Publications by authors named "Meltem Polat"

51 Publications

Acute Haemorrhagic Oedema of Infancy as a manifestation of COVID-19 Infection.

J Paediatr Child Health 2022 07 16;58(7):1282-1283. Epub 2022 Jun 16.

Department of Pediatric Infectious Disease, Gazi University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/jpc.16056DOI Listing
July 2022

Acute Generalized Exanthematous Pustulosis Associated With a COVID-19 Infection.

Pediatr Infect Dis J 2022 Sep 2;41(9):e406. Epub 2022 Jun 2.

Department of Pediatric Infectious Diseases, Yildirim Beyazit University Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000003604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359680PMC
September 2022

Prevalence of Anosmia in 10.157 Pediatric COVID-19 Cases: Multicenter Study from Turkey.

Pediatr Infect Dis J 2022 06 6;41(6):473-477. Epub 2022 May 6.

Hacettepe University Hospital, Ankara, Turkey.

Introduction: COVID-19-related anosmia is a remarkable and disease-specific finding. With this multicenter cohort study, we aimed to determine the prevalence of anosmia in pediatric cases with COVID-19 from Turkey and make an objective assessment with a smell awareness questionnaire.

Material And Methods: This multicenter prospective cohort study was conducted with pediatric infection clinics in 37 centers in 19 different cities of Turkey between October 2020 and March 2021. The symptoms of 10.157 COVID-19 cases 10-18 years old were examined. Age, gender, other accompanying symptoms, and clinical severity of the disease of cases with anosmia and ageusia included in the study were recorded. The cases were interviewed for the smell awareness questionnaire at admission and one month after the illness.

Results: Anosmia was present in 12.5% (1.266/10.157) of COVID-19 cases 10-18 years of age. The complete records of 1053 patients followed during the study period were analyzed. The most common symptoms accompanying symptoms with anosmia were ageusia in 885 (84%) cases, fatigue in 534 cases (50.7%), and cough in 466 cases (44.3%). Anosmia was recorded as the only symptom in 84 (8%) of the cases. One month later, it was determined that anosmia persisted in 88 (8.4%) cases. In the smell awareness questionnaire, the score at admission was higher than the score one month later (P < 0.001).

Discussion: With this study, we have provided the examination of a large case series across Turkey. Anosmia and ageusia are specific symptoms seen in cases of COVID-19. With the detection of these symptoms, it should be aimed to isolate COVID-19 cases in the early period and reduce the spread of the infection. Such studies are important because the course of COVID-19 in children differs from adults and there is limited data on the prevalence of anosmia.
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http://dx.doi.org/10.1097/INF.0000000000003526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083317PMC
June 2022

Bacteremic and Nonbacteremic Brucellosis in Children in Turkey.

J Trop Pediatr 2022 01;68(1)

Department of Pediatric Infectious Disease, SBU Ankara Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara 06080, Turkey.

Introduction: Human brucellosis is one of the most common zoonotic infections in the world. The definitive diagnosis of brucellosis is based on cultured Brucella organisms from blood or other tissue samples. We aimed to compare bacteremic and nonbacteremic brucellosis patients with demographical, epidemiological, clinical and laboratory features and determine the predictive factors affecting blood culture positivity.

Materials And Methods: Children aged 1 month to 18 years who were followed up with the diagnosis of brucellosis between January 2005 and March 2021 were included in this retrospective study. According to the isolation of Brucella melitensis in blood culture, the patients were divided into two groups as bacteremic and nonbacteremic and compared in terms of demographic, clinical and laboratory characteristics.

Results: One hundred eighty-nine (116 male, 61.4%) patients diagnosed with brucellosis were included in the study. There were 76 (40.2%) bacteremic and 113 (59.8%) nonbacteremic patients. Bacteremic patients were younger than nonbacteremic patients. Fever, arthralgia, hepatomegaly and splenomegaly were significantly higher in the culture positive group. High levels of C-reactive protein (CRP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were found to be significant in the bacteremic group.

Conclusion: In our study, history of fever and arthralgia, hepatomegaly and splenomegaly in physical examination and high CRP, ALT and AST levels in the biochemical analysis were important factors determining blood culture positivity.
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http://dx.doi.org/10.1093/tropej/fmab114DOI Listing
January 2022

A Case of Multisystem Inflammatory Syndrome in a 12-Year-old Male After COVID-19 mRNA Vaccine.

