Publications by authors named "Mehrdad Karimi"

76 Publications

Medicinal herbs: Potential polypills in cardiovascular diseases.

J Clin Hypertens (Greenwich) 2021 Feb 26. Epub 2021 Feb 26.

Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/jch.14203DOI Listing
February 2021

The Antidepressant Effects of Lavender (Lavandula angustifolia Mill.): A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Complement Ther Med 2021 Feb 4:102679. Epub 2021 Feb 4.

Department of Traditional Medicine, School of Persian medicine, Tehran University of Medical Sciences, Tehran, 1668753961, Iran. Electronic address:

Background And Aims: Antidepressant drugs are accompanied with high rate of adverse effects. Lavender is one of the most common herbal drugs mentioned in Traditional Persian literature with potential efficacy on mental disorders and less serious side effects. Thus, the aim of this study was to determine the efficacy of lavender on depression severity by preforming a systematic review and meta-analysis.

Methods: Databases including PubMed, Scopus, Cochrane library, Embase and Web of science were searched for relevant articles till December 2020. Quality of studies were evaluated by Jadad scale and the Cochrane collaboration tool. Depression as endpoint measure or as a subscale of any valid assessment tool was subjected to quantitative data analyses. Both fixed and random effects meta-analysis were conducted for data synthesis.

Results: Out of 342 screened studies, 17 articles were included in the meta-analysis. Results showed significant efficacy of lavender in decreasing depression scores compared to the control group (pooled Standardized Mean Difference (SMD)= -0.66, 95% CI: -0.85 to -0.46;P < 0.001, I = 68.2%;). Subgroup analysis proved that the effect of lavender was marginally more pronounced in participants with diagnosed depression (pooled SMD= -0.62, 95% CI: -1.26 to 0.01, P = 0.055; I = 88.1 %) while its effect was statistically significant in patients having other diseases with concomitant depressive symptoms (pooled SMD= -0.65, 95% CI: -1.84 to -0.46, P < 0.001; I = 52.1%), and the oral route (pooled SMD= -0.56, 95% CI: -1.07 to -0.05, P = 0.032; I = 85.2%;) was the most effective route of administration.

Conclusions: This systematic review and meta-analysis concluded that lavender has significant antidepressant effects. However, due to some limitations, further large clinical trials are recommended with more homogeneous populations and rigorous designs.
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http://dx.doi.org/10.1016/j.ctim.2021.102679DOI Listing
February 2021

Academic Stress and Adolescents Mental Health: A Multilevel Structural Equation Modeling (MSEM) Study in Northwest of Iran.

J Res Health Sci 2020 Oct 31;20(4):e00496. Epub 2020 Oct 31.

Department of Epidemiology and Biostatistics, School of Public Health, Knowledge Utilization Research center, Tehran University of Medical Sciences. Tehran, Iran.

Background: We aimed to determine the relation of different sources of academic stress and adolescents´ mental health through mediator variables on the student and school levels.

Study Design: A cross-sectional study.

Methods: Overall, 1724 students aged 12-19 yr were selected from 53 high schools in Qazvin City, central Iran through stratified cluster sampling. The sources of academic stress include family conditions, education system, future concerns, academic competitions, interaction with teachers, school disciplines, peer pressure, parental involvement, and financial problems. Academic self-efficacy and self-concept were the mediator constructs. The students and schools´ information were considered on levels 1 and 2, respectively. A Multilevel Structural Equation Modeling (MSEM) analysis was done.

Results: High value of academic stress was associated with reduction of mental health. On the student level, the academic stress caused by the families 0.31 (95% CI: 0.28, 0.34), peers 0.29 (95% CI: 0.27, 0.32), and the education system 0.21 (95% CI: 0.18, 0.24) had the highest impact on the adolescents' mental health, respectively. There was a direct and indirect relation between academic stress and mental health through the self-concept. On the school level, only family conditions stress had a relation with mental health (P=0.015, b=1.08). Academic self-efficacy showed no significant relation in the model.

Conclusion: The stress from the family is the most important source of stress associated with adolescent mental health. Self-concept unlike academic self-efficacy had an important mediating role in the relation between different sources of academic stress and adolescents' mental health.
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http://dx.doi.org/10.34172/jrhs.2020.30DOI Listing
October 2020

Re: A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy.

J Obstet Gynaecol 2020 Dec 4. Epub 2020 Dec 4.

Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1080/01443615.2020.1821622DOI Listing
December 2020

Comparison of Platelet Count Reduction in Patients awaiting Liver Transplantation with and without Primary Sclerosing Cholangitis: A Cohort Study.

Arch Iran Med 2020 11 1;23(11):732-739. Epub 2020 Nov 1.

Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Thrombocytopenia is the most well-known hematological abnormality occurring in patients with liver cirrhosis. However, the rate of platelet count reduction is not the same across different chronic liver disease etiologies. Therefore, the aim of the present study was to compare the differences in the platelet count levels between primary sclerosing cholangitis-related cirrhosis (PSC-C) and other causes of liver disease.

Methods: In this cohort study, the association between PSC-C and risk of platelet count reduction was investigated. The platelet counts were repeatedly measured among 242 consecutive cirrhotic patients (144 males and 98 females) including 67 patients with PSC-C and 175 patients with non-PSC-C who were on the waiting list for liver transplantation. The Poisson regression analysis was used to assess the relationship between platelet count reduction and PSC-C, after adjusting for potential confounding factors.

