Melissa S Jurica

Melissa S Jurica

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Melissa S Jurica

Melissa S Jurica

Publications by authors named "Melissa S Jurica"

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A two-step probing method to compare lysine accessibility across macromolecular complex conformations.

RNA Biol 2019 10 29;16(10):1346-1354. Epub 2019 Jun 29.

Department of Molecular, Cell and Developmental Biology, University California , Santa Cruz , USA.

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http://dx.doi.org/10.1080/15476286.2019.1632777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779377PMC
October 2019

Human RNF113A participates of pre-mRNA splicing in vitro.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1002/jcb.28163DOI Listing
December 2018

Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity.

Org Lett 2018 11 5;20(22):7293-7297. Epub 2018 Nov 5.

Department of Molecular Cell and Developmental Biology and Center for Molecular Biology of RNA , University of California , Santa Cruz , California 95064 , United States.

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http://pubs.acs.org/doi/10.1021/acs.orglett.8b03228
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http://dx.doi.org/10.1021/acs.orglett.8b03228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519444PMC
November 2018

Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.

RNA 2018 06 27;24(6):769-777. Epub 2018 Feb 27.

Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA.

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http://dx.doi.org/10.1261/rna.065458.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959246PMC
June 2018

Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition.

J Org Chem 2018 05 26;83(9):5187-5198. Epub 2018 Apr 26.

Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA , University of California, Santa Cruz , California 95064 , United States.

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http://dx.doi.org/10.1021/acs.joc.8b00593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972027PMC
May 2018

Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester.

Org Lett 2018 01 8;20(1):96-99. Epub 2017 Dec 8.

Department of Molecular Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California , Santa Cruz, California 95064, United States.

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http://dx.doi.org/10.1021/acs.orglett.7b03456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972028PMC
January 2018

Modulating splicing with small molecular inhibitors of the spliceosome.

Wiley Interdiscip Rev RNA 2017 03 21;8(2). Epub 2016 Jul 21.

Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.

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http://dx.doi.org/10.1002/wrna.1381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253128PMC
March 2017

Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene.

Org Biomol Chem 2016 Jun 18;14(23):5263-71. Epub 2016 May 18.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1039/c6ob00725bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333946PMC
June 2016

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages.

RNA 2016 Mar 7;22(3):350-9. Epub 2016 Jan 7.

Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA.

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http://rnajournal.cshlp.org/lookup/doi/10.1261/rna.053108.11
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http://dx.doi.org/10.1261/rna.053108.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748813PMC
March 2016

The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes.

J Biol Chem 2015 Nov 25;290(46):27524-31. Epub 2015 Sep 25.

From the Department of Molecular, Cell and Developmental Biology, Center for Molecular Biology of RNA, and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.673210
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http://dx.doi.org/10.1074/jbc.M115.673210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646004PMC
November 2015

Nuclear cyclophilins affect spliceosome assembly and function in vitro.

Biochem J 2015 Jul 13;469(2):223-33. Epub 2015 May 13.

Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, CA 95064, U.S.A. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, U.S.A.

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http://dx.doi.org/10.1042/BJ20150396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537404PMC
July 2015

Chromatin structure analysis of single gene molecules by psoralen cross-linking and electron microscopy.

Methods Mol Biol 2015 ;1228:93-121

Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA.

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http://dx.doi.org/10.1007/978-1-4939-1680-1_9DOI Listing
June 2015

Enantioselective synthesis of spliceostatin E and evaluation of biological activity.

Org Lett 2014 Dec 25;16(23):6200-3. Epub 2014 Nov 25.

‡Department of Molecular Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, United States.

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http://pubs.acs.org/doi/10.1021/ol503127r
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http://dx.doi.org/10.1021/ol503127rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260646PMC
December 2014

Isolation and accumulation of spliceosomal assembly intermediates.

Methods Mol Biol 2014 ;1126:179-92

Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, CA, USA.

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http://dx.doi.org/10.1007/978-1-62703-980-2_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038131PMC
October 2014

Total synthesis of GEX1Q1, assignment of C-5 stereoconfiguration and evaluation of spliceosome inhibitory activity.

Org Lett 2014 Jun 28;16(11):3154-7. Epub 2014 May 28.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907, United States.

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http://pubs.acs.org/doi/10.1021/ol501345d
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http://dx.doi.org/10.1021/ol501345dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051430PMC
June 2014

Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives.

J Org Chem 2014 Jun 30;79(12):5697-709. Epub 2014 May 30.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , 560 Oval Drive, West Lafayette, Indiana 4790, United States.

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http://dx.doi.org/10.1021/jo500800kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066912PMC
June 2014

Linking stochastic fluctuations in chromatin structure and gene expression.

