Publications by authors named "Melanie Newport"

85Publications

Multiplexed gene expression analysis of HLA class II-associated podoconiosis implicates chronic immune activation in its pathogenesis.

Trans R Soc Trop Med Hyg 2020 Oct 24. Epub 2020 Oct 24.

Brighton and Sussex Centre for Global Health Research, Department of Global Health & Infection, Brighton & Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PX, UK.

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http://dx.doi.org/10.1093/trstmh/traa107DOI Listing
October 2020

The TACTIC experience: establishing an international, interdisciplinary network to tackle antimicrobial resistance.

J Med Microbiol 2020 Oct 9;69(10):1213-1220. Epub 2020 Sep 9.

Brighton and Sussex Centre for Global Health Research, Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, BN1 9PX, UK.

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http://dx.doi.org/10.1099/jmm.0.001249DOI Listing
October 2020

Predicting the environmental suitability and population at risk of podoconiosis in Africa.

PLoS Negl Trop Dis 2020 08 27;14(8):e0008616. Epub 2020 Aug 27.

Department of Disease Control, London School of Hygiene & Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0008616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480865PMC
August 2020

Host genetic susceptibility to mycetoma.

PLoS Negl Trop Dis 2020 04 30;14(4):e0008053. Epub 2020 Apr 30.

The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

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http://dx.doi.org/10.1371/journal.pntd.0008053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192380PMC
April 2020

The health and economic burden of podoconiosis in Ethiopia.

Trans R Soc Trop Med Hyg 2020 04;114(4):284-292

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, OX3 7LG, Oxford, UK.

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http://dx.doi.org/10.1093/trstmh/traa003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139123PMC
April 2020

Baseline Cytokine Profiles of Tuberculin-Specific CD4 T Cells in Non-Muscle-Invasive Bladder Cancer May Predict Outcomes of BCG Immunotherapy.

Cancer Immunol Res 2018 10 17;6(10):1212-1219. Epub 2018 Aug 17.

Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, Brighton, United Kingdom.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0046DOI Listing
October 2018

Lymphoedema management in podoconiosis - Authors reply.

Lancet Glob Health 2018 09;6(9):e963

Centre for Environmental and Developmental Studies and School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia; Wellcome Trust Centre for Global Health Research, Brighton and Sussex Medical School, Brighton, BN1 9PX, UK. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(18)30330-9DOI Listing
September 2018

Predicted distribution and burden of podoconiosis in Cameroon.

BMJ Glob Health 2018 22;3(3):e000730. Epub 2018 Jun 22.

Parasites and Vector Biology Research Unit (PAVBRU), Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

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http://dx.doi.org/10.1136/bmjgh-2018-000730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014185PMC
June 2018

Lymphoedema management to prevent acute dermatolymphangioadenitis in podoconiosis in northern Ethiopia (GoLBeT): a pragmatic randomised controlled trial.

Lancet Glob Health 2018 07 15;6(7):e795-e803. Epub 2018 May 15.

Wellcome Trust Centre for Global Health Research, Brighton and Sussex Medical School, Brighton, UK; School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(18)30124-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562300PMC
July 2018

Global epidemiology of podoconiosis: A systematic review.

PLoS Negl Trop Dis 2018 03 1;12(3):e0006324. Epub 2018 Mar 1.

Wellcome Trust Brighton and Sussex Centre for Global Health Research, Brighton and Sussex Medical School, Brighton, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0006324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849362PMC
March 2018

The global atlas of podoconiosis.

Lancet Glob Health 2017 05;5(5):e477-e479

Wellcome Trust Brighton and Sussex Centre for Global Health Research, Brighton and Sussex Medical School, Brighton, BN1 9PX, UK.

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http://dx.doi.org/10.1016/S2214-109X(17)30140-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390851PMC
May 2017

The Art of HIV Elimination: Past and Present Science.

