Publications by authors named "Mehmet Yilmaz"

617 Publications

Distal transradial angiography.

Turk Kardiyol Dern Ars 2021 Jun;49(4):251-253

Department of Cardiology, Siyami Ersek Chest and Chest Surgery Training and Research Hospital, İstanbul, Turkey.

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http://dx.doi.org/10.5543/tkda.2021.21114DOI Listing
June 2021

Silver nanoparticle-decorated titanium dioxide nanowire systems bioinspired poly(L-DOPA) thin film as a surface-enhanced Raman spectroscopy (SERS) platform, and photocatalyst.

Phys Chem Chem Phys 2021 Jun;23(23):13396-13404

Department of Chemical Engineering, Ataturk University, 25240 Erzurum, Turkey. and East Anatolia High Technology Application and Research Center (DAYTAM), Ataturk University, 25240 Erzurum, Turkey and Department of Nanoscience and Nanoengineering, Ataturk University, 25240 Erzurum, Turkey.

Silver nanostructure decorated-titanium dioxide (TiO2) nanocomposite systems with their unique characteristics provide extraordinary performance in various applications including surface-enhanced Raman spectroscopy (SERS), and photocatalysis. Despite the recent progress, novel, simple, effective, low-cost, reducing and stabilizing agent-free, and easy-to-tune approaches are heavily demanded for the preparation of these nanocomposites. In this context, we propose the fabrication of silver nanostructure decorated TiO2 nanowires (TiO2 NWs) through a thin interphase layer of the polymer of 3,4-dihydroxyphenyl-l-alanine (PLDOPA). In the first step, TiO2 NWs were synthesized through the hydrothermal method and then a conformal thin film of PLDOPA was deposited onto the TiO2 NWs ([email protected]) by oxidative polymerization of l-DOPA. Having various functional groups including catechol and amine, the PLDOPA thin-film reduced the silver ions onto the TiO2 NWs and stabilized the resultant nanocomposites without the employment of any surfactant, reducing agent, and seed material. By simply tuning the amount of silver ions, we could manipulate the size, morphology, and interparticle distance of silver nanostructures decorated onto the [email protected] colloidal composite system ([email protected]@Ag NP). The [email protected]@Ag nanocomposite systems provided unique properties as an ideal SERS platform and photocatalyst. The optimized [email protected]@Ag nanosystem demonstrated a high SERS activity, reproducibility, and self-cleaning property with an enhancement factor of 5.1 × 105. As a photocatalyst, the [email protected]@Ag NP systems provided remarkable performance under visible light irradiation in the catalytic degradation of methylene blue.
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http://dx.doi.org/10.1039/d1cp01322jDOI Listing
June 2021

Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing.

Nat Commun 2021 06 7;12(1):3361. Epub 2021 Jun 7.

Oncode Institute & Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.

In routine diagnostic pathology, cancer biopsies are preserved by formalin-fixed, paraffin-embedding (FFPE) procedures for examination of (intra-) cellular morphology. Such procedures inadvertently induce DNA fragmentation, which compromises sequencing-based analyses of chromosomal rearrangements. Yet, rearrangements drive many types of hematolymphoid malignancies and solid tumors, and their manifestation is instructive for diagnosis, prognosis, and treatment. Here, we present FFPE-targeted locus capture (FFPE-TLC) for targeted sequencing of proximity-ligation products formed in FFPE tissue blocks, and PLIER, a computational framework that allows automated identification and characterization of rearrangements involving selected, clinically relevant, loci. FFPE-TLC, blindly applied to 149 lymphoma and control FFPE samples, identifies the known and previously uncharacterized rearrangement partners. It outperforms fluorescence in situ hybridization (FISH) in sensitivity and specificity, and shows clear advantages over standard capture-NGS methods, finding rearrangements involving repetitive sequences which they typically miss. FFPE-TLC is therefore a powerful clinical diagnostics tool for accurate targeted rearrangement detection in FFPE specimens.
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http://dx.doi.org/10.1038/s41467-021-23695-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184748PMC
June 2021

Hematopoietic Stem Cell Transplantation for Patients with Paroxysmal Nocturnal Hemoglobinuria with or Without Aplastic Anemia: Multicenter Turkish Experience.

