Mel Krajden

Mel Krajden

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Mel Krajden

Mel Krajden

Publications by authors named "Mel Krajden"

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Deriving the optimal limit of detection for an HCV point-of-care test for viraemic infection: Analysis of a global dataset.

J Hepatol 2019 Jul 21;71(1):62-70. Epub 2019 Feb 21.

Boston Medical Center, Section of Infectious Diseases, Boston University School of Public Health, Boston, USA; Department of Epidemiology, Section of Infectious Diseases, Boston University School of Public Health, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.02.011DOI Listing
July 2019

Measles Lymphadenopathy in a Child With PFAPA Syndrome.

Pediatr Dev Pathol 2018 Sep-Oct;21(5):497-501. Epub 2017 Sep 7.

2 Division of Pediatric Rheumatology, Department of Pediatrics, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1177/1093526617727970DOI Listing
June 2019

What is killing people with hepatitis C virus infection? Analysis of a population-based cohort in Canada.

Int J Drug Policy 2019 Jun 19. Epub 2019 Jun 19.

Clinical Prevention Services, British Columbia Centre for Disease Control, Vancouver, BC, Canada; School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.drugpo.2019.06.003DOI Listing
June 2019

In-hospital post-transplant acute hepatitis A viral (HAV) infection in a liver transplant recipient who was HAV seropositive pre-transplant.

Saudi J Gastroenterol 2019 Jan-Feb;25(1):67-70

Division of Gastroenterology, University of British Columbia and the Liver Transplant Program, Vancouver General Hospital, Vancouver, Canada.

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http://dx.doi.org/10.4103/sjg.SJG_230_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373217PMC
April 2019

Applying core theory and spatial analysis to identify hepatitis C virus infection "core areas" in British Columbia, Canada.

J Viral Hepat 2019 Mar 11;26(3):373-383. Epub 2018 Dec 11.

School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/jvh.13043DOI Listing
March 2019

Medical Information Commons to Support Learning Healthcare Systems: Examples From Canada.

J Law Med Ethics 2019 Mar;47(1):97-105

Tania Bubela, Ph.D., J.D., F.C.A.H.S., is an expert in health and intellectual property law and policy, combining her training in genetics (Ph.D. Biology, University of Sydney) and law (Gold medalist, University of Alberta). She is the Dean of Faculty of Health Sciences at Simon Fraser University (Burnaby, British Columbia), developing sector-leading policies, processes, practices, and infrastructure to support excellence in interdisciplinary education, research, and engagement that will improve health, health equity, and well-being. Shelagh K. Genuis, Ph.D., is the project manager for the Genome Canada's Precision Medicine Policy Network, based in the Faculty of Medicine and Dentistry at the University of Alberta, Alberta. Naveed Z. Janjua, M.D., Ph.D., is a Senior Scientist at the BC Centre for Disease Control and Clinical Associate Professor at School of Population and Public Health, University of British Columbia. Mel Krajden, M.D., F.R.C.P.C., is the Director of BC's Public Health Laboratory and the Medical Head, Hepatitis at the British Columbia Centre for Disease Control. He is also a Professor of Pathology and Laboratory Medicine at the University of British Columbia. He has extensive clinical trials expertise and is a Co-investigator/Mentor on the CIHR funded National Research Training Program (CanHepC). Nicole Mittmann, Ph.D., is the Chief Research Officer at CCO. She is an Assistant Professor at the University of Toronto in the Department of Pharmacology and Toxicology and an Associate Scientist at Sunnybrook Health Sciences Centre. Katerina Podolak is the Group Manager for Data Acquisition and Disclosure at Cancer Care Ontario, working with data partners to bring data into CCO, and health system partners who want access to CCO data. Katerina has extensive experience with information management in the hospital setting, as well as Ontario's Ministry of Health and Long-term Care. Larry Svenson, Ph.D., F.R.S.P.H., is the Provincial Health Analytics Officer and Executive Director for Analytics and Performance Reporting at Alberta Health. He is also an Associate Professor with the Division of Preventive Medicine at the University of Alberta and an Adjunct Professor with the School of Public Health at the University of Alberta and the Cumming School of Medicine at the University of Calgary.