Results: During the five years of follow-up, comparison between the two groups revealed that significantly higher levels of platelet were found in PSC-C patients when compared to the non-PSC-C group [148 (106-280) (×10 /µL) vs. 79 (50-110) (×10 /µL), respectively, < 0.001]. After adjusting for confounding factors, a significant association was observed between non-PSC-C and the risk of platelet count reduction (relative risk, RR: 14.81, 95% CI: 1.21-160.42; = 0.03).

Conclusion: The findings indicate that PSC-C patients present with mild degrees of thrombocytopenia compared to other causes of chronic liver disease.
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http://dx.doi.org/10.34172/aim.2020.97DOI Listing
November 2020

Phytotherapy for Wound Healing: The Most Important Herbal Plants in Wound Healing Based on Iranian Ethnobotanical Documents.

Mini Rev Med Chem 2021 ;21(4):500-519

Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Wound healing is a process that starts with the inflammatory response after the occurrence of any damage. This process initiates by restoring the wound surface coating tissue, migrating fibroblasts to form the required collagen, forming a healing tissue and finally, leading to contortion and extraction of the wound. Today, various drugs are used to heal wounds. However, the drugs used to repair wounds have some defects and side effects. In spite of all attempts to accelerate wound healing definitely, no safe drug has been introduced for this purpose. Therefore, the necessity to identify herbal plants in ethnopharmacology and ethnobotany documents with healing effects is essential. In this article, we tried to review and present effective Iranian medicinal plants and herbal compounds used for wound healing. Searching was performed on databases, including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The keywords used included wound healing, skin treatment, medicinal plants, ethnobotany, and phytotherapy. In this regard, 139 medicinal plants effective on wound healing were identified based on ethnopharmacology and ethnobotanical sources of Iran. Plants such as Salvia officinalis, Echium amoenum, Verbascum spp., G1ycyrrhiza glabra, Medicago sativa, Mentha pulegium, Datura stramonium L., Alhagi spp., Aloe vera, Hypericum perforatum, Pistacia atlantica and Prosopis cineraria are the most important and useful medicinal plants used for wound healing in Iran. These native Iranian medicinal plants are rich in antioxidants and biological compounds and might be used for wound healing and preparation of new drugs.
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http://dx.doi.org/10.2174/1389557520666201119122608DOI Listing
January 2021

Evaluation of lipid ratios and triglyceride-glucose index as risk markers of insulin resistance in Iranian polycystic ovary syndrome women.

Lipids Health Dis 2020 Nov 8;19(1):235. Epub 2020 Nov 8.

Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Background: Insulin resistance has a vital role in the pathophysiology of polycystic ovary syndrome (PCOS). Previous investigations have shown that some lipid ratios could be a simple clinical indicator of insulin resistance (IR) in some disorders and ethnicities. The present study was conducted to evaluate the correlation between triglyceride to HDL-cholesterol (TG/HDL-C), total cholesterol to HDL-cholesterol (TC/HDL-C), as well as fasting triglyceride-glucose (TyG) indices with IR (as measured by homeostasis model assessment of IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and fasting glucose to insulin ratio (FGIR)) among the Iranian women diagnosed with PCOS.

Methods: In the current study, a total of 305 women with PCOS were evaluated. TG/HDL-C, TC/HDL-C, and TyG indices were calculated. Fasting insulin level was measured using ELISA technique. IR was defined as a HOMA-IR value of ≥2.63, FG-IR value of < 8.25, and QUICKI value of < 0.33.

Results: The insulin-resistant (IR) and insulin-sensitive (IS) groups, established by the HOMA-IR, FG-IR, and QUICKI values were different in terms of TG/HDL-C, TC/HDL-C, and TyG indices. These indices were associated with IR even after adjusting for age and BMI. ROC curve analyses showed that TyG, TG/HDL-C, and TC/HDL-C strongly predicted HOMA-IR with area under the curve (AUC) of 0.639, 0.619, and 0.623, respectively (P < 0.05). Further, TC/HDL-C was a good predictor of FG-IR with AUC of 0.614 (P = 0.04).

Conclusion: TyG, TG/HDL-C, and TC/HDL-C indices might be good indicators of IR among Iranian women diagnosed with PCOS.
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http://dx.doi.org/10.1186/s12944-020-01410-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648985PMC
November 2020

The Early Report of Herpetic Whitlow by Bahal-Dawlah Razi in 15th Century CE.

Infez Med 2020 Sep;28(3):450-452

Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of History of Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

A herpetic whitlow is a lesion (whitlow) on a finger or thumb caused by herpes simplex virus. It is a painful infection that typically affects the fingers or thumbs. Occasionally infection occurs on the toes or on the nail cuticle. Symptoms of herpetic whitlow include tenderness, swelling and reddening of the infected finger skin, fever and swollen lymph nodes. Although, it is believed that the first recorded observations were in 1909 CE by H. G. Adamson, in the medieval period, Bah?' al-Dawlah N?rbakhsh? Razi (1501 CE) described herpetic whitlow, under the title of Dakhes in Khulasat al-Tajarib (The Summary of Experience), his book on medicine. Some of Baha al-Dawlah's descriptions and his etiology of Dakhes are based on humoral theories and cannot be concurred with current medical concepts, but more symptoms and clinical manifestations are consistent with current definitions. It seems the earliest description of herpetic whitlow in the medical history.
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September 2020

Lavender and dodder combined herbal syrup versus citalopram in major depressive disorder with anxious distress: A double-blind randomized trial.

J Integr Med 2020 Sep 15;18(5):409-415. Epub 2020 Jun 15.

Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran 1668753961, Iran. Electronic address:

Background: Major depressive disorder (MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Persian medicine, lavender-dodder syrup is one formula often recommended for such disorders.

