Melania Pintilie

Melania Pintilie

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Melania Pintilie

Publications by authors named "Melania Pintilie"

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Systemic Therapy Use and Outcomes After Relapse from Preoperative Radiation and Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma.

Oncologist 2019 Jul 26;24(7):e510-e517. Epub 2018 Nov 26.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1634/theoncologist.2018-0501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656469PMC
July 2019

Meningioma Screening With MRI in Childhood Leukemia Survivors Treated With Cranial Radiation.

Int J Radiat Oncol Biol Phys 2019 Jul 14;104(3):640-643. Epub 2019 Mar 14.

Radiation Medicine Program, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada; Pediatric Oncology Group of Ontario (POGO), Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.057DOI Listing
July 2019

HPV-independent Vulvar Squamous Cell Carcinoma is Associated With Significantly Worse Prognosis Compared With HPV-associated Tumors.

Int J Gynecol Pathol 2019 Jul 3. Epub 2019 Jul 3.

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan (G.A.) Departments of Radiation Oncology (M.L.Y., J.C., M.M.) Obstetrics and Gynecology, Division of Gynecologic Oncology (S.F.) Medical Oncology (H.M.) Laboratory Medicine and Pathobiology (S.K.R., I.W., D.G., B.A.C.) Biostatistics (M.P.), Princess Margaret Cancer Centre/University Health Network, and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/PGP.0000000000000620DOI Listing
July 2019

Repeatability and reproducibility of MRI-based radiomic features in cervical cancer.

Radiother Oncol 2019 Jun 19;135:107-114. Epub 2019 Mar 19.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01678140193010
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http://dx.doi.org/10.1016/j.radonc.2019.03.001DOI Listing
June 2019

Effect of Coexisting KRAS and TP53 Mutations in Patients Treated With Chemotherapy for Non-small-cell Lung Cancer.

Clin Lung Cancer 2019 May 19;20(3):e338-e345. Epub 2018 Dec 19.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.cllc.2018.12.009DOI Listing
May 2019

Genomic Classifier for Guiding Treatment of Intermediate-Risk Prostate Cancers to Dose-Escalated Image Guided Radiation Therapy Without Hormone Therapy.

Int J Radiat Oncol Biol Phys 2019 01 29;103(1):84-91. Epub 2018 Aug 29.

Princess Margaret Cancer Centre, University Health Network, Ontario, Canada; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore; Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Oncology Academic Program, Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1016/j.ijrobp.2018.08.030DOI Listing
January 2019

Measurement of Tumor Hypoxia in Patients With Locally Advanced Cervical Cancer Using Positron Emission Tomography with F-Fluoroazomyin Arabinoside.

Int J Radiat Oncol Biol Phys 2018 11 2;102(4):1202-1209. Epub 2018 Mar 2.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183032
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http://dx.doi.org/10.1016/j.ijrobp.2018.02.030DOI Listing
November 2018

The prognostic effect of single and multiple cancer-related somatic mutations in resected non-small-cell lung cancer.

Lung Cancer 2018 09 19;123:22-29. Epub 2018 Jun 19.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183043
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http://dx.doi.org/10.1016/j.lungcan.2018.06.023DOI Listing
September 2018

Hazards and incidents: Detection and learning in radiation medicine, a comparison of 2 educational interventions.

Pract Radiat Oncol 2017 Nov - Dec;7(6):e431-e438. Epub 2017 Feb 27.

Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Techna Institute, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2017.02.006DOI Listing
July 2018

Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC).

BMC Cancer 2018 04 16;18(1):429. Epub 2018 Apr 16.

Department of Muldisciplinary Oncology and Therapeutic Innovations, Assistance Publique des Hôpitaux de Marseille (AP-HM), Aix-Marseille University, Chemin des Bourrely, 13195, Marseille, Cedex 20, France.

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http://dx.doi.org/10.1186/s12885-018-4215-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902896PMC
April 2018

The impact of active breathing control on internal mammary lymph node coverage and normal tissue exposure in breast cancer patients planned for left-sided postmastectomy radiation therapy.

Pract Radiat Oncol 2017 Jul - Aug;7(4):228-233. Epub 2016 Dec 7.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2016.11.010DOI Listing
March 2018

Long-Term Outcomes of Phase 1 and 2 Studies of SBRT for Hepatic Colorectal Metastases.

