Publications by authors named "Meng Wang"

3,342 Publications

  • Page 1 of 1

Ultrasound-guided injection of botulinum toxin type A blocks cardiac sympathetic ganglion to improve cardiac remodeling in a large animal model of chronic myocardial infarction.

Heart Rhythm 2022 Aug 7. Epub 2022 Aug 7.

Department of Cardiology, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous Research Center, Wuhan University; Department of Cardiology Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, China. Electronic address:

Background: Strategies to improve various cardiovascular diseases by blocking cardiac sympathetic ganglion have been increasingly available currently. Botulinum toxin type A (BTA), a typical neurotoxin, has been shown to block neural transmission in a safe and long-lasting manner.

Objective: The aim of the current preclinical study was to assess efficacy of BTA microinjection to alleviate cardiac remodeling after chronic myocardial infarction (MI) by blocking cardiac sympathetic ganglion in a canine model.

Methods: Beagles were randomly divided into a control group (saline microinjection with sham surgery), MI group (saline microinjection with MI) and MI+BTA group (BTA microinjection with MI). Ultrasound-guided percutaneous BTA or saline injection into the left stellate ganglion (LSG) was performed followed by MI induction via left anterior descending artery occlusion (LADO) or sham surgery. After 30 days, electrocardiogram, Doppler echocardiography, LSG function, neural activity and ventricular electrophysiological detection were performed in all experimental dogs. At the end, LSG and ventricular tissues were collected for further detection.

Results: BTA treatment significantly inhibited LSG function and neural activity and improved heart rate variability. Additionally, BTA application alleviated ventricle remodeling, ameliorated cardiac function and prevented ventricular arrhythmias after 30-day chronic LADO-induced MI.

Conclusion: Ultrasound-guided percutaneous microinjection of BTA can block cardiac sympathetic ganglion to improve cardiac remodeling in a large animal model of chronic LADO-induced MI. Ultrasound-guided BTA microinjection has potential for clinical application as a novel cardiac sympathetic ganglion blockade strategy for MI.
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http://dx.doi.org/10.1016/j.hrthm.2022.08.002DOI Listing
August 2022

Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma.

Endocrine 2022 Aug 10. Epub 2022 Aug 10.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.

Purpose: Growth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of growth hormone and insulin-like growth factor 1, causing increased morbidity and mortality. Previous studies have investigated the transcription of GHPA. However, the gene regulatory landscape has not been fully characterized. The objective of our study was to unravel the changes in chromatin accessibility and transcription in GHPA.

Methods: Six patients diagnosed with GHPA in the Department of Neurosurgery at Huashan Hospital were enrolled in our study. Primary pituitary adenoma tissues and adjacent normal pituitary specimens with no morphologic abnormalities from these six patients were obtained at surgery. RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) were applied to investigate the underlying relationship between gene expression and chromatin accessibility changes in GHPA.

Results: Totally, 1528 differential expression genes (DEGs) were identified by transcriptomics analyses, including 725 up-regulated and 803 down-regulated. Further, we obtained 64 significantly DEGs including 10 DEGs were elevated and 54 DEGs were negligibly expressed in tumors tissues. The up-regulated DEGs were mainly involved in terms related to synapse formation, nervous system development and secretory pathway. In parallel, 3916 increased and 2895 decreased chromatin-accessible regions were mapped by ATAC-seq. Additionally, the chromatin accessible changes were frequently located adjacent to transcription factor CTCF and Rfx2 binding site.

Conclusions: Our results are the first to demonstrate the landscape of chromatin accessibility in GHPA, which may contribute to illustrate the underlying transcriptional regulation mechanism of this disease.
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http://dx.doi.org/10.1007/s12020-022-03155-zDOI Listing
August 2022

Recombinant LH supplementation improves cumulative live birth rates in the GnRH antagonist protocol: a multicenter retrospective study using a propensity score-matching analysis.

Reprod Biol Endocrinol 2022 Aug 8;20(1):114. Epub 2022 Aug 8.

Reproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510000, China.

Background: Luteinizing hormone (LH) is critical in follicle growth and oocyte maturation. However, the value of recombinant LH (r-LH) supplementation to recombinant follicle stimulating hormone (r-FSH) during controlled ovarian stimulation in the gonadotrophin releasing hormone (GnRH) antagonist regimen is controversial.

Methods: This multicenter retrospective cohort study recruited 899 GnRH antagonist cycles stimulated with r-LH and r-FSH in 3 reproductive centers and matched them to 2652 r-FSH stimulating cycles using propensity score matching (PSM) for potential confounders in a 1:3 ratio. The primary outcome was the cumulative live birth rate (CLBR) per complete cycle.

Results: The baseline characteristics were comparable in the r-FSH/r-LH and r-FSH groups after PSM. The r-FSH/r-LH group achieved a higher CLBR than the r-FSH group (66.95% vs. 61.16%, p = 0.006). R-LH supplementation also resulted in a higher 2-pronuclear embryo rate, usable embryo rate, and live birth rate in both fresh embryo transfer cycles and frozen-thawed embryo transfer (FET) cycles. No significant differences were found in the rate of moderate and severe ovarian hyperstimulation syndrome (OHSS), or cycle cancellation rate in the prevention of OHSS.

Conclusions: R-LH supplementation to r-FSH in the GnRH antagonist protocol was significantly associated with a higher CLBR and live birth rate in fresh and FET cycles, and improved embryo quality without increasing the OHSS rate and cycle cancellation rate.
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http://dx.doi.org/10.1186/s12958-022-00985-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358814PMC
August 2022

Phialocetones A-J, C lactones from the rhizospheric soil-derived fungus Phialocephala sp. YUD18001 associated with Gastrodia elata.

Phytochemistry 2022 Aug 5:113359. Epub 2022 Aug 5.

Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, China; College of Pharmacy, Dali University, Dali, 671000, China. Electronic address:

Ten undescribed C polyketide phialocetones A-J, featuring twelve-, six- and five-membered lactone moieties, were isolated from a rhizospheric soil-derived Phialocephala sp. YUD18001 associated with Gastrodia elata. Their structures were established by NMR spectroscopic analysis and HRMS, while their absolute configurations were determined by computational methods and chemical reactions. All isolated compounds were evaluated for their anti-inflammatory and cytotoxic activities. As a result, phialocetone D exhibited moderate effects against NO production in lipopolysaccharide (LPS)-induced RAW264.7 cells with an IC value of 14.77 μM, while phialocetone E showed cytotoxicity against HL-60 and SW480 cell lines with IC values of 19.04 and 10.22 μM, respectively.
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http://dx.doi.org/10.1016/j.phytochem.2022.113359DOI Listing
August 2022

Observation of a State X(2600) in the π^{+}π^{-}η' System in the Process J/ψ→γπ^{+}π^{-}η'.

Phys Rev Lett 2022 Jul;129(4):042001

Institute of High Energy Physics, Beijing 100049, People's Republic of China.

Based on (10087±44)×10^{6}  J/ψ events collected with the BESIII detector, the process J/ψ→γπ^{+}π^{-}η^{'} is studied using two largest decay channels of the η^{'} meson, η^{'}→γπ^{+}π^{-} and η^{'}→ηπ^{+}π^{-}, η→γγ. A new resonance, which we denote as the X(2600), is observed with a statistical significance larger than 20σ in the π^{+}π^{-}η^{'} invariant mass spectrum, and it has a connection to a structure around 1.5  GeV/c^{2} in the π^{+}π^{-} invariant mass spectrum. A simultaneous fit on the π^{+}π^{-}η^{'} and π^{+}π^{-} invariant mass spectra with the two η^{'} decay modes indicates that the mass and width of the X(2600) state are 2618.3±2.0_{-1.4}^{+16.3}  MeV/c^{2} and 195±5_{-17}^{+26}  MeV, where the first uncertainties are statistical, and the second systematic.
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http://dx.doi.org/10.1103/PhysRevLett.129.042001DOI Listing
July 2022

The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-β Signaling and Upregulating HAS2.

Mol Cell Biol 2022 Aug 8:e0010722. Epub 2022 Aug 8.

Department of Reproductive Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

HAS2 antisense RNA 1 (HAS2-AS1) is a long noncoding RNA that has increased expression in mature granulosa cells (GCs) and contributes to cumulus expansion by regulating HAS2 expression. However, the roles of HAS2-AS1 during the pathological process of polycystic ovary syndrome (PCOS) are still unclear. This study investigated the roles of HAS2-AS1 in patients with PCOS. Here, a significant upregulation of HAS2-AS1 was found in the primary GCs from patients with PCOS, which was positively correlated with the level of the protein HAS2. The knockdown of HAS2 restored the upregulation of HAS2-AS1 in promoting migration but could not restore the effects of HAS2-AS1 overexpression in promoting proliferation and repressing apoptosis. Transforming growth factor β (TGF-β) upregulated HAS2-AS1 levels, while HAS2-AS1 functioned as a feedback inhibition factor repressing TGF-β signaling by inhibiting TGF-β receptor type 2 (TGFBR2) expression. HAS2-AS1 bonded with EZH2 and guided the polycomb complex 2 to the TGFBR2 promoter region. HAS2-AS1 overexpression induced H3K27 hypermethylation in the TGFBR2 promoter region and then repressed TGFBR2 transcription in KGN cells and primary GCs. In conclusion, we identified for the first time that HAS2-AS1 is upregulated in patients with PCOS and represses TGF-β signaling via inducing TGFBR2 promoter region hypermethylation, which allowed us to explore the pathological processes of PCOS.
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http://dx.doi.org/10.1128/mcb.00107-22DOI Listing
August 2022

Enhancement of antibacterial and growth-promoting effects of Paenibacillus polymyxa by optimizing its fermentation process.

J Appl Microbiol 2022 Jul 30. Epub 2022 Jul 30.

Key Laboratory for Green Chemical Process of Ministry of Education, School of Environmental Ecology and Bioengineering, Wuhan Institute of Technology, Wuhan, China.

Aims: We aimed to enhance the antibacterial and growth-promoting effects of Paenibacillus polymyxa by improving the yield of spores, lipopeptides and indole-3-acetic acid (IAA) in the fermentation process.

Methods And Results: Through medium optimization by the response surface method and feeding fermentation, the number of spores reached 2.37 × 10  cfu ml with an increase of 38%, the content of lipopeptides reached 60.8 mg L with an increase of 89%, and the content of IAA reached 24.3 mg L with an increase of 176%, respectively, comparing with the original (un-optimized) culture conditions. The fermentation culture of P. polymyxa from the optimized medium and feeding fermentation resulted in higher colonization of P. polymyxa in soils than that from the original culture during the 49 days for testing. Comparing with the supernatant of the original culture, the supernatant of the P. polymyxa culture from the optimized medium and feeding fermentation showed enhanced antibacterial effects and plant growth-promoting effects. The enhanced antibacterial effect was shown as the increase of the inhibition zone by 59%, 45% and 26% against Ralstonia solanacearum, Erwinia carotovora and Xanthomonas campestris. The enhanced growth-promoting effects on tomato and strawberry plants were the increase of plant height by 47% and 5%, root length by 23% and 15% and root weight by 65% and 110%.

Conclusions: The combination of medium optimization and feeding fermentation effectively improved the yield of spores, lipopeptides and IAA. Lipopeptides and IAA lead to enhanced antibacterial and plant growth-promoting effects of the P. polymyxa product.

Significance And Impact Of This Study: The optimized fermentation method significantly improved the yield of spores, lipopeptides and IAA, thus providing theoretical and technical support for enhancing the antibacterial and growth-promoting effects of P. polymyxa products in agriculture.
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http://dx.doi.org/10.1111/jam.15750DOI Listing
July 2022

Prognostic Signature and Tumor Immune Landscape of N7-Methylguanosine-Related lncRNAs in Hepatocellular Carcinoma.

Front Genet 2022 22;13:906496. Epub 2022 Jul 22.

Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Despite great advances in the treatment of liver hepatocellular carcinoma (LIHC), such as immunotherapy, the prognosis remains extremely poor, and there is an urgent need to develop novel diagnostic and prognostic markers. Recently, RNA methylation-related long non-coding RNAs (lncRNAs) have been demonstrated to be novel potential biomarkers for tumor diagnosis and prognosis as well as immunotherapy response, such as N6-methyladenine (m6A) and 5-methylcytosine (m5C). N7-Methylguanosine (m7G) is a widespread RNA modification in eukaryotes, but the relationship between m7G-related lncRNAs and prognosis of LIHC patients as well as tumor immunotherapy response is still unknown. In this study, based on the LIHC patients' clinical and transcriptomic data from TCGA database, a total of 992 m7G-related lncRNAs that co-expressed with 22 m7G regulatory genes were identified using Pearson correlation analysis. Univariate regression analysis was used to screen prognostic m7G-related lncRNAs, and the least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression were applied to construct a 9-m7G-related-lncRNA risk model. The m7G-related lncRNA risk model was validated to exhibit good prognostic performance through Kaplan-Meier analysis and ROC analysis. Together with the clinicopathological features, the m7G-related lncRNA risk score was found to be an independent prognostic factor for LIHC. Furthermore, the high-risk group of LIHC patients was unveiled to have a higher tumor mutation burden (TMB), and their tumor microenvironment was more prone to the immunosuppressive state and exhibited a lower response rate to immunotherapy. In addition, 47 anti-cancer drugs were identified to exhibit a difference in drug sensitivity between the high-risk and low-risk groups. Taken together, the m7G-related lncRNA risk model might display potential value in predicting prognosis, immunotherapy response, and drug sensitivity in LIHC patients.
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http://dx.doi.org/10.3389/fgene.2022.906496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354608PMC
July 2022

The role of synergistic interplay among proactive personality, leader creativity expectations, and role clarity in stimulating employee creativity.

Front Psychol 2022 22;13:699411. Epub 2022 Jul 22.

School of Humanities, Social Sciences & Law, Harbin Institute of Technology, Harbin, China.

This study investigates the interplay among proactive personality, leader creativity expectations, and role clarity in stimulating employee creativity based on the theoretical frameworks of role theory. Questionnaires were distributed to obtain 290 leader-employee dyads from China to examine hypotheses conditional process analysis. The results show that proactive personality has a positive effect on employee creativity, leader creativity expectations did not play a significant moderating role on the relationship between proactive personality and employee creativity. The interaction between leader creativity expectations and role clarity has a significant moderating effect on the relationship between proactive personality and employee creativity. These findings are discussed in terms of their theoretical and practical significance.
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http://dx.doi.org/10.3389/fpsyg.2022.699411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354752PMC
July 2022

Intratumoral IL-28B Gene Delivery Elicits Antitumor Effects by Remodeling of the Tumor Microenvironment in H22-Bearing Mice.

J Immunol Res 2022 28;2022:1345971. Epub 2022 Jul 28.

Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

IL-28B, belonging to type III interferons (IFN-s), exhibits a potent antitumor activity with reduced regulated T cells (Tregs) population, yet the effect of IL-28B on the tumor microenvironment (TME) and if IL-28B can downregulate Tregs directly are still unknown. In this study, we investigated the effects of IL-28B on Tregs in the spleen and TME in H22 tumor-bearing mice and verified the downregulation of IL-28B on Tregs . We found that rAd-mIL-28B significantly inhibited tumor growth and reduced the frequency of splenic CD4Foxp3 T cells. The levels of CXCL13, ICAM-1, MCP-5, and IL-7 in the serum, and the levels of IL-15 and sFasL in the tumor tissue decreased significantly after rAd-mIL-28B treatment relative to rAd-EGFP. Furthermore, the percentage of CD8 cells in the TME was significantly increased in the rAd-mIL-28B group compared with the untreated group. , splenocytes were stimulated with anti-CD3/CD28 and IL-2 in the presence of TGF- with or without IL-28B for three days and followed by flow cytometric, RT-PCR, and IL-10 production analysis. The results showed that IL-28B significantly reduced the proportion of induced Foxp3 cells. It demonstrated that IL-28B may be used as a promising immunotherapy strategy against cancer.
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http://dx.doi.org/10.1155/2022/1345971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352479PMC
August 2022

Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy.

Int Urol Nephrol 2022 Aug 5. Epub 2022 Aug 5.

Department of Nephrology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in the developed world. Podocyte injury is a critical cellular event involved in the progression of DN. Our previous studies demonstrated that platelet-derived microparticles (PMPs) mediated endothelial injury in diabetic rats. This study aimed to investigate whether PMPs are deposited in podocytes and to assess their potential effects on podocyte injury in DN.

Methods: The deposition of PMPs in podocytes was assessed by immunofluorescent staining and electron microscopy. The changes in renal pathology and ultra-microstructure were assessed by periodic acid-Schiff staining and electron microscopy, respectively. The expression of inflammatory cytokines and extracellular matrix proteins was measured by immuno-histochemical staining and western blot.

Results: PMPs were widely deposited in podocytes of glomeruli in diabetic patients and animal models and closely associated with DN progression. Interestingly, aspirin treatment significantly inhibited the accumulation of PMPs in the glomeruli of diabetic rats, alleviated mesangial matrix expansion and fusion of foot processes, and decreased the protein expression of inflammatory cytokines and extracellular matrix secretion. An in vitro study further confirmed the deposition of PMPs in podocytes. Moreover, PMP stimulation induced the phenotypic transition of podocytes through decreased podocin protein expression and increased protein expression of α-SMA and fibronectin, which was correlated with increased production of inflammatory cytokines.

Conclusion: Our findings demonstrated for the first time that the deposition of PMPs in podocytes contributed to the development of DN.
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http://dx.doi.org/10.1007/s11255-022-03332-zDOI Listing
August 2022

Association of ambient fine particulate matter exposure with gestational diabetes mellitus and blood glucose levels during pregnancy.

