Melanie Ehrlich

Melanie Ehrlich

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Melanie Ehrlich

Publications by authors named "Melanie Ehrlich"

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DNA hypermethylation in disease: mechanisms and clinical relevance.

Authors:
Melanie Ehrlich

Epigenetics 2019 Jul 8:1-23. Epub 2019 Jul 8.

a Tulane Cancer Center and Tulane Center for Bioinformatics and Genomics , Tulane University Health Sciences Center , New Orleans , LA , USA.

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http://dx.doi.org/10.1080/15592294.2019.1638701DOI Listing
July 2019

Data showing atherosclerosis-associated differentially methylated regions are often at enhancers.

Data Brief 2019 Apr 7;23:103812. Epub 2019 Mar 7.

Tulane Cancer Center, Tulane University Health Sciences Center, LA 70112, USA.

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http://dx.doi.org/10.1016/j.dib.2019.103812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660590PMC
April 2019

Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes.

Epigenomics 2019 Feb 28;11(2):169-186. Epub 2019 Jan 28.

Center for Bioinformatics & Genomics, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.2217/epi-2018-0150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371847PMC
February 2019

Atherosclerosis-associated differentially methylated regions can reflect the disease phenotype and are often at enhancers.

Atherosclerosis 2019 Jan 27;280:183-191. Epub 2018 Nov 27.

Tulane Cancer Center, Tulane University Health Sciences Center, LA, 70112, USA; Center for Bioinformatics and Genomics, Tulane University Health Sciences Center, USA; Hayward Genetics Center, Tulane University Health Sciences Center, New Orleans, LA, 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348116PMC
January 2019

Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression.

Epigenetics 2017 02 2;12(2):123-138. Epub 2016 Dec 2.

b Center for Bioinformatics and Genomics, Tulane University Health Sciences Center , New Orleans , LA , USA.

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http://dx.doi.org/10.1080/15592294.2016.1265713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330441PMC
February 2017

DNA Hypomethylation in Intragenic and Intergenic Enhancer Chromatin of Muscle-Specific Genes Usually Correlates with their Expression.

Yale J Biol Med 2016 12 23;89(4):441-455. Epub 2016 Dec 23.

Program in Bioinformatics and Genomics, Tulane University Health Sciences Center, New Orleans, LA; Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, LA; Hayward Genetics Center, Tulane University Health Sciences Center, New Orleans, LA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168824PMC
December 2016

DNA methylation and differentiation: silencing, upregulation and modulation of gene expression.

Epigenomics 2013 ;5(5):553-68

Hayward Human Genetics Program, Tulane Cancer Center, and Center for Bioinformatics & Genomics, Tulane Health Sciences Center, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.2217/epi.13.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864898PMC
April 2016

Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood.

Epigenomics 2016 Jan 12;8(1):13-31. Epub 2016 Jan 12.

Human Genetics Program, Center for Bioinformatics & Genomics, Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.2217/epi.15.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863877PMC
January 2016

Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation.

BMC Cancer 2015 Oct 29;15:816. Epub 2015 Oct 29.

Human Genetics Program, Tulane Cancer Center, and Center for Bioinformatics and Genomics, Tulane University Health Sciences Center, 1430 Tulane Ave., New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1186/s12885-015-1777-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625569PMC
October 2015

DNA cytosine methylation and hydroxymethylation at the borders.

Epigenomics 2014 ;6(6):563-6

Tulane Cancer Center, New Orleans LA 70112, USA.

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http://dx.doi.org/10.2217/epi.14.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321890PMC
August 2015

Tissue-specific epigenetics in gene neighborhoods: myogenic transcription factor genes.

Hum Mol Genet 2015 Aug 3;24(16):4660-73. Epub 2015 Jun 3.

Program in Human Genetics, Tulane Cancer Center, and Center for Bioinformatics and Genomics, Tulane Health Sciences Center, New Orleans, LA 70122, USA,

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddv198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512632PMC
August 2015

Development-linked changes in DNA methylation and hydroxymethylation in humans: interview with Dr Melanie Ehrlich.

Authors:
Melanie Ehrlich

Epigenomics 2015 Aug 28;7(5):691-4. Epub 2015 Aug 28.

Hayward Genetics Program, Tulane Cancer Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA.

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https://www.futuremedicine.com/doi/10.2217/epi.15.44
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http://dx.doi.org/10.2217/epi.15.44DOI Listing
August 2015

Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine.

Epigenetics 2014 Jun 26;9(6):842-50. Epub 2014 Mar 26.

Program in Human Genetics; Tulane Cancer Center; Center for Bioinformatics and Genomics; Tulane Health Sciences Center; New Orleans, LA USA.

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http://dx.doi.org/10.4161/epi.28597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065182PMC
June 2014

Myogenic differential methylation: diverse associations with chromatin structure.

Biology (Basel) 2014 Jun 19;3(2):426-51. Epub 2014 Jun 19.

