Publications by authors named "Melkam Kebede"

21Publications

Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes.

Authors:
Louise Cottle Wan Jun Gan Ian Gilroy Jaswinder S Samra Anthony J Gill Thomas Loudovaris Helen E Thomas Wayne J Hawthorne Melkam A Kebede Peter Thorn

Diabetologia 2021 Mar 5;64(3):618-629. Epub 2021 Jan 5.

Charles Perkins Centre, Discipline of Physiology, School of Medical Sciences, University of Sydney, Camperdown, NSW, Australia.

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March 2021

Pancreatic β-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion.

Authors:
Christian H Burns Belinda Yau Anjelica Rodriguez Jenna Triplett Drew Maslar You Sun An Reini E N van der Welle Ross G Kossina Max R Fisher Gregory W Strout Peter O Bayguinov Tineke Veenendaal David Chitayat James A J Fitzpatrick Judith Klumperman Melkam A Kebede Cedric S Asensio

Diabetes 2021 Feb 9;70(2):436-448. Epub 2020 Nov 9.

Department of Biological Sciences, University of Denver, Denver, CO

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February 2021

Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix.

Authors:
Reena Singh Louise Cottle Thomas Loudovaris Di Xiao Pengyi Yang Helen E Thomas Melkam A Kebede Peter Thorn

Stem Cells Transl Med 2021 Mar 4;10(3):492-505. Epub 2020 Nov 4.

Charles Perkins Centre, Discipline of Physiology, School of Medical Sciences, University of Sydney, Camperdown, New South Wales, Australia.

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March 2021

A fluorescent timer reporter enables sorting of insulin secretory granules by age.

Authors:
Belinda Yau Lori Hays Cassandra Liang D Ross Laybutt Helen E Thomas Jenny E Gunton Lindy Williams Wayne J Hawthorne Peter Thorn Christopher J Rhodes Melkam A Kebede

J Biol Chem 2020 07 27;295(27):8901-8911. Epub 2020 Apr 27.

Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia

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July 2020

Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion.

Authors:
Wei Ma Jenny Chang Jason Tong Uda Ho Belinda Yau Melkam A Kebede Peter Thorn

J Cell Sci 2020 03 30;133(6). Epub 2020 Mar 30.

Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia

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March 2020

Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells.

Authors:
Belinda Yau Zachary Blood Yousun An Zhiduan Su Melkam A Kebede

Sci Rep 2019 12 19;9(1):19466. Epub 2019 Dec 19.

Charles Perkins Centre, School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.

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December 2019

Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.

Authors:
Samantha M Solon-Biet Victoria C Cogger Tamara Pulpitel Devin Wahl Ximonie Clark Elena Bagley Gabrielle C Gregoriou Alistair M Senior Qiao-Ping Wang Amanda E Brandon Ruth Perks John O'Sullivan Yen Chin Koay Kim Bell-Anderson Melkam Kebede Belinda Yau Clare Atkinson Gunbjorg Svineng Timothy Dodgson Jibran A Wali Matthew D W Piper Paula Juricic Linda Partridge Adam J Rose David Raubenheimer Gregory J Cooney David G Le Couteur Stephen J Simpson

Nat Metab 2019 05 29;1(5):532-545. Epub 2019 Apr 29.

Charles Perkins Centre, The University of Sydney NSW, Australia.

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May 2019

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation.

Authors:
Jacqueline Stöckli Armella Zadoorian Kristen C Cooke Vinita Deshpande Belinda Yau Gaia Herrmann Melkam A Kebede Sean J Humphrey David E James

Mol Metab 2019 07 6;25:83-94. Epub 2019 May 6.

Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia. Electronic address:

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July 2019

TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis.

Authors:
Siân P Cartland Scott W Genner Gonzalo J Martínez Stacy Robertson Maaike Kockx Ruby Cy Lin John F O'Sullivan Yen Chin Koay Pradeep Manuneedhi Cholan Melkam A Kebede Andrew J Murphy Seth Masters Martin R Bennett Wendy Jessup Leonard Kritharides Carolyn Geczy Sanjay Patel Mary M Kavurma

iScience 2019 Feb 4;12:41-52. Epub 2019 Jan 4.

Heart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia. Electronic address:

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February 2019

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.

Authors:
James G Burchfield Melkam A Kebede Christopher C Meoli Jacqueline Stöckli P Tess Whitworth Amanda L Wright Nolan J Hoffman Annabel Y Minard Xiuquan Ma James R Krycer Marin E Nelson Shi-Xiong Tan Belinda Yau Kristen C Thomas Natalie K Y Wee Ee-Cheng Khor Ronaldo F Enriquez Bryce Vissel Trevor J Biden Paul A Baldock Kyle L Hoehn James Cantley Gregory J Cooney David E James Daniel J Fazakerley

J Biol Chem 2018 04 13;293(15):5731-5745. Epub 2018 Feb 13.

