Melanie H Cobb

Melanie H Cobb

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Melanie H Cobb

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The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α.

Biochemistry 2019 Dec 10;58(51):5102-5106. Epub 2019 Dec 10.

Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine , University of Miami , Miami , Florida 33136 , United States.

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http://dx.doi.org/10.1021/acs.biochem.9b00891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942998PMC
December 2019

Measuring Relative Insulin Secretion using a Co-Secreted Luciferase Surrogate.

J Vis Exp 2019 Jun 25(148). Epub 2019 Jun 25.

Department of Pharmacology, University of Texas Southwestern Medical Center.

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http://dx.doi.org/10.3791/59926DOI Listing
June 2019

WNK pathways in cancer signaling networks.

Cell Commun Signal 2018 11 3;16(1):72. Epub 2018 Nov 3.

Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX, 75390-9041, USA.

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http://dx.doi.org/10.1186/s12964-018-0287-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215617PMC
November 2018

Pulling a MAST1 on Cisplatin Resistance.

Cancer Cell 2018 08;34(2):183-185

Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.010DOI Listing
August 2018

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.

Transl Oncol 2018 Apr 2;11(2):292-299. Epub 2018 Feb 2.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884185PMC
April 2018

OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.

Proc Natl Acad Sci U S A 2018 04 26;115(15):3840-3845. Epub 2018 Mar 26.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1802339115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899495PMC
April 2018

Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization.

Dev Cell 2018 03 1;44(5):624-633.e4. Epub 2018 Mar 1.

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849535PMC
March 2018

Mechanisms of the amplifying pathway of insulin secretion in the β cell.

Pharmacol Ther 2017 Nov 18;179:17-30. Epub 2017 May 18.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United States.

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http://dx.doi.org/10.1016/j.pharmthera.2017.05.003DOI Listing
November 2017

WNK1 is an unexpected autophagy inhibitor.

Autophagy 2017 May 15;13(5):969-970. Epub 2017 Feb 15.

a Department of Pharmacology , University of Texas Southwestern Medical Center , Dallas , TX , USA.

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http://dx.doi.org/10.1080/15548627.2017.1286431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446055PMC
May 2017

Assaying Protein Kinase Activity with Radiolabeled ATP.

J Vis Exp 2017 05 26(123). Epub 2017 May 26.

Department of Pharmacology, University of Texas Southwestern Medical Center;

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http://dx.doi.org/10.3791/55504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608137PMC
May 2017

Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis.

FEBS Open Bio 2017 02 18;7(2):174-186. Epub 2017 Jan 18.

Department of Pharmacology UT Southwestern Medical Center Dallas TX USA.

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http://dx.doi.org/10.1002/2211-5463.12172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292669PMC
February 2017

Multistep regulation of autophagy by WNK1.

Proc Natl Acad Sci U S A 2016 12 28;113(50):14342-14347. Epub 2016 Nov 28.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1617649113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167150PMC
December 2016

Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils.

Sci Signal 2016 12 13;9(458):ra122. Epub 2016 Dec 13.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/scisignal.aag0486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479306PMC
December 2016

Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism.

J Biol Chem 2016 Oct 1;291(43):22414-22426. Epub 2016 Sep 1.

From the Department of Pharmacology,

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http://dx.doi.org/10.1074/jbc.M116.732511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077182PMC
October 2016

Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II.

Circ Res 2016 Sep 2;119(7):810-26. Epub 2016 Aug 2.

From the Department of Molecular Biology and Center for Regenerative Science and Medicine (D.M.B., Y.K., K.X., D.B.A., O.C.) and Department of Pharmacology (C.W., M.H.C.), University of Texas Southwestern Medical Center, Dallas; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia (P.R.N., G.E.D.); Department of Biology, University of North Carolina, Chapel Hill (L.A.W.); and Division of Experimental Hematology and Cancer Biology, Children's Hospital Research Foundation, University of Cincinnati, OH (Y.Z.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026621PMC
September 2016

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.

Cell Rep 2016 08 21;16(5):1259-1272. Epub 2016 Jul 21.

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972690PMC
August 2016

Hypertension: the missing WNKs.

Am J Physiol Renal Physiol 2016 07 23;311(1):F16-27. Epub 2016 Mar 23.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; and

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http://dx.doi.org/10.1152/ajprenal.00358.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967160PMC
July 2016

Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells.

Mol Endocrinol 2015 Aug 13;29(8):1114-22. Epub 2015 Jul 13.

