SimpleXMLElement Object ( [PubmedArticle] => Array ( [0] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Process [Owner] => NLM ) [PMID] => 32956023 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 06 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1531-2267 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 52 [Issue] => 10 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 10 [Day] => 01 ) ) [Title] => Physiological genomics [ISOAbbreviation] => Physiol Genomics ) [ArticleTitle] => Genetic background influences the impact of KLOTHO deficiency. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 512-516 ) [ELocationID] => 10.1152/physiolgenomics.00094.2020 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Genetic background is a key but sometimes overlooked factor that profoundly impacts disease susceptibility and presentation in both humans and disease models. Here we show that deficiency of KLOTHO protein, an important renal regulator of mineral homeostasis and a cofactor for FGF23, causes different phenotypes in 129S1/SvlmJ (129) and C57BL/6J (B6) mouse strains. The 129 strain is more severely affected, with decreased longevity, decreased body weight, and increased amounts of kidney calcification compared with B6 mice. Reciprocal F1 crosses of the strains also indicate a parentage effect on the phenotype with F1 KLOTHO-deficient progeny of B6 mothers and 129 fathers having more kidney calcification than progeny of 129 mothers and B6 fathers. Comparing and contrasting the genetic architecture leading to different phenotypes associated with specific inbred mouse strains may reveal previously unrecognized and important metabolic interactions affecting chronic kidney disease. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Salloum [ForeName] => Jawad S [Initials] => JS [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers - New Jersey Medical School, Newark, New Jersey. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Garsetti [ForeName] => Diane E [Initials] => DE [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers - New Jersey Medical School, Newark, New Jersey. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rogers [ForeName] => Melissa B [Initials] => MB [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers - New Jersey Medical School, Newark, New Jersey. ) ) ) ) [Language] => eng [GrantList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Grant] => Array ( [0] => SimpleXMLElement Object ( [GrantID] => R01 HL134947 [Acronym] => HL [Agency] => NHLBI NIH HHS [Country] => United States ) [1] => SimpleXMLElement Object ( [GrantID] => R56 AG050762 [Acronym] => AG [Agency] => NIA NIH HHS [Country] => United States ) [2] => SimpleXMLElement Object ( [GrantID] => R56AG050762 [Acronym] => AG [Agency] => NIA NIH HHS [Country] => United States ) [3] => SimpleXMLElement Object ( [GrantID] => R01HL114751 [Acronym] => HL [Agency] => NHLBI NIH HHS [Country] => United States ) ) ) [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Research Support, N.I.H., Extramural ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 09 [Day] => 21 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Physiol Genomics [NlmUniqueID] => 9815683 [ISSNLinking] => 1094-8341 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => 129S1/SvlmJ (129) [1] => C57Bl/6J (B6) [2] => KLOTHO [3] => parent of origin [4] => renal disease ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pmc-release ) [Year] => 2021 [Month] => 10 [Day] => 01 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] 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Array ( [CitedMedium] => Internet ) [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Sep [Day] => 21 ) ) [Title] => Physiological genomics [ISOAbbreviation] => Physiol Genomics ) [ArticleTitle] => MicroRNA Profiles in Calcified and Healthy Aorta Differ: Therapeutic Impact of miR-145 and miR-378. [ELocationID] => 10.1152/physiolgenomics.00074.2020 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Our goal was to elucidate microRNAs (miRNAs) that may repress the excess bone morphogenetic protein (BMP) signaling observed during pathological calcification in the Klotho mouse model of kidney disease. We hypothesized that restoring healthy levels of miRNAs that post-transcriptionally repress osteogenic calcific factors may decrease aortic calcification. Our relative abundance profiles of miRNAs in healthy aorta differ greatly from those in calcified mouse aorta. Many of these miRNAs are predicted to regulate proteins involved in BMP signaling and may control osteogenesis. Two differentially regulated miRNAs, miR-145 and miR-378, were selected based on three criteria: reduced levels in calcified aorta, the ability to target more than one protein in the BMP signaling pathway, and conservation of targeted sequences between humans and mice. Forced expression using a lentiviral vector demonstrated that restoring normal levels repressed the synthesis of BMP2 and other pro-osteogenic proteins and inhibited pathological aortic calcification in Klotho mice with renal insufficiency. This study identified miRNAs that may impact BMP signaling in both sexes and demonstrated the efficacy of selected miRNAs in reducing aortic calcification in vivo. Calcification of the aorta and the aortic valve resulting from abnormal osteogenesis is common in those with kidney disease, diabetes, and high cholesterol. Such vascular osteogenesis is a clinically significant feature. The calcification modulating miRNAs described here are candidates for biomarkers and "miRNA replacement therapies" in the context of chronic kidney disease and other pro-calcific conditions. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tang [ForeName] => Ying [Initials] => Y [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Rutgers - New Jersey Medical School, Microbiology, Biochemistry, & Molecular Genetics, Newark, NJ, United States. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shah [ForeName] => Tapan A [Initials] => TA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Rutgers - New Jersey Medical School, Microbiology, Biochemistry, & Molecular Genetics, Newark, NJ, United States. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Yurkow [ForeName] => Edward J [Initials] => EJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Rutgers University Molecular Imaging Center (RUMIC), Rutgers University, Piscataway, NJ, United States. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rogers [ForeName] => Melissa B [Initials] => MB [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Rutgers - New Jersey Medical School, Microbiology, Biochemistry, & Molecular Genetics, Newark, NJ, United States. ) ) ) ) [Language] => eng [GrantList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Grant] => Array ( [0] => SimpleXMLElement Object ( [GrantID] => R01HL114751 [Agency] => The national heart, lung,and Blood Institute [Country] => SimpleXMLElement Object ( ) ) [1] => SimpleXMLElement Object ( [GrantID] => R56 AG050762 [Acronym] => AG [Agency] => NIA NIH HHS [Country] => United States ) [2] => SimpleXMLElement Object ( [GrantID] => R56AG050762 [Agency] => National Institutes of Aging [Country] => SimpleXMLElement Object ( ) ) [3] => SimpleXMLElement Object ( [GrantID] => 20POST35210235 [Agency] => American Heart Association (AHA) [Country] => SimpleXMLElement Object ( ) ) [4] => SimpleXMLElement Object ( [GrantID] => R01 HL134947 [Acronym] => HL [Agency] => NHLBI NIH HHS [Country] => United States ) ) ) [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 09 [Day] => 21 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Physiol Genomics [NlmUniqueID] => 9815683 [ISSNLinking] => 1094-8341 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => bone morphogenetic proteins [1] => gene regulation [2] => microRNA [3] => signal transduction [4] => vascular calcification ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 9 [Day] => 21 [Hour] => 17 [Minute] => 12 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 9 [Day] => 22 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 9 [Day] => 22 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32956022 [1] => 10.1152/physiolgenomics.00074.2020 ) ) ) ) [2] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Data-Review [Owner] => NLM ) [PMID] => 32873388 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 09 [Day] => 02 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1876-4452 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 60 [Issue] => 5 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Sep ) ) [Title] => Science & justice : journal of the Forensic Science Society [ISOAbbreviation] => Sci Justice ) [ArticleTitle] => Use of RGB values in the Periodic Acid-Schiff color test to determine the presence of vaginal fluid. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 480-485 ) [ELocationID] => Array ( [0] => S1355-0306(20)30021-6 [1] => 10.1016/j.scijus.2020.06.004 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => This study demonstrates how RGB color values from microscopic smears stained with the Periodic Acid-Schiff reagent under standardized microscopy conditions can be used to indicate the presence of vaginal secretions. Based on data obtained in the study, a numeric threshold determined from the sum of separate values for red, blue and green was determined to differentiate vaginal-based samples with other body fluids. Using this threshold, 55 of 57 vaginal-based samples tested positive for the presence of vaginal secretion. Conversely, 27 of 29 smears prepared from other body fluids yielded negative results. However, when graphing RGB sum values against a calculated RGB integer no overlap in data was obtained between all vaginal-based samples and other body fluid samples, clearly differentiating them. One-way ANOVA testing with a 95% confidence interval indicated that vaginal samples from different age groups showed no difference in RGB sum values. Similarly, the location that vaginal swabs were collected (from the outside of a condom or a vaginal swab) also showed no statistical difference using one-way ANOVA at 95% confidence. Furthermore, refrigerated test swabs aged up to 15 months showed no demonstrable differences. Pair-wise t-testing using RGB sum values, however, did show significant differences between vaginal samples and all other body fluids tested. Finally, the method successfully differentiated between pre-and post-coital penile swabs and finger swabs taken before and after digital vaginal penetration in anecdotal comparisons using the method. [CopyrightInformation] => Copyright © 2020 The Chartered Society of Forensic Sciences. Published by Elsevier B.V. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rogers [ForeName] => Melissa [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Forensic Science Program, Cedar Crest College, Allentown, PA 18104, United States. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Lal-Paterson [ForeName] => Amrita [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Delaware Division of Forensic Science, Wilmington, DE, United States. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kishbaugh [ForeName] => Janine [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Forensic Science Program, Cedar Crest College, Allentown, PA 18104, United States. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Quarino [ForeName] => Lawrence [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Forensic Science Program, Cedar Crest College, Allentown, PA 18104, United States. Electronic address: laquarin@cedarcrest.edu. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 06 [Day] => 17 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Sci Justice [NlmUniqueID] => 9508563 [ISSNLinking] => 1355-0306 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Periodic Acid Shiff reagent [1] => RGB color system [2] => Vaginal secretion identification ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 02 [Day] => 01 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 06 [Day] => 12 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 06 [Day] => 14 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 9 [Day] => 3 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 9 [Day] => 3 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 9 [Day] => 3 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32873388 [1] => S1355-0306(20)30021-6 [2] => 10.1016/j.scijus.2020.06.004 ) ) ) ) [3] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Process [Owner] => NLM ) [PMID] => 32483343 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1476-5438 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 28 [Issue] => 12 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 ) ) [Title] => European journal of human genetics : EJHG [ISOAbbreviation] => Eur J Hum Genet ) [ArticleTitle] => National Newborn Screening for cystic fibrosis in the Republic of Ireland: genetic data from the first 6.5 years. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1669-1674 ) [ELocationID] => 10.1038/s41431-020-0661-5 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Cystic fibrosis (CF) is the most common life-limiting autosomal recessive disease in the Republic of Ireland (ROI), with a previously quoted incidence of 1 in 1353 and carrier rate of 1 in 19. The National Newborn Screening (NBS) for CF was incorporated in July 2011 in the ROI. A cut-off point of the top 1% Immunoreactive Trypsinogen (IRT) was taken as an indication for 38 CFTR variant panel to maximise identification of affected CF cases and to minimise detection of carriers. All neonates from July 2011 to Dec 2017 with an elevated IRT on NBS were tested with 38 CFTR mutation panel and included. Clinical and laboratory database were analysed. In the first 6.5 years a total of 5,053 newborns (1.16% of total births) were screened with 38 CFTR panel. 170 CF affected cases, 320 unaffected carriers, 32 CF Screening Positive Inconclusive Diagnosis (CFSPID) were identified. There was one missed diagnosis. The most common disease-causing variant was c.1521_1523delCTT (p.(Phe508del)) followed by c.1652G>A (p.(Gly551Asp)). 95 out of 170 (55%) affected newborns were homozygous for c.1521_1523delCTT (p.(Phe08del)) and 25 (15%) carried at least one copy of c.1652G>A (p.(Gly551Asp)). Hence, 70% of affected newborns were eligible for CFTR modulator treatment. The NBS programme has identified almost triple the number of affected newborn with c.1652G>A (p.(Gly551Asp)) than previously quoted figures and identified less than 50% of carriers than predicted. The revised incidence and carrier frequency of CF in the ROI is 1 in 2570 and 1 in 25, respectively. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sasaki [ForeName] => Erina [Initials] => E [Identifier] => 0000-0003-1448-1151 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Genetics, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland. sasakierina06@gmail.com. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kostocenko [ForeName] => Marija [Initials] => M [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Genetics, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland. ) [1] => SimpleXMLElement Object ( [Affiliation] => Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland. ) ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Lang [ForeName] => Niamh [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Genetics, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Clark [ForeName] => Tara [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Genetics, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rogers [ForeName] => Melissa [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Genetics, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Muldowney [ForeName] => Rebecca [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Genetics, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Walsh [ForeName] => Olivia [Initials] => O [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Newborn Bloodspot Screening Laboratory, Department of Paediatric Laboratory Medicine, Children's Health Ireland (CHI) at Temple Street, Dublin, Ireland. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => O'Grady [ForeName] => Loretta [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Newborn Bloodspot Screening Laboratory, Department of Paediatric Laboratory Medicine, Children's Health Ireland (CHI) at Temple Street, Dublin, Ireland. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Edge [ForeName] => Gillian [Initials] => G [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Newborn Bloodspot Screening Laboratory, Department of Paediatric Laboratory Medicine, Children's Health Ireland (CHI) at Temple Street, Dublin, Ireland. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ward [ForeName] => Alana [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Genetics, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland. ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Linnane [ForeName] => Barry [Initials] => B [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Graduate Entry Medical School and Centre for Interventions in Infection, Inflammation and Immunity [4i], University of Limerick, Limerick, Ireland. ) [1] => SimpleXMLElement Object ( [Affiliation] => National Children's Research 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1832-1839 ) [ELocationID] => 10.1038/s41431-018-0234-z [Abstract] => SimpleXMLElement Object ( [AbstractText] => The high incidence of cystic fibrosis (CF) is due to the frequency of the c.1521_1523delCTT variant in the cystic fibrosis transmembrane conductance regulator (CFTR), but its age and origin are uncertain. This gap limits attempts to shed light on the presumed heterozygote selective advantage that accounts for the variant's high prevalence among Caucasian Europeans and Europe-derived populations. In addition, explaining the nature of heterozygosity to screened individuals with one c.1521_1523delCTT variant is challenging when families raise questions about these issues. To address this gap, we obtained DNA samples from 190 patients bearing c.1521_1523delCTT and their parents residing in geographically distinct European populations plus a Germany-derived population in the USA. We identified microsatellites spanning CFTR and reconstructed haplotypes at 10 loci to estimate the time/age of the most recent common ancestor (tMRCA) with the Estiage program. We found that the age estimates differ between northwestern populations, where the mean tMRCA values vary between 4600 and 4725 years, and the southeastern populations where c.1521_1523delCTT seems to have been introduced only about 1000 years ago. The tMRCA values of Central Europeans were intermediate. Thus, our data resolve a controversy by establishing an early Bronze Age origin of the c.1521_1523delCTT allele and demonstrating its likely spread from northwest to southeast during ancient migrations. 