Pediatr Infect Dis J 2022 03;41(3):e87-e89

From the Department of Pediatric Infectious Disease.

The pathophysiology of multisystem inflammatory syndrome (MIS) in children (MIS-C) is unknown. It occurs several weeks after COVID-19 infection or exposure; however, MIS is rarely reported after COVID-19 vaccination, and cases are mostly in adults. Herein, we present a 12-year-old male who had no prior COVID-19 infection or exposure and developed MIS-C after his first dose of COVID-19 mRNA vaccine.
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http://dx.doi.org/10.1097/INF.0000000000003432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828314PMC
March 2022

Bloodstream infections due to Trichosporon species in paediatric patients: Results from the first national study from Turkey.

J Mycol Med 2022 Mar 21;32(1):101229. Epub 2021 Nov 21.

Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey.

Background: Invasive Trichosporon infections are rarely seen opportunistic fungal infections in children and mainly affect immunocompromised patients. This multicenter retrospective study has rewieved the characteristics, risk factors, treatment modalities and outcomes of bloodstream infections caused by Trichosporon species in children diagnosed over the past ten years in Turkey.

Methods: The study was performed with the participation of 12 of 55 hospitals invited from Turkey. In each center, the patients with bloodstream infections caused by Trichosporon spp. between January 2010 and December 2020 were retrospectively ascertained and the results were reported to the study coordinator by means of a simple case report. Data were collected on patient demographics, underlying condition(s), treatment of.infections caused by Trichosporon spp, and 7 and 30- day mortality rates.

Results: A total of 28 cases with fungemia caused by Trichosporon spp. were included in the study. The most common underlying disease was paediatric cancers (39.3%). T. asahii infections were detected in 78.5 % (n=22) of patients. A various spectrum of antifungal treatment regimens were used including intravenous amphotericin B monotherapy in 35.7%, intravenous amphotericin B and voriconazole combination in 32.1% and intravenous voriconazole monotherapy in 28.6% of the patients. The overall mortality rate was 28.5 %. The mortality rates were 12.5% in the voricanozole, 30% in the amphotericin B and 33.3% in combined voriconazole -amphotericin B arms CONCLUSIONS: Invasive Trichosporon infections with an important impact of patients quality of life are almost related to underlying diseases with an overall mortality rate of 28.5%. Voriconazole was found to be associated with lower mortality rates when compared with other treatment regimens.
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http://dx.doi.org/10.1016/j.mycmed.2021.101229DOI Listing
March 2022

Multisystem inflammatory syndrome in children associated with SARS-CoV-2: extracardiac radiological findings.

Br J Radiol 2022 Jan;95(1129):20210570

Department of Pediatric Radiology, Dr. Sami Ulus Gynecology, Obstetricsand Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Objective: Multisystem inflammatory syndrome in children (MIS-C) is seen as a serious delayed complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of this study was to describe the most common imaging features of MIS-C associated with SARS-CoV-2.

Methods: A retrospective review was made of the medical records and radiological imaging studies of 47 children (26 male, 21 female) in the age range of 25 months-15 years who were diagnosed with MIS-C between August 2020 and March 2021. Chest radiographs were available for all 47 patients, thorax ultrasound for 6, chest CT for 4, abdominal ultrasound for 42, abdomen CT for 9, neck ultrasound for 4, neck CT for 2, brain CT for 1, and brain MRI for 3.

Results: The most common finding on chest radiographs was perihilar-peribronchial thickening (46%). The most common findings on abdominal ultrasonography were mesenteric inflammation (42%), and hepatosplenomegaly (38%, 28%). Lymphadenopathy was determined in four patients who underwent neck ultrasound, one of whom had deep neck infection on CT. One patient had restricted diffusion and T2 hyperintensity involving the corpus callosum splenium on brain MRI, and one patient had epididymitis related with MIS-C.

Conclusion: Pulmonary manifestations are uncommon in MIS-C. In the abdominal imaging, mesenteric inflammation, hepatosplenomegaly, periportal edema, ascites and bowel wall thickening are the most common findings.