Turk J Haematol 2021 May 31. Epub 2021 May 31.

Ege University School of Medicine, Department of Hematology, Izmir, Turkey.

Objective: Although inhibition of complement system at different steps is a promising therapy modality in PNH (paroxysmal paroxysmal nocturnal hemoglobinuria) patients, allogeneic hematopoetic stem cell transplantation (HCT) is still the only curative therapy especially for patients with intractable hemolysis or bone marrow failure. The aim of this study is to evaluate the outcomes of allogeneic HCT in PNH patients with or without aplastic anemia ( PNH-AA).

Material And Methods: 35 PNH / PNH-AA patients who were treated with allegeneic HCT in ten transplantation centers in Turkey were retrospectively analyzed.

Results: 16 (45.7 %) and 19 (54.3 %) patients were diagnosed as classical PNH and PNH / AA respectively. The median age of the patients was 32 ( 18-51) 2-year overall survival (OS) and GVHD-free, failure-free survival (GFFS) was 81.2 % and 78.1 % , respectively. 2 year OS in classical PNH and PNH /AA was 81.3 % and % 79.9 (p =0,87), respectively and 2 year GFFS in PNH and PNH/AA was 79% and 76% (0,977) without statistical significance. OS and GFFS rates did not differ between transplantations with matched sibling donor (MSD) and matched unrelated donor (MUD), neither.

Conclusion: Allo HCT with MSD or MUD is a good option in selected patients with classical PNH and PNH / AA. Especially, patients with debilitating and refractory hemolysis and patients with bone marrow failure might form the excellent group for allo - HCT.
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http://dx.doi.org/10.4274/tjh.galenos.2021.2021.0105DOI Listing
May 2021

Is 'Omega Sign' anatomical endoscopic enucleation of the prostate technique reproducible?

Andrologia 2021 May 31:e14137. Epub 2021 May 31.

Department of Urology, Gazi University Faculty of Medicine, Ankara, Turkey.

We aimed to evaluate the learning curve of the surgically standardised 'Omega Sign' anatomical endoscopic enucleation (AEEP) of the prostate surgery technique for junior surgeons. This study is a retrospective comparison of cases that underwent AEEP by a mentor surgeon and three junior surgeons who have completed their learning curve. A video-based laser enucleation of the prostate assessment tool (LEAT) composed of 8 steps of the technique was used to assess a senior surgeon and junior surgeons' surgical compatibility and consistency. The surgeon who defined Omega Sign technique was determined as group 1, and cases by three junior surgeons were identified as group 2. The end points were to assess the reproducibility and repeatability and operative post-operative outcomes of the technique. 55 patients' videos were rated by five experienced endourologists. There was no significant difference in LEAT scores between the groups among all steps. The most symmetry was found in the 1st and 3rd steps. Inter-rater consistency was also high for each step, with no statistically significant difference between the evaluators. The standardised anatomical 'Omega Sign' technique is reproducible for the junior surgeons. The operative steps can be performed with high consistency, and the functional and perioperative outcomes are comparable with the senior surgeon.
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http://dx.doi.org/10.1111/and.14137DOI Listing
May 2021

Comment on 'A novel technique in the management of severe postpartum uterine atony bleeding: Three vertical uterine compression sutures'.

Eur J Obstet Gynecol Reprod Biol 2021 May 8. Epub 2021 May 8.

Department of Obstetrics and Gynaecology, Duzce University School of Medicine, Duzce, Turkey.

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http://dx.doi.org/10.1016/j.ejogrb.2021.05.009DOI Listing
May 2021

Mixed reality applications in urology: Requirements and future potential.