PLoS Biol 2013 6;11(8):e1001621. Epub 2013 Aug 6.

Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, USA.

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http://dx.doi.org/10.1371/journal.pbio.1001621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735467PMC
March 2014

A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes.

J Biomol Screen 2013 Oct 14;18(9):1110-20. Epub 2013 Jun 14.

1Department of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA.

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http://dx.doi.org/10.1177/1087057113493117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902173PMC
October 2013

Rearrangements within human spliceosomes captured after exon ligation.

RNA 2013 Mar 23;19(3):400-12. Epub 2013 Jan 23.

Department of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA.

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http://dx.doi.org/10.1261/rna.034223.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677250PMC
March 2013

Spliceosome database: a tool for tracking components of the spliceosome.

Nucleic Acids Res 2013 Jan 30;41(Database issue):D132-41. Epub 2012 Oct 30.

Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, 1156 High Street, Santa Cruz, CA 95064, USA.

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http://dx.doi.org/10.1093/nar/gks999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531166PMC
January 2013

Coordination of copper to the membrane-bound form of α-synuclein.

Biochemistry 2013 Jan 26;52(1):53-60. Epub 2012 Dec 26.

Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.

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http://dx.doi.org/10.1021/bi301475qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544399PMC
January 2013

Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.

PLoS One 2011 Apr 19;6(4):e19061. Epub 2011 Apr 19.

Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019061PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079748PMC
April 2011

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

Nucleic Acids Res 2010 Oct 6;38(19):6664-72. Epub 2010 Jun 6.

Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, CA, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkq494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965229PMC
October 2010

The role of exon sequences in C complex spliceosome structure.

J Mol Biol 2009 Nov 15;394(2):363-75. Epub 2009 Sep 15.

Department of Molecular, Cell and Developmental Biology, University of California, 1156 High Street, Santa Cruz, CA 95064, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783800PMC
November 2009

Detailed close-ups and the big picture of spliceosomes.

Authors:
Melissa S Jurica

Curr Opin Struct Biol 2008 Jun 10;18(3):315-20. Epub 2008 Jun 10.

Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, CA 95064, United States.

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http://dx.doi.org/10.1016/j.sbi.2008.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474778PMC
June 2008

Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3.

J Biol Chem 2008 Mar 22;283(13):8145-52. Epub 2008 Jan 22.

Department of Molecular, Cell, and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, CA 95064, USA.

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http://dx.doi.org/10.1074/jbc.M707984200DOI Listing
March 2008

A protein-based EM label for RNA identifies the location of exons in spliceosomes.

Nat Struct Mol Biol 2008 Feb 27;15(2):213-5. Epub 2008 Jan 27.

Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, 1156 High Street, Santa Cruz, California 95064, USA.

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http://dx.doi.org/10.1038/nsmb.1378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004785PMC
February 2008

Searching for a wrench to throw into the splicing machine.

Authors:
Melissa S Jurica

Nat Chem Biol 2008 Jan;4(1):3-6

Center for Molecular Biology of RNA and the Department of Cell, Developmental and Molecular Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, USA.

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http://www.nature.com/articles/nchembio0108-3
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http://dx.doi.org/10.1038/nchembio0108-3DOI Listing
January 2008

Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

RNA 2005 Dec;11(12):1869-83

Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.

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http://dx.doi.org/10.1261/rna.2155905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370875PMC
December 2005

Three-dimensional structure of C complex spliceosomes by electron microscopy.

Nat Struct Mol Biol 2004 Mar 15;11(3):265-9. Epub 2004 Feb 15.

Howard Hughes Medical Institute, Rosenstiel Basic Medical Sciences Research Center, Department of Biochemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.

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http://dx.doi.org/10.1038/nsmb728DOI Listing
March 2004

Homology modeling and mutational analysis of Ho endonuclease of yeast.

Genetics 2004 Feb;166(2):721-8

Department of Life Sciences, Ben Gurion University of the Negev, Beersheva, 84105 Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470740PMC
http://dx.doi.org/10.1534/genetics.166.2.721DOI Listing
February 2004

Pre-mRNA splicing: awash in a sea of proteins.

Mol Cell 2003 Jul;12(1):5-14

Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02454, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00270-3DOI Listing
July 2003

5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.

Genes Dev 2002 Nov;16(21):2778-91

Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, Massachusetts 02454, USA.

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http://dx.doi.org/10.1101/gad.1030602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187475PMC
November 2002

Capturing splicing complexes to study structure and mechanism.

Methods 2002 Nov;28(3):336-45

Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02454, USA.

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http://dx.doi.org/10.1016/s1046-2023(02)00240-2DOI Listing
November 2002

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

RNA 2002 Apr;8(4):426-39

Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370266PMC
http://dx.doi.org/10.1017/s1355838202021088DOI Listing
April 2002