Int J Radiat Oncol Biol Phys 2017 10 13;99(2):388-395. Epub 2017 Apr 13.

Radiation Medicine Program, Princess Margaret Cancer Centre, and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.04.010DOI Listing
October 2017

Human tissue Kallikreins: Blood levels and response to radiotherapy in intermediate risk prostate cancer.

Radiother Oncol 2017 09 17;124(3):427-432. Epub 2017 Apr 17.

Ontario Cancer Institute, Radiation Medicine Program, Princess Margaret Cancer Centre (University Health Network), Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.03.023DOI Listing
September 2017

Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors.

Eur Urol 2017 07 1;72(1):22-31. Epub 2016 Nov 1.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.10.013DOI Listing
July 2017

Improved outcomes with dose escalation in localized prostate cancer treated with precision image-guided radiotherapy.

Radiother Oncol 2017 06 20;123(3):459-465. Epub 2017 Apr 20.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.04.003DOI Listing
June 2017

Plerixafor Improves Primary Tumor Response and Reduces Metastases in Cervical Cancer Treated with Radio-Chemotherapy.

Clin Cancer Res 2017 Mar 3;23(5):1242-1249. Epub 2016 Oct 3.

Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1730DOI Listing
March 2017

Patient-Derived Xenograft Establishment from Human Malignant Pleural Mesothelioma.

Clin Cancer Res 2017 Feb 28;23(4):1060-1067. Epub 2016 Sep 28.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0844DOI Listing
February 2017

Long-term outcomes of a phase II trial of moderate hypofractionated image-guided intensity modulated radiotherapy (IG-IMRT) for localized prostate cancer.

Radiother Oncol 2017 01 9;122(1):93-98. Epub 2016 Nov 9.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University of Toronto, Department of Radiation Oncology, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2016.10.017DOI Listing
January 2017

Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts.

Br J Cancer 2017 01 22;116(1):50-57. Epub 2016 Nov 22.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario MG5 2M9, Canada.

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http://dx.doi.org/10.1038/bjc.2016.383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220149PMC
January 2017

Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts.

Oncotarget 2017 Jan;8(2):3064-3071

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.13619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356865PMC
January 2017

Progression to Stage 4 chronic kidney disease and death, acute kidney injury and hospitalization risk: a retrospective cohort study.

Nephrol Dial Transplant 2016 07 20;31(7):1122-30. Epub 2015 Nov 20.

Division of Nephrology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada Institute of Health Policy Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/ndt/gfv389DOI Listing
July 2016

A proposal for cellularity assessment for EGFR mutational analysis with a correlation with DNA yield and evaluation of the number of sections obtained from cell blocks for immunohistochemistry in non-small cell lung carcinoma.

J Clin Pathol 2016 Jul 5;69(7):607-11. Epub 2016 Jan 5.

Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jclinpath-2015-203437DOI Listing
July 2016

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302.

Oncotarget 2016 Jun;7(23):33571-80

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.9654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085103PMC
June 2016

Developing a prognostic micro-RNA signature for human cervical carcinoma.

PLoS One 2015 16;10(4):e0123946. Epub 2015 Apr 16.

Ontario Cancer Institute, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123946PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399941PMC
May 2016

Association between Metformin Use and Mortality after Cervical Cancer in Older Women with Diabetes.

Cancer Epidemiol Biomarkers Prev 2016 Mar 31;25(3):507-12. Epub 2015 Dec 31.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1008DOI Listing
March 2016

Assessment of intravascular granulomas in testicular seminomas and their association with tumour relapse and dissemination.

J Clin Pathol 2016 Jan 20;69(1):47-52. Epub 2015 Jul 20.

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2015-202997
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http://dx.doi.org/10.1136/jclinpath-2015-202997DOI Listing
January 2016

Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study.

Int J Radiat Oncol Biol Phys 2016 Jan 18;94(1):111-117. Epub 2015 Sep 18.

Department of Medical Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2015.09.009DOI Listing
January 2016

Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial.