Advances In Knowledge: The imaging findings of MIS-C are non-specific and can mimic many other pathologies. Radiologists should be aware that these findings may indicate the correct diagnosis of MIS-C.
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http://dx.doi.org/10.1259/bjr.20210570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722242PMC
January 2022

Unusual Presentation of MIS-C Mimicking Deep Neck Infection In Two Children.

Klin Padiatr 2021 Sep 13;233(5):254-257. Epub 2021 Sep 13.

Department of Pediatric Infectious Disease, Dr Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1055/a-1541-8091DOI Listing
September 2021

Transient Ileo-Ileal Intussusception as a Manifestation of Multisystem Inflammatory Syndrome in Children.

J Paediatr Child Health 2021 Sep 4;57(9):1546-1548. Epub 2021 Aug 4.

Department of Pediatric Infectious Diseases, Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/jpc.15669DOI Listing
September 2021

Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus-2 pandemic in Turkey: A single-centre experience.

J Paediatr Child Health 2022 Jan 3;58(1):129-135. Epub 2021 Aug 3.

Department of Pediatric Infectious Disease, SBU Ankara Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Aim: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may result in a life-threatening hyperinflammatory condition named multisystem inflammatory syndrome in children (MIS-C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outcomes of patients with MIS-C.

Methods: We performed a retrospective study of patients with MIS-C managed between August 2020 and March 2021 at Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital in Turkey.

Results: A total of 45 patients (23 male, 51%) with a median age of 8.7 years (interquartile range: 5.6-11.7 years) were enrolled to study. The SARS-CoV-2 serology was positive in 43 (95%) patients. Organ-system involvement included the dermatologic in 41 (91%), cardiovascular in 39 (87%), hematologic in 36 (80%) and gastrointestinal in 36 (80%) patients. Acute anterior uveitis was diagnosed in nine (20%) patients. Two patients presented with clinical findings of deep neck infection such as fever, neck pain, trismus, swelling and induration on the cervical lymph node. One patient presented with Henoch-Schonlein purpura-like eruption. Coronary artery dilatation was detected in five (11%) patients. For treatment of MIS-C, intravenous immunoglobulin was used in 44 (98%) patients, methylprednisolone in 27 (60%) and anakinra in 9 (20%) patients. The median duration of hospitalisation was nine days. All patients recovered.

Conclusions: Children with MIS-C might have variable clinical presentations. Acute anterior uveitis might be a prominent presentation of MIS-C and require ophthalmological examination. It is essential to make patient-based decisions and apply a stepwise approach for the treatment of this life-threatening disease.
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http://dx.doi.org/10.1111/jpc.15674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447466PMC
January 2022

Crimean-Congo Hemorrhagic Fever Mimicking Multisystem Inflammatory Syndrome in Children Associated With COVID-19: A Diagnostic Challenge.

Pediatr Infect Dis J 2021 12;40(12):e524-e525

Department of Pediatric Intensive Care, Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000003269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575102PMC
December 2021

Oral fosfomycin for treating lower urinary tract infections due to multidrug-resistant in female adolescents.

J Chemother 2022 Apr 21;34(2):97-102. Epub 2021 Jul 21.

Faculty of Medicine, Department of Pediatric Nephrology, Pamukkale University, Denizli, Turkey.

Fosfomycin trometamol (FT) has shown promising activity against multidrug-resistant (MDR) uropathogens; however, clinical data are limited in pediatric patients. We conducted a retrospective study to describe the clinical and microbiological outcomes of uncomplicated lower urinary tract infections (LUTIs) due to MDR treated with oral FT in female adolescents. A total of 70 outpatients, with a median age of 13 years (range 12-16 years), were included. FT was initiated as definitive treatment of UTIs in all patients due to documented resistance against alternative oral agents. All patients received a single dose of 3 g oral FT. The post-treatment clinical and microbiological cure rates were 97% (68/70) and 94% (66/70), respectively. Only two (3%) patients reported mild, self-limited diarrhea. UTI relapse occurred in two (3%) patients. Our results suggest that oral FT might be an alternative option for outpatient treatment of uncomplicated LUTIs due to MDR in female adolescents.
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http://dx.doi.org/10.1080/1120009X.2021.1955203DOI Listing
April 2022

Pyomyositis of the Iliopsoas and Piriformis Muscles Caused by Panton-valentine Leukocidin-positive Staphylococcus aureus.