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http://dx.doi.org/10.1177/1073110519840488DOI Listing
March 2019

Estimating the impact of early hepatitis C virus clearance on hepatocellular carcinoma risk.

J Viral Hepat 2018 Dec 28;25(12):1481-1492. Epub 2018 Aug 28.

British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/jvh.12977DOI Listing
December 2018

Hepatitis C virus reinfection after successful treatment with direct-acting antiviral therapy in a large population-based cohort.

J Hepatol 2018 Nov 22;69(5):1007-1014. Epub 2018 Aug 22.

British Columbia Centre for Disease Control, Vancouver, BC, Canada; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.07.025DOI Listing
November 2018

Comparative performance of human papillomavirus messenger RNA versus DNA screening tests at baseline and 48 months in the HPV FOCAL trial.

J Clin Virol 2018 Nov 10;108:32-37. Epub 2018 Sep 10.

BC Centre for Disease Control, Vancouver, BC, Canada; Lower Mainland Pathology & Laboratory Medicine, Provincial Health Services Authority, Vancouver, BC, Canada; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13866532183022
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http://dx.doi.org/10.1016/j.jcv.2018.09.004DOI Listing
November 2018

Syndemic Characterization of HCV, HBV, and HIV Co-infections in a Large Population Based Cohort Study.

EClinicalMedicine 2018 Oct-Nov;4-5:99-108. Epub 2018 Nov 5.

School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.eclinm.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537523PMC
November 2018

Transplanting Hepatitis C-Seropositive, Nucleic Acid Test-Negative Donor Organs Into Hepatitis C-Negative Recipients.

Hepatology 2018 09;68(3):1208-1209

Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/hep.30121DOI Listing
September 2018

HIV serology signal-to-cutoff ratio as a rapid method to predict confirmation of HIV infection.

Eur J Clin Microbiol Infect Dis 2018 Aug 3;37(8):1589-1593. Epub 2018 Jun 3.

Department of Pathology and Laboratory Medicine, University of British Columbia, 2329 West Mall, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s10096-018-3290-yDOI Listing
August 2018

Identifying injection drug use and estimating population size of people who inject drugs using healthcare administrative datasets.

Int J Drug Policy 2018 05 23;55:31-39. Epub 2018 Feb 23.

British Columbia Centre for Disease Control, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.drugpo.2018.02.001DOI Listing
May 2018

Late hepatitis B and C diagnosis in relation to disease decompensation and hepatocellular carcinoma development.

J Hepatol 2017 11 4;67(5):909-917. Epub 2017 Jul 4.

BC Centre for Disease Control, 655 West 12th Avenue, Vancouver, British Columbia V5Z 4R4, Canada; University of British Columbia, 2329 West Mall, Vancouver, British Columbia V6T 1Z4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.06.025DOI Listing
November 2017

Post-Loop Electrosurgical Excision Procedure High-Risk Human Papillomavirus Testing as a Test of Cure: The British Columbia Experience.

J Low Genit Tract Dis 2017 Oct;21(4):284-288

1BC Cancer Agency, Vancouver, British Columbia, Canada; 2Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; 3BC Centre for Disease Control, Vancouver, British Columbia, Canada; and 4Lower Mainland Laboratories, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/LGT.0000000000000349DOI Listing
October 2017

Hepatitis C cross-genotype immunity and implications for vaccine development.

Sci Rep 2017 09 26;7(1):12326. Epub 2017 Sep 26.

School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/s41598-017-10190-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615075PMC
September 2017

Will Infant Hepatitis B Vaccination Protect Into Adulthood?: Extended Canadian Experience After a 2-, 4- and 6-month Immunization Schedule.

Pediatr Infect Dis J 2017 06;36(6):609-615

From the *Vaccine Evaluation Center, Vancouver, British Columbia, Canada; †University of British Columbia, Vancouver, British Columbia, Canada; ‡Vancouver Coastal Health Authority, Vancouver, British Columbia, Canada; and §BC Centre for Disease Control, Vancouver, British Columbia, Canada.