Ann Med Surg (Lond) 2021 Jun 13;66:102394. Epub 2021 May 13.

German Research Center for Artificial Intelligence, Department Augmented Vision, Kaiserslautern, Germany.

Background: Mixed reality (MR), the computer-supported augmentation of a real environment with virtual elements, becomes ever more relevant in the medical domain, especially in urology, ranging from education and training over surgeries. We aimed to review existing MR technologies and their applications in urology.

Methods: A non-systematic review of current literature was performed using the PubMed-Medline database using the medical subject headings (MeSH) term "mixed reality", combined with one of the following terms: "virtual reality", "augmented reality", ''urology'' and "augmented virtuality". The relevant studies were utilized.

Results: MR applications such as MR guided systems, immersive VR headsets, AR models, MR-simulated ureteroscopy and smart glasses have enormous potential in education, training and surgical interventions of urology. Medical students, urology residents and inexperienced urologists can gain experience thanks to MR technologies. MR applications are also used in patient education before interventions.

Conclusions: For surgical support, the achievable accuracy is often not sufficient. The main challenges are the non-rigid nature of the genitourinary organs, intraoperative data acquisition, online and multimodal registration and calibration of devices. However, the progress made in recent years is tremendous in all respects and the gap is constantly shrinking.
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http://dx.doi.org/10.1016/j.amsu.2021.102394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141462PMC
June 2021

A new seton tightening method for anal fistula treatment: sailor's knot.

Ann Ital Chir 2021 ;92:201-205

Aim: There are certain problems experienced while retightening the seton material during the patient follow-ups, such as pain and anaesthesia requirements in perianal fistula. The aim of the present study was to compare a sailor's knot with other seton tightening methods for the surgical treatment of perianal fistulas.

Material And Methods: The records of 105 patients who underwent surgeries for perianal fistulas using the seton method between 2016 and 2019 were analysed retrospectively. The demographic characteristics, complaints, fistula localizations, surgery types, hospital stay lengths, postoperative complications and imaging modalities of the patients included in the study were recorded. The patients were divided into two groups according to the surgical treatment method. Those patients who underwent seton procedures with a sailor's knot were included in Group 1. Group 2 included those patients who underwent other seton procedures, including silk and penrose drain procedures. Groups were compared with regard to success rates and postoperative recurrence.

Results: There was no statistically significant difference between the groups in terms of the age, gender, fistula type and follow-up duration. Success rate in all patient was 88.6%, 91.2% in group 1 and 87.1% in group 2 (p=0.36). The number of patients with a kind of incontinence was 7 (7.1%), 3 (5.8%) in Group 1 and 4 (7.4%) in Group 2 (p = 0.297).

Conclusion: There were no statistically significant differences with regard to complications and recurrences between the sailor's knot and the other seton tightening methods used for the treatment of anal fistulas. The sailor's knot is recommended with regard to its easy application and seton retightening with satisfactory outcomes.

Key Words: Perianal fistula, Sailor's knot, Seton.
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January 2021

Laser enucleation for prostates larger than 100 mL: Comparison of HoLEP and ThuLEP.

Andrologia 2021 May 24:e14125. Epub 2021 May 24.

Department of Urology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Recently, with the advancements in laser technology, Holmium laser enucleation of the prostate (HoLEP) and Thulium laser enucleation of the prostate (ThuLEP) have come to the fore in the surgical treatment of benign prostatic hyperplasia (BPH). We aimed to evaluate and compare the outcomes of HoLEP and ThuLEP in patients with >100 ml prostate volume. Patients who underwent HoLEP and ThuLEP between July 2017 and March 2020 were reviewed retrospectively. The patients were divided into two groups as HoLEP (Group 1, n = 121) and ThuLEP (Group 2, n = 104). Perioperative parameters, functional outcomes, continence status, intra and post-operative complications were compared between groups in the post-operative 1st and 6th month. No significant difference was found in terms of total laser energy (TLE), morcellation efficiency (ME), enucleated tissue weight (ETW), complication rates (CR) and continence status of patients between both groups (p > .05). In favour of ThuLEP group, there were statistically significant differences regarding total operation time (TOT), laser efficiency (LE), enucleation time (ET) and enucleation efficiency (EE) between groups (p ≤ .05). HoLEP and ThuLEP can be used safely and effectively in prostates larger than 100 ml.
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http://dx.doi.org/10.1111/and.14125DOI Listing
May 2021