J AIDS Clin Res 2015 Nov;6

Faculty of Medicine and Faculty of Social and Human Sciences, University of Southampton, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072486PMC
http://dx.doi.org/10.4172/2155-6113.1000525DOI Listing
November 2015

An Improved F(st) Estimator.

PLoS One 2015 28;10(8):e0135368. Epub 2015 Aug 28.

Center for Research on Genomics and Global Health, NHGRI, NIH, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135368PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552798PMC
May 2016

DNA entropy reveals a significant difference in complexity between housekeeping and tissue specific gene promoters.

Comput Biol Chem 2015 Oct 8;58:19-24. Epub 2015 May 8.

The James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.

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http://dx.doi.org/10.1016/j.compbiolchem.2015.05.001DOI Listing
October 2015

Understanding of research, genetics and genetic research in a rapid ethical assessment in north west Cameroon.

Int Health 2016 05 12;8(3):197-203. Epub 2015 May 12.

Department of Microbiology and Parasitology, University of Buea, PO Box 63, Buea, Cameroon Research Foundation in Tropical Diseases and Environment, PO Box 474, Buea, Cameroon.

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http://dx.doi.org/10.1093/inthealth/ihv034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866326PMC
May 2016

The specialty choices of graduates from Brighton and Sussex Medical School: a longitudinal cohort study.

BMC Med Educ 2015 Mar 13;15:46. Epub 2015 Mar 13.

Brighton & Sussex Medical School, BSMS Teaching Building, University of Sussex, Brighton, East Sussex BN1 9PX, UK.

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http://dx.doi.org/10.1186/s12909-015-0328-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365809PMC
March 2015

The genetic regulation of infant immune responses to vaccination.

Front Immunol 2015 2;6:18. Epub 2015 Feb 2.

Division of Clinical Medicine, Brighton and Sussex Medical School , Brighton , UK.

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http://dx.doi.org/10.3389/fimmu.2015.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313718PMC
February 2015

Novel genomic signals of recent selection in an Ethiopian population.

Eur J Hum Genet 2015 Aug 5;23(8):1085-92. Epub 2014 Nov 5.

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/ejhg.2014.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351897PMC
August 2015

Old tracer for a new purpose: potential role for 99mTc-2-Methoxyisobutylisonitrile (99mTc-MIBI) in renal transplant care.

Nucl Med Commun 2014 Oct;35(10):1058-66

aDepartment of Nuclear Medicine bSussex Kidney Unit cClinical Investigation and Research Unit, Brighton and Sussex University Hospitals NHS Trust dBrighton Sussex Medical School, Brighton, UK eDepartment of Nephrology, Royal Melbourne Hospital, Melbourne, Victoria, Australia fInstitute of Nuclear Medicine, University College London, London, UK.

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http://dx.doi.org/10.1097/MNM.0000000000000165DOI Listing
October 2014

A 21-year-old student with fever and profound jaundice.

PLoS Negl Trop Dis 2014 9;8(1):e2534. Epub 2014 Jan 9.

Royal Tropical Institute, KIT Biomedical Research, WHO/FAO/OIE and National Collaborating Center for Reference and research on Leptospirosis, Meibergdreef, Amsterdam, The Netherlands.

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http://gooa.las.ac.cn/external/download/884330/2933121/20140
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http://dx.plos.org/10.1371/journal.pntd.0002534
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http://dx.doi.org/10.1371/journal.pntd.0002534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886912PMC
September 2014

Individual correlates of podoconiosis in areas of varying endemicity: a case-control study.

PLoS Negl Trop Dis 2013 5;7(12):e2554. Epub 2013 Dec 5.

Department of Earth Sciences, Addis Ababa University, Addis Ababa, Ethiopia ; Brighton and Sussex Medical School, Falmer, Brighton, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0002554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854961PMC
July 2014

On the pathway to better birth outcomes? A systematic review of azithromycin and curable sexually transmitted infections.

Expert Rev Anti Infect Ther 2013 Dec 6;11(12):1303-32. Epub 2013 Nov 6.