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http://Insights.ovid.com/crossref?an=00006454-201706000-0001
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http://dx.doi.org/10.1097/INF.0000000000001543DOI Listing
June 2017

Development and validation of a real-time, reverse transcription PCR assay for rapid and low-cost genotyping of hepatitis C virus genotypes 1a, 1b, 2, and 3a.

J Virol Methods 2017 06 20;244:17-22. Epub 2017 Feb 20.

British Columbia Centre for Disease Control Public Health Laboratory, Provincial Health Services Authority, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2017.02.009DOI Listing
June 2017

Identifying those infected with hepatitis C virus.

CMAJ 2017 06;189(25):E869

Professor, Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC.

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http://dx.doi.org/10.1503/cmaj.733099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489395PMC
June 2017

Independent Scientists Provide Guidance for the Future of Cervical Cancer Screening.

J Obstet Gynaecol Can 2017 05;39(5):326-327

Faculty of Medicine, University of British Columbia and Women's Health Research Institute, Vancouver, BC.

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http://dx.doi.org/10.1016/j.jogc.2017.02.006DOI Listing
May 2017

Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan.

Can J Gastroenterol Hepatol 2016 27;2016:5743521. Epub 2016 Apr 27.

Department of Microbiology & Immunology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5.

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http://dx.doi.org/10.1155/2016/5743521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904693PMC
March 2017

Long-term effect of sustained virological response on hepatocellular carcinoma in patients with hepatitis C in Canada.

J Hepatol 2017 03 4;66(3):504-513. Epub 2016 Nov 4.

British Columbia Centre for Disease Control, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.jhep.2016.10.028DOI Listing
March 2017

Incidence, risk factors, and prevention of hepatitis C reinfection: a population-based cohort study.

Lancet Gastroenterol Hepatol 2017 03 23;2(3):200-210. Epub 2016 Dec 23.

School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada; British Columbia Centre for Disease Control, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(16)30182-0DOI Listing
March 2017

Aptima HPV Assay versus Hybrid Capture 2 HPV test for primary cervical cancer screening in the HPV FOCAL trial.

J Clin Virol 2017 02 11;87:23-29. Epub 2016 Dec 11.

BC Centre for Disease Control, 655 West 12th Ave, Vancouver, BC, V5Z 4R4, Canada; Lower Mainland Laboratories, 655 West 12th Ave, Vancouver, BC, V5Z 4R4, Canada; University of British Columbia, Faculty of Medicine, 2329 West Mall, Vancouver, BC, V6T 1Z4, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13866532163061
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http://dx.doi.org/10.1016/j.jcv.2016.12.004DOI Listing
February 2017

The Population Level Cascade of Care for Hepatitis C in British Columbia, Canada: The BC Hepatitis Testers Cohort (BC-HTC).

EBioMedicine 2016 Oct 25;12:189-195. Epub 2016 Aug 25.

British Columbia Centre for Disease Control (BCCDC), 655 West 12th Avenue, Vancouver, BC V5Z 4R4, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6Z 1Y6, Canada.

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http://dx.doi.org/10.1016/j.ebiom.2016.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078584PMC
October 2016

Restrictions for reimbursement of direct-acting antiviral treatment for hepatitis C virus infection in Canada: a descriptive study.

CMAJ Open 2016 Oct-Dec;4(4):E605-E614. Epub 2016 Oct 14.

The Kirby Institute (Marshall, Grebely), UNSW Australia, Sydney, Australia; Department of Epidemiology, Biostatistics and Occupational Health (Saeed), McGill University, Montréal, Que.; Faculty of Medicine (Klein), McGill University, Montréal, Que.; Faculty of Medicine (Barrett), Dalhousie University, Halifax, NS; Department of Medicine (Cooper), University of Ottawa, Ottawa, Ont.; Centre for Social Research in Health (Treloar), UNSW Australia, Sydney, Australia; Centre de recherche du Centre hospitalier de l'Université de Montréal (Bruneau, Shoukry), Montréal, Que.; Liver Centre (Feld), Toronto Western Hospital, University Health Network/University of Toronto, Toronto, Ont.; Vancouver Coastal Health (Gallagher); BC Centre for Disease Control (Krajden), Vancouver, BC; Department of Medicine (Taylor), Brown University, Providence, RI.

