Melanie Laschinger

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.

J Hepatol 2020 Dec 26;73(6):1347-1359. Epub 2020 Jun 26.

Institute of Molecular Immunology and Experimental Oncology, University Hospital München rechts der Isar; Technical University of Munich, Munich, Germany.

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December 2020

TLR3 promotes hepatocyte proliferation after partial hepatectomy by stimulating uPA expression and the release of tissue-bound HGF.

Authors:

Christian Stöß Melanie Laschinger Baocai Wang Miao Lu Felicitas Altmayr Daniel Hartmann Norbert Hüser Bernhard Holzmann

FASEB J 2020 08 15;34(8):10387-10397. Epub 2020 Jun 15.

Department of Surgery, School of Medicine, Technical University of Munich, Munich, Germany.

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August 2020

The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver.

Authors:

Melanie Laschinger Yang Wang Gabriela Holzmann Baocai Wang Christian Stöß Miao Lu Marcus Brugger Annika Schneider Percy Knolle Dirk Wohlleber Sarah Schulze Katja Steiger Kazutake Tsujikawa Felicitas Altmayr Helmut Friess Daniel Hartmann Norbert Hüser Bernhard Holzmann

FASEB J 2020 06 23;34(6):8125-8138. Epub 2020 Apr 23.

Department of Surgery, School of Medicine, Technical University of Munich, Munich, Germany.

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June 2020

Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.

Nat Immunol 2020 05 23;21(5):555-566. Epub 2020 Apr 23.

Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany.

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May 2020

Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial-mesenchymal transition and colorectal cancer aggressiveness.

Authors:

Fabian C Franke Benjamin O Slusarenko Thomas Engleitner Widya Johannes Melanie Laschinger Roland Rad Ulrich Nitsche Klaus-Peter Janssen

Int J Cancer 2020 Sep 16;147(6):1715-1731. Epub 2020 Mar 16.

Department of Surgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

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September 2020

Cytosolic nucleic acid sensors of the innate immune system promote liver regeneration after partial hepatectomy.

Authors:

Sarah Schulze Christian Stöß Miao Lu Baocai Wang Melanie Laschinger Katja Steiger Felicitas Altmayr Helmut Friess Daniel Hartmann Bernhard Holzmann Norbert Hüser

Sci Rep 2018 08 16;8(1):12271. Epub 2018 Aug 16.

Technical University of Munich, School of Medicine, Department of Surgery, Ismaninger Str. 22, 81675, Munich, Germany.

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August 2018

Peroxisome Proliferator-Activated Receptor gamma negatively regulates liver regeneration after partial hepatectomy via the HGF/c-Met/ERK1/2 pathways.

Authors:

Zhangjun Cheng Lei Liu Xue-Jun Zhang Miao Lu Yang Wang Volker Assfalg Melanie Laschinger Guido von Figura Yoshiaki Sunami Christoph W Michalski Jörg Kleeff Helmut Friess Daniel Hartmann Norbert Hüser

Sci Rep 2018 08 8;8(1):11894. Epub 2018 Aug 8.

Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Surgery, Munich, 81675, Germany.

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August 2018

The Oncolytic Adenovirus XVir-N-31 as a Novel Therapy in Muscle-Invasive Bladder Cancer.

Authors:

Eva Lichtenegger Florestan Koll Helena Haas Klaus Mantwill Klaus-Peter Janssen Melanie Laschinger Jürgen Gschwend Katja Steiger Peter C Black Igor Moskalev Roman Nawroth Per Sonne Holm

Hum Gene Ther 2019 01 3;30(1):44-56. Epub 2018 Aug 3.

1 Department of Urology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

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January 2019

BRG1 promotes hepatocarcinogenesis by regulating proliferation and invasiveness.

Authors:

Benedikt Kaufmann Baocai Wang Suyang Zhong Melanie Laschinger Pranali Patil Miao Lu Volker Assfalg Zhangjun Cheng Helmut Friess Norbert Hüser Guido von Figura Daniel Hartmann

PLoS One 2017 12;12(7):e0180225. Epub 2017 Jul 12.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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September 2017

Impact of NKT Cells and LFA-1 on Liver Regeneration under Subseptic Conditions.

