Publications by authors named "Mehrdad Shamloo"

52Publications

Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer's Disease.

Neurobiol Dis 2020 Sep 22;146:105089. Epub 2020 Sep 22.

Department of Neurosurgery, Stanford University School of Medicine, 1050 Arastradero Road, Building A, Palo Alto, CA 94304, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2020.105089DOI Listing
September 2020

PGE signaling via the neuronal EP2 receptor increases injury in a model of cerebral ischemia.

Proc Natl Acad Sci U S A 2019 05 29;116(20):10019-10024. Epub 2019 Apr 29.

Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1818544116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525498PMC
May 2019

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.

Acta Neuropathol 2019 06 29;137(6):961-980. Epub 2019 Mar 29.

Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, M322 Alway Building, Stanford, CA, 94305-5120, USA.

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http://dx.doi.org/10.1007/s00401-019-01995-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531417PMC
June 2019

Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith-Magenis syndrome.

Proc Natl Acad Sci U S A 2018 10 1;115(42):10744-10749. Epub 2018 Oct 1.

Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1806796115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196530PMC
October 2018

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo.

Sci Rep 2018 09 19;8(1):14034. Epub 2018 Sep 19.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1038/s41598-018-32228-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145916PMC
September 2018

Activity-dependent modulation of hippocampal synaptic plasticity via PirB and endocannabinoids.

Mol Psychiatry 2019 08 18;24(8):1206-1219. Epub 2018 Apr 18.

Departments of Biology and Neurobiology, and Bio-X, Stanford University, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1038/s41380-018-0034-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372352PMC
August 2019

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease.

Oncotarget 2018 Jan 22;9(5):6128-6143. Epub 2017 Dec 22.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.18632/oncotarget.23640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814200PMC
January 2018

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

EMBO Mol Med 2018 03;10(3)

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA

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http://dx.doi.org/10.15252/emmm.201708166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840540PMC
March 2018

Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist.

Neuropharmacology 2017 04 13;116:371-386. Epub 2017 Jan 13.

Stanford University School of Medicine, Department of Neurosurgery, 1050 Arastradero Road, Building A, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385159PMC
April 2017

Potential biomarkers to follow the progression and treatment response of Huntington's disease.

J Exp Med 2016 11 7;213(12):2655-2669. Epub 2016 Nov 7.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305

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http://dx.doi.org/10.1084/jem.20160776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110026PMC
November 2016

Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.

Neuron 2016 Oct 29;92(2):392-406. Epub 2016 Sep 29.

Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA; Neurosciences Program, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098476PMC
October 2016

Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats.

Pharmacol Res 2016 11 10;113(Pt A):62-70. Epub 2016 Aug 10.

Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged H-6720, Hungary; Pharmahungary Group, Dom ter 9, Szeged H-6720, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.08.013DOI Listing
November 2016

β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.

Ann Clin Transl Neurol 2014 May;1(5):348-360

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA ; Behavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1002/acn3.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036739PMC
May 2014

A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.

J Neurosci 2014 May;34(19):6425-37

Departments of Biomedical Imaging, Neuroscience, and Pathology, Genentech Inc., South San Francisco, California 94080, Stanford Behavioral and Functional Neuroscience Laboratory, Stanford University, Stanford, California 94305, and Laboratory of Brain Development and Repair, The Rockefeller University, New York, New York 10065.

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http://dx.doi.org/10.1523/JNEUROSCI.4963-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608138PMC
May 2014

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

J Neurosci 2013 Nov;33(48):18712-27

Department of Neurology and Neurological Sciences and Behavioral and Functional Neuroscience Laboratory, Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California 94305, Department of Psychiatry, Weill Cornell Medical College, New York, New York 10021, and Department of Neurology and Laboratory for Computational Neurochemistry and Drug Discovery, Department of Veterans Affairs Medical Center and Department of Neurology, University of California, San Francisco, San Francisco, California 94121.

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http://dx.doi.org/10.1523/JNEUROSCI.1310-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841443PMC
November 2013

A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke.

PLoS One 2013 18;8(7):e69233. Epub 2013 Jul 18.

Behavioral and Functional Neuroscience Laboratory, Institute for Neuro-Innovation and Translational Neurosciences, School of Medicine, Stanford, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069233PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715457PMC
February 2014

Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model.

Brain Behav 2012 Sep 16;2(5):698-706. Epub 2012 Jul 16.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine Stanford, California.

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http://dx.doi.org/10.1002/brb3.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489820PMC
September 2012

Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders.

PLoS One 2012 28;7(9):e46604. Epub 2012 Sep 28.

Behavioral and Functional Neuroscience Laboratory, School of Medicine, Stanford University, Palo Alto, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046604PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460929PMC
February 2013

Mouse model of Timothy syndrome recapitulates triad of autistic traits.

Proc Natl Acad Sci U S A 2011 Sep 30;108(37):15432-7. Epub 2011 Aug 30.

Department of Molecular and Cellular Physiology, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, CA 94305-5345, USA.

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http://dx.doi.org/10.1073/pnas.1112667108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174658PMC
September 2011

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.

Proc Natl Acad Sci U S A 2011 Aug 1;108(33):13764-9. Epub 2011 Aug 1.

Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1111093108
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http://dx.doi.org/10.1073/pnas.1111093108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158170PMC
August 2011

Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair.

Stem Cells 2011 Feb;29(2):274-85

Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California 94305-5487, USA.

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http://dx.doi.org/10.1002/stem.584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524414PMC
February 2011

Sex-specific cognitive deficits and regional brain volume loss in mice exposed to chronic, sublethal hypoxia.

Pediatr Res 2011 Jul;70(1):15-20

Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1203/PDR.0b013e31821b98a3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547599PMC
July 2011

Long-term behavioral assessment of function in an experimental model for ischemic stroke.

J Neurosci Methods 2011 Mar 21;196(2):247-57. Epub 2011 Jan 21.

Behavioral and Functional Neuroscience Laboratory, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, United States.

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http://dx.doi.org/10.1016/j.jneumeth.2011.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539723PMC
March 2011

The asparaginyl endopeptidase legumain after experimental stroke.

J Cereb Blood Flow Metab 2010 Oct 17;30(10):1756-66. Epub 2010 Mar 17.

Department of Clinical Sciences, Wallenberg Neuroscience Center, University of Lund, Sweden.

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http://dx.doi.org/10.1038/jcbfm.2010.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023405PMC
October 2010

Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia.

J Biol Chem 2005 Dec 3;280(51):42290-9. Epub 2005 Oct 3.

AGY Therapeutics, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1074/jbc.M505804200DOI Listing
December 2005

Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion.

J Cereb Blood Flow Metab 2004 Jan;24(1):54-61

Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1097/01.WCB.0000095920.70924.F5DOI Listing
January 2004

Persistent phosphorylation of synaptic proteins following middle cerebral artery occlusion.

J Cereb Blood Flow Metab 2002 Sep;22(9):1107-13

Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University Hospital, Sweden.

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http://dx.doi.org/10.1097/00004647-200209000-00008DOI Listing
September 2002