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http://dx.doi.org/10.9778/cmajo.20160008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173474PMC
October 2016

Deep sequencing increases hepatitis C virus phylogenetic cluster detection compared to Sanger sequencing.

Infect Genet Evol 2016 09 6;43:329-37. Epub 2016 Jun 6.

BC Centre for Disease Control, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2016.06.015DOI Listing
September 2016

Recommendations for Implementing Human Papillomavirus-Based Cervical Cancer Screening: Lessons Learned from the HPV FOCAL Trial.

J Obstet Gynaecol Can 2016 08 7;38(8):723-6. Epub 2016 Jun 7.

Faculty of Medicine, University of British Columbia, Vancouver BC; Women's Health Research Institute, Vancouver BC.

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http://dx.doi.org/10.1016/j.jogc.2016.04.009DOI Listing
August 2016

Twin epidemics of new and prevalent hepatitis C infections in Canada: BC Hepatitis Testers Cohort.

BMC Infect Dis 2016 07 19;16:334. Epub 2016 Jul 19.

Clinical Prevention Services, British Columbia Centre for Disease Control, Vancouver, BC, Canada.

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http://dx.doi.org/10.1186/s12879-016-1683-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952323PMC
July 2016

The spread of hepatitis C virus genotype 1a in North America: a retrospective phylogenetic study.

Lancet Infect Dis 2016 06 30;16(6):698-702. Epub 2016 Mar 30.

BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/S1473-3099(16)00124-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245154PMC
June 2016

Near real-time monitoring of HIV transmission hotspots from routine HIV genotyping: an implementation case study.

Lancet HIV 2016 05 7;3(5):e231-8. Epub 2016 Apr 7.

BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/S2352-3018(16)00046-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853759PMC
May 2016

Self-Collected versus Clinician-Collected Sampling for Chlamydia and Gonorrhea Screening: A Systemic Review and Meta-Analysis.

PLoS One 2015 13;10(7):e0132776. Epub 2015 Jul 13.

Division of STI/HIV Prevention and Control, BC Centre for Disease Control, Vancouver, British Columbia, Canada; University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500554PMC
April 2016

Symptomatic Congenital Cytomegalovirus Infection Is Underdiagnosed in British Columbia.

J Pediatr 2016 Feb 17;169:316-7. Epub 2015 Nov 17.

Child and Family Research Institute, Vancouver, British Columbia, Canada; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2015.10.069DOI Listing
February 2016

Decreasing Hepatitis C Incidence Among a Population With Repeated Tests: British Columbia, Canada, 1993-2011.

Am J Public Health 2015 Aug 11;105(8):1604-10. Epub 2015 Jun 11.

At the time of the writing, all of the authors were with the British Columbia Centre for Disease Control, Vancouver, Canada. Ann N. Burchell is with the Ontario HIV Treatment Network, Toronto, Canada.

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http://dx.doi.org/10.2105/AJPH.2015.302591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504305PMC
August 2015

A molecular phylogenetics-based approach for identifying recent hepatitis C virus transmission events.

Infect Genet Evol 2015 Jul 24;33:101-9. Epub 2015 Apr 24.

BC Centre for Disease Control, Vancouver, BC, Canada; University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.meegid.2015.04.017DOI Listing
July 2015

Detection of enterovirus D68 in Canadian laboratories.

J Clin Microbiol 2015 May 4;53(5):1748-51. Epub 2015 Mar 4.

Division of Microbiology, Department of Pathology and Laboratory Medicine, Capital District Health Authority (CDHA), Dalhousie University, Halifax, Nova Scotia, Canada Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada, University of Alberta, Edmonton, Alberta, Canada

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http://dx.doi.org/10.1128/JCM.03686-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400745PMC
May 2015

Global origin and transmission of hepatitis C virus nonstructural protein 3 Q80K polymorphism.