Authors:

Ann-Kathrin Jörger Lei Liu Karin Fehlner Tanja Weisser Zhangjun Cheng Miao Lu Bastian Höchst Andreas Bolzer Baocai Wang Daniel Hartmann Volker Assfalg Yoshiaki Sunami Anna Melissa Schlitter Helmut Friess Norbert Hüser Melanie Laschinger

PLoS One 2016 15;11(12):e0168001. Epub 2016 Dec 15.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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July 2017

Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia.

Authors:

Ihsan Ekin Demir Elke Tieftrunk Stephan Schorn Ömer Cemil Saricaoglu Paulo L Pfitzinger Steffen Teller Kun Wang Christine Waldbaur Magdalena U Kurkowski Sonja Maria Wörmann Victoria E Shaw Timo Kehl Melanie Laschinger Eithne Costello Hana Algül Helmut Friess Güralp O Ceyhan

Gut 2016 06 13;65(6):1001-14. Epub 2016 Jan 13.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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June 2016

Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion.

Authors:

Ihsan Ekin Demir Alexandra Boldis Paulo L Pfitzinger Steffen Teller Eva Brunner Natascha Klose Timo Kehl Matthias Maak Marina Lesina Melanie Laschinger Klaus-Peter Janssen Hana Algül Helmut Friess Güralp O Ceyhan

J Natl Cancer Inst 2014 Aug 8;106(8). Epub 2014 Aug 8.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany (IED, AB, PLP, ST, EB, NK, TK, MM, MeL, KPJ, HF, GOC); Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany (MaL, HA).

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August 2014

The severity of neural invasion is associated with shortened survival in colon cancer.

Authors:

Florian Liebl Ihsan Ekin Demir Robert Rosenberg Alexandra Boldis Esra Yildiz Kristina Kujundzic Timo Kehl Dominic Dischl Tibor Schuster Matthias Maak Karen Becker Rupert Langer Melanie Laschinger Helmut Friess Güralp O Ceyhan

Clin Cancer Res 2013 Jan 12;19(1):50-61. Epub 2012 Nov 12.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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January 2013

The mammalian actin-binding protein 1 is critical for spreading and intraluminal crawling of neutrophils under flow conditions.

Authors:

Ingrid Hepper Jürgen Schymeinsky Ludwig T Weckbach Sascha M Jakob David Frommhold Michael Sixt Melanie Laschinger Markus Sperandio Barbara Walzog

J Immunol 2012 May 26;188(9):4590-601. Epub 2012 Mar 26.

Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University Munich, 80336 Munich, Germany.

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May 2012

LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming.

Authors:

Sandra Balkow Stefanie Heinz Patricia Schmidbauer Waldemar Kolanus Bernhard Holzmann Stephan Grabbe Melanie Laschinger

Blood 2010 Sep 8;116(11):1885-94. Epub 2010 Jun 8.

Department of Dermatology, Johannes-Gutenberg-Universität Mainz, Mainz, Germany.

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September 2010

Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer.

Authors:

Martin Loos Dennis M Hedderich Malte Ottenhausen Nathalia A Giese Melanie Laschinger Irene Esposito Jörg Kleeff Helmut Friess

BMC Cancer 2009 Dec 26;9:463. Epub 2009 Dec 26.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str 22, 81675 Munich, Germany.

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December 2009

Intact LFA-1 deactivation promotes T-cell activation and rejection of cardiac allograft.

Authors:

Norbert Hüser Annette Fasan Monika Semmrich Patricia Schmidbauer Bernhard Holzmann Melanie Laschinger

Int Immunol 2010 Jan 27;22(1):35-44. Epub 2009 Nov 27.

Department of Surgery, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany.

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January 2010

Calculated withdrawal of low-dose immunosuppression based on a detailed immunological monitoring after kidney transplantation between monocygotic twins.

Authors:

Norbert Hüser Edouard Matevossian Patricia Schmidbauer Volker Assfalg Juergen E Scherberich Manfred Stangl Bernhard Holzmann Helmut Friess Melanie Laschinger

Transpl Immunol 2009 Dec 17;22(1-2):38-43. Epub 2009 Sep 17.

Department of Surgery, Technische Universität München, D-81675 Munich, Germany.

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December 2009

Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation.