Pediatr Infect Dis J 2021 09;40(9):e358-e359

Department of Radiology, Pamukkale University School of Medicine, Denizli, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000003217DOI Listing
September 2021

ACUTE EPIDIDYMITIS ASSOCIATED WITH MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN.

J Paediatr Child Health 2021 04 11;57(4):594-595. Epub 2021 Mar 11.

Department of Pediatric Infectious Disease, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/jpc.15441DOI Listing
April 2021

Hair Loss as a Late Complication of Multisystem Inflammatory Syndrome in Children.

Pediatr Infect Dis J 2021 06;40(6):e251-e252

Department of Pediatric Infectious Disease, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000003115DOI Listing
June 2021

Tularemia in Children.

Pediatr Infect Dis J 2021 04;40(4):e170

Sami Ulus Research and Education Hospital, Pediatric Infectious Diseases Unit, Ankara, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000003025DOI Listing
April 2021

EPSTEIN-BARR VIRUS-ASSOCIATED HAEMORRHAGIC BULLOUS HENOCH-SCHONLEIN PURPURA.

J Paediatr Child Health 2020 12;56(12):1993

Department of Pediatric Infectious Diseases, Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/jpc.15187DOI Listing
December 2020

Vaccine failures in pediatric cases caused by streptococcus pneumoniae serotype 19A.

Hum Vaccin Immunother 2020 10 23;16(10):2509-2510. Epub 2020 Jul 23.

Public Health General Directorate , Ankara, Turkey.

Community-acquired pneumonia (CAP) is a leading cause of childhood mortality and morbidity worldwide. PCV-13 has implemented incidence of CAP undoubtedly in a very good way but continuous surveillance for vaccine failures is still very important for future vaccination programs. To support this opinion we report seven children (age of the seven patients ranged between 10 months and 5 y, 10 months old patients were vaccinated 3 times with PCV13 whereas others were fully vaccinated as 3 + 1) infected with Streptococcus pneumoniae Serotype 19A in last 4 y (2015-2018).
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http://dx.doi.org/10.1080/21645515.2020.1767450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646504PMC
October 2020

Multi-assay investigation of viral etiology in pediatric central nervous system infections.

J Infect Dev Ctries 2020 06 30;14(6):572-579. Epub 2020 Jun 30.

Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: In an attempt to identify a wide spectrum of viral infections, cerebrospinal fluid (CSF) specimens were collected from pediatric cases with the preliminary diagnosis of viral encephalitis/meningoencephalitis in two reference hospitals, from October 2011 to December 2015.

Methodology: A combination of nucleic acid-based assays, including in house generic polymerase chain reaction (PCR) assays for enteroviruses, flaviviruses and phleboviruses, a commercial real-time PCR assay for herpesviruses and a commercial real time multiplex PCR, enabling detection of frequently-observed viral, bacterial and fungal agents were employed for screening.

Results: The microbial agent could be characterized in 10 (10%) of the 100 specimens. Viral etiology could be demonstrated in 7 (70%) specimens, which comprises Human Herpesvirus 6 (4/7), Herpes Simplex virus type1 (2/7) and Enteroviruses (1/7). In 3 specimens (30%), Streptococcus pneumoniae, Listeria monocytogenes and Staphylococcus aureus were detected via the multiplex PCR, which were also isolated in bacteriological media. All specimens with detectable viral nucleic acids, as well as unreactive specimens via nucleic acid testing remained negative in bacteriological cultures.

Conclusions: Herpes and enteroviruses were identified as the primary causative agents of central nervous system infections in children. Enterovirus testing must be included in the diagnostic work-up of relevant cases.
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http://dx.doi.org/10.3855/jidc.12327DOI Listing
June 2020

Antibiotic Stewardship in Urinary Tract Infection in Pediatrics.

Pediatr Infect Dis J 2020 08;39(8):e218-e219

Pediatric Infectious Diseases Unit, Pamukkale University, Denizli, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000002644DOI Listing
August 2020

Meningococcemia Due to Nongroupable Neisseria meningitidis in a Splenectomized Child.

Pediatr Infect Dis J 2020 05;39(5):e57

Health Sciences University Ankara Hematology and Oncology Research Hospital, Department of Pediatric Infectious Diseases, Ankara, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000002608DOI Listing
May 2020

Letter to the editor.