Environ Res 2022 Aug 2:114008. Epub 2022 Aug 2.

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China. Electronic address:

Background: Previous studies have examined the associations between ambient fine particulate matter (PM) exposure and gestational diabetes mellitus (GDM). However, limited studies explored the relationships between PM exposure and blood glucose levels during pregnancy, especially in highly polluted areas.

Objectives: To examine the associations of prenatal ambient PM exposure with GDM and blood glucose levels, and to identify the sensitive exposure windows in a highly air-polluted area.

Methods: From July 2016 to October 2017, a birth cohort study was conducted in Beijing, China. Participants were interviewed in each trimester regarding demographics, lifestyle, living and working environment, and medical conditions. Participant's daily ambient PM levels from 3 m before last menstrual period (LMP) to the third trimester was estimated by a hybrid spatiotemporal model. Indoor air quality index was calculated based on environmental tobacco smoke, ventilation, cooking, painting, pesticide, and herbicide use. Distributed lag non-linear model was applied to explore the sensitive weeks of PM exposure.

Results: Of 165 pregnant women, 23 (13.94%) developed GDM. After adjusting for potential confounders, PM exposure during the 1st trimester was associated with higher odds of GDM (10 μg/m increase: OR = 1.89, 95% CI: 1.04-3.49). Each 10 μg/m increase in PM during the 2nd trimester was associated with 17.70% (2.21-33.20), 15.99% (2.96-29.01), 18.82% (4.11-33.52), and 17.10% (3.28-30.92) increase in 1-h, 2-h, Δ1h-fasting (1-h minus fasting), and Δ2h-fasting (2-h minus fasting) blood glucose levels, respectively. PM exposure at 24th-27th weeks after LMP was associated with increased GDM risk. We identified sensitive exposure windows of 21st-24th weeks for higher 1-h and 2-h blood glucose levels and of 20th-22nd weeks for increased Δ1h-fasting and Δ2h-fasting.

Conclusions: Ambient PM exposure during the second trimester was associated with higher odds of GDM and higher blood glucose levels. Avoiding exposure to high air pollution levels during the sensitive windows might prevent women from developing GDM.
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http://dx.doi.org/10.1016/j.envres.2022.114008DOI Listing
August 2022

Comprehensive Quality Evaluation of the Root Bark of Morus alba L. Based on High-Performance Liquid Chromatography Fingerprinting and Chemometric Analyses.

Chem Biodivers 2022 Aug 4. Epub 2022 Aug 4.

Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, No. 10, Poyang Lake Road, Jinghai District, Tianjin, CHINA.

The quality of the root bark of Morus alba L. (SBP) herbs currently circulating in the market is variable. In order to ensure clinical effectiveness, a high-performance liquid chromatography (HPLC) fingerprinting method combined with chemical pattern recognition should be established to control the quality of SBP herbs. The differences of 23 batches of SBP were analyzed by exploratory cluster analysis based on shared fingerprint peak data, and the results indicated that the processing method to remove the cork layer from SBP materials is an important influencing factor on SBP quality. Principal component analysis indicated that SBP samples with the cork layer removed can be clearly distinguished from samples without cork layer removal. The potential chemical markers (kuwanon G, morusin and oxyresveratrol) were screened by partial least squares discriminant analysis. Finally, the contents of the main components were determined, indicating that the processing method of SBP materials can affect content of bioactive ingredients and that cork layer removal leads to a more uniform chemometric profile. The HPLC-based chemometrics approach described here will support the development of quality standards in SBP products.
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http://dx.doi.org/10.1002/cbdv.202200362DOI Listing
August 2022

YciR, a Specific 3'-Phosphodiesterase, Plays a Role in the Pathogenesis of Uropathogenic CFT073.

Front Microbiol 2022 18;13:910906. Epub 2022 Jul 18.

National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources, College of Resources and Environment, Shandong Agricultural University, Tai'an, China.

Urinary tract infections (UTIs), with the characteristics of recurrence and resistance to antibiotics due to misuse, remain a common health and economic issue for patients. Uropathogenic (UPEC), which is capable of evading the immune response by forming intracellular bacterial communities (IBCs) in the cytoplasm of bladder epithelial cells (BECs) after invasion, has been shown to be the prevailing cause of UTIs. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small molecule responsible for eliciting the innate immune response of the host only if it has not been degraded by some phosphodiesterases (PDEs), such as YciR. The relationship between YciR and c-di-GMP levels in UPEC is inconclusive. In this study, we investigated the gene expression profile of UPEC in BECs and identified as an upregulated gene. Western blot revealed that YciR enhanced the virulence of UPEC by inhibiting the phosphorylation of NF-κB. The expression of could be repressed by HupB in a directly binding manner. We identified YciR, a novel PDE, and defined its possible function in innate immune evasion. We also demonstrated that YciR is an HupB-dependent PDE that degrades c-di-GMP and that a low concentration of c-di-GMP might make NF-κB less phosphorylated, thereby reducing the host's pro-inflammatory response. This is the first time that YciR has been identified as a virulence factor in the pathogenesis of UPEC. These findings further increase our understanding of the pathogenesis of UPEC and provide a theoretical basis for further studies.
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http://dx.doi.org/10.3389/fmicb.2022.910906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339999PMC
July 2022

A hybrid greedy political optimizer with fireworks algorithm for numerical and engineering optimization problems.

Sci Rep 2022 Aug 2;12(1):13243. Epub 2022 Aug 2.

School of Computer Science and Engineering, Central South University, Changsha, China.

