Melanie Verreault

Melanie Verreault

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Melanie Verreault

Melanie Verreault

Publications by authors named "Melanie Verreault"

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20Publications

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N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models.

Can J Gastroenterol Hepatol 2018 5;2018:6031074. Epub 2018 Apr 5.

Laboratory of Molecular Pharmacology, CHU de Québec Research Centre and the Faculty of Pharmacy, Laval University, Québec, QC, Canada.

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http://dx.doi.org/10.1155/2018/6031074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907406PMC
March 2019

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions.

Can J Gastroenterol Hepatol 2018 11;2018:8096314. Epub 2018 Apr 11.

Laboratory of Molecular Pharmacology, CHU-Québec Research Centre and the Faculty of Pharmacy, Laval University, Quebec City, QC, Canada.

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http://dx.doi.org/10.1155/2018/8096314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925157PMC
March 2019

Selective and sensitive quantification of the cytochrome P450 3A4 protein in human liver homogenates through multiple reaction monitoring mass spectrometry.

Proteomics 2016 11 10;16(21):2827-2837. Epub 2016 Oct 10.

Laboratory of Molecular Pharmacology, CHU de Québec Research Centre and the Faculty of Pharmacy, Laval University, Québec, Canada.

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http://dx.doi.org/10.1002/pmic.201500386DOI Listing
November 2016

UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling.

Cancer Res 2016 11 22;76(22):6701-6711. Epub 2016 Sep 22.

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1518DOI Listing
November 2016

Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction.

PLoS One 2013 14;8(11):e80994. Epub 2013 Nov 14.

Laboratory of molecular pharmacology, CHU-Québec Research Centre and the Faculty of Pharmacy, Laval University, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080994PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828276PMC
February 2015

PPARα: A Master Regulator of Bilirubin Homeostasis.

PPAR Res 2014 23;2014:747014. Epub 2014 Jul 23.

Laboratory of Molecular Pharmacology, CHU de Québec Research Centre and Faculty of Pharmacy, Laval University, Québec, QC, Canada G1V 4G2.

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http://dx.doi.org/10.1155/2014/747014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134828PMC
August 2014

The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.

Drug Metab Dispos 2013 Sep 11;41(9):1616-20. Epub 2013 Jun 11.

Laboratory of Molecular Pharmacology, CHU-Québec Research Centre, Faculty of Pharmacy, Laval University, Québec City, Québec, Canada.

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http://dx.doi.org/10.1124/dmd.113.052613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815633PMC
September 2013

Enantiomer selective glucuronidation of the non-steroidal pure anti-androgen bicalutamide by human liver and kidney: role of the human UDP-glucuronosyltransferase (UGT)1A9 enzyme.

Basic Clin Pharmacol Toxicol 2013 Aug 20;113(2):92-102. Epub 2013 May 20.

Laboratory of molecular pharmacology, CHU-Québec Research Centre and the Faculty of pharmacy, Laval University, Québec, QC, Canada.

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http://dx.doi.org/10.1111/bcpt.12071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815647PMC
August 2013

Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.

J Clin Endocrinol Metab 2012 Mar 14;97(3):E428-32. Epub 2011 Dec 14.

Laboratory of Molecular Pharmacology, Centre Hospitalier Universitaire de Québec Research Centre and Faculty of Pharmacy, Laval University, 2705 Boulevard Laurier, Québec (QC), Canada G1V 4G2.

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http://dx.doi.org/10.1210/jc.2011-2064DOI Listing
March 2012

PPARalpha L162V polymorphism alters the potential of n-3 fatty acids to increase lipoprotein lipase activity.

Mol Nutr Food Res 2010 Apr;54(4):543-50

Lipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada.

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http://dx.doi.org/10.1002/mnfr.200900085DOI Listing
April 2010

Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.

Drug Metab Rev 2010 Feb;42(1):110-22

Laboratory of Molecular Pharmacology, CHUQ Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.

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http://dx.doi.org/10.3109/03602530903219220DOI Listing
February 2010

The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver.

J Biol Chem 2010 Jan 4;285(2):1113-21. Epub 2009 Nov 4.

Laboratory of Molecular Pharmacology, CHUQ Research Center, and the Faculty of Pharmacy, Laval University, Québec, Québec G1V 4G2, Canada.

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http://dx.doi.org/10.1074/jbc.M109.073908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801239PMC
January 2010

Lipid-activated transcription factors control bile acid glucuronidation.

Mol Cell Biochem 2009 Jun 7;326(1-2):3-8. Epub 2009 Jan 7.

Laboratory of Molecular Pharmacology, Endocrinology and Genomic, CHUL Research Center, Laval University, Québec, Canada.

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http://dx.doi.org/10.1007/s11010-008-0001-5DOI Listing
June 2009

Calcitrol (1alpha,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells.

Mol Cancer Ther 2008 Feb;7(2):380-90

Centre Hospitalier Universitaire de Québec-Laval University Hospital Centre Research Center, Laval university, Sainte-Foy, Quebec, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0455DOI Listing
February 2008

Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.

Hepatology 2006 Nov;44(5):1158-70

Molecular Endocrinology and Oncology Research Center, CHUL Research Center and the faculty of pharmacy, Laval University, Québec, Canada.

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http://dx.doi.org/10.1002/hep.21362DOI Listing
November 2006

Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors.

Mol Pharm 2006 May-Jun;3(3):212-22

Molecular Endocrinology and Oncology Research Center, and the Faculty of Pharmacy, Laval University, Québec, Canada.

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http://dx.doi.org/10.1021/mp060020tDOI Listing
August 2006

Enzymatic production of bile Acid glucuronides used as analytical standards for liquid chromatography-mass spectrometry analyses.

Mol Pharm 2006 May-Jun;3(3):293-302

Molecular Endocrinology and Oncology Research Center, CHUL Research Center, and the Faculty of Pharmacy, Laval University, Québec, Canada.

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http://dx.doi.org/10.1021/mp060021lDOI Listing
August 2006

The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

Hepatology 2006 Aug;44(2):368-78

Molecular Endocrinology and Oncology Research Center, CHUL Research Center and the Faculty of Pharmacy, Laval University, Québec, Canada.

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http://doi.wiley.com/10.1002/hep.21259
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http://dx.doi.org/10.1002/hep.21259DOI Listing
August 2006