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Cre-lox mediated deletion of the UCS in a reporter transgene revealed that the UCS may repress Bmp2 in proepicardium, epicardium, and epicardium-derived cells (EPDC) and in tissues with known epicardial contributions (coronary vessels and valves). The UCS also repressed the transgene in the aorta, outlet septum, posterior cardiac plexus, cardiac and extra-cardiac nerves, and neural ganglia. We used homologous recombination and conditional deletion to generate three new alleles in which the Bmp2 3'UTR was altered as follows: a UCS flanked by loxP sites with or without a neomycin resistance targeting vector, or a deleted UCS. Deletion of the UCS was associated with elevated Bmp2 mRNA and BMP signaling levels, reduced fitness, and embryonic malformations. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 439-47 ) [ELocationID] => 10.1002/jcb.25290 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The amount, timing, and location of bone morphogenetic protein 2 (BMP2) synthesis influences the differentiation of pluripotent mesenchymal cells in embryos and adults. The BMP2 3'untranslated region (3'UTR) contains a highly conserved AU-rich element (ARE) embedded in a sequence that commonly represses gene expression in mesenchymal cells. Computational analyses indicate that this site also may bind several microRNAs (miRNAs). Although miRNAs frequently target AU-rich regions, this ARE is unusual because the miRNAs directly span the ARE. We began to characterize the factors that may regulate Bmp2 expression via this complex site. The activating protein HuR (Hu antigen R, ELAVL1, HGNC:3312) directly binds this ARE and can activate gene expression. An miRNA was demonstrated to reverse HuR-mediated activation. Mutational and RNA-interference evidence also supports an AUF1 (AU-factor-1, HNRNPD, HGNC:5036) contribution to the observed repressive activity of the 3'UTR in mesenchymal cells. A limited number of studies describe how miRNAs interact with ARE-binding proteins that bind adjacent sites. This study is among the first to describe protein/miRNA interactions at the same site. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 2127-38 ) [ELocationID] => 10.1002/jcb.25164 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The concentration, location, and timing of bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) gene expression must be precisely regulated. Abnormal BMP2 levels cause congenital anomalies and diseases involving the mesenchymal cells that differentiate into muscle, fat, cartilage, and bone. The molecules and conditions that influence BMP2 synthesis are diverse. Understandably, complex mechanisms control Bmp2 gene expression. This review includes a compilation of agents and conditions that can induce Bmp2. The currently known trans-regulatory factors and cis-regulatory elements that modulate Bmp2 expression are summarized and discussed. Bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) is a classical morphogen; a molecule that acts at a distance and whose concentration influences cell behavior. In mesenchymal cells, the concentration of BMP2 influences myogenesis, adipogenesis, chondrogenesis, and osteogenesis. Because the amount, timing, and location of BMP2 synthesis influence the allocation of cells to muscle, fat, cartilage, and bone, the mechanisms that regulate the Bmp2 gene are crucial. Key early mesodermal events that require precise Bmp2 regulation include heart specification and morphogenesis. Originally named for its osteoinductive properties, healing fractures requires BMP2. The human Bmp2 gene also has been linked to osteoporosis and osteoarthritis. In addition, all forms of pathological calcification in the vasculature and in cardiac valves involve the pro-osteogenic BMP2. The diverse tissues, mechanisms, and diseases influenced by BMP2 are too numerous to list here (see OMIM: 112261). However, in all BMP2-influenced pathologies, changes in the behavior and differentiation of pluripotent mesenchymal cells are a recurring theme. Consequently, much effort has been devoted to identifying the molecules and conditions that influence BMP2 synthesis and the complex mechanisms that control Bmp2 gene expression. This review begins with an overview of the Bmp2 gene's chromosomal neighborhood and then summarizes and evaluates known regulatory mechanisms and inducers. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 2387-93 ) [ELocationID] => 10.1161/ATVBAHA.114.302523 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population. [CopyrightInformation] => © 2014 American Heart Association, Inc. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Yutzey [ForeName] => Katherine E [Initials] => KE [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Demer [ForeName] => Linda L [Initials] => LL [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Body [ForeName] => Simon C [Initials] => SC [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Huggins [ForeName] => Gordon S [Initials] => GS [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Towler [ForeName] => Dwight A [Initials] => DA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Giachelli [ForeName] => Cecilia M [Initials] => CM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hofmann-Bowman [ForeName] => Marion A [Initials] => MA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mortlock [ForeName] => Douglas P [Initials] => DP [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rogers [ForeName] => Melissa B [Initials] => MB [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sadeghi [ForeName] => Mehran M [Initials] => MM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Aikawa [ForeName] => Elena [Initials] => E [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1906-14 ) [ELocationID] => 10.1519/JSC.0000000000000319 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The purpose of this study was to examine the effects of hot (37° C) and cool (10° C) environments on cycling time to exhaustion (TTE), pH, lactate, and core temperature (Tc). Eleven endurance-trained subjects completed 4 TTE trials: Hot 80% VO2max (H80), Cool 80% (C80), Hot 100% (H100), and Cool 100% VO2max (C100). Esophageal temperature and blood was sampled before, every 5 minutes, at exhaustion, and 3 minutes after exercise and analyzed for lactate, pH, and HCO3-. Multifactorial analysis of variance with repeated measures was used to determine differences between mean values (± SD). Time to exhaustion was shorter in H100 and C100 vs. H80 and C80 (5.64 ± 1.49 minutes, 5.83 ± 1.03 minutes, 12.82 ± 2.0 minutes, and 24.85 ± 6.0 minutes, respectively) and shorter in H80 vs. C80 (p < 0.01). The pH at exhaustion was different among all conditions (7.17 ± 0.06, 7.15 ± 0.07, 7.21 ± 0.04, and 7.24 ± 0.06 units for H100, C100, H80, and C80, respectively, p = 0.02). The Tc at exhaustion was lower in H100 and C100 (37.93 ± 0.67 and 37.62 ± 0.58° C) vs. H80 and C80 (38.54 ± 0.51° C and 38.53 ± 0.38° C) (p < 0.01). In H80 and C80, the higher Tc likely played a greater role in the termination of exercise, whereas, in H100 and C100, pH and metabolic changes may have been more important. Despite these differences, neither an upper limit for Tc nor a lower limit for pH was identified; thus, fatigue based entirely on peripheral factors was not supported, and a combination of peripheral and central processes must be considered. The practical implications of these findings are that aerobic exercise at or near VO2max may be impacted more by metabolic factors, whereas lower intensities (∼80% VO2max) may be affected more by heat stress; these differences should be considered when training for events of this type. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mitchell [ForeName] => Joel B [Initials] => JB [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Exercise Physiology Laboratory, Texas Christian University, Fort Worth, Texas. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rogers [ForeName] => Melissa M [Initials] => MM ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Basset [ForeName] => John T [Initials] => JT ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hubing [ForeName] => Kimberly A [Initials] => KA ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => J Strength Cond Res [NlmUniqueID] => 9415084 [ISSNLinking] => 1064-8011 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => Array ( [0] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Bicarbonates ) [1] => SimpleXMLElement Object ( [RegistryNumber] => 33X04XA5AT [NameOfSubstance] => Lactic Acid ) ) ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Adult ) [1] => SimpleXMLElement Object ( [DescriptorName] => Bicarbonates [QualifierName] => blood ) [2] => SimpleXMLElement Object ( [DescriptorName] => Body Temperature ) [3] => SimpleXMLElement Object ( [DescriptorName] => Cold Temperature ) [4] => SimpleXMLElement Object ( [DescriptorName] => Exercise Test ) [5] => SimpleXMLElement Object ( [DescriptorName] => Fatigue [QualifierName] => physiopathology ) [6] => SimpleXMLElement Object ( [DescriptorName] => Hot Temperature ) [7] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [8] => SimpleXMLElement Object ( [DescriptorName] => Hydrogen-Ion Concentration ) [9] => SimpleXMLElement Object ( [DescriptorName] => Lactic Acid [QualifierName] => blood ) [10] => SimpleXMLElement Object ( [DescriptorName] => Male ) [11] => SimpleXMLElement Object ( [DescriptorName] => Oxygen Consumption [QualifierName] => physiology ) [12] => SimpleXMLElement Object ( [DescriptorName] => Physical Endurance [QualifierName] => physiology ) [13] => SimpleXMLElement Object ( [DescriptorName] => Time Factors ) [14] => SimpleXMLElement Object ( [DescriptorName] => Young Adult ) ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2013 [Month] => 11 [Day] => 27 [Hour] => 6 [Minute] => 0 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2013 [Month] => 11 [Day] => 28 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2015 [Month] => 2 [Day] => 13 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 24276293 [1] => 10.1519/JSC.0000000000000319 ) ) ) ) [14] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 24210556 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2014 [Month] => 08 [Day] => 13 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2013 [Month] => 11 [Day] => 27 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1096-0457 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 118 [PubDate] => SimpleXMLElement Object ( [Year] => 2014 [Month] => Feb ) ) [Title] => Journal of experimental child psychology [ISOAbbreviation] => J Exp Child Psychol ) [ArticleTitle] => One of these things is not like the other: distinctiveness and executive function in preschoolers. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 143-51 ) [ELocationID] => Array ( [0] => 10.1016/j.jecp.2013.09.012 [1] => S0022-0965(13)00198-7 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => There is scant evidence that children younger than 7 years show a memory advantage for distinct information, a memory phenomenon termed the isolation effect (Journal of Experimental Psychology: Learning, Memory, and Cognition, 2001, Vol. 27, pp. 1359-1366). We investigated whether 4-, 5-, and 6-year-olds' developing organizational processing and executive function contributed to the isolation effect, demonstrated when recall was better for a semantically unique target (e.g., sheep, pig, watermelon, duck) rather than a semantically common target (e.g., apple, banana, watermelon, strawberry). To encourage organizational processing, children were asked to categorize each item presented. Children also completed working memory and cognitive flexibility tasks, and only children who scored high in cognitive flexibility demonstrated the isolation effect. [CopyrightInformation] => Copyright © 2013 Elsevier Inc. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Miller [ForeName] => Stephanie E [Initials] => SE [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Psychology, University of Mississippi, University, MS 38677, USA. Electronic address: semille5@olemiss.edu. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Chatley [ForeName] => Naomi [Initials] => N ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Marcovitch [ForeName] => Stuart [Initials] => S ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rogers [ForeName] => Melissa McConnell [Initials] => MM ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2013 [Month] => 11 [Day] => 07 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => J Exp Child Psychol [NlmUniqueID] => 2985128R [ISSNLinking] => 0022-0965 ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Age Factors ) [1] => SimpleXMLElement Object ( [DescriptorName] => Child ) [2] => SimpleXMLElement Object ( [DescriptorName] => Child, Preschool ) [3] => SimpleXMLElement Object ( [DescriptorName] => Concept Formation ) [4] => SimpleXMLElement Object ( [DescriptorName] => Executive Function ) [5] => SimpleXMLElement Object ( [DescriptorName] => Female ) [6] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [7] => SimpleXMLElement Object ( [DescriptorName] => Male ) [8] => SimpleXMLElement Object ( [DescriptorName] => Memory, Short-Term ) [9] => SimpleXMLElement Object ( [DescriptorName] => Mental Recall ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Cognitive flexibility [1] => Distinctiveness in memory [2] => Executive function [3] => Isolation effect [4] => Organizational processing [5] => Working memory ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2013 [Month] => 06 [Day] => 19 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2013 [Month] => 09 [Day] => 28 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2013 [Month] => 09 [Day] => 29 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2013 [Month] => 11 [Day] => 12 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2013 [Month] => 11 [Day] => 12 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2014 [Month] => 8 [Day] => 15 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 24210556 [1] => S0022-0965(13)00198-7 [2] => 10.1016/j.jecp.2013.09.012 ) ) ) ) [15] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 21508438 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2011 [Month] => 09 [Day] => 27 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2018 [Month] => 11 [Day] => 13 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1949-2553 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 2 [Issue] => 4 [PubDate] => SimpleXMLElement Object ( [Year] => 2011 [Month] => Apr ) ) [Title] => Oncotarget [ISOAbbreviation] => Oncotarget ) [ArticleTitle] => Mycoplasma and cancer: in search of the link. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 841-50 ) [ELocationID] => 10.1002/dvg.20757 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The Bmp2 3'untranslated region (UTR) sequence bears a sequence conserved between mammals and fishes that can post-transcriptionally activate or repress protein synthesis. We developed a map of embryonic cells in the mouse where this potent Bmp2 regulatory sequence functions by using a lacZ reporter transgene with a 3'UTR bearing two loxP sites flanking the ultra-conserved sequence. Cre-recombinase-mediated deletion of the ultra-conserved sequence caused strong ectopic expression in proepicardium, epicardium and epicardium-derived cells (EPDC) and in tissues with known epicardial contributions (coronary vessels and valves). Transient transfections of reporters in the epicardial/mesothelial cell (EMC) line confirmed this repression. Ectopic expression of the recombined transgene also occurred in the aorta, outlet septum, posterior cardiac plexus, cardiac and extracardiac nerves and neural ganglia. Bmp2 is dynamically regulated in the developing heart. 3'UTR-mediated mechanisms that restrain BMP2 synthesis may be relevant to congenital heart and vasculature malformations and to adult diseases involving aberrant BMP2 synthesis. [CopyrightInformation] => Copyright © 2011 Wiley-Periodicals, Inc. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kruithof [ForeName] => Boudewijn P T [Initials] => BP [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Cell Biology, University of Medicine and Dentistry (UMDNJ)-New Jersey Medical School (NJMS), Newark, New Jersey, USA. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Xu [ForeName] => Junwang [Initials] => J ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Fritz [ForeName] => David T [Initials] => DT ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Cabral [ForeName] => Carolina S [Initials] => CS ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 666-74 ) [ELocationID] => 10.1002/jcb.22975 [Abstract] => SimpleXMLElement Object ( [AbstractText] => BMP2 is a morphogen that controls mesenchymal cell differentiation and behavior. For example, BMP2 concentration controls the differentiation of mesenchymal precursors into myocytes, adipocytes, chondrocytes, and osteoblasts. Sequences within the 3'untranslated region (UTR) of the Bmp2 mRNA mediate a post-transcriptional block of protein synthesis. Interaction of cell and developmental stage-specific trans-regulatory factors with the 3'UTR is a nimble and versatile mechanism for modulating this potent morphogen in different cell types. We show here, that an ultra-conserved sequence in the 3'UTR functions independently of promoter, coding region, and 3'UTR context in primary and immortalized tissue culture cells and in transgenic mice. Our findings indicate that the ultra-conserved sequence is an autonomously functioning post-transcriptional element that may be used to modulate the level of BMP2 and other proteins while retaining tissue specific regulatory elements. 