Melanie Kucherlapati

Melanie Kucherlapati

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Melanie Kucherlapati

Melanie Kucherlapati

Publications by authors named "Melanie Kucherlapati"

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19Publications

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Global impact of somatic structural variation on the DNA methylome of human cancers.

Authors:
Yiqun Zhang Lixing Yang Melanie Kucherlapati Angela Hadjipanayis Angeliki Pantazi Christopher A Bristow Eunjung Alice Lee Harshad S Mahadeshwar Jiabin Tang Jianhua Zhang Sahil Seth Semin Lee Xiaojia Ren Xingzhi Song Huandong Sun Jonathan Seidman Lovelace J Luquette Ruibin Xi Lynda Chin Alexei Protopopov Peter J Park Raju Kucherlapati Chad J Creighton

Genome Biol 2019 10 15;20(1):209. Epub 2019 Oct 15.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13059-019-1818-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792267PMC
October 2019

Optical imaging with a novel cathepsin-activatable probe for enhanced detection of colorectal cancer.

Authors:
Shadi A Esfahani Pedram Heidari Melanie H Kucherlapati Jorge M Ferrer Raju S Kucherlapati Umar Mahmood

Am J Nucl Med Mol Imaging 2019 15;9(5):230-242. Epub 2019 Oct 15.

Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Charlestown, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872479PMC
October 2019

Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes.

Authors:
Melanie Kucherlapati

BMC Cancer 2018 Aug 14;18(1):818. Epub 2018 Aug 14.

Department of Genetics, Harvard Medical School, Boston, 02115, MA, USA.

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http://dx.doi.org/10.1186/s12885-018-4705-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092802PMC
August 2018

A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases.

Authors:
Yiqun Zhang Lixing Yang Melanie Kucherlapati Fengju Chen Angela Hadjipanayis Angeliki Pantazi Christopher A Bristow Eunjung A Lee Harshad S Mahadeshwar Jiabin Tang Jianhua Zhang Sahil Seth Semin Lee Xiaojia Ren Xingzhi Song Huandong Sun Jonathan Seidman Lovelace J Luquette Ruibin Xi Lynda Chin Alexei Protopopov Wei Li Peter J Park Raju Kucherlapati Chad J Creighton

Cell Rep 2018 07;24(2):515-527

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092947PMC
July 2018

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.

Authors:
A Gordon Robertson Juliann Shih Christina Yau Ewan A Gibb Junna Oba Karen L Mungall Julian M Hess Vladislav Uzunangelov Vonn Walter Ludmila Danilova Tara M Lichtenberg Melanie Kucherlapati Patrick K Kimes Ming Tang Alexander Penson Ozgun Babur Rehan Akbani Christopher A Bristow Katherine A Hoadley Lisa Iype Matthew T Chang Andrew D Cherniack Christopher Benz Gordon B Mills Roel G W Verhaak Klaus G Griewank Ina Felau Jean C Zenklusen Jeffrey E Gershenwald Lynn Schoenfield Alexander J Lazar Mohamed H Abdel-Rahman Sergio Roman-Roman Marc-Henri Stern Colleen M Cebulla Michelle D Williams Martine J Jager Sarah E Coupland Bita Esmaeli Cyriac Kandoth Scott E Woodman

Cancer Cell 2018 01;33(1):151

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http://dx.doi.org/10.1016/j.ccell.2017.12.013DOI Listing
January 2018

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.

Authors:
A Gordon Robertson Juliann Shih Christina Yau Ewan A Gibb Junna Oba Karen L Mungall Julian M Hess Vladislav Uzunangelov Vonn Walter Ludmila Danilova Tara M Lichtenberg Melanie Kucherlapati Patrick K Kimes Ming Tang Alexander Penson Ozgun Babur Rehan Akbani Christopher A Bristow Katherine A Hoadley Lisa Iype Matthew T Chang Andrew D Cherniack Christopher Benz Gordon B Mills Roel G W Verhaak Klaus G Griewank Ina Felau Jean C Zenklusen Jeffrey E Gershenwald Lynn Schoenfield Alexander J Lazar Mohamed H Abdel-Rahman Sergio Roman-Roman Marc-Henri Stern Colleen M Cebulla Michelle D Williams Martine J Jager Sarah E Coupland Bita Esmaeli Cyriac Kandoth Scott E Woodman

Cancer Cell 2017 08;32(2):204-220.e15

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619925PMC
August 2017

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Authors:
Yiqun Zhang Patrick Kwok-Shing Ng Melanie Kucherlapati Fengju Chen Yuexin Liu Yiu Huen Tsang Guillermo de Velasco Kang Jin Jeong Rehan Akbani Angela Hadjipanayis Angeliki Pantazi Christopher A Bristow Eunjung Lee Harshad S Mahadeshwar Jiabin Tang Jianhua Zhang Lixing Yang Sahil Seth Semin Lee Xiaojia Ren Xingzhi Song Huandong Sun Jonathan Seidman Lovelace J Luquette Ruibin Xi Lynda Chin Alexei Protopopov Thomas F Westbrook Carl Simon Shelley Toni K Choueiri Michael Ittmann Carter Van Waes John N Weinstein Han Liang Elizabeth P Henske Andrew K Godwin Peter J Park Raju Kucherlapati Kenneth L Scott Gordon B Mills David J Kwiatkowski Chad J Creighton

Cancer Cell 2017 06 18;31(6):820-832.e3. Epub 2017 May 18.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502825PMC
June 2017

Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice.