Objective: This study compares the effects of lavender-dodder syrup to the standard drug, citalopram, for treating MDD with anxious distress.

Design, Setting, Participants And Intervention: This six-week, double-blind, randomized, clinical trial was carried out in a psychiatric outpatient clinic. During the six-week intervention period, patients in citalopram group received citalopram tablets 20 mg/d plus 5 mL placebo syrup every 12 h; patients in group B received placebo tablets once daily plus 5 mL of lavender-dodder herbal syrup every 12 h.

Main Outcome Measures: Primary outcome measures, depression and anxiety, were evaluated using the Hamilton Depression/Anxiety Rating Scales, and were scored at the beginning of the study and at weeks three and six. Secondary outcome measures including response to treatment and remission rates were also compared between the two groups.

Results: Fifty-six participants with MDD and anxious distress were randomly assigned to two groups. Mean depression scores significantly decreased in citalopram and herbal groups at weeks three and six (time effect: P < 0.001), although the observed changes were not significantly different between the groups (intervention effect: P = 0.61). Mean anxiety scores were not significantly different between the two groups at week three (P = 0.75). However, at the end of week six, the observed decrease was significantly higher in the herbal syrup group than the citalopram group (intervention effect: P = 0.007).

Conclusion: The herbal syrup is an effective and tolerable supplement for treating MDD with anxious distress.

Trial Registration Number: IRCT2016102430459N1 on Iranian Registry of Clinical Trials.
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http://dx.doi.org/10.1016/j.joim.2020.06.002DOI Listing
September 2020

Effectiveness of Acupuncture Treatment on Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized, Assessor-Blinded, Controlled Trial.

Pain Res Manag 2020 29;2020:2504674. Epub 2020 Jun 29.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

Objective: This pilot study aims to evaluate the effectiveness and safety of acupuncture in the treatment of chemotherapy-induced peripheral neuropathy (CIPN).

Methods: This study was a pilot randomized controlled trial, which was conducted with cooperation between Beijing University of Chinese Medicine (BUCM), China, and Tehran University of Medical Science (TUMS), Iran. Forty participants with CIPN were randomly assigned (1 : 1) to receive twelve sessions of acupuncture (20 minutes each session over 4 weeks) or take one 300 mg tablet of vitamin B1 and three 300 mg capsules of gabapentin per day for 4 weeks, after which both groups were followed up for 4 weeks. The primary endpoint was CIPN symptom severity measured by the Numerical Rating Scale (NRS). The secondary endpoints included sensory neuropathy grade evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events (NCI-CTCAE), neurophysiological assessment of CIPN by the nerve conduction study (NCS), and the patient overall satisfaction with treatment. Safety was assessed at each visit.

Results: The NRS and NCI-CTCAE sensory neuropathy grading scales decreased significantly over time in both groups (both < 0.001), with a significantly higher reduction in the acupuncture group ( < 0.001 and = 0.03, respectively). In addition, the acupuncture group showed a higher overall satisfaction with the treatment at the end of treatment and after 4 weeks follow-up, in comparison with the vit B1 and gabapentin group ( = 0.01 and = 0.001, respectively). The NCS (except for the latency of the sural nerve) in the acupuncture group improved significantly ( < 0.05), while improvement in the vit B1 and gabapentin group was not observed ( > 0.05).

Conclusion: Our study revealed that acupuncture, as a kind of traditional Chinese therapeutic method, is significantly effective and safe in the treatment of CIPN. Moreover, acupuncture is more effective than using vitamin B1 and gabapentin as the conventional treatment. This trial is registered with the Iranian Registry of Clinical Trials (IRCT20190615043900N1).
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http://dx.doi.org/10.1155/2020/2504674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341378PMC
November 2020

The First Cigarette Smoking Experience and Future Smoking Behaviors Among Adolescents with Different Parental Risk: a Longitudinal Analysis in an Urban Iranian Population.

Int J Behav Med 2020 Dec;27(6):698-706

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Longitudinal research among Iranian adolescent smoking is limited. The current study aimed to investigate (1) the first smoking experience (FSE) and future smoking behaviors of adolescents with different parental risk factors and (2) the association between age of the FSE and future smoking behaviors over a 12-year follow-up.

Method: Based on Tehran Lipid and Glucose Study (TLGS) database, 1487 adolescents (12-18 years) with complete baseline parental data were recruited. Using two-step cluster analysis, families were classified as either high or low risk; these were based on parental risk factors including age, education, employment, and smoking status. Participants were examined four times in 12 years and their data were used for survival analysis. After exclusion of 24 cases who were smokers at baseline, Cox proportional hazard modeling was used to evaluate the effect of parental clusters on the FSE in 1463 nonsmoking adolescents who completed all prospective follow-ups. Logistic regression analysis was used to examine the effect of the age of FSE on future smoking behaviors.

Results: The mean age of adolescents was 14.63 ± 2.07 years at baseline. Adolescents in the high-risk cluster group were 49% more likely to try smoking for their first time, and 55% more likely to smoke in the future. Compared with girls, boys had 83% higher chance of trying their first cigarette. Moreover, 1-year delay in the FSE resulted in 25% reduction in the probability of smoking in the future.

Conclusion: The findings show that compared with adolescents living in low-risk families, teenagers living in high-risk families are at greater risk of smoking at an earlier age; therefore, this group could benefit from gender- and culture specific preventive interventions.
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http://dx.doi.org/10.1007/s12529-020-09910-8DOI Listing
December 2020

Effect of a Natural Eye Drop, Made of Mucilage on Improvement of Dry Eye Symptoms: A Randomized, Double-blind Clinical Trial.

