Publications by authors named "Meir Glick"

67Publications

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.

Authors:
Matthew J LaMarche Michael Acker Andreea Argintaru Daniel Bauer Julie Boisclair Homan Chan Christine Hiu-Tung Chen Ying-Nan Chen Zhouliang Chen Zhan Deng Michael Dore David Dunstan Jianmei Fan Peter Fekkes Brant Firestone Michelle Fodor Jorge Garcia-Fortanet Pascal D Fortin Cary Fridrich John Giraldes Meir Glick Denise Grunenfelder Huia-Xiang Hao Martin Hentemann Samuel Ho Andriana Jouk Zhao B Kang Rajesh Karki Mitsunori Kato Nick Keen Robert Koenig Laura R LaBonte Jay Larrow Gang Liu Shumei Liu Dyuti Majumdar Simon Mathieu Matthew J Meyer Morvarid Mohseni Rukundo Ntaganda Mark Palermo Lawrence Perez Minying Pu Timothy Ramsey John Reilly Patrick Sarver William R Sellers Martin Sendzik Michael D Shultz Joanna Slisz Kelly Slocum Troy Smith Stanley Spence Travis Stams Christopher Straub Victoriano Tamez Bakary-Barry Toure Christopher Towler Ping Wang Hongyun Wang Sarah L Williams Fan Yang Bing Yu Ji-Hu Zhang Suzanne Zhu

J Med Chem 2020 11 24;63(22):13578-13594. Epub 2020 Sep 24.

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November 2020

Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Authors:
Benjamin Ruprecht Julie Di Bernardo Zhao Wang Xuan Mo Oleg Ursu Matthew Christopher Rafael B Fernandez Li Zheng Brian D Dill Huijun Wang Yuting Xu Andy Liaw Jonathan D Mortison Nirodhini Siriwardana Brian Andresen Meir Glick James R Tata Victoria Kutilek Ivan Cornella-Taracido An Chi

Nat Chem Biol 2020 10;16(10):1149

Chemical Biology, Merck, Boston, MA, USA.

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October 2020

A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Authors:
Benjamin Ruprecht Julie Di Bernardo Zhao Wang Xuan Mo Oleg Ursu Matthew Christopher Rafael B Fernandez Li Zheng Brian D Dill Huijun Wang Yuting Xu Andy Liaw Jonathan D Mortison Nirodhini Siriwardana Brian Andresen Meir Glick James R Tata Victoria Kutilek Ivan Cornella-Taracido An Chi

Nat Chem Biol 2020 10 20;16(10):1111-1119. Epub 2020 Jul 20.

Chemical Biology, Merck, Boston, MA, USA.

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October 2020

Experimental Error, Kurtosis, Activity Cliffs, and Methodology: What Limits the Predictivity of Quantitative Structure-Activity Relationship Models?

Authors:
Robert P Sheridan Prabha Karnachi Matthew Tudor Yuting Xu Andy Liaw Falgun Shah Alan C Cheng Elizabeth Joshi Meir Glick Juan Alvarez

J Chem Inf Model 2020 04 15;60(4):1969-1982. Epub 2020 Apr 15.

Computational and Structural Chemistry, Merck & Company Inc., Boston, Massachusetts 02115, United States.

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April 2020

Diversity & tractability revisited in collaborative small molecule phenotypic screening library design.

Authors:
Brian R Lahue Meir Glick Matthew Tudor Scott Arne Johnson Janet Diratsouian Mary Jo Wildey Marybeth Burton Robert Mazzola Anne Mai Wassermann

Bioorg Med Chem 2020 01 20;28(1):115192. Epub 2019 Nov 20.

Computational & Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

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January 2020

Novel drug targets in 2018.

Authors:
Oleg Ursu Meir Glick Tudor Oprea

Nat Rev Drug Discov 2019 Mar 26. Epub 2019 Mar 26.

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March 2019

Dual Allosteric Inhibition of SHP2 Phosphatase.

Authors:
Michelle Fodor Edmund Price Ping Wang Hengyu Lu Andreea Argintaru Zhouliang Chen Meir Glick Huai-Xiang Hao Mitsunori Kato Robert Koenig Jonathan R LaRochelle Gang Liu Eric McNeill Dyuti Majumdar Gisele A Nishiguchi Lawrence B Perez Gregory Paris Christopher M Quinn Timothy Ramsey Martin Sendzik Michael David Shultz Sarah L Williams Travis Stams Stephen C Blacklow Michael G Acker Matthew J LaMarche

ACS Chem Biol 2018 03 18;13(3):647-656. Epub 2018 Jan 18.

Novartis Institutes for Biomedical Research , Cambridge , Massachusetts 02139 , United States.

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March 2018

CHEMGENIE: integration of chemogenomics data for applications in chemical biology.

Authors:
Peter S Kutchukian Charlie Chang Sean J Fox Erica Cook Richard Barnard David Tellers Huijun Wang Dante Pertusi Meir Glick Robert P Sheridan Iain M Wallace Anne Mai Wassermann

Drug Discov Today 2018 01 14;23(1):151-160. Epub 2017 Sep 14.

Modeling and Informatics, Merck & Co., Inc., Boston, MA, USA. Electronic address:

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January 2018

Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.

Authors:
John P Santa Maria Yumi Park Lihu Yang Nicholas Murgolo Michael D Altman Paul Zuck Greg Adam Chad Chamberlin Peter Saradjian Peter Dandliker Helena I M Boshoff Clifton E Barry Charles Garlisi David B Olsen Katherine Young Meir Glick Elliott Nickbarg Peter S Kutchukian

ACS Chem Biol 2017 09 29;12(9):2448-2456. Epub 2017 Aug 29.

