Publications by authors named "Melissa K McConechy"

35Publications

Prevalence of the EGFR T790M and other resistance mutations in the Australian population and histopathological correlation in a small subset of cases.

Pathology 2020 Jun 28;52(4):410-420. Epub 2020 Apr 28.

Histopathology Department, Douglass Hanly Moir Pathology, Macquarie Park, NSW, Australia; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia; Sydney Medical School, University of Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/j.pathol.2020.03.003DOI Listing
June 2020

Optimizing molecular residual disease detection using liquid biopsy postoperatively in early stage lung cancer.

Lung Cancer Manag 2020 Feb 21;9(2):LMT24. Epub 2020 Feb 21.

Department of Pathology and Laboratory Medicine, BC Cancer, Cancer Genetics & Genomics Laboratory, Vancouver, BC, Canada.

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http://dx.doi.org/10.2217/lmt-2019-0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186850PMC
February 2020

Interpretation of somatic POLE mutations in endometrial carcinoma.

J Pathol 2020 03 29;250(3):323-335. Epub 2020 Jan 29.

Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, Canada.

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http://dx.doi.org/10.1002/path.5372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065171PMC
March 2020

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers.

Gynecol Oncol 2017 12 9;147(3):642-647. Epub 2017 Oct 9.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258173135
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http://dx.doi.org/10.1016/j.ygyno.2017.09.032DOI Listing
December 2017

Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary.

Ann Med 2017 08 6;49(5):435-447. Epub 2017 Mar 6.

b Children's Hospital , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

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http://dx.doi.org/10.1080/07853890.2017.1294760DOI Listing
August 2017

Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.

Cancer 2017 03 6;123(5):802-813. Epub 2017 Jan 6.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/cncr.30496DOI Listing
March 2017

FOXL2 402C>G Mutation Can Be Identified in the Circulating Tumor DNA of Patients with Adult-Type Granulosa Cell Tumor.

J Mol Diagn 2017 01 1;19(1):126-136. Epub 2016 Nov 1.

Department of Pathology and Laboratory Medicine, University of British Columbia, and the Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.08.005DOI Listing
January 2017

Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research.

Sci Rep 2016 10 7;6:34949. Epub 2016 Oct 7.

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/srep34949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054533PMC
October 2016

In-depth molecular profiling of the biphasic components of uterine carcinosarcomas.

J Pathol Clin Res 2015 Jul 9;1(3):173-85. Epub 2015 Apr 9.

Department of Laboratory Medicine and Pathology Royal Alexandra Hospital and University of Alberta Edmonton Canada.

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http://dx.doi.org/10.1002/cjp2.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939881PMC
July 2015

Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment.

Gynecol Oncol 2016 10 14;143(1):46-53. Epub 2016 Jul 14.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, 2775 Laurel St., 6th Floor, Vancouver, British Columbia V5Z 1M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2016.07.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521211PMC
October 2016

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype.

J Natl Cancer Inst 2016 11 13;108(11). Epub 2016 Jun 13.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital and BC Cancer Agency, Vancouver, Canada (MKM, HMH, AT, WY, NR, CBG, DGH); Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (AF, LUK, SB, MA); Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland (AF, LUK, SB, MA); Centre of Gynaecologic Oncology Amsterdam (HSvM, MRB, GGK) and Department of Pathology (JBGH, GKJH, MJvdV, MCGB), Academic Medical Center, Amsterdam, the Netherlands; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland (NA, MH); Department of Obstetrics and Gynaecology, Tübingen University Hospital, Department of Women's Health, Tübingen, Germany (KZ, SYB, BK, SK); Department of Pathology (RB) and Department of Clinical Chemistry and Hematology (MA), Helsinki University Hospital, University of Helsinki and HUSLAB, Helsinki, Finland; Institute of Pathology, Tübingen University Hospital, Tübingen, Germany (AS); Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO (MH); Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada (DGH); Department of Human Genetics, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada (MKM)

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http://dx.doi.org/10.1093/jnci/djw134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241905PMC
November 2016

Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.

J Natl Cancer Inst 2016 Jun 1;108(6):djv428. Epub 2016 Feb 1.