Iran J Pharm Res 2019 ;18(3):1602-1611

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Dry eye disease is a relatively common eye disorder associated with decrease in quality of life. In this study, efficacy of an eye drop of mucilage on symptoms of dry eye disease was evaluated. In a randomized, double-blind, placebo-controlled clinical trial, sixty dry eye patients with ocular symptoms and total Ocular Surface Disease Index (OSDI) score of ≥12 were randomly assigned to receive either a natural ophthalmic drop, made of mucilage or placebo 4 times a day for 6 weeks. The patients were evaluated at pretreatment (baseline), weeks 4 and 6 post-treatment. The evaluation of the efficacy and safety were conducted based on the OSDI questionnaire, the noninvasive tear film break-up time (NI-BUT) with keratograph, the Schirmer test without anesthesia, and the osmolarity test, as well as by monitoring possible adverse events. After 6 weeks, within group analysis showed a significant improvement in total OSDI score ( < 0.001). In addition, between group comparison revealed a significant improvement in the OSDI score of the intervention group ( < 0.001). Although, NI-BUT was significantly improved in the group ( = 0.004), however no statistically significant difference was observed in between group analysis. There were no significant differences between two groups, or significant changes within the groups in the Schirmer test without anesthesia and the osmolarity test. No serious adverse events were reported. In conclusion, mucilage is a natural, inexpensiveness, and safe lubricant polymer that could have beneficial ocular effects on subjective symptoms of the patients with dry eye disease.
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http://dx.doi.org/10.22037/ijpr.2019.1100717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934964PMC
January 2019

Response Comment on "Validity and Reliability of the Iranian Version of the Short Form Social Well Being Scale in a General Urban Population".

Iran J Public Health 2020 Apr;49(4):820-821

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283167PMC
April 2020

UNaProd: A Universal Natural Product Database for of Iranian Traditional Medicine.

Evid Based Complement Alternat Med 2020 13;2020:3690781. Epub 2020 May 13.

Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Iranian traditional medicine (ITM) is a holistic medical system that uses a wide range of medicinal substances to treat disease. Reorganization and standardization of the data on ITM concepts is a necessity for optimal use of this rich source. In an initial step towards this goal, we created a database of ITM . . Primarily based on Makhzan al-Advieh, which is the most recent encyclopedia of in ITM with the largest number of monographs, a database of natural medicinal substances was created using both text mining methods and manual editing. UNaProd, a Universal Natural Product database for of ITM, is currently host to 2696 monographs, from herbal to animal to mineral compounds in 16 diverse attributes such as origin and scientific name. Currently, systems biology, and more precisely systems medicine and pharmacology, can be an aid in providing rationalizations for many traditional medicines and elucidating a great deal of knowledge they can offer to guide future research in medicine.

Conclusions: A database of is a stepping stone in creating a systems pharmacology platform of ITM that encompasses the relationships between the drugs, their targets, and diseases. UNaProd is hyperlinked to IrGO and CMAUP databases for and molecular features, respectively, and it is freely available at http://jafarilab.com/unaprod/.
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http://dx.doi.org/10.1155/2020/3690781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243028PMC
May 2020

Longitudinal association between body mass index and physical activity among adolescents with different parental risk: a parallel latent growth curve modeling approach.

Int J Behav Nutr Phys Act 2020 05 11;17(1):59. Epub 2020 May 11.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Data available on the association between physical activity (PA) and body mass index (BMI) in different periods of life is controversial. Using a parallel latent growth curve modeling (LGCM) approach, the current study aimed to investigate the influence of daily PA on adolescents' BMI over a 12 year follow-up, taking into account their parental risk.

Method: Participants comprised 1323 adolescents (53.5% girls), aged 12-18 years who had participated in the baseline phase of Tehran Lipid and Glucose Study (TLGS) (2001-2003), and were followed for an average period of 12 years. Physical activity, including leisure time and occupational activities, was assessed using the reliable and validated Iranian version of the Modifiable Activity Questionnaire (MAQ). Weight and height were objectively measured in order to calculateBMI.Atwo-step cluster analysis was conducted to classify parents into two high- and low-risk clusters. Parallel LGCM was fitted to estimate cross-sectional, prospective and parallel associations, which assessed the longitudinal association between simultaneous changes in PA and BMI during the study period. Analyses were stratified by gender and parental clusters.

Results: A rising trend of BMI per 3 years was observed in boys 1.39 kg.m(95% CI; 1.32, 1.48) and girls 0.9 kg.m(95% CI; 0.82, 0.98), as well as in the low risk 1.11 kg.m(95% CI; 1.03, 1.18) and high-risk 1.12 kg.m(95% CI; 1.03, 1.22) clusters. Moreover, a positive prospective association between PA at baseline and BMI change over the 12 year follow-up, was observed in adolescents in the low-risk parental cluster 0.27(95% CI; 0.14, 0.41) indicating that higher levels of PA at baseline may lead to greater BMI in adolescents over time. However, examining longitudinal parallel association between simultaneous changes of PA and BMI per 3 years revealed adverse associations for adolescents in the low-risk parental cluster - 0.07 (95% CI; - 0.13, - 0.01) and in boys - 0.06 (95% CI; - 0.11, - 0.01).

Conclusion: Despite a positive prospective association between BMI and PA at baseline, there was a weak inverse parallel association between these variables over time, particularly in boys and adolescents with low parental risk. These findings imply the potential role of other influential factors indetermining adolescents' weight status which need to be considered in the future plannings.
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http://dx.doi.org/10.1186/s12966-020-00961-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216717PMC
May 2020

Validity and Reliability of the Iranian Version of the Short Form Social Well Being Scale in a General Urban Population.