Clinical characteristics and therapeutic outcomes of paroxysmal nocturnal hemoglobinuria patients in Turkey: a multicenter experience.

Ann Hematol 2021 Jul 14;100(7):1667-1675. Epub 2021 May 14.

Ankara Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

The aim of this study is to collect paroxysmal nocturnal hemoglobinuria (PNH) patient data from hematology centers all over Turkey in order to identify clinical features and management of PNH patients. Patients with PNH were evaluated by a retrospective review of medical records from 19 different institutions around Turkey. Patient demographics, medical history, laboratory findings, and PNH-specific information, including symptoms at the diagnosis, complications, erythrocyte, and granulocyte clone size, treatment, and causes of death were recorded. Sixty patients (28 males, 32 females) were identified. The median age was 33 (range; 17-77) years. Forty-six patients were diagnosed as classic PNH and 14 as secondary PNH. Fatigue and abdominal pain were the most frequent presenting symptoms. After eculizumab became available in Turkey, most of the patients (n = 31/46, 67.4%) were switched to eculizumab. Three patients with classic PNH underwent stem cell transplantation. The median survival time was 42 (range; 7-183 months) months. This study is the first and most comprehensive review of PNH cases in Turkey. It provided us useful information to find out the differences between our patients and literature, which may help us understand the disease.
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http://dx.doi.org/10.1007/s00277-021-04554-4DOI Listing
July 2021

Predicting risk of erectile dysfunction in patients with nonalcoholic fatty liver disease.

Andrologia 2021 May 5:e14091. Epub 2021 May 5.

Department of Urology, Istanbul University Istanbul School of Medicine, Istanbul, Turkey.

Nonalcoholic fatty liver disease (NAFLD) is one of the risk factors for erectile dysfunction (ED). We aimed to predict the risk of ED in patients with NAFLD. The study included 146 male patients complaining impotence admitted to the urology outpatient clinic aged 24-80 years without a history of alcohol use who underwent abdominal ultrasonography between February 2018 and January 2019. 106 patients with NAFLD and 40 men without NAFLD were included in the study. Clinical and laboratory parameters, ED status according to International Index of Erectile Function-5 were compared between patients with and without NAFLD. The mean age of patients was 51.47 ± 10.34 years. NAFLD was detected in 72.6% of the patients. No statistically significant difference was found regarding mean age, BMI, IIEF-5 scores, DM status, serum glucose levels (p > .05). Fasting insulin levels, hypertension (HT), insulin resistance (IR) and ED status of the patients with NAFLD were significantly higher than patients without NAFLD (p < .05). NAFLD was found to be a significantly independent associated with ED. We also found that patients with NAFLD have risk of ED 2.92 times higher than without NAFLD (OR: 2.92). For the patients presenting with erectile dysfunction, hepatic steatosis should also be considered.
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http://dx.doi.org/10.1111/and.14091DOI Listing
May 2021

Combining vancomycin-modified gold nanorod arrays and colloidal nanoparticles as a sandwich model for the discrimination of Gram-positive bacteria and their detection via surface-enhanced Raman spectroscopy (SERS).

Analyst 2021 Jun 4;146(11):3642-3653. Epub 2021 May 4.