Department of Pathology and Laboratory Medicine, (MSA, HMH, JS, HLC, ANK, BSS, MKM, CBG, SK, DGH) and Department of Obstetrics and Gynaecology (MSA, DGH), University of British Columbia, Vancouver, Canada; Department of Molecular Oncology, British Columbia Cancer Agency Cancer Research Centre, Vancouver, Canada (YKW, AB, RM, DSG, SPS); Department of Women's Health, University Hospital Tuebingen, Tuebingen, Germany (MM, FAT, DW, SB, SK); Division of Anatomic Pathology, Synlab MVZ, Institute of Pathology, Mannheim, Germany (FK); Division of Gynecologic Pathology, Institute of Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany (AS); Department of Anatomical Pathology, Vancouver General Hospital, Vancouver, Canada (CBG).

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http://dx.doi.org/10.1093/jnci/djv428DOI Listing
June 2016

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.

Clin Cancer Res 2016 06 13;22(12):2865-73. Epub 2016 Jan 13.

Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://clincancerres.aacrjournals.org/content/early/2016/01/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2233DOI Listing
June 2016

Systematic analysis of somatic mutations impacting gene expression in 12 tumour types.

Nat Commun 2015 Oct 5;6:8554. Epub 2015 Oct 5.

Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3.

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http://dx.doi.org/10.1038/ncomms9554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600750PMC
October 2015

Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy.

Histopathology 2016 May 17;68(6):916-24. Epub 2015 Dec 17.

Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/his.12878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650229PMC
May 2016

Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma.

Int J Gynecol Cancer 2015 Sep;25(7):1187-93

*Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital; †University of British Columbia, Vancouver; ‡Department of Pathology and Laboratory Medicine, Calgary Laboratory Services; §University of Calgary, Calgary, Canada; ∥Department of Gynecology and Obstetrics, Tübingen University, Tübingen, Germany; ¶Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital; #University of Alberta; **Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada; ††Department of Public Health Sciences, Medical University of South Carolina; ‡‡Hollings Cancer Center, Charleston, SC; and §§Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, Canada.

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http://pdfs.journals.lww.com/ijgc/2015/09000/Polymerase_Epsi
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/IGC.0000000000000492DOI Listing
September 2015

VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock.

J Innate Immun 2015 17;7(5):545-53. Epub 2015 Apr 17.

Critical Care Research Laboratories, Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, B.C., Canada.

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http://dx.doi.org/10.1159/000381265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738836PMC
June 2016

Targeted mutation analysis of endometrial clear cell carcinoma.

Histopathology 2015 Apr 13;66(5):664-74. Epub 2015 Jan 13.

Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Center, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/his.12581DOI Listing
April 2015

Histotype-genotype correlation in 36 high-grade endometrial carcinomas.

Am J Surg Pathol 2013 Sep;37(9):1421-32

Departments of *Pathology and Laboratory Medicine ¶Gynecology and Obstetrics, University of British Columbia †Genetic Pathology Evaluation Center, Vancouver General Hospital, Vancouver, BC ‡Department of Pathology, University of Calgary, Calgary, AB §Department of Pathology, University of Toronto, Toronto, ON, Canada ∥Department of Pathology, Faculty of Medicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway #Department of Pathology, Massachusetts General Hospital **Department of Pathology, Brigham and Women's Hospital, Boston, MA ††Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0b013e31828c63edDOI Listing
September 2013

Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles.

Mod Pathol 2014 Jan 14;27(1):128-34. Epub 2013 Jun 14.

1] Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada [2] Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/modpathol.2013.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915240PMC
January 2014

Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas.

J Pathol 2011 Apr 7;223(5):567-73. Epub 2011 Mar 7.

Department of Pathology and Laboratory Medicine, University of British Columbia, British Columbia Cancer Agency, 3427-600 West 10th Avenue, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.2848DOI Listing
April 2011

A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock.

J Immunol 2011 Feb 21;186(4):2321-8. Epub 2011 Jan 21.

University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St. Paul's Hospital, Vancouver, British Columbia V6Z 1Y6, Canada.

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http://dx.doi.org/10.4049/jimmunol.1002864DOI Listing
February 2011