Iran J Public Health 2019 Aug;48(8):1478-1487

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: We aimed to investigate the reliability and validity of the Iranian version of the short form social well-being scale.

Methods: After linguistic validation, the Iranian version of social well-being scale was completed by 715 participants, aged ≥18 yr between Jan and Sep 2015. Concurrent validity was examined by calculating the Pearson's correlation coefficient between the dimensions of social well-being and social support. Internal consistency, Cronbach's alpha coefficient, confirmatory and explanatory factor analyses were also examined.

Results: The internal consistency as measured by Cronbach's alpha coefficients was 0.72 for total score. No ceiling and floor effect was found in total score or any of the subscales. The concurrent correlation coefficients between social well-being and social support ranged from good to excellent agreement. Exploratory factor analysis supported mainly comparable results with the original US English dialect version. The results of the confirmatory factor analysis for 5-factor models indicated acceptable fit for the proposed research models.

Conclusion: The findings support the initial reliability and validity of the Iranian version of the social well-being scale in the research and community settings in Iran.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145928PMC
August 2019

The Heart-Healthy Avicennian Diet for Prevention of Heart Disease.

Eur Heart J 2020 04;41(15):1465-1466

Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1093/eurheartj/ehaa125DOI Listing
April 2020

Oral and nasal probiotic administration for the prevention and alleviation of allergic diseases, asthma and chronic obstructive pulmonary disease.

Nutr Res Rev 2020 Apr 13:1-16. Epub 2020 Apr 13.

Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Interaction between a healthy microbiome and the immune system leads to body homeostasis, as dysbiosis in microbiome content and loss of diversity may result in disease development. Due to the ability of probiotics to help and modify microbiome constitution, probiotics are now widely used for the prevention and treatment of different gastrointestinal, inflammatory, and, more recently, respiratory diseases. In this regard, chronic respiratory diseases including chronic obstructive pulmonary disease (COPD), asthma and allergic rhinitis are among the most common and complicated respiratory diseases with no specific treatment until now. Accordingly, many studies have evaluated the therapeutic efficacy of probiotic administration (mostly via the oral route and much lesser nasal route) on chronic respiratory diseases. We tried to summarise and evaluate these studies to give a perspective of probiotic therapy via both the oral and nasal routes for respiratory infections (in general) and chronic respiratory diseases (specifically). We finally concluded that probiotics might be useful for allergic diseases. For asthmatic patients, probiotics can modulate serum cytokines and IgE and decrease eosinophilia, but with no significant reduction in clinical symptoms. For COPD, only limited studies were found with uncertain clinical efficacy. For intranasal administration, although some studies propose more efficiency than the oral route, more clinical evaluations are warranted.
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http://dx.doi.org/10.1017/S0954422420000116DOI Listing
April 2020

The relation of alexithymia and attachment with type 1 diabetes management in adolescents: a gender-specific analysis.

BMC Psychol 2020 Apr 6;8(1):30. Epub 2020 Apr 6.

Research Center for Social Determinants of Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O.Box: 19395-4763, Tehran, Iran.

Background: Several studies indicate the role of psychosocial factors in the management and control of chronic diseases in adolescents. In this regard, the roles of attachment and alexithymia in the management of type 1 diabetes in adolescents and related gender-specific patterns have rarely been the focus of empirical research. In this study we investigate the gender-specific relationship of alexithymia and attachment with self-care and blood glucose level in adolescents with type1 diabetes.

Methods: This is a cross-sectional study conducted on adolescents aged 12-18 years, with type 1 diabetes. Participants were recruited from diabetes clinics and the Iranian Diabetes Society. Data were collected using the Farsi versions of the Toronto Alexithymia Scale (FTAS-20), the Inventory of Parent and Peer Attachment (IPPA) and the Summary of Diabetes Self-Care Activities Scale (SDSCA). Blood glucose levels were measured by determining HbA1c which were abstracted from medical records. Data were analyzed using SPSS21 software.

Results: Participants were 150 adolescents (57% female), mean age 14.97 ± 2.30. Alexithymia (β = 0.10, P = 0.01), difficulty identifying feelings (β = 0.15, P = 0.03) and communication with mothers (β = - 0.08, P = 0.03) predicted HbA1c in girls, whereas no significant relationships were observed for HbA1c with alexithymia and attachment in boys. Factors that predicted self-care in girls were alexithymia (β = - 0.04, P = 0.02), difficulty identifying feelings (β = - 0.06, P = 0.04); in boys however in addition to these two factors predicting self-care [alexithymia (β = - 0.07, P = 0.01) and difficulty identifying feelings (β = - 0.11, P = 0.01)], we also found difficulty describing feelings (β = - 0.16, P = 0.02), communication with mother (β = 0.04, P = 0.04), alienation to mother (β = - 0.06, P = 0.03), to father (β = - 0.06, P = 0.01) and to peers (β = - 0.09, P = 0.03).

Conclusions: Our results suggest that, in a gender-specific pattern, alexithymia and attachment could affect self-care and blood glucose level in adolescents with type 1 diabetes; findings that can be used to facilitate more effective treatment strategies and interventions in this age group.
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http://dx.doi.org/10.1186/s40359-020-00396-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137281PMC
April 2020

Factors Associated With Length of Hospital Stay Following Liver Transplant Surgery.

Exp Clin Transplant 2020 06 4;18(3):313-319. Epub 2020 Mar 4.

>From the Department of Medical-Surgical Nursing, School of Nursing and Midwifery, University of Medical Sciences, Tehran, Iran.