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110 [Issue] => 2 [PubDate] => SimpleXMLElement Object ( [Year] => 2010 [Month] => May [Day] => 15 ) ) [Title] => Journal of cellular biochemistry [ISOAbbreviation] => J Cell Biochem ) [ArticleTitle] => A conserved post-transcriptional BMP2 switch in lung cells. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 509-21 ) [ELocationID] => 10.1002/jcb.22567 [Abstract] => SimpleXMLElement Object ( [AbstractText] => An ultra-conserved sequence in the bone morphogenetic protein 2 (BMP2) 3' untranslated region (UTR) markedly represses BMP2 expression in non-transformed lung cells. In contrast, the ultra-conserved sequence stimulates BMP2 expression in transformed lung cells. The ultra-conserved sequence functions as a post-transcriptional cis-regulatory switch. A common single-nucleotide polymorphism (SNP, rs15705, +A1123C), which has been shown to influence human morphology, disrupts a conserved element within the ultra-conserved sequence and altered reporter gene activity in non-transformed lung cells. This polymorphism changed the affinity of the BMP2 RNA for several proteins including nucleolin, which has an increased affinity for the C allele. Elevated BMP2 synthesis is associated with increased malignancy in mouse models of lung cancer and poor lung cancer patient prognosis. Understanding the cis- and trans-regulatory factors that control BMP2 synthesis is relevant to the initiation or progression of pathologies associated with abnormal BMP2 levels. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 2448-50 ) [ELocationID] => 10.1016/j.fertnstert.2010.02.029 [Abstract] => SimpleXMLElement Object ( [AbstractText] => We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males. [CopyrightInformation] => Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mocanu [ForeName] => Edgar [Initials] => E [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Human Assisted Reproduction Ireland, Rotunda Hospital, and Royal College of Surgeons in Ireland, Dublin, Ireland. emocanu@rcsi.ie ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shattock [ForeName] => Richard [Initials] => R ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Barton [ForeName] => David [Initials] => D ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rogers [ForeName] => Melissa [Initials] => M ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Conroy [ForeName] => Ronan [Initials] => R ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sheils [ForeName] => Orla [Initials] => O ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Collins [ForeName] => Claire [Initials] => C ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Martin [ForeName] => Cara [Initials] => C ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Harrison [ForeName] => Robert [Initials] => R ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => O'Leary [ForeName] => John [Initials] => J ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Evaluation Study [1] => Journal Article ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2010 [Month] => 04 [Day] => 09 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Fertil Steril [NlmUniqueID] => 0372772 [ISSNLinking] => 0015-0282 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => SimpleXMLElement Object ( [RegistryNumber] => 126880-72-6 [NameOfSubstance] => Cystic Fibrosis Transmembrane Conductance Regulator ) ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Azoospermia [QualifierName] => Array ( [0] => diagnosis [1] => genetics [2] => therapy ) ) [1] => SimpleXMLElement Object ( [DescriptorName] => Case-Control Studies ) [2] => SimpleXMLElement Object ( [DescriptorName] => Cystic Fibrosis [QualifierName] => Array ( [0] => diagnosis [1] => genetics ) ) [3] => SimpleXMLElement Object ( [DescriptorName] => Cystic Fibrosis Transmembrane Conductance Regulator [QualifierName] => genetics ) [4] => SimpleXMLElement Object ( [DescriptorName] => DNA Mutational Analysis ) [5] => SimpleXMLElement Object ( [DescriptorName] => Gene Frequency ) [6] => SimpleXMLElement Object ( [DescriptorName] => Genetic Carrier Screening ) [7] => SimpleXMLElement Object ( [DescriptorName] => Genetic Testing [QualifierName] => methods ) [8] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [9] => SimpleXMLElement Object ( [DescriptorName] => Infertility, Male [QualifierName] => Array ( [0] => etiology [1] => genetics [2] => therapy ) ) [10] => SimpleXMLElement Object ( [DescriptorName] => Male ) [11] => SimpleXMLElement Object ( [DescriptorName] => Mutation ) [12] => SimpleXMLElement Object ( [DescriptorName] => Predictive Value of Tests ) [13] => SimpleXMLElement Object ( [DescriptorName] => Prognosis ) [14] => SimpleXMLElement Object ( [DescriptorName] => Sperm Injections, Intracytoplasmic ) ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2009 [Month] => 11 [Day] => 07 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2010 [Month] => 02 [Day] => 13 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2010 [Month] => 02 [Day] => 15 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2010 [Month] => 4 [Day] => 13 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2010 [Month] => 4 [Day] => 13 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2010 [Month] => 12 [Day] => 14 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 20381036 [1] => S0015-0282(10)00308-0 [2] => 10.1016/j.fertnstert.2010.02.029 ) ) ) ) ) ) Melissa Rogers | PubFacts