Modeling & Informatics, Merck Research Laboratories , Boston, Massachusetts, United States.

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September 2017

Data to Decisions: Creating a Culture of Model-Driven Drug Discovery.

Authors:
Frank K Brown Farida Kopti Charlie Zhenyu Chang Scott A Johnson Meir Glick Chris L Waller

AAPS J 2017 09 2;19(5):1255-1263. Epub 2017 Aug 2.

MRL Information Technology, Merck & Co., Inc., 470 Atlantic Avenue, Boston, Massachusetts, 02110, USA.

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September 2017

Deorphanization strategies for dark chemical matter.

Authors:
Anne Mai Wassermann Matthew Tudor Meir Glick

Drug Discov Today Technol 2017 Mar 27;23:69-74. Epub 2017 Feb 27.

Chemistry Capabilities and Screening, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.

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March 2017

Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.

Authors:
Grazia Piizzi David T Parker Yunshan Peng Markus Dobler Anup Patnaik Som Wattanasin Eugene Liu Francois Lenoir Jill Nunez John Kerrigan David McKenney Colin Osborne Donghui Yu Leanne Lanieri Jade Bojkovic JoAnn Dzink-Fox Maria-Dawn Lilly Elizabeth R Sprague Yipin Lu Hongming Wang Srijan Ranjitkar Lili Xie Bing Wang Meir Glick Lawrence G Hamann Ruben Tommasi Xia Yang Charles R Dean

J Med Chem 2017 06 9;60(12):5002-5014. Epub 2017 Jun 9.

Infectious Diseases Area, Novartis Institutes for BioMedical Research , Emeryville, California 94608, United States.

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June 2017

Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.

Authors:
Dante A Pertusi Gregory O'Donnell Michelle F Homsher Kelli Solly Amita Patel Shannon L Stahler Daniel Riley Michael F Finley Eleftheria N Finger Gregory C Adam Juncai Meng David J Bell Paul D Zuck Edward M Hudak Michael J Weber Jennifer E Nothstein Louis Locco Carissa Quinn Adam Amoss Brian Squadroni Michelle Hartnett Mee Ra Heo Tara White S Alex May Evelyn Boots Kenneth Roberts Patrick Cocchiarella Alex Wolicki Anthony Kreamer Peter S Kutchukian Anne Mai Wassermann Victor N Uebele Meir Glick Andrew Rusinko J Christopher Culberson

SLAS Discov 2017 Sep 20;22(8):995-1006. Epub 2017 Apr 20.

1 Modeling and Informatics, Merck & Co., Inc., West Point, PA, USA.

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September 2017

Extending 'predict first' to the design-make-test cycle in small-molecule drug discovery.

Authors:
Scott Harrison Brian Lahue Zhengwei Peng Anthony Donofrio Charlie Chang Meir Glick

Future Med Chem 2017 04 12;9(6):533-536. Epub 2017 Apr 12.

Merck & Co., Inc., MRL, Boston, MA, USA.

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April 2017

Construction of a 3D-shaped, natural product like fragment library by fragmentation and diversification of natural products.

Authors:
Horst Prescher Guido Koch Tim Schuhmann Peter Ertl Alex Bussenault Meir Glick Ina Dix Frank Petersen Dimitrios E Lizos

Bioorg Med Chem 2017 02 8;25(3):921-925. Epub 2016 Dec 8.

Novartis Institutes for BioMedical Research Inc., Basel, Switzerland. Electronic address:

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February 2017

Public Domain HTS Fingerprints: Design and Evaluation of Compound Bioactivity Profiles from PubChem's Bioassay Repository.

Authors:
Kazi Yasin Helal Mateusz Maciejewski Elisabet Gregori-Puigjané Meir Glick Anne Mai Wassermann

J Chem Inf Model 2016 Feb 14;56(2):390-8. Epub 2016 Jan 14.

Pfizer Inc. , 610 Main Street, Cambridge, Massachusetts 02139, United States.

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February 2016

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.

Authors:
Ayako Honda Edmund Harrington Ivan Cornella-Taracido Pascal Furet Mark S Knapp Meir Glick Ellen Triantafellow William E Dowdle Dmitri Wiedershain Wieslawa Maniara Christine Moore Peter M Finan Lawrence G Hamann Brant Firestone Leon O Murphy Erin P Keaney

ACS Med Chem Lett 2016 Jan 13;7(1):72-6. Epub 2015 Nov 13.

Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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January 2016

Dark chemical matter as a promising starting point for drug lead discovery.

Authors:
Anne Mai Wassermann Eugen Lounkine Dominic Hoepfner Gaelle Le Goff Frederick J King Christian Studer John M Peltier Melissa L Grippo Vivian Prindle Jianshi Tao Ansgar Schuffenhauer Iain M Wallace Shanni Chen Philipp Krastel Amanda Cobos-Correa Christian N Parker John W Davies Meir Glick

Nat Chem Biol 2015 Dec 19;11(12):958-66. Epub 2015 Oct 19.

Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA.

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December 2015

Experimental design strategy: weak reinforcement leads to increased hit rates and enhanced chemical diversity.

Authors:
Mateusz Maciejewski Anne Mai Wassermann Meir Glick Eugen Lounkine

J Chem Inf Model 2015 May 14;55(5):956-62. Epub 2015 May 14.

†Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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May 2015

Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies.

Authors:
Peter S Kutchukian Anne Mai Wassermann Mika K Lindvall S Kirk Wright Johannes Ottl Jaison Jacob Clemens Scheufler Andreas Marzinzik Natasja Brooijmans Meir Glick

J Biomol Screen 2015 Jun 30;20(5):588-96. Epub 2014 Dec 30.

Novartis Institutes for BioMedical Research, Cambridge, MA, USA

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June 2015