Mel Greaves

Mel Greaves

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Mel Greaves

Mel Greaves

Publications by authors named "Mel Greaves"

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100Publications

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A causal mechanism for childhood acute lymphoblastic leukaemia.

Authors:
Mel Greaves

Nat Rev Cancer 2018 Aug;18(8):471-484

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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August 2018

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia.

Authors:
Mel Greaves

Nat Rev Cancer 2018 Aug;18(8):526

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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August 2018

Cancer cell transmission via the placenta.

Evol Med Public Health 2018 14;2018(1):106-115. Epub 2018 Apr 14.

School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.

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April 2018

Nothing in cancer makes sense except….

Authors:
Mel Greaves

BMC Biol 2018 02 21;16(1):22. Epub 2018 Feb 21.

Centre for Evolution and Cancer, The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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February 2018

Classifying the evolutionary and ecological features of neoplasms.

Nat Rev Cancer 2017 10 15;17(10):605-619. Epub 2017 Sep 15.

Department of Pathology, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, NOR2424, Los Angeles, California 90033, USA.

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October 2017

ETV6-RUNX1 Acute Lymphoblastic Leukaemia in Identical Twins.

Adv Exp Med Biol 2017 ;962:217-228

Centre for Evolution and Cancer, The Institute of Cancer Research, London, SM2 5NG, UK.

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September 2017

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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June 2016

Leukaemia 'firsts' in cancer research and treatment.

Authors:
Mel Greaves

Nat Rev Cancer 2016 Mar;16(3):163-72

Centre for Evolution and Cancer, The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton SM2 5NG, UK.

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March 2016

Infection and the Perils of B-cell Activation.

Cancer Discov 2015 Dec;5(12):1244-6

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California.

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December 2015

Cancer's Darwinian dilemma: an evolutionary tale in three acts.

Authors:
Mel Greaves

BMJ 2015 Dec 15;351:h6581. Epub 2015 Dec 15.

Centre for Evolution and Cancer, Institute of Cancer Research, Sutton, UK

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December 2015

Evolutionary Adaptations to Risk of Cancer: Evidence From Cancer Resistance in Elephants.

JAMA 2015 Nov;314(17):1806-7

Centre for Evolution and Cancer, Institute of Cancer Research, London, England.

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November 2015

Evolutionary determinants of cancer.

Authors:
Mel Greaves

Cancer Discov 2015 Aug 20;5(8):806-20. Epub 2015 Jul 20.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.

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August 2015

When one mutation is all it takes.

Authors:
Mel Greaves

Cancer Cell 2015 Apr;27(4):433-4

Centre for Evolution and Cancer, The Institute of Cancer Research, London, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. Electronic address:

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April 2015

Genetic and functional diversity of propagating cells in glioblastoma.

Stem Cell Reports 2015 Jan 18;4(1):7-15. Epub 2014 Dec 18.

Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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January 2015

Response to Jablonski and Chaplin.

Authors:
Mel Greaves

Proc Biol Sci 2014 Aug;281(1789):20140940

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK

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August 2014

Was skin cancer a selective force for black pigmentation in early hominin evolution?

Authors:
Mel Greaves

Proc Biol Sci 2014 Apr 26;281(1781):20132955. Epub 2014 Feb 26.

Centre for Evolution and Cancer, Division of Molecular Pathology, Institute of Cancer Research, , Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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April 2014

Does everyone develop covert cancer?

Authors:
Mel Greaves

Nat Rev Cancer 2014 Apr;14(4):209-10

Centre for Evolution and Cancer, The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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April 2014

Retrospective. Janet Rowley (1925-2013).

Authors:
Mel Greaves

Science 2014 Feb;343(6171):626

The Institute of Cancer Research, London SM2 5NG, UK.

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February 2014

Cancer: Persistence of leukaemic ancestors.

Nature 2014 Feb 12;506(7488):300-1. Epub 2014 Feb 12.

Centre for Evolution and Cancer, The Institute of Cancer Research, London SM2 5NG, UK.

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February 2014

Single-cell mutational profiling and clonal phylogeny in cancer.

Genome Res 2013 Dec 20;23(12):2115-25. Epub 2013 Sep 20.

The Institute of Cancer Research, London, SM2 5NG, United Kingdom;

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December 2013

The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia.

Genes Chromosomes Cancer 2013 Oct 26;52(10):954-60. Epub 2013 Jul 26.

Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.

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October 2013

Acute lymphoblastic leukaemia.

Lancet 2013 Jun 22;381(9881):1943-55. Epub 2013 Mar 22.

Department of Oncology, St Jude Children's Research Hospital and University of Tennessee Health Science Center, Memphis, TN 38105, USA.

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June 2013

Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblastic leukemia.

Proc Natl Acad Sci U S A 2013 Apr 8;110(18):7429-33. Epub 2013 Apr 8.

Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom.

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April 2013

Clonal expansion in B-CLL: fungal drivers or self-service?

Authors:
Mel Greaves

J Exp Med 2013 Jan;210(1):1-3

Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, England, UK.

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January 2013

Cancer stem cells as 'units of selection'.

Authors:
Mel Greaves

Evol Appl 2013 Jan 23;6(1):102-8. Epub 2012 Oct 23.

Division of Molecular Pathology, Haemato-Oncology Research Unit, The Institute of Cancer Research Sutton, UK.

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January 2013

Clonal evolution in cancer.

Nature 2012 Jan 18;481(7381):306-13. Epub 2012 Jan 18.

Division of Molecular Pathology, The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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January 2012

ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor.

Blood 2011 Nov 7;118(18):4910-8. Epub 2011 Sep 7.

Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Sutton, UK.

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November 2011

Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia.

Blood 2011 Nov 29;118(20):5559-64. Epub 2011 Sep 29.

Centro Ricerca Tettamanti, Clinica Pediatrica, Universita di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy.

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November 2011

The retrovirus XMRV is not directly involved in the pathogenesis of common types of lymphoid malignancy.

Cancer Epidemiol Biomarkers Prev 2011 Oct 22;20(10):2232-6. Epub 2011 Aug 22.

LRF Virus Centre, MRC and University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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October 2011

Cancer stem cells renew their impact.

Authors:
Mel Greaves

Nat Med 2011 Sep 7;17(9):1046-8. Epub 2011 Sep 7.

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September 2011

Tyrosine kinase inhibitor insensitivity of non-cycling CD34+ human acute myeloid leukaemia cells with FMS-like tyrosine kinase 3 mutations.

Br J Haematol 2011 Aug 21;154(4):457-65. Epub 2011 Jun 21.

Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Surrey Department of Clinical Cytogenetics, The Royal Marsden Hospital, Sutton, Surrey.

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August 2011

Leukemogenesis and ageing: 'fit for transformation'?

Authors:
Mel Greaves

Aging (Albany NY) 2011 Feb;3(2):79-80

Section of Haemato‐Oncology, The Institute of Cancer Research, Sutton, UK.

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February 2011

Fusion genes in cord blood.

Blood 2011 Jan;117(1):369-70; author reply 370-1

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January 2011

Cancer stem cells: back to Darwin?

Authors:
Mel Greaves

Semin Cancer Biol 2010 Apr 30;20(2):65-70. Epub 2010 Mar 30.

Section of Haemato-Oncology, The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

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April 2010

Darwin and evolutionary tales in leukemia. The Ham-Wasserman Lecture.

Authors:
Mel Greaves

Hematology Am Soc Hematol Educ Program 2009 :3-12

Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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March 2010

Immunologically silent cancer clone transmission from mother to offspring.

Proc Natl Acad Sci U S A 2009 Oct 12;106(42):17882-5. Epub 2009 Oct 12.

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138519, Japan.

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October 2009

Backtracking of leukemic clones to birth.

Methods Mol Biol 2009 ;538:7-27

Laboratory for Molecular Epidemiology, University of California, 2331 Eunice St, Berkeley, San Francisco, CA 94708, USA.

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May 2009

The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

J Clin Invest 2009 Apr 16;119(4):826-36. Epub 2009 Mar 16.

Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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April 2009

Covert preleukemia driven by MLL gene fusion.

Genes Chromosomes Cancer 2009 Jan;48(1):98-107

Department of Paediatric Haematology and Oncology, Childhood Leukaemia Investigation Prague, Charles University Prague, 2nd Medical School, Czech Republic.

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January 2009

Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia.

Genes Chromosomes Cancer 2008 Apr;47(4):333-40

Section of Haemato-Oncology, The Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey, UK.

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April 2008

HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention.

Cancer Immunol Immunother 2008 Jan 12;57(1):53-61. Epub 2007 Jul 12.

Cancer Immunogenetics Laboratory, St Mary's Hospital, University of Manchester, Manchester, M13 0JH, UK.

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January 2008

NOTCH1 mutation can be an early, prenatal genetic event in T-ALL.

Blood 2008 Jan 27;111(1):376-8. Epub 2007 Sep 27.

Section of Haemato-Oncology, Institute of Cancer Research, London.

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January 2008

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

Science 2008 Jan;319(5861):336-9

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

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January 2008

Godwits and blast crises: in memory of David Galton.

Authors:
Mel Greaves

Leuk Lymphoma 2007 Dec;48(12):2280-2

The Institute of Cancer Research, London, UK.

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December 2007

Allergy and risk of childhood leukaemia: results from the UKCCS.

Int J Cancer 2007 Aug;121(4):819-24

Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom.

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August 2007

Darwinian medicine: a case for cancer.