Department of Pharmacology (E.M.W., M.L.G., J.D., K.M., E.M.R., M.H.C.) and the Green Center for Systems Biology (J.D., E.M.R.), University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041; and Department of Physiology and Pharmacology (E.M.W., J.G.), Des Moines University, Des Moines, Iowa 50312.

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http://dx.doi.org/10.1210/ME.2014-1181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517997PMC
August 2015

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.

Biochemistry 2015 Aug 3;54(32):5063-71. Epub 2015 Aug 3.

†Department of Pharmacology and ‡Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b00593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167558PMC
August 2015

A Kinase Divided.

Cancer Cell 2015 Aug;28(2):145-7

Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.07.008DOI Listing
August 2015

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.

Proc Natl Acad Sci U S A 2014 Oct 29;111(41):14788-93. Epub 2014 Sep 29.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, and Pharmacology, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235;

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http://dx.doi.org/10.1073/pnas.1410419111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205603PMC
October 2014

ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade.

EMBO J 2014 Aug 10;33(16):1735-6. Epub 2014 Jul 10.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.15252/embj.201489205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195756PMC
August 2014

Ras transformation uncouples the kinesin-coordinated cellular nutrient response.

Proc Natl Acad Sci U S A 2014 Jul 7;111(29):10568-73. Epub 2014 Jul 7.

Department of Pharmacology and

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http://dx.doi.org/10.1073/pnas.1411016111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115560PMC
July 2014

Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling.

J Biol Chem 2014 May 2;289(20):14370-9. Epub 2014 Apr 2.

From the Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041

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http://dx.doi.org/10.1074/jbc.M114.565069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022903PMC
May 2014

G protein-coupled receptors and the regulation of autophagy.

Trends Endocrinol Metab 2014 May 18;25(5):274-82. Epub 2014 Apr 18.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082244PMC
May 2014

Chloride sensing by WNK1 involves inhibition of autophosphorylation.

Sci Signal 2014 May 6;7(324):ra41. Epub 2014 May 6.

1Department of Biophysics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/scisignal.2005050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123527PMC
May 2014

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):18826-31. Epub 2013 Nov 4.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041.

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http://dx.doi.org/10.1073/pnas.1318676110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839713PMC
November 2013

Minireview: Nutrient sensing by G protein-coupled receptors.

Mol Endocrinol 2013 Aug 2;27(8):1188-97. Epub 2013 Jul 2.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1210/me.2013-1100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725341PMC
August 2013

Off-target effects of MEK inhibitors.

Biochemistry 2013 Aug 22;52(31):5164-6. Epub 2013 Jul 22.

Department of Pharmacology, University of Texas Southwestern Medical Center , Dallas, Texas 75390-9041, United States.

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http://dx.doi.org/10.1021/bi4007644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859837PMC
August 2013

Chromatin-tethered MAPKs.

Curr Opin Cell Biol 2013 Apr 20;25(2):272-7. Epub 2013 Feb 20.

Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, United States.

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http://dx.doi.org/10.1016/j.ceb.2013.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654648PMC
April 2013

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.

Proc Natl Acad Sci U S A 2013 Apr 3;110(16):6524-9. Epub 2013 Apr 3.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1073/pnas.1303932110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631659PMC
April 2013

Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3.

Autophagy 2013 Mar 7;9(3):418-9. Epub 2012 Dec 7.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

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http://dx.doi.org/10.4161/auto.22911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590263PMC
March 2013

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

J Biol Chem 2012 Nov 18;287(45):37868-79. Epub 2012 Sep 18.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.398750
Publisher Site
http://dx.doi.org/10.1074/jbc.M112.398750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488059PMC
November 2012

Protein kinase WNK3 regulates the neuronal splicing factor Fox-1.

Proc Natl Acad Sci U S A 2012 Oct 1;109(42):16841-6. Epub 2012 Oct 1.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.1215406109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479510PMC
October 2012

The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

Mol Cell 2012 Sep 6;47(6):851-62. Epub 2012 Sep 6.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749915PMC
September 2012

Signal control through Raf: in sickness and in health.

Cell Res 2012 Jan 6;22(1):14-22. Epub 2011 Dec 6.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1038/cr.2011.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351917PMC
January 2012

A small molecule differentiation inducer increases insulin production by pancreatic β cells.

Proc Natl Acad Sci U S A 2011 Dec 5;108(51):20713-8. Epub 2011 Dec 5.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://www.pnas.org/content/108/51/20713.full.pdf
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http://dx.doi.org/10.1073/pnas.1118526109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251102PMC
December 2011

WNK1 is required for mitosis and abscission.