This paper proposes a novel hybrid optimization algorithm named GPOFWA, which integrates political optimizer (PO) with fireworks algorithm (FWA) to solve numerical and engineering optimization problems. The original PO uses subgroup optimal solutions such as party leaders and constituency winners to guide the movement of the search agent. However, the number of such subgroup optimal solutions is limited, which leads to insufficient global exploration capabilities of PO. In addition, the recent past-based position updating strategy (RPPUS) of PO lacks effective verification of the updated candidate solutions, which reduces the convergence speed of the algorithm. The proposed hybrid algorithm uses the spark explosion mechanism in FWA to perform explosion spark and Gauss explosion spark operations on the subgroup optimal solutions (party leader and constituency winner) respectively based on the greedy strategy, which optimizes the subgroup optimal solution and enhances the exploitative ability of the algorithm. Moreover, Gaussian explosion sparks are also used to correct the candidate solutions after RPPUS, which makes up for the shortcomings of the original PO. In addition, a new subgroup optimal solution called the Converged Mobile Center (CMC) based on two-way consideration is designed to guide the movement of search agents and maintain the population diversity. We test the presented hybrid algorithm on 30 well-known benchmark functions, CEC2019 benchmark functions and three engineering optimization problems. The experimental results show that GPOFWA is superior to many statE-of-thE-art methods in terms of the quality of the resulting solution.
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http://dx.doi.org/10.1038/s41598-022-17076-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345870PMC
August 2022

Ketogenic diet: new avenues to overcome colorectal cancer.

Signal Transduct Target Ther 2022 Aug 2;7(1):262. Epub 2022 Aug 2.

Department of Biochemistry and Molecular Biology, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

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http://dx.doi.org/10.1038/s41392-022-01113-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346118PMC
August 2022

Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study.

Arterioscler Thromb Vasc Biol 2022 Aug 1:ATVBAHA121316533. Epub 2022 Aug 1.

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (M.W., D.M.).

Background: Effects of animal source foods (ASF) on atherosclerotic cardiovascular disease (ASCVD) and underlying mechanisms remain controversial. We investigated prospective associations of different ASF with incident ASCVD and potential mediation by gut microbiota-generated trimethylamine N-oxide, its L-carnitine-derived intermediates γ-butyrobetaine and crotonobetaine, and traditional ASCVD risk pathways.

Methods: Among 3931 participants from a community-based US cohort aged 65+ years, ASF intakes and trimethylamine N-oxide-related metabolites were measured serially over time. Incident ASCVD (myocardial infarction, fatal coronary heart disease, stroke, other atherosclerotic death) was adjudicated over 12.5 years median follow-up. Cox proportional hazards models with time-varying exposures and covariates examined ASF-ASCVD associations; and additive hazard models, mediation proportions by different risk pathways.

Results: After multivariable-adjustment, higher intakes of unprocessed red meat, total meat, and total ASF associated with higher ASCVD risk, with hazard ratios (95% CI) per interquintile range of 1.15 (1.01-1.30), 1.22 (1.07-1.39), and 1.18 (1.03-1.34), respectively. Trimethylamine N-oxide-related metabolites together significantly mediated these associations, with mediation proportions (95% CI) of 10.6% (1.0-114.5), 7.8% (1.0-32.7), and 9.2% (2.2-44.5), respectively. Processed meat intake associated with a nonsignificant trend toward higher ASCVD (1.11 [0.98-1.25]); intakes of fish, poultry, and eggs were not significantly associated. Among other risk pathways, blood glucose, insulin, and C-reactive protein, but not blood pressure or blood cholesterol, each significantly mediated the total meat-ASCVD association.

Conclusions: In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.
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http://dx.doi.org/10.1161/ATVBAHA.121.316533DOI Listing
August 2022

The Prevalence of Activities of Daily Living Impairment in Patients With Heart Failure: A Systematic Review and Meta-Analysis.

Front Cardiovasc Med 2022 14;9:952926. Epub 2022 Jul 14.

Department of Nursing, The First Affiliated Hospital of Soochow University, Suzhou, China.

Objectives: The prevalence of activities of daily living (ADL) in patients with heart failure (HF) reported in current studies were inconsistent, ranging from 11.1 to 70.5%. The purpose of this study is to quantify the prevalence of ADL impairment in HF patients.

Methods: PubMed, Embase, Cochrane, CINAHL, CNKI, SinoMed, VIP, and Wanfang databases were systematically searched for relevant studies (up to March 2, 2022). Cross-sectional, case-control, or cohort studies with detailed descriptions of overall ADL impairment in HF were included. Stata 16.0 was used for statistical analysis. Fixed-effect or random-effect model was adopted according to heterogeneity which was evaluated by Cochran's and values. Sensitivity analysis, subgroup analysis, and meta-regression were performed to investigate the sources of heterogeneity.

Results: A total of 12 studies with 15,795 HF patients were included in the meta-analysis, and the pooled prevalence of ADL impairment in patients with HF was 38.8% (95%CI: 28.2-49.3%; = 99.5%, < 0.001). No possible sources of heterogeneity were found in subgroup analysis and meta-regression. Funnel plots and Egger's test showed no publication bias ( = 0.595).

Conclusion: The prevalence of ADL impairment is relatively high in HF patients. Differences in the prevalence of ADL impairment in patients with HF may be influenced by country, region, and assessment time. We suggest that more researchers could focus on the changes of ADL impairment in HF patients during different disease periods in different regions and countries.
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http://dx.doi.org/10.3389/fcvm.2022.952926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330145PMC
July 2022

The Effects of Bone Cement Volume in Percutaneous Vertebroplasty for Thoracolumbar Junction Vertebral Compression Fractures: A Clinical Comparative Study.

Mediators Inflamm 2022 22;2022:4230065. Epub 2022 Jul 22.

Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

We compared the outcomes of patients treated with different volumes of polymethyl methacrylate bone cement during percutaneous vertebroplasty (PVP) for thoracolumbar vertebral compression fractures. We performed a comparative, retrospective study of 316 patients who underwent PVP for a single-level thoracolumbar vertebral compression fracture. Patients were divided into two groups: group A (≤5 mL; = 146) and group B (>5 mL; = 170). The visual analogue scale (VAS) for pain and the Roland-Morris Disability Questionnaire (RDQ) scores were compared between the two groups at 1 week and at 1, 6, 12, and 24 months after PVP. The incidence of cement leakage into the intervertebral discs was evaluated by a postoperative lateral radiograph assessment. Patients were evaluated for new fractures 1 and 2 years after PVP or when new fractures were suspected. Among the 316 patients enrolled, 245 completed the clinical research. No difference between groups A and B in terms of the VAS, RDQ, and rate of complications at all time points after surgery was observed. The presence of intervertebral disc leakage was a relative risk (RR) for subsequent total vertebral fracture (RR, 6.42; 95% confidence interval (CI), 2.72-14.19; < 0.0001) and adjacent vertebral fracture (RR, 8.03; 95% CI, 2.74-23.54; = 0.0001). A high volume of bone cement may increase the rate of subsequent total and adjacent vertebral fractures. However, the occurrence of intervertebral disc leakage is the principal risk factor for these negative outcomes of PVP.
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http://dx.doi.org/10.1155/2022/4230065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337957PMC
August 2022

Saliva cortisol as a biomarker of injury in youth sport-related concussion.