J Infect Dis 2015 Apr 10;211(8):1288-95. Epub 2014 Nov 10.

BC Centre for Excellence in HIV/AIDS Department of Medicine, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1093/infdis/jiu613DOI Listing
April 2015

Probability of a false-negative HIV antibody test result during the window period: a tool for pre- and post-test counselling.

Int J STD AIDS 2015 Mar 16;26(4):215-24. Epub 2014 Jul 16.

British Columbia Centre for Disease Control, Vancouver, BC, Canada Family Practice, University of British Columiba, Vancouver, BC, Canada.

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http://journals.sagepub.com/doi/10.1177/0956462414542987
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http://dx.doi.org/10.1177/0956462414542987DOI Listing
March 2015

Sexually transmitted infection trends among gay or bisexual men from a clinic-based sentinel surveillance system in British Columbia, Canada.

Sex Transm Dis 2015 Mar;42(3):153-9

From the *British Columbia Centre for Disease Control (BCCDC), Vancouver, BC, Canada; †School of Population and Public Health and ‡Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; §BC Public Health Microbiology and Reference Laboratory, Vancouver, BC, Canada; and ¶Fraser Health Authority, Surrey, BC, Canada.

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http://dx.doi.org/10.1097/OLQ.0000000000000250DOI Listing
March 2015

Case series of rash associated with influenza B in school children.

Influenza Other Respir Viruses 2015 Jan 10;9(1):32-7. Epub 2014 Nov 10.

British Columbia Centre for Disease Control, Vancouver, BC, Canada; University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/irv.12296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280815PMC
January 2015

Process monitoring of an HIV treatment as prevention program in British Columbia, Canada.

J Acquir Immune Defic Syndr 2014 Nov;67(3):e94-e109

*British Columbia Centre for Excellence in HIV/AIDS, Providence Health Care, Vancouver, Canada; †Division of AIDS, Department of Medicine, University of British Columbia, Vancouver, Canada; ‡Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada; §British Columbia Centre for Disease Control, Vancouver, Canada; ‖Vancouver Coastal Health Authority, Vancouver, Canada; ¶Fraser Health Authority, Surrey, Canada; #First Nations Health Authority, West Vancouver, Canada; **Interior Health Authority, Kelowna, Canada; ††Northern Health Authority, Prince George, Canada; ‡‡Oak Tree Clinic, Provincial Health Services Authority, Vancouver, Canada; and §§Vancouver Island Health Authority, Victoria, Canada.

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http://dx.doi.org/10.1097/QAI.0000000000000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257704PMC
November 2014

Pooled nucleic acid testing increases the diagnostic yield of acute HIV infections in a high-risk population compared to 3rd and 4th generation HIV enzyme immunoassays.

J Clin Virol 2014 Sep 3;61(1):132-7. Epub 2014 Jul 3.

Clinical Prevention Services, BC Centre for Disease Control, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada; Faculty of Medicine, University of British Columbia, 2194 Health Sciences Mall, Vancouver, BC V6 T 1Z3, Canada.

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http://dx.doi.org/10.1016/j.jcv.2014.06.024DOI Listing
September 2014

Obstetrical and neonatal outcomes among women infected with hepatitis C and their infants.

J Obstet Gynaecol Can 2014 Sep;36(9):785-794

Division of Gastroenterology, University of British Columbia, Vancouver BC.

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http://dx.doi.org/10.1016/S1701-2163(15)30480-1DOI Listing
September 2014

Test uptake and case detection of syphilis, HIV, and hepatitis C among women undergoing prenatal screening in British Columbia, 2007 to 2011.

J Obstet Gynaecol Can 2014 Jun;36(6):482-490

British Columbia Centre for Disease Control, Vancouver BC; School of Population and Public Health, University of British Columbia, Vancouver BC.

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http://dx.doi.org/10.1016/S1701-2163(15)30561-2DOI Listing
June 2014