J Transl Med 2016 Jan 13;14:12. Epub 2016 Jan 13.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University Health Network, 610 University Ave, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1186/s12967-015-0747-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712499PMC
January 2016

Clinical characteristics and early treatment outcomes of follicular lymphoma in young adults.

Br J Haematol 2015 Aug 22;170(3):384-90. Epub 2015 Apr 22.

Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/bjh.13451DOI Listing
August 2015

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

J Clin Oncol 2015 Aug 29;33(22):2472-80. Epub 2015 Jun 29.

Erin L. Stewart, Celine Mascaux, Nhu-An Pham, Shingo Sakashita, Jenna Sykes, Lucia Kim, Naoki Yanagawa, Ghassan Allo, Kota Ishizawa, Dennis Wang, Chang-Qi Zhu, Ming Li, Christine Ng, Ni Liu, Melania Pintilie, Petra Martin, Tom John, Igor Jurisica, Natasha B. Leighl, Benjamin G. Neel, Thomas K. Waddell, Frances A. Shepherd, Geoffrey Liu, Ming-Sound Tsao, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Lucia Kim, Inha University College of Medicine, Incheon, South Korea; and Tom John, Austin Hospital, Heidelberg, Australia.

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http://jco.ascopubs.org/content/33/22/2472.full.pdf
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http://200.40.135.66:90/toc/0873/2015/0873-20150801-22-09.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.60.1492
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http://dx.doi.org/10.1200/JCO.2014.60.1492DOI Listing
August 2015

Spatial genomic heterogeneity within localized, multifocal prostate cancer.

Nat Genet 2015 Jul 25;47(7):736-45. Epub 2015 May 25.

1] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [2] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [3] Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3315DOI Listing
July 2015

Establishment of orthotopic primary cervix cancer xenografts.

Methods Mol Biol 2015 ;1249:381-91

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre and University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-2013-6_28DOI Listing
June 2015

NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma.

Clin Cancer Res 2015 Jun 4;21(11):2499-505. Epub 2015 Mar 4.

Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-14-2206DOI Listing
June 2015

Identification of a Low-Risk Luminal A Breast Cancer Cohort That May Not Benefit From Breast Radiotherapy.

J Clin Oncol 2015 Jun 11;33(18):2035-40. Epub 2015 May 11.

Fei-Fei Liu, Anthony W. Fyles, Wei Shi, Susan J. Done, Naomi Miller, Melania Pintilie, and David R. McCready, Princess Margaret Cancer Centre/University Health Network; Sharon Nofech-Mozes, Sunnybrook Odette Cancer Center; Martin C. Chang, Mt. Sinai Hospital, University of Toronto, Toronto; Timothy J. Whelan, Juravinski Cancer Centre, McMaster University, Hamilton, ON; David Voduc, Torsten O. Nielsen, and Lorna M. Weir, British Columbia Cancer Agency, Vancouver; and Ivo A. Olivotto, British Columbia Cancer Agency, Victoria, BC, Canada.

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http://dx.doi.org/10.1200/JCO.2014.57.7999DOI Listing
June 2015

Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle.

J Control Release 2015 May 21;206:122-30. Epub 2015 Mar 21.

Drug Discovery Program, Ontario Institute for Cancer Research, 101 College Street, Suite 800, Toronto, Ontario M5G 0A3, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409566PMC
May 2015

ESRD and death after heart failure in CKD.

J Am Soc Nephrol 2015 Mar 4;26(3):715-22. Epub 2014 Sep 4.

Dalla Lana School of Public Health, Division of Nephrology, Sunnybrook Health Sciences Centre, and Institute of Health Policy Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;

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http://dx.doi.org/10.1681/ASN.2014030253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341483PMC
March 2015

Integrating RAS status into prognostic signatures for adenocarcinomas of the lung.

Clin Cancer Res 2015 Mar 21;21(6):1477-86. Epub 2015 Jan 21.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Canada. Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Canada. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1749DOI Listing
March 2015

Technical challenges of sparing infrahyoid swallowing organs at risk in oropharynx squamous cell cancer treated with IMRT.

Med Dosim 2014 17;39(2):146-51. Epub 2014 Jan 17.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.meddos.2013.11.006DOI Listing
January 2015

A single institution experience of extranodal natural killer/T cell lymphoma of nasal type.