J Neurotrauma 2022 Jul 29. Epub 2022 Jul 29.

University of Calgary, Clinical Neurosciences, Calgary, Alberta, Canada;

Increasing rates of sport-related concussion (SRC) in youth impose a significant burden on public health systems and the lives of young athletes. Accurate prediction for those likely to develop persistent post-concussion symptomology (PPCS) using a fluid biomarker, reflecting both acute injury and recovery processes, would provide the opportunity for early intervention. Cortisol, a stress hormone released through the hypothalamic-pituitary-adrenal (HPA) axis following injury may provide a missing physiological link to clinical recovery. This cohort study investigated the change in saliva cortisol following SRC and the association between cortisol and symptom burden in pediatric ice hockey players. Further, the association between cortisol levels and medical clearance to return to play is explored. In total, cortisol samples from 233 players were included; 165 athletes (23.6% female) provided pre-injury saliva and 68 athletes (19.1% female) provided post-SRC saliva samples for cortisol analysis. Quantile (median) regressions were used to compare cortisol between pre-injury and post-SRC groups, and the association between total symptoms (/22) and symptom severity scores (/132) reported on the SCAT3/SCAT5) and post-SRC cortisol (adjusting for age, sex, history of concussion, and time from injury to sample collection). Results demonstrated significantly lower saliva cortisol in post-SRC athletes compared to the pre-injury group (β=-0.62, 95% CI [-1.08, -0.16], p=0.009). Post-SRC cortisol was not significantly associated with SCAT3/SCAT5 symptom totals or symptom severity scores, however females were found to report more symptoms (β=6.95, 95% CI [0.35, 13.55], p=0.040) and greater symptom severity (β=23.87, 95% CI [9.58, 38.15], p=0.002) compared to males. Exploratory time-to-event analysis revealed a point estimate suggesting a potential association between low cortisol levels and days to medical clearance to return to play. While preliminary, these findings suggest that the HPA-axis may be dysregulated post-SRC. Furthermore, our exploratory analysis and case presentation of post-injury outliers highlight the need to further research cortisol as a prognostic biomarker to inform individualized sex-specific care after SRC.
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http://dx.doi.org/10.1089/neu.2022.0190DOI Listing
July 2022

ARIMA and ARIMA-ERNN models for prediction of pertussis incidence in mainland China from 2004 to 2021.

BMC Public Health 2022 07 29;22(1):1447. Epub 2022 Jul 29.

School of Public Health, Fudan University, Shanghai, 200032, China.

Objective: To compare an autoregressive integrated moving average (ARIMA) model with a model that combines ARIMA with the Elman recurrent neural network (ARIMA-ERNN) in predicting the incidence of pertussis in mainland China.

Background: The incidence of pertussis has increased rapidly in mainland China since 2016, making the disease an increasing public health threat. There is a pressing need for models capable of accurately predicting the incidence of pertussis in order to guide prevention and control measures. We developed and compared two models for predicting pertussis incidence in mainland China.

Methods: Data on the incidence of pertussis in mainland China from 2004 to 2019 were obtained from the official website of the Chinese Center for Disease Control and Prevention. An ARIMA model was established using SAS (ver. 9.4) software and an ARIMA-ERNN model was established using MATLAB (ver. R2019a) software. The performances of these models were compared.

Results: From 2004 to 2019, there were 104,837 reported cases of pertussis in mainland China, with an increasing incidence over time. The incidence of pertussis showed obvious seasonal characteristics, with the peak lasting from March to September every year. Compared with the mean squared error (MSE), mean absolute error (MAE), and mean absolute percentage error (MAPE) of the ARIMA model, those of the ARIMA-ERNN model were 81.43%, 95.97% and 80.86% lower, respectively, in fitting performance. In terms of prediction performance, the MAE, MSE and MAPE were 37.75%, 56.88% and 43.75% lower, respectively.

Conclusion: The fitting and prediction performances of the ARIMA-ERNN model were better than those of the ARIMA model. This provides theoretical support for the prediction of infectious diseases and should be beneficial to public health decision making.
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http://dx.doi.org/10.1186/s12889-022-13872-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338508PMC
July 2022

The effect of endometriosis on IVF/ICSI and perinatal outcome : a systematic review and meta-analysis.

J Gynecol Obstet Hum Reprod 2022 Jul 26:102446. Epub 2022 Jul 26.

Center for Reproductive Medicine, Shandong University, Jinan, Shandong 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

Purpose: The purpose of the study was whether endometriosis influences IVF/ICSI and subsequent pregnancy and obstetric outcomes.

Methods: Searches were performed on PubMed, EMBASE, Medline and Web of Science. Most of the included studies were retrospective case control study and retrospective cohort study.The risk ratio with 95% confidence intervals were calculated using the random and fixed effects model. Random effects models were applied in the case of significant heterogeneity (I>50%), and fixed effects models were used if the heterogeneity was not significant.The main outcome measure was the live birth rate.

Results: Seventy studies were included in our analysis. Compared with the control group, the implantation rate (p = 0.04) and the number of oocyte retrieved (p<0.00001) were significantly lower in women with endometriosis. About late pregnancy complications, there were significant statistical differences in multiple pregnancies rate, placenta previa rate, ectopic pregnancy rate, postpartum hemorrhage rate between the two groups (P<0.05). All other major reproductive and obstetric outcomes were similar in women with and without endometriosis.