Authors:

Gabriele Hoermannsperger Gabriele Hörmannsperger Thomas Clavel Micha Hoffmann Caroline Reiff Denise Kelly Gunnar Loh Michael Blaut Gabriele Hölzlwimmer Melanie Laschinger Dirk Haller

PLoS One 2009 6;4(2):e4365. Epub 2009 Feb 6.

Chair for Biofunctionality, ZIEL-Research Center for Nutrition and Food Science, Technische Universität München, Freising-Weihenstephan, Germany.

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March 2009

Clinical significance and regulation of the costimulatory molecule B7-H1 in pancreatic cancer.

Authors:

Martin Loos Nathalia A Giese Jörg Kleeff Thomas Giese Matthias M Gaida Frank Bergmann Melanie Laschinger Markus W Büchler Helmut Friess

Cancer Lett 2008 Sep 16;268(1):98-109. Epub 2008 May 16.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany.

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September 2008

Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways.

Authors:

Katia De Filippo Robert B Henderson Melanie Laschinger Nancy Hogg

J Immunol 2008 Mar;180(6):4308-15

Leukocyte Adhesion Laboratory, Cancer Research United Kingdom, London Research Institute, London, United Kingdom.

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March 2008

RhoH is important for positive thymocyte selection and T-cell receptor signaling.

Authors:

Tatjana Dorn Ursula Kuhn Gerd Bungartz Sebastian Stiller Martina Bauer Joachim Ellwart Thorsten Peters Karin Scharffetter-Kochanek Monika Semmrich Melanie Laschinger Bernhard Holzmann Wolfgang E F Klinkert Per Thor Straten Tania Køllgaard Michael Sixt Cord Brakebusch

Blood 2007 Mar 21;109(6):2346-55. Epub 2006 Nov 21.

Max Planck Institute of Biochemistry, Heisenberg Group Regulation of Cytoskeletal Organization, Martinsried, Germany.

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March 2007

P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice.

Authors:

Britta Engelhardt Birgit Kempe Stephanie Merfeld-Clauss Melanie Laschinger Bruce Furie Martin K Wild Dietmar Vestweber

J Immunol 2005 Jul;175(2):1267-75

Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH-3012 Bern, Switzerland.

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July 2005

Importance of integrin LFA-1 deactivation for the generation of immune responses.

Authors:

Monika Semmrich Andrew Smith Carolin Feterowski Sandra Beer Britta Engelhardt Dirk H Busch Bernadett Bartsch Melanie Laschinger Nancy Hogg Klaus Pfeffer Bernhard Holzmann

J Exp Med 2005 Jun 13;201(12):1987-98. Epub 2005 Jun 13.

Department of Surgery, Immunology, and Hygiene, Technische Universität München, 81675 Munich, Germany.

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June 2005

How T cells use LFA-1 to attach and migrate.

Authors:

Nancy Hogg Andrew Smith Alison McDowall Katherine Giles Paula Stanley Melanie Laschinger Robert Henderson

Immunol Lett 2004 Mar;92(1-2):51-4

Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK.

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March 2004

T-cell integrins: more than just sticking points.

Authors:

Nancy Hogg Melanie Laschinger Katherine Giles Alison McDowall

J Cell Sci 2003 Dec;116(Pt 23):4695-705

Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK.

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December 2003

Detection of endothelial/lymphocyte interaction in spinal cord microvasculature by intravital videomicroscopy.

Authors:

Britta Engelhardt Peter Vajkoczy Melanie Laschinger

Methods Mol Med 2003 ;89:83-93

Max-Planck Institute for Physiological and Clinical Research, Bad Neuheim, Germany.

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November 2003

Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo.

Authors:

Melanie Laschinger Peter Vajkoczy Britta Engelhardt

Eur J Immunol 2002 Dec;32(12):3598-606

Max-Planck-Institute for Physiological and Clinical Research, Bad Nauheim, Germany.

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December 2002

Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis.

Authors:

Carsten Alt Melanie Laschinger Britta Engelhardt

Eur J Immunol 2002 Aug;32(8):2133-44

Max-Planck Institute for Physiological and Clinical Research, W. G. Kerckhoff-Institute, Department of Vascular Cell Biology, Bad Nauheim, Germany.

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August 2002

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