electrochemical detection toward Pb(II) have been achieved, and their good performance is generally attributed to the adsorption property of nanomaterials. However, the design of sensing interfaces from the electronic structure and electron transfer process is limited. Here, [email protected] acquired an ultra-high detection sensitivity of 103.11 µA µM toward Pb(II), outperforming the results previously reported. The interfacial oxygen atoms build an electron bridge for Co activating CoO. Particularly, new energy levels of oxygen atoms were generated and matched with that of Pb(II). The strong orbital coupling effect between O and Pb makes the [email protected] sensitive and selective toward Pb(II). Compared with Co metal and CoO, Pb(II) got more electrons from [email protected], and longer Pb-O bonds were formed, allowing more Pb(II) to be catalyzed and reduced. Also, the superior stability and reproducibility of electrochemical detection make electrodes practicably. This work reveals that metals can stimulate intrinsically catalytic activity of their metal oxides, with the generation of orbit energy levels that match to a specific analyte. It provides a promising strategy for constructing sensitive and selective sensing interfaces toward ultra-low concentration analyte in body fluid and other complex samples.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126157DOI Listing
August 2021

Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports: a retrospective, multi-cohort, diagnostic study.

Cancer Biol Med 2021 Sep 7. Epub 2021 Sep 7.

Department of Maxillofacial and Otorhinolaryngology Oncology, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China.

Objective: Large volume radiological text data have been accumulated since the incorporation of electronic health record (EHR) systems in clinical practice. We aimed to determine whether deep natural language processing algorithms could aid radiologists in improving thyroid cancer diagnosis.

Methods: Sonographic EHR data were obtained from the EHR database. Pathological reports were used as the gold standard for diagnosing thyroid cancer. We developed thyroid cancer diagnosis based on natural language processing (THCaDxNLP) to interpret unstructured sonographic text reports for thyroid cancer diagnosis. We used the area under the receiver operating characteristic curve (AUROC) as the primary metric to measure the performance of the THCaDxNLP. We compared the performance of thyroid ultrasound radiologists aided with THCaDxNLP those without THCaDxNLP using 5 independent test sets.

Results: We obtained a total number of 788,129 sonographic radiological reports. The number of thyroid sonographic data points was 132,277, 18,400 of which were thyroid cancer patients. Among the 5 test sets, the numbers of patients per set were 439, 186, 82, 343, and 171. THCaDxNLP achieved high performance in identifying thyroid cancer patients (the AUROC ranged from 0.857-0.932). Thyroid ultrasound radiologists aided with THCaDxNLP achieved significantly higher performances than those without THCaDxNLP in terms of accuracy (93.8% 87.2%; one-sided -test, adjusted = 0.003), precision (92.5% 86.0%; = 0.018), and F1 metric (94.2% 86.4%; = 0.007).

Conclusions: THCaDxNLP achieved a high AUROC for the identification of thyroid cancer, and improved the accuracy, sensitivity, and precision of thyroid ultrasound radiologists. This warrants further investigation of THCaDxNLP in prospective clinical trials.
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http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0509DOI Listing
September 2021

Containing the Transmission of COVID-19: A Modeling Study in 160 Countries.

Front Med (Lausanne) 2021 18;8:701836. Epub 2021 Aug 18.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.

It is much valuable to evaluate the comparative effectiveness of the coronavirus disease 2019 (COVID-19) prevention and control in the non-pharmacological intervention phase of the pandemic across countries and identify useful experiences that could be generalized worldwide. In this study, we developed a susceptible-exposure-infectious-asymptomatic-removed (SEIAR) model to fit the daily reported COVID-19 cases in 160 countries. The time-varying reproduction number ( ) that was estimated through fitting the mathematical model was adopted to quantify the transmissibility. We defined a synthetic index ( ) based on the value of to reflect the national capability to control COVID-19. The goodness-of-fit tests showed that the SEIAR model fitted the data of the 160 countries well. At the beginning of the epidemic, the values of of countries in the European region were generally higher than those in other regions. Among the 160 countries included in the study, all European countries had the ability to control the COVID-19 epidemic. The Western Pacific Region did best in continuous control of the epidemic, with a total of 73.76% of countries that can continuously control the COVID-19 epidemic, while only 43.63% of the countries in the European Region continuously controlled the epidemic, followed by the Region of Americas with 52.53% of countries, the Southeast Asian Region with 48% of countries, the African Region with 46.81% of countries, and the Eastern Mediterranean Region with 40.48% of countries. Large variations in controlling the COVID-19 epidemic existed across countries. The world could benefit from the experience of some countries that demonstrated the highest containment capabilities.
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http://dx.doi.org/10.3389/fmed.2021.701836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416347PMC
August 2021
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