London School of Hygiene and Tropical Medicine Keppel Street, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1586/14787210.2013.851601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906303PMC
December 2013

Prediction of HLA class II alleles using SNPs in an African population.

PLoS One 2012 28;7(6):e40206. Epub 2012 Jun 28.

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040206PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386230PMC
January 2013

Hepatitis E infection is an under recognized cause of acute decompensation in patients with chronic liver disease.

Dig Liver Dis 2012 Nov 15;44(11):930-4. Epub 2012 May 15.

Department of Gastroenterology, Brighton and Sussex University Hospitals, Brighton, UK.

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http://dx.doi.org/10.1016/j.dld.2012.04.011DOI Listing
November 2012

HLA class II locus and susceptibility to podoconiosis.

N Engl J Med 2012 Mar;366(13):1200-8

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-5635, USA.

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http://dx.doi.org/10.1056/NEJMoa1108448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350841PMC
March 2012

Genome-wide association studies and susceptibility to infectious diseases.

Brief Funct Genomics 2011 Mar;10(2):98-107

Infectious Diseases and Global Health at Brighton and Sussex Medical School, UK.

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http://dx.doi.org/10.1093/bfgp/elq037DOI Listing
March 2011

Why hasn't human genetics told us more about tuberculosis?

Int J Tuberc Lung Dis 2009 Sep;13(9):1049-50

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September 2009

International Health and Tropical Medicine 08: Proceedings of a Residential Meeting of the Royal Society of Tropical Medicine and Hygiene, 17-19 September 2008, Brighton, UK.

Trans R Soc Trop Med Hyg 2009 Nov 3;103(11):1075-80. Epub 2009 Aug 3.

Department of Medicine, Brighton and Sussex Medical School, Falmer, Sussex BN1 9PX, UK.

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https://academic.oup.com/trstmh/article-lookup/doi/10.1016/j
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http://dx.doi.org/10.1016/j.trstmh.2009.05.010DOI Listing
November 2009

Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy.

J Infect Dis 2009 Mar;199(6):795-800

Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276835PMC
http://dx.doi.org/10.1086/597069DOI Listing
March 2009

Reducing the global genomic inequity gap: development of an african genome project.

Public Health Genomics 2009 30;12(4):251-2. Epub 2009 Jan 30.

Department of Medicine, Brighton and Sussex Medical School, Falmer, UK.

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http://dx.doi.org/10.1159/000197973DOI Listing
June 2009

Proceedings of a joint meeting between the Norwegian Society of Infectious Diseases and the Royal Society of Tropical Medicine and Hygiene, Oslo, 20 June 2008.

Trans R Soc Trop Med Hyg 2009 Apr 27;103(4):321-4. Epub 2008 Dec 27.

Department of Medicine, Brighton and Sussex Medical School, Falmer, Sussex BN1 9PS, UK.

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http://dx.doi.org/10.1016/j.trstmh.2008.11.010DOI Listing
April 2009

The reflective elective: using the elective to develop medical students' skills in career planning.

Br J Hosp Med (Lond) 2008 Jul;69(7):409-11

Postgraduate Deanery for Kent Surrey and Sussex, London.

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http://dx.doi.org/10.12968/hmed.2008.69.7.30418DOI Listing
July 2008

Podoconiosis: non-infectious geochemical elephantiasis.

Trans R Soc Trop Med Hyg 2007 Dec 31;101(12):1175-80. Epub 2007 Oct 31.

Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia.