Authors:
Benedikt Kortüm Christoph Campregher Michaela Lang Vineeta Khare Matthias Pinter Rayko Evstatiev Gerald Schmid Martina Mittlböck Theresa Scharl Melanie H Kucherlapati Winfried Edelmann Christoph Gasche

Gut 2015 Dec 26;64(12):1905-12. Epub 2014 Nov 26.

Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1136/gutjnl-2014-307663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680183PMC
December 2015

MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas.

Authors:
Ayumu Taguchi Jung-Hyun Rho Qingxiang Yan Yuzheng Zhang Yang Zhao Hanwen Xu Satyendra Chandra Tripathi Hong Wang Dean E Brenner Melanie Kucherlapati Raju Kucherlapati Adam T Boutin Y Alan Wang Ronald A DePinho Ziding Feng Paul D Lampe Samir M Hanash

Cancer Prev Res (Phila) 2015 Nov 4;8(11):1112-9. Epub 2015 Sep 4.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633385PMC
November 2015

An EGFR targeted PET imaging probe for the detection of colonic adenocarcinomas in the setting of colitis.

Authors:
N Selcan Turker Pedram Heidari Raju Kucherlapati Melanie Kucherlapati Umar Mahmood

Theranostics 2014 1;4(9):893-903. Epub 2014 Jul 1.

1. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA;

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http://dx.doi.org/10.7150/thno.9425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107290PMC
April 2015

Genotype directed therapy in murine mismatch repair deficient tumors.

Authors:
Melanie H Kucherlapati Shadi Esfahani Peiman Habibollahi Junning Wang Eric R Still Roderick T Bronson Umar Mahmood Raju S Kucherlapati

PLoS One 2013 23;8(7):e68817. Epub 2013 Jul 23.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720855PMC
March 2014

Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.

Authors:
Marina Kovalenko Ella Dragileva Jason St Claire Tammy Gillis Jolene R Guide Jaclyn New Hualing Dong Raju Kucherlapati Melanie H Kucherlapati Michelle E Ehrlich Jong-Min Lee Vanessa C Wheeler

PLoS One 2012 7;7(9):e44273. Epub 2012 Sep 7.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044273PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436885PMC
May 2013

Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.

Authors:
Michael A McIlhatton Jessica Tyler Laura A Kerepesi Tina Bocker-Edmonston Melanie H Kucherlapati Winfried Edelmann Raju Kucherlapati Levy Kopelovich Richard Fishel

Cancer Prev Res (Phila) 2011 May 24;4(5):684-93. Epub 2011 Mar 24.

Department of Molecular Virology, Immunology & Medical Genetics, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991477PMC
May 2011

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.

Authors:
David A McDonald Robert Shenkar Changbin Shi Rebecca A Stockton Amy L Akers Melanie H Kucherlapati Raju Kucherlapati James Brainer Mark H Ginsberg Issam A Awad Douglas A Marchuk

Hum Mol Genet 2011 Jan 11;20(2):211-22. Epub 2010 Oct 11.

Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1093/hmg/ddq433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005897PMC
January 2011

An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.

Authors:
Melanie H Kucherlapati Kyeryoung Lee Andrew A Nguyen Alan B Clark Harry Hou Andrew Rosulek Hua Li Kan Yang Kunhua Fan Martin Lipkin Roderick T Bronson Linda Jelicks Thomas A Kunkel Raju Kucherlapati Winfried Edelmann

Gastroenterology 2010 Mar 18;138(3):993-1002.e1. Epub 2009 Nov 18.

Department of Medicine/Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1053/j.gastro.2009.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862591PMC
March 2010

Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.

Authors:
Melanie H Kucherlapati Kan Yang Kunhua Fan Mari Kuraguchi Dmitriy Sonkin Andrew Rosulek Martin Lipkin Roderick T Bronson Bruce J Aronow Raju Kucherlapati

Proc Natl Acad Sci U S A 2008 Oct 1;105(40):15493-8. Epub 2008 Oct 1.

Harvard Partners Center for Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0802933105
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http://dx.doi.org/10.1073/pnas.0802933105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563082PMC
October 2008

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

Authors:
Mari Kuraguchi Xiu-Ping Wang Roderick T Bronson Rebecca Rothenberg Nana Yaw Ohene-Baah Jennifer J Lund Melanie Kucherlapati Richard L Maas Raju Kucherlapati

PLoS Genet 2006 Sep 28;2(9):e146. Epub 2006 Jul 28.

Harvard-Partners Center for Genetics and Genomics, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0020146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564426PMC
September 2006

Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract.

Authors:
Melanie H Kucherlapati Andrew A Nguyen Roderick T Bronson Raju S Kucherlapati

Cancer Res 2006 Apr;66(7):3576-83

Harvard-Partners Center for Genetics and Genomics, Harvard Medical School, New Research Building 160B, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-05-2699DOI Listing
April 2006

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.

Authors:
Melanie Kucherlapati Kan Yang Mari Kuraguchi Jie Zhao Maria Lia Joerg Heyer Michael F Kane Kunhua Fan Robert Russell Anthony M C Brown Burkhard Kneitz Winfried Edelmann Richard D Kolodner Martin Lipkin Raju Kucherlapati

Proc Natl Acad Sci U S A 2002 Jul 15;99(15):9924-9. Epub 2002 Jul 15.

Department of Medicine and Harvard Partners Center for Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.152321699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126601PMC
July 2002