Objectives: Length of stay is considered an important surrogate for transplant survival rate and resource utilization. Therefore, in the present study, our aim was to determine factors affecting length of hospital stay.

Materials And Methods: We retrospectively analyzed records of patients who underwent liver transplant at the Tehran University of Medical Sciences Liver Transplantation Center from March 2014 to March 2016.

Results: For our final analyses, there were 161 adult recipients, including 106 males (65.8%) and 55 females (34.1%). Univariate analyses showed that body mass index, Modelfor End-Stage Liver Disease score, duration of surgery, number of administered packed red blood cells and fibrinogen during surgery, reoperation, retransplant, bacterial infection, pleural effusion, ascites, renal failure that required dialysis, and wound infection were risk factors for length of hospital stay. After multivariate linear regression analysis, only body mass index (β = 0.016; P = .028), Model for End-Stage Liver Disease score (β = 0.017; P = .002), surgical duration (β = 0.002; P = .001), reoperation (β = 0.016; P < .001), presence of pleural effusion (β = 0.212; P = .042), and management of bacterial infection (β = 0.21; P = .03) and psychiatric problems after liver transplant (β = 0.213; P = .025) were independent risk factors for length of hospital stay.

Conclusions: The present study showed that multiple preoperative, intraoperative, and postoperative variables could have an impact on length of hospitalization. Therefore, methods for assessing these factors could improve patient outcomes and resource savings in liver transplant centers.
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http://dx.doi.org/10.6002/ect.2019.0077DOI Listing
June 2020

Diabetes in women and health-related quality of life in the whole family: a structural equation modeling.

Health Qual Life Outcomes 2019 Dec 5;17(1):178. Epub 2019 Dec 5.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Although several studies indicate the effects of diabetes type 2 on health-related quality of life (HRQoL) in female subjects, the related impact of the disease on HRQoL in their family members has rarely been the focus of the empirical research. In this study we aim to investigate associations between diabetes in women and the HRQoL in these women and their family members, using the structural equation modeling (SEM).

Methods: This family-based study was conducted on 794 women (11.1% with diabetes) as well as their spouses and children who participated in the Tehran Lipid and Glucose Study (TLGS) from 2014 to 2016. Data on HRQoL were collected using the Iranian version of the Short-Form 12-Item Health Survey version 2 (SF-12v2) and the Pediatric Quality of Life Inventory version™ 4.0 (PedsQL). SEM was conducted to evaluate the network of associations among studied variables. Data were analyzed using IBM SPSS Statistics & AMOS version 23 software.

Results: Mean age of women was 41.37 ± 5.32 years. Diabetes in women significantly affected their mental HRQoL (β = - 0.11, P < 0.01) but showed no significant direct associations with physical and mental HRQoL in their spouses or their children. However, poor mental HRQoL in women with diabetes was associated with decrease in both physical (β = - 0.02, P = 0.013) and mental (β = - 0.03, P < 0.01) HRQoL in their spouses and total HRQoL score in children (β = - 0.02, P < 0.01).

Conclusions: Among women with diabetes type 2, beyond its effect on their mental HRQoL per se, demonstrated a negative association with the self-assessment of health status in their spouses and children. Such familial consequences are mainly attributed to the negative effect of the disease on the mental rather than the physical HRQoL in women with diabetes.
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http://dx.doi.org/10.1186/s12955-019-1252-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896711PMC
December 2019

Traditional, complementary and alternative medicine in children constipation: a systematic review.

Daru 2019 Dec 16;27(2):811-826. Epub 2019 Nov 16.

School of Traditional Medicine, Tehran University of Medical Sciences, Building of the Ahmadiyeh, No 27, Corner Alley Tabriz, Sarparast Shomali Str, Taleghani Ave, Tehran, 1416663361, Iran.

Objectives: This review aims to evaluate the efficacy and safety of complementary and alternative medicine methods for constipation in the pediatric population.

Evidence Acquisition: Medical literature search was performed in several databases for a variety of Traditional, Complementary and Alternative Medicine in childhood constipation. Databases included Web of Science, Scopus, Embase, Cochrane Library, PubMed, ScienceDirect, Google scholar and a number of Persian databases including IranDoc, Magiran and SID. No time limitation was determined. Clinical trials or case series that had evaluated the effectiveness of CAM therapies in functional constipation of 1-18 year old children were included. Papers not in English or Persian language were excluded. Related articles were screened independently by two reviewers according to their titles and abstracts. A data extraction form was filled in for each eligible paper. Quality assessment of eligible documents was also performed.

Results: 30 studies were included, comprising 27 clinical trials and 3 case series. Ten documents were on herbal medicine, nine on traditional medicine, ten on manual therapies and one on homeopathy. Except for two herbal and one reflexology interventions, all studies reported positive effects on childhood constipation, with the majority being statistically significant. As the number of studies in each method was limited, we could not perform a meta-analysis.

Conclusion: The scarcity of research on the efficacy and safety of different types of complementary and alternative medicine methods in children with constipation necessitates conducting more studies in each field. Graphical abstract.
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http://dx.doi.org/10.1007/s40199-019-00297-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895286PMC
December 2019

The Role of Phlebotomy (Fasd) and Cupping in the Treatment of Epilepsy from Perspective of Persian Medicine.

Iran J Public Health 2019 Jul;48(7):1392-1394

Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708528PMC
July 2019

Effect of sweet almond syrup versus methylphenidate in children with ADHD: A randomized triple-blind clinical trial.

Complement Ther Clin Pract 2019 Aug 19;36:170-175. Epub 2019 Jul 19.

Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Purpose: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common health disorders among children. Some patients do not respond to methylphenidate or cannot tolerate its side effects. Sweet almond syrup as a Persian Medicine preparation has been used for many years. This study aims to evaluate the efficacy and safety of sweet almond for ADHD children.

Materials And Methods: Fifty children aged 6-14 years with ADHD were recruited to the study. The participants were randomly assigned to two groups to receive either methylphenidate or sweet almond syrup. The outcomes were assessed using the Parent and Teacher ADHD Rating Scale every two weeks for 8 weeks.

Results: Results showed that the two treatments had similar effects on symptom reduction in ADHD children. No significant differences were observed between the two groups (F=2.3, df=1, p=0.13, F=0.57, df=1, p=0.47).

Conclusion: Sweet almond may be an effective treatment for ADHD children.
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http://dx.doi.org/10.1016/j.ctcp.2019.07.008DOI Listing
August 2019

Distribution of body mass index in children with different parental risk: Findings of a family-based cohort study in a West-Asian population.

Sci Rep 2019 06 28;9(1):9375. Epub 2019 Jun 28.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Using quantile regression analysis, the current study, conducted within the framework of the Tehran Lipid and Glucose Study (TLGS) aimed to assess the effects of parental risk clusters on different percentiles of Body Mass Index (BMI) distribution in children. Participants included 2296 school-aged children who had participated in the baseline assessment of the TLGS and were followed for an approximate duration of fifteen years. Parental socio-demographic, behavioral and clinical characteristics were considered to determine risk clusters. Comparing of the high- to the low-risk parental clusters showed that after adjusting for age in boys, BMI was significantly higher at the 75 (1.82, p = 03), 85 (1.78, p = 0.007) and 95 (1.66, p = 0.03) percentiles; and in girls it was significantly higher at the 25 (1.45, p = 0.003), 50 (1.05, p = 0.015), 95 (2.31, p = 0.018) and 97 (2.44, p = 0.006) percentiles in the high risk cluster. Our data indicate that during a long-term follow up, children with a high-risk family are more likely to have higher BMI, compared to their counterparts in low-risk families, a difference observed mainly at the upper percentiles of BMI distribution for both genders and at all ages, findings that should be considered for strategies aimed at preventing childhood obesity and its consequences.
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http://dx.doi.org/10.1038/s41598-019-45543-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599208PMC
June 2019

Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety.

Phytother Res 2019 Feb 19;33(2):350-359. Epub 2018 Nov 19.

Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.

Aloysia citriodora (A. citriodora) has a long history of traditional use for sedation and treatment of insomnia in different societies. This study was carried out to assess the efficacy of A. citriodora in patients with insomnia. One hundred patients were randomly divided into two groups of A. citriodora (total essential oil 1.66 mg/10 ml and total amount of flavonoid in terms of quercetin 3.22 mg/10 ml of the syrup) and placebo. They were advised to use 10 cc of the syrups; an hour before the bedtime for a period of 4 weeks. Participants were assessed using Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) questionnaires at the baseline and then 2 and 4 weeks after the enrollment. Mean scores of global PSQI and its four components including sleep latency, habitual sleep efficiency, daytime dysfunction, and subjective sleep quality and also ISI score in the A. citriodora group improved significantly after 4 weeks of treatment when compared with the placebo group (p < 0.001, for all of them). Also, improvement of global score of PSQI and ISI was observed in the intervention group as compared with the placebo group, 2 weeks after the enrollment (p < 0.001). The results of this study showed that oral intake of A. citriodora can be suggested as a complementary treatment for patients with insomnia.
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http://dx.doi.org/10.1002/ptr.6228DOI Listing
February 2019

Factors Associated with Pre-Hypertension Among Tehranian Adults: A Novel Application of Structural Equation Models.

Int J Endocrinol Metab 2018 Jul 29;16(3):e59706. Epub 2018 Jun 29.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

Background: Pre-hypertension is proposed as an independent risk factor for the incidence of cardiovascular diseases.

Objectives: This study aimed to explore the main factors associated with pre-hypertension via testing a hypothesized model in Tehranian adults.

Methods: The study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS) between 2009 - 2011 on 4640 adults without hypertension, aged ≥ 20 years.

Results: The mean age of participants was 38.61 ± 12.14 years and 56.6% of them were female. More than one third of the studied participants had pre-hypertension (35.4%) with significantly higher prevalence in males compared to females (46.5% vs. 26.9%; χ = 190.7, P < 0.001). Age, waist circumference (WC), and serum triglyceride concentrations (TG) were directly associated with pre-hypertension in both men (β = 0.16, β = 0.25, and β = 0.11, respectively) and women (β = 0.16, β = 0.21 and β = 0.09, respectively). Physical activity, only in men (β = 0.07), and marital status only, in women (β = -0.06), were also directly associated with pre-hypertension. Both healthy and poor dietary patterns showed indirect associations with pre-hypertension in both genders via WC and TG. Higher age and lower education in both genders, being married only in men, and unemployed status only in women, were positively associated with pre-hypertension via behavioral and cardio-metabolic factors.

Conclusions: Level of TG and WC in both genders are direct modifiable associated factors of pre-hypertension. These findings could be considered in designing future health promotion programs aimed at preventing high blood pressure and its consequences among Tehranian adults.
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http://dx.doi.org/10.5812/ijem.59706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113714PMC
July 2018

Numerical investigation of the effect of vessel size and distance on the cryosurgery of an adjacent tumor.

J Therm Biol 2018 Oct 7;77:45-54. Epub 2018 Aug 7.