From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.

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April 2018

The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.

Authors:
Mark P Keller Pradyut K Paul Mary E Rabaglia Donnie S Stapleton Kathryn L Schueler Aimee Teo Broman Shuyun Isabella Ye Ning Leng Christopher J Brandon Elias Chaibub Neto Christopher L Plaisier Shane P Simonett Melkam A Kebede Gloria M Sheynkman Mark A Klein Nitin S Baliga Lloyd M Smith Karl W Broman Brian S Yandell Christina Kendziorski Alan D Attie

PLoS Genet 2016 Dec 9;12(12):e1006466. Epub 2016 Dec 9.

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America.

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December 2016

Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry.

Authors:
Julien Ghislain Ghislaine Fontés Caroline Tremblay Melkam A Kebede Vincent Poitout

Endocrinology 2016 Mar 15;157(3):1299-306. Epub 2015 Dec 15.

Montreal Diabetes Research Center (J.G., G.F., C.T., M.A.K., V.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (J.G., G.F., C.T., M.A.K., V.P.), and Departments of Medicine (V.P.) and Biochemistry (V.P.), University of Montreal, Montréal, Québec, Canada H2X 0A9.

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March 2016

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.

Authors:
Melkam A Kebede Angie T Oler Trillian Gregg Allison J Balloon Adam Johnson Kelly Mitok Mary Rabaglia Kathryn Schueler Donald Stapleton Candice Thorstenson Lindsay Wrighton Brendan J Floyd Oliver Richards Summer Raines Kevin Eliceiri Nabil G Seidah Christopher Rhodes Mark P Keller Joshua L Coon Anjon Audhya Alan D Attie

J Clin Invest 2014 Oct 26;124(10):4240-56. Epub 2014 Aug 26.

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October 2014

Insights into obesity and diabetes at the intersection of mouse and human genetics.

Authors:
Melkam A Kebede Alan D Attie

Trends Endocrinol Metab 2014 Oct 15;25(10):493-501. Epub 2014 Jul 15.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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October 2014

Zinc, insulin, and the liver: a ménage à trois.

Authors:
Thomas V O'Halloran Melkam Kebede Steven J Philips Alan D Attie

J Clin Invest 2013 Oct 24;123(10):4136-9. Epub 2013 Sep 24.

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October 2013

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1.

Authors:
Melkam Kebede Mourad Ferdaoussi Arturo Mancini Thierry Alquier Rohit N Kulkarni Michael D Walker Vincent Poitout

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2376-81. Epub 2012 Jan 30.

Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universite de Montreal, and Department of Medicine, University of Montreal, Montreal, QC, Canada H3T 1J4.

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February 2012

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Authors:
Thierry Alquier Marie-Line Peyot Martin G Latour Melkam Kebede Christina M Sorensen Stephane Gesta C Ronald Kahn Richard D Smith Thomas L Jetton Thomas O Metz Marc Prentki Vincent Poitout

Diabetes 2009 Nov 31;58(11):2607-15. Epub 2009 Aug 31.

Montréal Diabetes Research Center, Research Centre of the Montréal University Hospital, University of Montréal, Montréal, QC, Canada.

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November 2009

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

Authors:
Melkam Kebede Thierry Alquier Martin G Latour Meriem Semache Caroline Tremblay Vincent Poitout

Diabetes 2008 Sep 16;57(9):2432-7. Epub 2008 Jun 16.

Montréal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada

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September 2008

Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function.

Authors:
Melkam Kebede Jenny Favaloro Jenny E Gunton D Ross Laybutt Margaret Shaw Nicole Wong Barbara C Fam Kathryn Aston-Mourney Christian Rantzau Anthony Zulli Joseph Proietto Sofianos Andrikopoulos

Diabetes 2008 Jul 28;57(7):1887-95. Epub 2008 Mar 28.

Department of Medicine, Heidelberg Repatriation Hospital, University of Melbourne, Heidelberg Heights, Victoria, Australia.

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July 2008

Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis.

Authors:
Benjamin J Lamont Sherley Visinoni Barbara C Fam Melkam Kebede Blaise Weinrich Stavroula Papapostolou Helene Massinet Joseph Proietto Jenny Favaloro Sofianos Andrikopoulos

Endocrinology 2006 Jun 23;147(6):2764-72. Epub 2006 Feb 23.

Department of Medicine (Austin Health and Northern Health), University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081, Australia.

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June 2006