J Paediatr Child Health 2020 03;56(3):489

Department of Radiology, Pamukkale University Medical Center, Denizli, Turkey.

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http://dx.doi.org/10.1111/jpc.14822DOI Listing
March 2020

Risk factors for bacteremia in children with febrile neutropenia

Turk J Med Sci 2019 08 8;49(4):1198-1205. Epub 2019 Aug 8.

Department of Pediatric Hematology, Faculty of Medicine, Gazi University, Ankara, Turkey

Background/aim: Bacteremia remains an important cause of morbidity and mortality during febrile neutropenia (FN) episodes. We aimed to define the risk factors for bacteremia in febrile neutropenic children with hemato-oncological malignancies.

Materials And Methods: The records of 150 patients aged ≤18 years who developed FN in hematology and oncology clinics were retrospectively evaluated. Patients with bacteremia were compared to patients with negative blood cultures.

Results: The mean age of the patients was 7.5 ± 4.8 years. Leukemia was more prevalent than solid tumors (61.3% vs. 38.7%). Bacteremia was present in 23.3% of the patients. Coagulase-negative staphylococci were the most frequently isolated microorganism. Leukopenia, severe neutropenia, positive peripheral blood and central line cultures during the previous 3 months, presence of a central line, previous FN episode(s), hypotension, tachycardia, and tachypnea were found to be risk factors for bacteremia. Positive central line cultures during the previous 3 months and presence of previous FN episode(s) were shown to increase bacteremia risk by 2.4-fold and 2.5-fold, respectively.

Conclusion: Presence of a bacterial growth in central line cultures during the previous 3 months and presence of any previous FN episode(s) were shown to increase bacteremia risk by 2.4-fold and 2.5-fold, respectively. These factors can predict bacteremia in children with FN.
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http://dx.doi.org/10.3906/sag-1901-90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018307PMC
August 2019

Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models.

EMBO Mol Med 2019 07 6;11(7):e10201. Epub 2019 Jun 6.

Laboratory of Genome Dynamics in the Immune System, INSERM, UMR 1163, Paris, France.

PARN, poly(A)-specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated with Høyeraal-Hreidarsson (HH) syndrome, a rare telomere biology disorder that, because of its severity, is likely not exclusively due to hTR down-regulation. Whether PARN deficiency was affecting the expression of telomere-related genes was still unclear. Using cells from two unrelated HH individuals carrying novel PARN mutations and a human PARN knock-out (KO) cell line with inducible PARN complementation, we found that PARN deficiency affects both telomere length and stability and down-regulates the expression of TRF1, TRF2, TPP1, RAP1, and POT1 shelterin transcripts. Down-regulation of dyskerin-encoding DKC1 mRNA was also observed and found to result from p53 activation in PARN-deficient cells. We further showed that PARN deficiency compromises ribosomal RNA biogenesis in patients' fibroblasts and cells from heterozygous Parn KO mice. Homozygous Parn KO however resulted in early embryonic lethality that was not overcome by p53 KO. Our results refine our knowledge on the pleiotropic cellular consequences of PARN deficiency.
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http://dx.doi.org/10.15252/emmm.201810201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609912PMC
July 2019

Ventilator associated pneumonia due to carbapenem resistant microorganisms in children.

Minerva Pediatr 2019 Aug;71(4):349-357

Unit of Pediatric Infectious Diseases, Medical Faculty, Gazi University, Ankara, Turkey.

Background: Infections due to carbapenem resistant pathogens have become a major health threat especially for hospitalized patients. Acinetobacter baumanii (AB) and Pseudomonas aeruginosa (PA) are important pathogens causing ventilator-associated pneumonia (VAP) with a trend of high resistance to carbapenems. The aim of this study is to investigate the risk factors for VAP due to carbapenem resistant Acinetobacter baumanii (CRAB) and Pseudomonas aeruginosa (CRPA) in children.

Methods: Between 2009 and 2013, an active, prospective observational study was conducted in Gazi University Hospital. Patients from Pediatric Intensive Care Unit (PICU), between 1 month and 12 years of age with VAP due to AB and PA were included.