Publications by authors named "Melissa Rogers"

34Publications

Genetic background influences the impact of KLOTHO deficiency.

Physiol Genomics 2020 10 21;52(10):512-516. Epub 2020 Sep 21.

Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers - New Jersey Medical School, Newark, New Jersey.

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October 2020

MicroRNA Profiles in Calcified and Healthy Aorta Differ: Therapeutic Impact of miR-145 and miR-378.

Physiol Genomics 2020 Sep 21. Epub 2020 Sep 21.

Rutgers - New Jersey Medical School, Microbiology, Biochemistry, & Molecular Genetics, Newark, NJ, United States.

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September 2020

Use of RGB values in the Periodic Acid-Schiff color test to determine the presence of vaginal fluid.

Sci Justice 2020 Sep 17;60(5):480-485. Epub 2020 Jun 17.

Forensic Science Program, Cedar Crest College, Allentown, PA 18104, United States. Electronic address:

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September 2020

Common Cell Lines Used to Study Bone Morphogenetic Proteins (BMPs).

Methods Mol Biol 2019 ;1891:1-8

Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA.

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June 2019

Unanswered Questions Regarding Sex and BMP/TGF-β Signaling.

J Dev Biol 2018 Jun 16;6(2). Epub 2018 Jun 16.

Rutgers-New Jersey Medical School, Microbiology, Biochemistry, & Molecular Genetics, Newark, NJ 07103, USA.

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June 2018

Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.

Genesis 2017 07 22;55(7). Epub 2017 May 22.

Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers NJMS, Newark, New Jersey.

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July 2017

Competing Repressive Factors Control Bone Morphogenetic Protein 2 (BMP2) in Mesenchymal Cells.

J Cell Biochem 2016 Feb;117(2):439-47

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey.

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February 2016

Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells.

J Cell Biochem 2015 Oct;116(10):2127-38

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ.

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October 2015

Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.

Arterioscler Thromb Vasc Biol 2014 Nov 4;34(11):2387-93. Epub 2014 Sep 4.

From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).

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November 2014

Fatigue during high-intensity endurance exercise: the interaction between metabolic factors and thermal stress.

J Strength Cond Res 2014 Jul;28(7):1906-14

Exercise Physiology Laboratory, Texas Christian University, Fort Worth, Texas.

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July 2014

One of these things is not like the other: distinctiveness and executive function in preschoolers.

J Exp Child Psychol 2014 Feb 7;118:143-51. Epub 2013 Nov 7.

Department of Psychology, University of Mississippi, University, MS 38677, USA. Electronic address:

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February 2014

Mycoplasma and cancer: in search of the link.

Authors:
Melissa B Rogers

Oncotarget 2011 Apr;2(4):271-3

UMDNJ - NJ Medical School, Newark, New Jersey, USA.

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April 2011

An in vivo map of bone morphogenetic protein 2 post-transcriptional repression in the heart.

Genesis 2011 Nov 14;49(11):841-50. Epub 2011 Oct 14.

Department of Cell Biology, University of Medicine and Dentistry (UMDNJ)-New Jersey Medical School (NJMS), Newark, New Jersey, USA.

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November 2011

An autonomous BMP2 regulatory element in mesenchymal cells.

J Cell Biochem 2011 Feb;112(2):666-74

Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry (UMDNJ)-New Jersey Medical School (NJMS), Newark, New Jersey 07101-1709, USA.

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February 2011

A conserved post-transcriptional BMP2 switch in lung cells.

J Cell Biochem 2010 May;110(2):509-21

Department of Biochemistry and Molecular Biology, UMDNJ-NJMS, Newark, New Jersey 07101, USA.

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May 2010

All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.

Fertil Steril 2010 Nov 9;94(6):2448-50. Epub 2010 Apr 9.

Human Assisted Reproduction Ireland, Rotunda Hospital, and Royal College of Surgeons in Ireland, Dublin, Ireland.

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November 2010