Publications by authors named "Melissa Pappalardi"

15Publications

Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors.

ACS Med Chem Lett 2020 Feb 27;11(2):133-140. Epub 2019 Dec 27.

Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

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February 2020

Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.

J Pharmacol Exp Ther 2017 12 19;363(3):336-347. Epub 2017 Sep 19.

GlaxoSmithKline, King of Prussia, Pennsylvania (JLA, DFA, DF, TS, KJD, MP, MB, KW) and while at GlaxoSmithKline, King of Prussia, Pennsylvania (LL, EHDF, CE-M).

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December 2017

Long residence time inhibition of EZH2 in activated polycomb repressive complex 2.

ACS Chem Biol 2014 Mar 31;9(3):622-9. Epub 2013 Dec 31.

Cancer Epigenetics Discovery Performance Unit, Cancer Research, Oncology R&D and ‡Platform Technology and Sciences, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, United States.

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March 2014

An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation.

Anal Biochem 2006 Jun 19;353(1):69-74. Epub 2006 Apr 19.

Department of Enzymology and Mechanistic Pharmacology, MMPD CEDD, GlaxoSmithKline, Collegeville, PA 19426, USA.

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June 2006