Center for Bioinformatics and Genomics, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.3390/biology3020426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085616PMC
June 2014

DNA methylation and differentiation: HOX genes in muscle cells.

Epigenetics Chromatin 2013 Aug 2;6(1):25. Epub 2013 Aug 2.

Hayward Human Genetics Program and Tulane Cancer Center, Tulane Health Sciences Center, New Orleans LA, USA.

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http://dx.doi.org/10.1186/1756-8935-6-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750649PMC
August 2013

DNA hypomethylation and hemimethylation in cancer.

Adv Exp Med Biol 2013 ;754:31-56

Human Genetics Program, Tulane University, New Orleans, LA 70122, USA.

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http://link.springer.com/10.1007/978-1-4419-9967-2_2
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http://dx.doi.org/10.1007/978-1-4419-9967-2_2DOI Listing
December 2012

Diagnosis by sequencing: correction of misdiagnosis from FSHD2 to LGMD2A by whole-exome analysis.

Eur J Hum Genet 2012 Sep 29;20(9):999-1003. Epub 2012 Feb 29.

Centre for Genetics and Genomics, School of Biology, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1038/ejhg.2012.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421126PMC
September 2012

Deciphering transcription dysregulation in FSH muscular dystrophy.

J Hum Genet 2012 Aug 21;57(8):477-84. Epub 2012 Jun 21.

Human Genetics Program and Center for Bioinformatics and Genomics, Tulane Cancer Center, Tulane University, New Orleans, LA 70122, USA.

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http://www.nature.com/articles/jhg201274
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http://dx.doi.org/10.1038/jhg.2012.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562129PMC
August 2012

Gene expression during normal and FSHD myogenesis.

BMC Med Genomics 2011 Sep 27;4:67. Epub 2011 Sep 27.

Human Genetics Program, Tulane Medical School, New Orleans, LA, USA.

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http://dx.doi.org/10.1186/1755-8794-4-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204225PMC
September 2011

DNA ploidy, nuclear size, proliferation index and DNA-hypomethylation in ovarian cancer.

Gynecol Oncol 2011 Apr 20;121(1):24-31. Epub 2011 Jan 20.

Department of Gynecology and Obstetrics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria, Austria.

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http://dx.doi.org/10.1016/j.ygyno.2010.12.332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062717PMC
April 2011

DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2.

Nucleic Acids Res 2009 Dec;37(22):7381-93

Human Genetics Program and Department of Biochemistry and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1093/nar/gkp833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794184PMC
December 2009

DNA hypomethylation in cancer cells.

Authors:
Melanie Ehrlich

Epigenomics 2009 Dec;1(2):239-59

Hayward Genetics Program, Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, 1430 TulaneAvenue, New Orleans, LA 70112, USA.

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https://www.futuremedicine.com/doi/10.2217/epi.09.33
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http://dx.doi.org/10.2217/epi.09.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873040PMC
December 2009

Modeling dependence in methylation patterns with application to ovarian carcinomas.

Stat Appl Genet Mol Biol 2009 22;8:Article 40. Epub 2009 Sep 22.

Tulane University, USA.

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http://dx.doi.org/10.2202/1544-6115.1489DOI Listing
November 2009

Hemimethylation footprints of DNA demethylation in cancer.

Epigenetics 2009 Apr 23;4(3):165-75. Epub 2009 Apr 23.

Hayward Human Genetics Center, Tulane Medical School, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.4161/epi.4.3.8277DOI Listing
April 2009

Will the transcription control elements in chromatin please stand up?

Authors:
Melanie Ehrlich

Epigenetics 2008 Jul-Aug;3(4):179-80. Epub 2008 Jul 22.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562314PMC
http://dx.doi.org/10.4161/epi.3.4.6653DOI Listing
November 2008

DNA methylation and cancer-associated genetic instability.

Authors:
Melanie Ehrlich

Adv Exp Med Biol 2005 ;570:363-92

Tulane Cancer Center, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.1007/1-4020-3764-3_13DOI Listing
September 2008

Epigenetics of a tandem DNA repeat: chromatin DNaseI sensitivity and opposite methylation changes in cancers.

Nucleic Acids Res 2008 Apr 16;36(7):2196-207. Epub 2008 Feb 16.

Human Genetics Program and Department of Biochemistry and Tulane Cancer Center, Tulane Medical School, Department of Mathematics, Tulane University, New Orleans, LA 70112, USA.

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http://nar.oxfordjournals.org/content/36/7/2196.full.pdf
Web Search
http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkn055
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http://dx.doi.org/10.1093/nar/gkn055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367708PMC
April 2008

Hybridization analysis of D4Z4 repeat arrays linked to FSHD.

Chromosoma 2007 Apr 28;116(2):107-16. Epub 2006 Nov 28.

Program in Human Genetics and Department of Biochemistry, Tulane Medical School, New Orleans, LA, USA.