Results: During this period, 74 children experienced 126 VAP episodes due to Acinetobacter baumanii (N.=58) and Pseudomonas aeruginosa (N.=68). Among these, 93.1% (N.=54) of AB and 51.5% (N.=35) of PA were carbapenem resistant. In univariate analysis, length of stay in PICU until the diagnosis of VAP, presence of central venous catheters, prior use of cefepime, ciprofloxacin, colistin, and teicoplanin were associated with VAP due to CRPA (P=0.02, P=0.02, P=0.006, P=0.01, P=0.001, and P=0.009 respectively). Significant association was not found between the development of VAP due to CRAB and the investigated risk factors. Regression analyses revealed previous use of cefepime (OR, 2.11; 95% CI, 0.016-0.595, P=0.039) and colistin (OR: 2.33; 95% CI: 0.061-0.789, P=0.023) to be independently associated with VAP due to CRPA.

Conclusions: This study suggests that broad spectrum antibiotic usage was the most important risk factor for the development of VAP due to CRPA.
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http://dx.doi.org/10.23736/S0026-4946.17.04284-0DOI Listing
August 2019

Antibiotic Stewardship in Pediatrics.

Pediatr Infect Dis J 2019 09;38(9):e235

Pediatric Infectious Diseases Unit, Ankara Hematology and Oncology Research Hospital, Health Sciences University, Ankara, Turkey Pediatric Infectious Diseases Unit, Pamukkale University, Denizli, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000002360DOI Listing
September 2019

Pediatric cases caused by Streptococcus pneumoniae Serotype 3.

Hum Vaccin Immunother 2019 16;15(4):873. Epub 2019 Jan 16.

c Microbiology Department , Public Health General Directorate , Ankara , Turkey.

Streptococcus pneumoniae causes invasive pneumococcal disease (IPD), leading to high morbidity and mortality worldwide. Although nonvaccine serotypes constitute a major issue in the aspect of invasive pneumococcal disease, serotypes included in PCV13 still continue to be a problem. Vaccination with very high coverage and multicenter surveillance studies would be beneficial to decrease carriage of vaccine and nonvaccine serotypes of pneumococcus and monitor changing seroepidemiology.
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http://dx.doi.org/10.1080/21645515.2018.1554975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605843PMC
October 2019

Tigecycline salvage therapy for ventriculoperitoneal shunt meningitis due to extensively drug-resistant Acinetobacter baumannii.

Eur J Pediatr 2019 Jan 23;178(1):117-118. Epub 2018 Oct 23.

Department of Pediatric Infectious Diseases, Health Sciences University Ankara Hematology and Oncology Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1007/s00431-018-3271-2DOI Listing
January 2019

Parental vaccine knowledge and behaviours: a survey of Turkish families.

East Mediterr Health J 2018 Jul 17;24(5):451-458. Epub 2018 Jul 17.

Department of Social Paediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey.

Background: Personal and herd immunity require durability in high vaccination coverage rates, and this mainly depends on the interaction between parental and service/provider factors.

Aims: The aim of this study was to assess Turkish parents' knowledge and behaviours concerning childhood vaccination and their association with familial sociodemographic characteristics.

Methods: A cross-sectional survey, including a questionnaire, was conducted with parents of children aged between 1 day and 120 months.

Results: Of the 903 index children, 881 (97.6%) were up to date for all vaccinations by age. Demographic variables were not related to belief in protection through vaccination or rejection of obligatory vaccines. Mean age, education level, occupation of mother (P = 0.006, P < 0.001, and P = 0.01, respectively) and father (P = 0.002, P < 0.001, and P = 0.006, respectively), average monthly household income (P < 0.001), and experience of vaccine side-effects (P = 0.02) were associated with knowledge about optional childhood vaccines. Father's education level was independently associated with knowledge about optional childhood vaccines.

Conclusions: Having any experience of vaccine side-effects and parental sociodemographic characteristics, especially father's education level, affect Turkish parents' knowledge of childhood optional vaccines.
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http://dx.doi.org/10.26719/2018.24.5.451DOI Listing
July 2018

Fatal meningococcemia due to Neisseria meningitidis serogroup Y in a vaccinated child receiving eculizumab.

Hum Vaccin Immunother 2018 29;14(11):2802. Epub 2018 Jun 29.

c National Reference Laboratory for Respiratory Pathogens, Microbiology Reference Laboratories Department, Public Health Institution of Turkey , Ankara , Turkey.

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http://dx.doi.org/10.1080/21645515.2018.1486157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314419PMC
June 2019
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