Conclusions: Our results demonstrate women with or without endometriosis have similar reproductive outcomes, but women with endometriosis who conceived after assisted reproductive technology are in high risk pregnancy.
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http://dx.doi.org/10.1016/j.jogoh.2022.102446DOI Listing
July 2022

Chromatin structure in cancer.

BMC Mol Cell Biol 2022 Jul 28;23(1):35. Epub 2022 Jul 28.

Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43205, USA.

In the past decade, we have seen the emergence of sequence-based methods to understand chromosome organization. With the confluence of in situ approaches to capture information on looping, topological domains, and larger chromatin compartments, understanding chromatin-driven disease is becoming feasible. Excitingly, recent advances in single molecule imaging with capacity to reconstruct "bulk-cell" features of chromosome conformation have revealed cell-to-cell chromatin structural variation. The fundamental question motivating our analysis of the literature is, can altered chromatin structure drive tumorigenesis? As our community learns more about rare disease, including low mutational frequency cancers, understanding "chromatin-driven" pathology will illuminate the regulatory structures of the genome. We describe recent insights into altered genome architecture in human cancer, highlighting multiple pathways toward disruptions of chromatin structure, including structural variation, noncoding mutations, metabolism, and de novo mutations to architectural regulators themselves. Our analysis of the literature reveals that deregulation of genome structure is characteristic in distinct classes of chromatin-driven tumors. As we begin to integrate the findings from single cell imaging studies and chromatin structural sequencing, we will be able to understand the diversity of cells within a common diagnosis, and begin to define structure-function relationships of the misfolded genome.
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http://dx.doi.org/10.1186/s12860-022-00433-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331575PMC
July 2022

Aging factor and its prediction models of chromium ecotoxicity in soils with various properties.

Sci Total Environ 2022 Jul 25;847:157622. Epub 2022 Jul 25.

Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China. Electronic address:

Aging of pollutants determines bioavailability and toxicity thresholds of environmental pollutants in soil. However, the ecotoxicity of chromium (Cr) rarely considers the effect of aging as well as soil properties. In order to explore the aging characteristics and establish their quantitative relationship with different soil properties, this study selected 7 soils with different properties through exogenous addition of Cr and determined its toxicity on barley root elongation. From 14d to 540d, EC and EC of barley root elongation ranged from 21.40 to 312.52 (mg·kg) and 50.15 to 883.88 (mg·kg) respectively. The hormesis appeared in the dose-response curve of acid soil as relative barley root elongation reached >110 % compared with the control. Extended aging time of Cr from 14d to 540d was associated with the attenuation of the toxicity of Cr, as the aging factor increased from 1.26 to 6.09 for EC, from 0.88 to 4.98 for EC. The prediction model of AF and soil properties is lg (AF) = 0.306lg Clay+0.026lg CEC + 0.240 (R = 0.872, P < 0.01). The results demonstrated that with the extension of aging time, the toxicity of Cr decreased at 360d and reached a slow reaction stage, after that soil OC, Clay and CEC could well explain the aging procedure of Cr (VI). These results are beneficial for risk assessment of Cr contaminated soils and establishment of a soil environmental quality criteria for Cr.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157622DOI Listing
July 2022

A new insight into Cd reduction by flooding in paddy soil: The different dominant roles of Fe and S on Cd immobilization under fluctuant pe + pH conditions.

Sci Total Environ 2022 Jul 25;847:157604. Epub 2022 Jul 25.

Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China. Electronic address:

The unsteady comprehensive system of pe + pH strongly affects the fate of Cd in paddy soils. However, the specific pe + pH threshold determining Cd bioavailability is largely unknown especially considering the roles of Fe and S reduction. The experiment set different water managements to obtain paddy soil samples with unstable pe + pH, and chemical analysis, X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) characterization were applied to reveal the dynamic process and mechanism about how Fe and S controlled Cd mobilization. The results showed that low pe + pH was favorable to soil Cd immobilization. Compared with high and medium pe + pH, the exchangeable Cd content decreased by 67.57 % and 64.71 % at low pe + pH, respectively. The XPS results showed that the contents of Fe(II) and S(-II) increased to 65.1 % and 75.2 % at low pe + pH condition, which was higher than that in other treatments. In the process of flooding for reducing Cd mobility, first it was attributed to the formation of amorphous iron oxides that can provide amount of adsorption sites for Cd. After then, S began to play a dominant role to combine with Cd to form CdS with continuous decreased pe + pH. Therefore, Fe and S played the different dominant roles on Cd immobilization in paddy soil, and soil pe + pH value could work as a threshold.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157604DOI Listing
July 2022

Pharmacokinetics, Bioequivalence, and Safety Studies of a Generic Selective Tyrosine Kinase Inhibitor Nilotinib Capsule Versus a Branded Product in Healthy Chinese Volunteers.

Clin Pharmacol Drug Dev 2022 Jul 28. Epub 2022 Jul 28.

Department of Pharmacy, The Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, P.R. China.

Nilotinib, a second-generation tyrosine kinase inhibitor (TKI), has been approved in the United States and Europe as a treatment for patients with newly diagnosed chronic myeloid leukemia (CML)-chronic phase (CP) and patients with CML-CP or chronic myeloid leukemia-accelerated phase (CML-AP) who are resistant or intolerant to imatinib (a first-generation TKI). This study compared the bioequivalence and safety of the test nilotinib capsule and reference nilotinib capsule (Tasigna, Novartis) in healthy Chinese volunteers under fasting conditions for marketing authorization in China. The results of the study are reported for the first time. This was a single-dose, randomized, open-label, two-period, and cross-over study. Thirty healthy volunteers were randomly assigned to receive a single dose of a 200-mg test or reference capsule under fasting conditions in each period with a 10-day washout. Plasma samples were analyzed with liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were calculated with WinNonlin software. The geometric mean ratio and the corresponding 90% confidence intervals of C , AUC , and AUC for nilotinib between the two fixed-dose combination formulations were within the bioequivalence acceptance range of 80%-125%, therefore the generic and branded formulations were bioequivalent in healthy Chinese volunteers.
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http://dx.doi.org/10.1002/cpdd.1148DOI Listing
July 2022

Design and characterization of gambogic acid-loaded mixed micelles system for enhanced oral bioavailability.