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https://academic.oup.com/trstmh/article-lookup/doi/10.1016/j
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http://dx.doi.org/10.1016/j.trstmh.2007.08.013DOI Listing
December 2007

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Authors:
Paul R Burton David G Clayton Lon R Cardon Nick Craddock Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem H Ouwehand Nilesh J Samani John A Todd Peter Donnelly Jeffrey C Barrett Dan Davison Doug Easton David M Evans Hin-Tak Leung Jonathan L Marchini Andrew P Morris Chris C A Spencer Martin D Tobin Antony P Attwood James P Boorman Barbara Cant Ursula Everson Judith M Hussey Jennifer D Jolley Alexandra S Knight Kerstin Koch Elizabeth Meech Sarah Nutland Christopher V Prowse Helen E Stevens Niall C Taylor Graham R Walters Neil M Walker Nicholas A Watkins Thilo Winzer Richard W Jones Wendy L McArdle Susan M Ring David P Strachan Marcus Pembrey Gerome Breen David St Clair Sian Caesar Katharine Gordon-Smith Lisa Jones Christine Fraser Elaine K Green Detelina Grozeva Marian L Hamshere Peter A Holmans Ian R Jones George Kirov Valentina Moskivina Ivan Nikolov Michael C O'Donovan Michael J Owen David A Collier Amanda Elkin Anne Farmer Richard Williamson Peter McGuffin Allan H Young I Nicol Ferrier Stephen G Ball Anthony J Balmforth Jennifer H Barrett Timothy D Bishop Mark M Iles Azhar Maqbool Nadira Yuldasheva Alistair S Hall Peter S Braund Richard J Dixon Massimo Mangino Suzanne Stevens John R Thompson Francesca Bredin Mark Tremelling Miles Parkes Hazel Drummond Charles W Lees Elaine R Nimmo Jack Satsangi Sheila A Fisher Alastair Forbes Cathryn M Lewis Clive M Onnie Natalie J Prescott Jeremy Sanderson Christopher G Matthew Jamie Barbour M Khalid Mohiuddin Catherine E Todhunter John C Mansfield Tariq Ahmad Fraser R Cummings Derek P Jewell John Webster Morris J Brown Mark G Lathrop John Connell Anna Dominiczak Carolina A Braga Marcano Beverley Burke Richard Dobson Johannie Gungadoo Kate L Lee Patricia B Munroe Stephen J Newhouse Abiodun Onipinla Chris Wallace Mingzhan Xue Mark Caulfield Martin Farrall Anne Barton Ian N Bruce Hannah Donovan Steve Eyre Paul D Gilbert Samantha L Hilder Anne M Hinks Sally L John Catherine Potter Alan J Silman Deborah P M Symmons Wendy Thomson Jane Worthington David B Dunger Barry Widmer Timothy M Frayling Rachel M Freathy Hana Lango John R B Perry Beverley M Shields Michael N Weedon Andrew T Hattersley Graham A Hitman Mark Walker Kate S Elliott Christopher J Groves Cecilia M Lindgren Nigel W Rayner Nicolas J Timpson Eleftheria Zeggini Melanie Newport Giorgio Sirugo Emily Lyons Fredrik Vannberg Adrian V S Hill Linda A Bradbury Claire Farrar Jennifer J Pointon Paul Wordsworth Matthew A Brown Jayne A Franklyn Joanne M Heward Matthew J Simmonds Stephen C L Gough Sheila Seal Michael R Stratton Nazneen Rahman Maria Ban An Goris Stephen J Sawcer Alastair Compston David Conway Muminatou Jallow Melanie Newport Giorgio Sirugo Kirk A Rockett Suzannah J Bumpstead Amy Chaney Kate Downes Mohammed J R Ghori Rhian Gwilliam Sarah E Hunt Michael Inouye Andrew Keniry Emma King Ralph McGinnis Simon Potter Rathi Ravindrarajah Pamela Whittaker Claire Widden David Withers Niall J Cardin Dan Davison Teresa Ferreira Joanne Pereira-Gale Ingeleif B Hallgrimsdo'ttir Bryan N Howie Zhan Su Yik Ying Teo Damjan Vukcevic David Bentley Matthew A Brown Alastair Compston Martin Farrall Alistair S Hall Andrew T Hattersley Adrian V S Hill Miles Parkes Marcus Pembrey Michael R Stratton Sarah L Mitchell Paul R Newby Oliver J Brand Jackie Carr-Smith Simon H S Pearce R McGinnis A Keniry P Deloukas John D Reveille Xiaodong Zhou Anne-Marie Sims Alison Dowling Jacqueline Taylor Tracy Doan John C Davis Laurie Savage Michael M Ward Thomas L Learch Michael H Weisman Mathew Brown

Nat Genet 2007 Nov 21;39(11):1329-37. Epub 2007 Oct 21.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ng.2007.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680141PMC
November 2007

Podoconiosis: the most neglected tropical disease?