Authors:
Mel Greaves

Nat Rev Cancer 2007 03 15;7(3):213-21. Epub 2007 Feb 15.

Section of Haemato-Oncology, The Institute of Cancer Research, London, UK.

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March 2007

Infection, immune responses and the aetiology of childhood leukaemia.

Authors:
Mel Greaves

Nat Rev Cancer 2006 Mar;6(3):193-203

The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom.

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March 2006

The putative role of transforming viruses in childhood acute lymphoblastic leukemia.

Haematologica 2006 Feb;91(2):240-3

LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK.

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February 2006

The causation of childhood leukemia: a paradox of progress?

Authors:
Mel Greaves

Discov Med 2006 Feb;6(31):24-8

Section of Haemato-Oncology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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February 2006

Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model.

Oncogene 2005 Nov;24(51):7579-91

Molecular Pathology Group, Heinrich-Pette-Institut für Experimentelle Immunologie und Virologie, D-20251 Hamburg, Germany.

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November 2005

Molecular pathogenesis of MLL-associated leukemias.

Int J Hematol 2005 Jul;82(1):9-20

Section of Haemato-Oncology, Institute of Cancer Research, London, UK.

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July 2005

Detecting small-area similarities in the epidemiology of childhood acute lymphoblastic leukemia and diabetes mellitus, type 1: a Bayesian approach.

Am J Epidemiol 2005 Jun;161(12):1168-80

Pediatric Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, 30 Hyde Terrace, Leeds LS2 9LN, United Kingdom.

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June 2005

Developmental impact of leukemic fusion genes on stem cell fate.

Ann N Y Acad Sci 2005 Jun;1044:16-23

Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

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June 2005

Directing oncogenic fusion genes into stem cells via an SCL enhancer.

Proc Natl Acad Sci U S A 2005 Jan 13;102(4):1133-8. Epub 2005 Jan 13.

Section of Haemato-Oncology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom.

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January 2005

In utero origins of childhood leukaemia.

Authors:
Mel Greaves

Early Hum Dev 2005 Jan 19;81(1):123-9. Epub 2004 Nov 19.

Chester Beatty Laboratories, Institute of Cancer Research, Section of Haemato-Oncology, 237 Fulham Road, London SW3 6JB, United Kingdom.

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January 2005

TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia.

Clin Cancer Res 2004 Aug;10(16):5355-60

Leukemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, London, United Kingdom.

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August 2004

Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.

Proc Natl Acad Sci U S A 2004 Jun 20;101(22):8443-8. Epub 2004 May 20.

Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.

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June 2004

The small oligomerization domain of gephyrin converts MLL to an oncogene.

Blood 2004 May 29;103(10):3876-82. Epub 2004 Jan 29.

Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom.

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May 2004

Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.

Oncogene 2004 May;23(24):4275-83

Section of Haematological Oncology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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May 2004

Protracted postnatal natural histories in childhood leukemia.

Genes Chromosomes Cancer 2004 Apr;39(4):335-40

LRF Centre, Institute of Cancer Research, London, United Kingdom.

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April 2004

Biological models for leukaemia and lymphoma.

Authors:
Mel F Greaves

IARC Sci Publ 2004 (157):351-72

Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK.

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April 2004

The role of the MLL gene in infant leukemia.

Int J Hematol 2003 Dec;78(5):390-401

LRF Centre for Cell and Molecular Biology of Leukaemia, Institute of Cancer Research, London, UK.

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December 2003

Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets.

Leuk Lymphoma 2003 Dec;44(12):2099-102

CLIP--Childhood Leukaemia Investigation, Prague, Czech Republic.

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December 2003

Leukemia in twins: lessons in natural history.

Blood 2003 Oct 5;102(7):2321-33. Epub 2003 Jun 5.

Leukemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, London SW3 6JB, United Kingdom.

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October 2003

Origins of chromosome translocations in childhood leukaemia.

Nat Rev Cancer 2003 Sep;3(9):639-49

LRF Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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September 2003

Pre-natal origins of childhood leukemia.

Authors:
Mel Greaves

Rev Clin Exp Hematol 2003 Sep;7(3):233-45

Leukaemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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September 2003

Prenatal chromosomal diversification of leukemia in monozygotic twins.

Genes Chromosomes Cancer 2003 Aug;37(4):406-11

Molecular Haematology Unit, Institute of Child Health, London, United Kingdom.

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August 2003

The histone deacetylase 9 gene encodes multiple protein isoforms.

J Biol Chem 2003 May 17;278(18):16059-72. Epub 2003 Feb 17.

Leukemia Research Fund Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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May 2003

Cancer causation: the Darwinian downside of past success?

Authors:
Mel Greaves

Lancet Oncol 2002 Apr;3(4):244-51

Cell Biology and the Leukaemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK.

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April 2002