Pharm Dev Technol 2022 Aug 5:1-7. Epub 2022 Aug 5.

College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, China.

The aim of this study was to develop a gambogic acid-loaded mixed micelles (GA-M) system, using Kolliphor HS15 and lecithin, for enhancement of oral bioavailability. GA-M was prepared using the thin film hydration method, and particle size and zeta potential indexes were used to determine the optimized formulation was optimized with taking particle size, zeta potential as indexes. The optimal GA-M system had a mean particle size in the nanometer range (87.22 ± 0.68 nm) and zeta potential greater than 20 mV in magnitude (-21.63 ± 1.69 mV) at a 1:1 proportion of HS15: lecithin. Additionally, the carriers had a high entrapment efficiency (98.32 ± 3.52%) and drug loading (4.68 ± 0.17%). Furthermore, the GA release characteristics followed first-order kinetics, suggesting that the release of the molecule was achieved both by medium diffusion and structural erosion. Transport elucidation in Caco-2 cells demonstrated that the efflux ratio of encapsulated GA was dramatically decreased from 1.42 to 0.76, and pharmacokinetic studies showed that the oral bioavailability of GA-M was 2.3 times higher than that of free GA, indicating that HS15/lecithin mixed micelles could promote absorption in the gastrointestinal tract. Overall, these results present a micelle system suitable for oral delivery, with increased solubility and oral bioavailability of GA.
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http://dx.doi.org/10.1080/10837450.2022.2107012DOI Listing
August 2022

A Novel Tannic Acid-Based Carbon-Supported Cobalt Catalyst for Transfer Hydrogenation of Biomass Derived Ethyl Levulinate.

Front Chem 2022 11;10:964128. Epub 2022 Jul 11.

College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot, China.

The catalytic conversion of ethyl levulinate (EL) to γ-valerolactone (GVL) is an important intermediate reaction in the conversion and utilization of biomass resources. The development of novel and efficient catalysts is significantly important for this reaction. In this work, using the biomass-derived tannic acid as carbon precursor and the transition metal cobalt as active component, a novel tannic acid carbon supported cobalt catalyst (Co/TAC) was prepared by pyrolysis and subsequent hydrazine hydrate reduction method. The hydrogenation of EL and other carbonyl compounds by hydrogen transfer reaction was used to evaluate the performance of the catalysts. The effects of different preparation and reaction conditions on the performance of the catalysts were investigated, and the structures of the prepared catalysts were characterized in detail. The results showed that the carbonization temperature of the support had a significant effect on the activity of the catalyst for the reaction. Under the optimized conditions, the Co/TAC-900 catalyst obtained the highest GVL yield of 91.3% under relatively mild reaction conditions. Furthermore, the prepared catalyst also showed high efficiency for the hydrogenation of various ketone compounds with different structures. This work provides a new reference for the construction of the catalysts during the conversion of biomass and a potential pathway for the high-value utilization of tannin resource.
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http://dx.doi.org/10.3389/fchem.2022.964128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309337PMC
July 2022

Modified Micro-Mechanics Based Multiscale Model for Damage Analysis of Open-Hole Composite Laminates under Compression.

Materials (Basel) 2022 Jul 22;15(15). Epub 2022 Jul 22.

College of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China.

The multiscale model based on micro-mechanics failure theory is modified to consider complex internal structures, including a fiber random arrangement pattern and interface with the clustering method. Then, a feed-forward-neural-network (FFNN)-based damage evolution method is developed to evaluate the macroscale property degradation. The progressive damage analysis of open-hole laminates under compression is conducted to validate the modified multiscale method. The predicted results reveal that the interface results in the premature initiation of damage, and the fiber random arrangement pattern contributes to the decrease in the predicted compression responses. The developed FFNN-based method aimed at degradation results in an increase in the predicted compression strength. For the fiber random distribution pattern, the increase in percentage of predicted compressive strength is 6.0%, which is much larger than the value for the fiber diamond distribution pattern.
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http://dx.doi.org/10.3390/ma15155105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332073PMC
July 2022

Application of Grey Lotka-Volterra Model in Water-Economy-Industry-Technology Innovation System in Beijing-Tianjin-Hebei Region.

Int J Environ Res Public Health 2022 Jul 23;19(15). Epub 2022 Jul 23.

School of Management Engineering and Business, Hebei University of Engineering, Handan 056038, China.

With the proposal of China's high-quality development strategy, how to promote regional stability and coordinated development based on a deep understanding of the main contradictions and changes in China's society has become the focus of research. High-quality development is a brand-new coordinated development concept, which aims to optimize the economic structure, transform the development model, enhance the development momentum, and take innovation as the primary driving force. How to promote the coordinated development of this region has become a hot issue considered by scholars. The Beijing-Tianjin-Hebei region is the capital economic circle of China, and the purpose of this study is to promote the coordinated and stable development of the region. On this premise, this paper firstly adopts the composite Grey Lotka-Volterra (GLV) model and Fractional GM(1,1) (FGM(1,1)) model to research Water Resources system-Economic System-Industrial System-Technology Innovation System in the Beijing-Tianjin-Hebei region. Secondly, by analyzing the research data, it is found that the relationship between the system is very complex, and the stability calculation results are all below 0. Then, the analysis of the research results shows that there is no obvious coordination among the three regions, and they have not yet reached a state of mutual promotion and stable and coordinated development. Finally, four suggestions are put forward for the coordinated development of the Beijing-Tianjin-Hebei region. This can not only provide direction for the future development of the region but also have reference significance for the development of other regions. Further, accelerate the coordination and unity of all factors of production in China and promote China's development at a deeper and higher level.
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http://dx.doi.org/10.3390/ijerph19158969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332305PMC
July 2022
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