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http://dx.doi.org/10.1007/s00412-006-0080-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828046PMC
April 2007

Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF).

Orphanet J Rare Dis 2006 Mar 1;1. Epub 2006 Mar 1.

Human Genetics Program, Tulane University Health Sciences Center 1430 Tulane Ave, New Orleans, LA 70112, USA.

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http://ojrd.biomedcentral.com/articles/10.1186/1750-1172-1-2
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http://dx.doi.org/10.1186/1750-1172-1-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459120PMC
March 2006

Analysis of repetitive element DNA methylation by MethyLight.

Nucleic Acids Res 2005 2;33(21):6823-36. Epub 2005 Dec 2.

Department of Surgery, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/nar/gki987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1301596PMC
December 2005

Both hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in cancer.

Mol Cancer Res 2005 Nov;3(11):617-26

Human Genetics Program, Department of Biochemistry, and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-05-0146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420408PMC
November 2005

Interphase chromosomal abnormalities and mitotic missegregation of hypomethylated sequences in ICF syndrome cells.

Chromosoma 2005 Jul 27;114(2):118-26. Epub 2005 Apr 27.

Department of Clinical Genetics, University Hospital, 22185 Lund, Sweden.

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http://dx.doi.org/10.1007/s00412-005-0343-7DOI Listing
July 2005

A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others.

Cancer Biol Ther 2005 Apr 21;4(4):440-8. Epub 2005 Apr 21.

Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.4161/cbt.4.4.1622DOI Listing
April 2005

DNA hypomethylation is prevalent even in low-grade breast cancers.

Cancer Biol Ther 2004 Dec 9;3(12):1225-31. Epub 2004 Dec 9.

Department of Biochemistry, Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.4161/cbt.3.12.1222DOI Listing
December 2004

Histone modification in constitutive heterochromatin versus unexpressed euchromatin in human cells.

J Cell Biochem 2004 Oct;93(2):286-300

Human Genetics Program and Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.1002/jcb.20146DOI Listing
October 2004

DNA hypomethylation and ovarian cancer biology.

Cancer Res 2004 Jul;64(13):4472-80

Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0238DOI Listing
July 2004

Cytogenetic and immuno-FISH analysis of the 4q subtelomeric region, which is associated with facioscapulohumeral muscular dystrophy.

Chromosoma 2004 May 11;112(7):350-9. Epub 2004 May 11.

Human Genetics Program and Department of Biochemistry, Tulane Medical School, New Orleans, LA 70112, USA.

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http://link.springer.com/10.1007/s00412-004-0280-x
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http://dx.doi.org/10.1007/s00412-004-0280-xDOI Listing
May 2004

Testing the position-effect variegation hypothesis for facioscapulohumeral muscular dystrophy by analysis of histone modification and gene expression in subtelomeric 4q.

Hum Mol Genet 2003 Nov 23;12(22):2909-21. Epub 2003 Sep 23.

Human Genetics Program and Department of Biochemistry, Tulane Medical School, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1093/hmg/ddg323DOI Listing
November 2003

The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease.

Authors:
Melanie Ehrlich

Clin Immunol 2003 Oct;109(1):17-28

Human Genetics Program and Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA.

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October 2003

Imatinib (ST1571) provides only limited selectivity for CML cells and treatment might be complicated by silent BCR-ABL genes.

Cancer Biol Ther 2003 Jan-Feb;2(1):103-8

Tulane Cancer Center and Humon Genetics Program, Tulane Medical School, New Orleans, Lousiana 70112, USA.

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http://dx.doi.org/10.4161/cbt.240DOI Listing
July 2003

Expression of various genes is controlled by DNA methylation during mammalian development.

Authors:
Melanie Ehrlich

J Cell Biochem 2003 Apr;88(5):899-910

Program in Human Genetics, Department of Biochemistry, and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1002/jcb.10464DOI Listing
April 2003

Satellite DNA hypomethylation in karyotyped Wilms tumors.

Cancer Genet Cytogenet 2003 Mar;141(2):97-105

Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, LA, USA.

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http://dx.doi.org/10.1016/s0165-4608(02)00668-4DOI Listing
March 2003

Hypomethylation and hypermethylation of DNA in Wilms tumors.

Oncogene 2002 Sep;21(43):6694-702

Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana, LA 70112, USA.

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http://dx.doi.org/10.1038/sj.onc.1205890DOI Listing
September 2002

DNA methylation in cancer: too much, but also too little.

Authors:
Melanie Ehrlich

Oncogene 2002 Aug;21(35):5400-13

Human Genetics Program/SL31, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana, LA 70122, USA.

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http://dx.doi.org/10.1038/sj.onc.1205651DOI Listing
August 2002

DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements.

Authors:
Melanie Ehrlich

J Nutr 2002 08;132(8 Suppl):2424S-2429S

Tulane Medical School, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1093/jn/132.8.2424SDOI Listing
August 2002