Lancet 2007 Mar;369(9565):888-9

Faculty of Medicine, Addis Ababa, Ethiopia.

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http://linkinghub.elsevier.com/retrieve/pii/S014067360760425
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http://dx.doi.org/10.1016/S0140-6736(07)60425-5DOI Listing
March 2007

Podoconiosis: a tropical model for gene-environment interactions?

Trans R Soc Trop Med Hyg 2007 Jan 1;101(1):91-6. Epub 2006 Aug 1.

Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia.

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http://dx.doi.org/10.1016/j.trstmh.2006.05.002DOI Listing
January 2007

Oedema with proteinuria in Gambian children--a descriptive study.

Pediatr Nephrol 2006 Mar 11;21(3):339-43. Epub 2006 Jan 11.

MRC Laboratories, Banjul, The Gambia.

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http://dx.doi.org/10.1007/s00467-005-2123-2DOI Listing
March 2006

Hunting for immune response regulatory genes: vaccination studies in infant twins.

Expert Rev Vaccines 2005 Oct;4(5):739-46

Department of Medicine, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PS, UK.

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http://dx.doi.org/10.1586/14760584.4.5.739DOI Listing
October 2005

Acute lower respiratory tract infections and respiratory syncytial virus in infants in Guinea-Bissau: a beneficial effect of BCG vaccination for girls community based case-control study.

Vaccine 2005 Jan;23(10):1251-7

Bandim Health Project, Apartado 861, Bissau, Guinea-Bissau; Danish Epidemiology Science Centre, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark.

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http://dx.doi.org/10.1016/j.vaccine.2004.09.006DOI Listing
January 2005

Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies.

Lancet 2004 Dec 11-17;364(9451):2113-21

Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, CRC B3-419, 10 Center Drive, MSC 1684, Bethesda, MD 20892-1684, USA.

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http://dx.doi.org/10.1016/S0140-6736(04)17552-1DOI Listing
January 2005

Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.

Hum Mol Genet 2004 Aug 2;13(15):1633-9. Epub 2004 Jun 2.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/ddh169DOI Listing
August 2004

Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis.

FEMS Immunol Med Microbiol 2004 Jun;41(2):157-60

Department of Medicine, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1016/j.femsim.2004.02.004DOI Listing
June 2004

The genetics of nontuberculous mycobacterial infection.

Authors:
Melanie Newport

Expert Rev Mol Med 2003 Feb 28;5(6):1-13. Epub 2003 Feb 28.

Cambridge Institute for Medical Research, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1017/S1462399403005908DOI Listing
February 2003

Delay in motor development of twins in Africa: a prospective cohort study.

Twin Res 2003 Aug;6(4):279-84

University Department of Paediatrics, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1375/136905203322296629DOI Listing
August 2003

Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis.

J Infect Dis 2002 Dec 22;186(12):1808-14. Epub 2002 Nov 22.

Medical Research Council Laboratories, Banjul, The Gambia.

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http://dx.doi.org/10.1086/345920DOI Listing
December 2002

IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.

J Infect Dis 2002 Jun 17;185(11):1684-7. Epub 2002 May 17.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1086/340516DOI Listing
June 2002

Prevention of infectious diseases by neonatal and early infantile immunization: prospects for the new millennium.

Curr Opin Infect Dis 2000 Jun;13(3):241-246

aMRC Laboratories, Banjul, The Gambia, West Africa, and bWellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1097/00001432-200006000-00007DOI Listing
June 2000