Biomedical Engineering Department, Amirkabir University of Technology, 424 Hafez Ave, Tehran 15875-4413, Iran. Electronic address:

Cryosurgery is an efficient cancer treatment which can be used for non-invasive ablation of some internal tumors such as liver and prostate. Tumors are usually located near the large blood vessels and the heat convection may affect the progression of the ice ball. Hence it is necessary to predict the surgery procedure and its consequences earlier. In spite of the recent studies it is still unclear that which arteries will significantly affect the freezing treatment of tumors and which can be ignored. Therefore a numerical model of a spherical 3 cm diameter liver tumor, subjected to cryosurgery was developed. The specific thermophysical properties were applied to the tumor and healthy tissues in frozen and unfrozen states. A simplified Hepatic artery with different anatomical diameters was placed in different positions relative to the tumor and energy and momentum equations were solved. The temperature distribution and the shape of the resultant ice ball were discussed. The results showed that a 4 mm diameter artery in the vicinity of a tumor will increase the minimum temperature achieved at the tumor boundary by 12.5 °C and therefore significantly affects the cryosurgery outcome. This may cause insufficient freezing which leads to incomplete death of tumor cells, failure of the surgery and tumor regenesis. Eventually it was shown that injection of gold and FeO nanoparticles to the surrounding tissue of the artery can enhance the heat transfer and progression of the ice ball, making temperature distribution similar to the no vessel state. Development of computational models can provide the physicians an applicable tool which helps them recognize how efficient a treatment method will be for a specific case and design a suitable cryosurgery plan.
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http://dx.doi.org/10.1016/j.jtherbio.2018.08.001DOI Listing
October 2018

Implementing Electric Potential Difference as a New Practical Parameter for Rapid and Specific Measurement of Minimum Inhibitory Concentration of Antibiotics.

Curr Microbiol 2018 Oct 5;75(10):1290-1298. Epub 2018 Jun 5.

Department of Microbial Biotechnology, School of Biology and Center of Excellence in Phylogeny Living Organisms, College of Science, University of Tehran, Tehran, Iran.

New methods to determine antimicrobial susceptibility of bacterial pathogens especially the minimum inhibitory concentration (MIC) of antibiotics have great importance in pharmaceutical industry and treatment procedures. In the present study, the MIC of several antibiotics was determined against some pathogenic bacteria using macrodilution test. In order to accelerate and increase the efficiency of culture-based method to determine antimicrobial susceptibility, the possible relationship between the changes in some physico-chemical parameters including conductivity, electrical potential difference (EPD), pH and total number of test strains was investigated during the logarithmic phase of bacterial growth in presence of antibiotics. The correlation between changes in these physico-chemical parameters and growth of bacteria was statistically evaluated using linear and non-linear regression models. Finally, the calculated MIC values in new proposed method were compared with the MIC derived from macrodilution test. The results represent significant association between the changes in EPD and pH values and growth of the tested bacteria during the exponential phase of bacterial growth. It has been assumed that the proliferation of bacteria can cause the significant changes in EPD values. The MIC values in both conventional and new method were consistent to each other. In conclusion, cost and time effective antimicrobial susceptibility test can be developed based on monitoring the changes in EPD values. The new proposed strategy also can be used in high throughput screening of biocompounds for their antimicrobial activity in a relatively shorter time (6-8 h) in comparison with the conventional methods.
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http://dx.doi.org/10.1007/s00284-018-1523-zDOI Listing
October 2018

Perceived social support and health-related quality of life (HRQoL) in Tehranian adults: Tehran lipid and glucose study.

Health Qual Life Outcomes 2018 May 10;16(1):90. Epub 2018 May 10.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Several studies have demonstrated the positive association between perceived social support and health-related quality of life (HRQoL) in certain groups; however, few studies have assessed this relationship in general population and between genders. This study aimed to investigate associations between socio-demographic factors, perceived social support and HRQoL among an urban Iranian population.

Methods: The study population were 1036 adults who had participated in Tehran Lipid and Glucose Study (TLGS). Data on socio-demographic information, perceived social support and HRQoL were collected using standard questionnaires by trained interviewers. Perceived social support and HRQoL were assessed using Iranian versions of the Multidimensional Scale of Perceived Social Support (MSPSS) and Short-Form 12-Item Health Survey version 2 (SF-12v2) respectively. Data on sets of associations among socio-demographic factors, perceived social support and quality of life were analyzed using Structural Equation Modeling (SEM) with IBM SPSS AMOS software.

Results: Mean ages were 50.3 ± 16.3 and 49.6 ± 14.0 years in men and women respectively and 40.9% of participants were male. In terms of perceived social support scores, except for family subscale scores (p = 0.003), there were no significant differences between men and women. However, men had significantly higher HRQoL scores, compared to women in all subscales. The findings of SEM analysis demonstrated that being married in both genders (p < 0.001) and lower age in men (p < 0.05) were significantly associated with higher level of perceived social support. In terms of physical HRQoL, being single and higher perceived social support in both genders and lower age and not having any chronic diseases, only in women were associated with higher physical HRQoL. However, for mental HRQoL, age and perceived social support had significant direct associations with mental HRQoL in both genders (p < 0.001); in women, being single (p < 0.05) and not having chronic diseases (p < 0.001) were also significantly associated with better mental HRQoL.

Conclusion: Perceived social support was found to be both directly and indirectly associated with physical and mental aspects of HRQoL in both genders. Current structural models provide beneficial information for planning health promotion programs aimed at improving HRQoL among Tehranian adults.
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http://dx.doi.org/10.1186/s12955-018-0914-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946411PMC
May 2018