Leuk Lymphoma 2015 Jan;56(1):80-4

Department of Radiation Oncology, University of Toronto , ON , Canada.

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http://dx.doi.org/10.3109/10428194.2014.909039DOI Listing
January 2015

Time from first detectable PSA following radical prostatectomy to biochemical recurrence: A competing risk analysis.

Can Urol Assoc J 2015 Jan-Feb;9(1-2):E14-21

Division of Urology and Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, Israel.

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http://dx.doi.org/10.5489/cuaj.2147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301963PMC
January 2015

Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact.

Nat Commun 2014 Nov 28;5:5469. Epub 2014 Nov 28.

1] Department of Molecular Structure and Function, The Hospital For Sick Children, 686 Bay Street, Toronto, Ontario, Canada M5G0A4 [2] Princess Margaret Cancer Centre, 101 College Street, Toronto, Ontario, Canada M5G 1L7 [3] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5G 0A4.

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http://dx.doi.org/10.1038/ncomms6469DOI Listing
November 2014

High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone.

Int J Cancer 2014 Oct 25;135(7):1692-9. Epub 2014 Apr 25.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.28403DOI Listing
October 2014

Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer.

J Thorac Oncol 2014 Sep;9(9):1255-63

*Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre and McMaster University, Hamilton, Ontario; †Department of Pathology, University Health Network, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario; ‡Department of Pathology, Jewish General Hospital and Lady David Institute, McGill University, Montreal, Québec; §Cross Cancer Institute and Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, Alberta; ‖Department of Molecular Pathology, University of Alberta Hospital, Edmonton, Alberta; ¶Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia; #Department of Pathology, Aichi Cancer Center Hospital, Nagoya, Japan; **Department of Pathology, British Columbia Cancer Agency and University of British Columbia, Vancouver, British Columbia; ††Department of Pathology, McGill University Health Centre, Montreal, Québec; ‡‡Department of Human Genetics, McGill University, Montreal, Québec; §§Department of Pathology, Health Sciences North, Sudbury, Ontario; ‖‖Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta; ¶¶Department of Pathology, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario; ##Centre hospitalier de l'Universite de Montreal, Montreal, Québec; ***Department of Pathology, London Health Sciences Centre, London, Ontario; †††Department of Molecular Genetics, University of Toronto, Toronto, Ontario; ‡‡‡Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, MA; §§§Pfizer Oncology Canada, Kirkland, Québec; and ‖‖‖Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Université Laval, Québec, Québec.

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http://dx.doi.org/10.1097/JTO.0000000000000239DOI Listing
September 2014

Risk of end-stage renal disease and death after cardiovascular events in chronic kidney disease.

Circulation 2014 Aug 4;130(6):458-65. Epub 2014 Jun 4.

From the Department of Medicine (M.S., D.N.), the Division of Nephrology, Sunnybrook Health Sciences Centre (D.N.), the Dalla Lana School of Public Health (M.P.), and the Institute of Health Policy Management and Evaluation, Faculty of Medicine (D.N.), University of Toronto, Toronto, Ontario, Canada; the Division of Nephrology, Seven Oaks General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada (N.T.); the Department of Biostatistics, University Health Network, Toronto, Ontario, Canada (M.P.); and the Division of Nephrology, Tufts Medical Centre, Boston, MA (A.S.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.007106DOI Listing
August 2014

CKD stage at nephrology referral and factors influencing the risks of ESRD and death.

Am J Kidney Dis 2014 Jun 28;63(6):928-36. Epub 2014 Jan 28.

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Division of Nephrology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2013.12.008DOI Listing
June 2014

Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies.

Genome Med 2012 12;4(11):84. Epub 2012 Nov 12.

Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada ; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.

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http://genomemedicine.biomedcentral.com/articles/10.1186/gm3
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http://dx.doi.org/10.1186/gm385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580418PMC
May 2014

Assessment of hypoxia in the stroma of patient-derived pancreatic tumor xenografts.

Cancers (Basel) 2014 Feb 26;6(1):459-71. Epub 2014 Feb 26.

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Center, University Health Network, 610 University Ave., Toronto, ON M5G2M9, Canada.

