Publications by authors named "Mei Yee Koh"

17Publications

EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.

Mol Cell 2012 Dec 1;48(5):771-84. Epub 2012 Nov 1.

Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526114PMC
December 2012

Passing the baton: the HIF switch.

Trends Biochem Sci 2012 Sep 18;37(9):364-72. Epub 2012 Jul 18.

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.tibs.2012.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433036PMC
September 2012

The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.

Cancer Res 2011 Jun 21;71(11):4015-27. Epub 2011 Apr 21.

Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas 77230-1429, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268651PMC
June 2011

HIF-1alpha and cancer therapy.

Recent Results Cancer Res 2010 ;180:15-34

Department of Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/978-3-540-78281-0_3DOI Listing
March 2010

Inhibiting the hypoxia response for cancer therapy: the new kid on the block.

Clin Cancer Res 2009 Oct 29;15(19):5945-6. Epub 2009 Sep 29.

Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760048PMC
October 2009

HAF : the new player in oxygen-independent HIF-1alpha degradation.

Cell Cycle 2009 May;8(9):1359-66

Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.8.9.8303
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700049PMC
http://dx.doi.org/10.4161/cc.8.9.8303DOI Listing
May 2009

Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.

Mol Cell Biol 2008 Dec 6;28(23):7081-95. Epub 2008 Oct 6.

Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1128/MCB.00773-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593390PMC
December 2008

HIF-1 regulation: not so easy come, easy go.

Trends Biochem Sci 2008 Nov 21;33(11):526-34. Epub 2008 Sep 21.

Department of Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.tibs.2008.08.002DOI Listing
November 2008

The hypoxic inducible stress response as a target for cancer drug discovery.

Semin Oncol 2006 Aug;33(4):486-97

Oxford Medical School, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1053/j.seminoncol.2006.04.011DOI Listing
August 2006

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.

J Biol Chem 2004 Oct 23;279(44):46113-21. Epub 2004 Aug 23.

Cancer Research UK Paterson Institute for Cancer Research, Manchester, and School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1074/jbc.M408550200DOI Listing
October 2004