Proc Natl Acad Sci U S A 2011 Jan 10;108(4):1385-90. Epub 2011 Jan 10.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1018567108
Publisher Site
http://dx.doi.org/10.1073/pnas.1018567108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029763PMC
January 2011

Reconstitution of the nuclear transport of the MAP kinase ERK2.

Methods Mol Biol 2010 ;661:273-85

Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/978-1-60761-795-2_16DOI Listing
December 2010

Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback.

Proc Natl Acad Sci U S A 2010 Dec 6;107(51):22314-9. Epub 2010 Dec 6.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.1016630108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009760PMC
December 2010

Exposing contingency plans for kinase networks.

Cell 2010 Dec;143(6):867-9

Department of Pharmacology, UT Southwestern Medical Center at Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.cell.2010.11.046DOI Listing
December 2010

Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells.

J Biol Chem 2010 Jun 27;285(26):19710-9. Epub 2010 Apr 27.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M109.087486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888381PMC
June 2010

WNK kinases and blood pressure control.

Curr Hypertens Rep 2009 Dec;11(6):421-6

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http://dx.doi.org/10.1007/s11906-009-0072-zDOI Listing
December 2009

Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription.

Proc Natl Acad Sci U S A 2009 Dec 16;106(52):22181-6. Epub 2009 Dec 16.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0912596106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799777PMC
December 2009

Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2.

J Biol Chem 2009 Oct 14;284(43):29437-45. Epub 2009 Aug 14.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M109.048181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785576PMC
October 2009

MAP-ping unconventional protein-DNA interactions.

Cell 2009 Oct;139(3):462-3

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.cell.2009.10.007DOI Listing
October 2009

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.

Mol Cell 2009 Jul;35(1):11-25

Brain Tumor Center and Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715139PMC
July 2009

MAP kinases and their roles in pancreatic beta-cells.

Cell Biochem Biophys 2004 ;40(3 Suppl):191-200

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

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http://link.springer.com/content/pdf/10.1385/CBB:40:3:191.pd
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http://dx.doi.org/10.1385/cbb:40:3:191DOI Listing
April 2009

Regulation of a third conserved phosphorylation site in SGK1.

J Biol Chem 2009 Feb 9;284(6):3453-60. Epub 2008 Dec 9.

Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M807502200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635031PMC
February 2009

Crystal structure of domain-swapped STE20 OSR1 kinase domain.

Protein Sci 2009 Feb;18(2):304-13

Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 75390-9041, USA.

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http://dx.doi.org/10.1002/pro.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708061PMC
February 2009

Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.

J Biol Chem 2009 Jan 22;284(5):3117-24. Epub 2008 Nov 22.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M806286200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631948PMC
January 2009

PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites.

Proc Natl Acad Sci U S A 2009 Jan 9;106(3):761-6. Epub 2009 Jan 9.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0811739106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630079PMC
January 2009

The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.

Structure 2009 Jan;17(1):96-104

Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-8816, USA.

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http://dx.doi.org/10.1016/j.str.2008.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689539PMC
January 2009

Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells.

Proc Natl Acad Sci U S A 2008 Sep 28;105(36):13315-20. Epub 2008 Aug 28.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0806465105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533187PMC
September 2008

The roles of MAPKs in disease.

Cell Res 2008 Apr;18(4):436-42

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1038/cr.2008.37DOI Listing
April 2008

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.

J Biol Chem 2007 Nov 11;282(45):32613-22. Epub 2007 Sep 11.

Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1074/jbc.M706591200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423411PMC
November 2007

WNKs: protein kinases with a unique kinase domain.

Exp Mol Med 2007 Oct;39(5):565-73

Department of Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/emm.2007.62DOI Listing
October 2007

Mutations in ERK2 binding sites affect nuclear entry.

J Biol Chem 2007 Sep 26;282(39):28759-67. Epub 2007 Jul 26.

Departments of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M703460200DOI Listing
September 2007

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.

Proc Natl Acad Sci U S A 2007 Jul 5;104(28):11518-25. Epub 2007 Jul 5.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0704618104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913886PMC
July 2007

Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.

J Biol Chem 2007 Jun 28;282(25):17985-96. Epub 2007 Mar 28.

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M702664200DOI Listing
June 2007

TAO kinases mediate activation of p38 in response to DNA damage.

EMBO J 2007 Apr 29;26(8):2005-14. Epub 2007 Mar 29.

Department of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852793PMC
April 2007

Mxi2 promotes stimulus-independent ERK nuclear translocation.

EMBO J 2007 Feb 25;26(3):635-46. Epub 2007 Jan 25.

Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas (CSIC), Departamento de Biología Molecular, Unidad de Biomedicina CSIC--Universidad de Cantabria, Santander, Spain.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7601523
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http://dx.doi.org/10.1038/sj.emboj.7601523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794381PMC
February 2007

Expression and characterization of MAP kinases in bacteria.

Methods 2006 Nov;40(3):209-12

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1016/j.ymeth.2006.06.012DOI Listing
November 2006

Characterization of mitogen-activated protein kinase (MAPK) dimers.

Biochemistry 2006 Nov;45(44):13175-82

Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1021/bi061041wDOI Listing
November 2006

Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.

Pediatr Nephrol 2006 Sep 9;21(9):1231-6. Epub 2006 May 9.

Department of Medicine, Room J5-104, MC-8856, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-8856, USA.

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http://dx.doi.org/10.1007/s00467-006-0106-6DOI Listing
September 2006

The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs.

J Biol Chem 2006 Sep 23;281(35):25601-11. Epub 2006 Jun 23.

Medical School, University of Crete, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete 710 03, Greece.

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http://dx.doi.org/10.1074/jbc.M605185200DOI Listing
September 2006

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

Proc Natl Acad Sci U S A 2006 Jul 10;103(29):10883-8. Epub 2006 Jul 10.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0604607103
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544143PMC
July 2006

The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy.

J Biol Chem 2006 Jun 4;281(23):15645-52. Epub 2006 Apr 4.

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M513866200DOI Listing
June 2006

The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

Arch Biochem Biophys 2006 May 13;449(1-2):8-16. Epub 2006 Mar 13.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1016/j.abb.2006.02.023DOI Listing
May 2006

Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals.

Mol Cell Biol 2006 Apr;26(8):3039-47

Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1128/MCB.26.8.3039-3047.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1446939PMC
April 2006

Activation of MEKK1 by Rho GTPases.

Methods Enzymol 2006 ;406:468-78

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)06035-6DOI Listing
March 2006

TGF-beta regulation by Emilin1: new links in the etiology of hypertension.

Cell 2006 Mar;124(5):893-5

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.cell.2006.02.031DOI Listing
March 2006

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.

J Biol Chem 2005 Oct 4;280(40):34218-23. Epub 2005 Aug 4.

Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M505735200DOI Listing
October 2005

Properties of WNK1 and implications for other family members.

J Biol Chem 2005 Jul 9;280(29):26653-8. Epub 2005 May 9.

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M502598200DOI Listing
July 2005

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter.

J Biol Chem 2005 Jul 16;280(29):26751-9. Epub 2005 May 16.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M503158200
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July 2005

WNK1 activates SGK1 to regulate the epithelial sodium channel.

Proc Natl Acad Sci U S A 2005 Jul 8;102(29):10315-20. Epub 2005 Jul 8.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1073/pnas.0504422102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177404PMC
July 2005

Context-dependent regulation of NeuroD activity and protein accumulation.

Mol Cell Neurosci 2005 Apr;28(4):727-36

Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Boulder, CO 80309-0347, USA.

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http://dx.doi.org/10.1016/j.mcn.2004.12.004DOI Listing
April 2005

WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.

Cell Res 2005 Jan;15(1):6-10

Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, USA.

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http://dx.doi.org/10.1038/sj.cr.7290256DOI Listing
January 2005

Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways.

Mol Cell Biol 2004 Dec;24(23):10145-50

Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.

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http://dx.doi.org/10.1128/MCB.24.23.10145-10150.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529024PMC
December 2004

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.

Structure 2004 Oct;12(10):1891-900

Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.str.2004.07.021DOI Listing
October 2004

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.

Mol Cell 2004 Sep;15(5):741-51

Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.07.018DOI Listing
September 2004

Protein kinase function and glutathionylation.

Biochem J 2004 Aug;381(Pt 3):e1-2

Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1042/BJ20040873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1133907PMC
August 2004

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.

Structure 2004 Jul;12(7):1303-11

Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.str.2004.04.014DOI Listing
July 2004

Structure of MAPKs.

Methods Mol Biol 2004 ;250:127-44

Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

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http://dx.doi.org/10.1385/1-59259-671-1:127DOI Listing
April 2004

Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.

J Biol Chem 2004 Mar 5;279(12):11129-36. Epub 2004 Jan 5.

Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M313562200DOI Listing
March 2004

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.

J Biol Chem 2004 Mar 5;279(13):12840-7. Epub 2004 Jan 5.

Department of Pharmacology, the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M310031200DOI Listing
March 2004