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http://dx.doi.org/10.3390/cancers6010459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980617PMC
February 2014

Validation of a histology-independent prognostic gene signature for early-stage, non-small-cell lung cancer including stage IA patients.

J Thorac Oncol 2014 Jan;9(1):59-64

*Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; and Departments of †Computer Science, ‡Medical Biophysics, §Medicine, and ‖Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153016
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http://dx.doi.org/10.1097/JTO.0000000000000042DOI Listing
January 2014

Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes.

J Control Release 2013 Nov 7;172(1):351-357. Epub 2013 Sep 7.

TECHNA Institute and Ontario Cancer Institute, University Health Network, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Departments of Radiation Oncology, Medical Biophysics, and IBBME, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2013.08.296DOI Listing
November 2013

Trends in the utilization of brachytherapy in cervical cancer in the United States.

Int J Radiat Oncol Biol Phys 2013 Sep 9;87(1):111-9. Epub 2013 Jul 9.

Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2013.05.033DOI Listing
September 2013

Human papilloma virus genome is rare in North American non-small cell lung carcinoma patients.

Lung Cancer 2013 Mar 14;79(3):215-20. Epub 2012 Dec 14.

Department of Pathology, University Health Network, Princess Margaret Hospital site and Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.lungcan.2012.11.018DOI Listing
March 2013

Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer.

Prostate 2012 Sep 27;72(12):1295-305. Epub 2011 Dec 27.

Department of Radiation Oncology, Medical Biophysics, Laboratory Medicine and Pathology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pros.22478
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http://dx.doi.org/10.1002/pros.22478DOI Listing
September 2012

Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx).

Cancers (Basel) 2012 Aug 29;4(3):821-45. Epub 2012 Aug 29.

Ontario Cancer Institute/Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.3390/cancers4030821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712708PMC
August 2012

Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissue.

Cancer Epidemiol Biomarkers Prev 2012 Jul 26;21(7):1097-104. Epub 2012 Apr 26.

Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-1
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http://dx.doi.org/10.1158/1055-9965.EPI-11-1123-TDOI Listing
July 2012

Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation.

Cancer 2012 Jun 25;118(12):3105-15. Epub 2011 Oct 25.

Ontario Cancer Institute/Princess Margaret Hospital and The Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.26635DOI Listing
June 2012

Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer.

Clin Cancer Res 2012 Apr 31;18(7):2108-14. Epub 2012 Mar 31.

Radiation Medicine Program, Princess Margaret Hospital and Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2711DOI Listing
April 2012

Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability.

J Cell Sci 2012 Jan 20;125(Pt 1):189-99. Epub 2012 Jan 20.

Ontario Cancer Institute, Princess Margaret Hospital (University Health Network), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1242/jcs.092262DOI Listing
January 2012

Optimized application of penalized regression methods to diverse genomic data.

Bioinformatics 2011 Dec;27(24):3399-406

Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btr591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232376PMC
December 2011

A pathway-based association analysis model using common and rare variants.

BMC Proc 2011 Nov 29;5 Suppl 9:S85. Epub 2011 Nov 29.

Department of Biostatistics, Princess Margaret Hospital, 610 University Ave,, Toronto, ON M5G 2M9, Canada.

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http://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-
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http://dx.doi.org/10.1186/1753-6561-5-S9-S85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287926PMC
November 2011

[An introduction to competing risks analysis].

Authors:
Melania Pintilie

Rev Esp Cardiol 2011 Jul 31;64(7):599-605. Epub 2011 May 31.

Department of Biostatistics, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.recesp.2011.03.017DOI Listing
July 2011

MicroRNA-301 mediates proliferation and invasion in human breast cancer.

Cancer Res 2011 Apr 10;71(8):2926-37. Epub 2011 Mar 10.

Department of Medical Biophysics, Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3369DOI Listing
April 2011

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer.

Proc Natl Acad Sci U S A 2011 Apr 7;108(17):7160-5. Epub 2011 Apr 7.

The Campbell Family Institute for Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1073/pnas.1014506108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084093PMC
April 2011

The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small cell lung cancer.

Clin Cancer Res 2011 Jan 16;17(1):134-41. Epub 2010 Nov 16.

Melbourne Centre for Clinical Sciences, Ludwig Institute for Cancer Research, Melbourne, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2224DOI Listing
January 2011