East Anatolia High Technology Application and Research Center (DAYTAM), Ataturk University, 25240 Erzurum, Turkey. and Department of Chemical Engineering, Ataturk University, 25240 Erzurum, Turkey and Department of Nanoscience and Nanoengineering, Ataturk University, 25240 Erzurum, Turkey.

This study reports the development of a highly sensitive antibiotic-based discrimination and sensor platform for the detection of Gram-positive bacteria through surface-enhanced Raman spectroscopy (SERS). Herein, a combination of gold nanorod arrays (GNAs) and colloidal gold nanoparticles (AuNPs) was used as a SERS platform. To specifically capture Gram-positive bacteria, both GNAs and AuNPs were functionalized with thiol-modified vancomycin (HS-Van) molecules. Three different strains of bacteria (Bacillus subtilis and Staphylococcus aureus as Gram-positive, and Escherichia coli as Gram-negative) were employed to test the proposed system. HS-Van functionalized GNAs ([email protected]) captured Gram-positive bacteria with high specificity. Also, the bacteria captured by [email protected] ([email protected]@Bct) systems showed high signal-to-noise SERS signals with high reproducibility. Addition of [email protected] to [email protected]@Bct resulted in the emergence of a sandwich system ([email protected]@[email protected]@AuNP). This system led to a further enhanced SERS signal. The chemometric analysis of [email protected]@[email protected]@AuNP enabled the obvious discrimination and detection of Gram-positive bacteria. For comparison, we also tested a smooth gold surface with the same procedure and a similar trend was observed with lower SERS activity.
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http://dx.doi.org/10.1039/d1an00321fDOI Listing
June 2021

Intravascular escape during lumbar transforaminal anterior epidural steroid injection: A retrospective study.

Agri 2021 Apr;33(2):84-88

Division of Algology, Department of Anesthesiology and Reanimation, Adnan Menderes University Faculty of Medicine, Aydın, Turkey.

Objectives: Demonstrate of accidental intravascular injection during lumbar transforaminal anterior epidural steroid injection (TAESI) performed with three-dimensional imaging angiography (3DIA) and fluoroscopy.

Methods: We assessed 20 (9 males and 11 females) patients (with a total of 40 levels) whose images were received with simultaneously 3DIA and fluoroscopy-guided TAESI between January 2016 and September 2016 as retrospective. Injections were carried out in the lumbar fourth intervertebral space bilaterally and performed in the same way all of the cases.

Results: The mean age and body mass index of the patients were 47.9±2.72 years and 26.95±1.21, respectively. There were 10 patients with disc herniation, seven patients with spinal stenosis, and three patients with failed back surgery syndrome. In 3D imaging, vascular escape was detected in the 7 levels (17.5%) which were thought to be no escape in the fluoroscopy imaging.

Conclusion: In chronic lumbar radiculopathy patients, intravascular escapes may occur during the fluoroscopic TAESI procedure. To avoid intravascular injections during TAESI procedure, it may be appropriate to use different imaging methods that can give more detailed results such as 3D angiography.
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http://dx.doi.org/10.14744/agri.2020.54280DOI Listing
April 2021

Poly(L-DOPA)-mediated bimetallic core-shell nanostructures of gold and silver and their employment in SERS, catalytic activity, and cell viability.

Nanotechnology 2021 May 10;32(31). Epub 2021 May 10.

East Anatolia High Technology Application and Research Center (DAYTAM), Ataturk University, 25240 Erzurum, Turkey.

Core-shell gold nanorod (AuNR)@silver (Ag) nanostructures with their unique properties have gained enormous interest and are widely utilized in various applications including sensor systems, catalytic reactions, diagnosis, and therapy. Despite the recent progress, simple, effective, low-cost, and easy-to-tune strategies are heavily required to fabricate these nanoparticles (NP) systems. For this, we propose the employment of the polymer of 3,4-dihydroxyphenyl-L-alanine (L-DOPA) as a ligand molecule. A conformal thin layer of polymer of L-DOPA (PLDOPA) with its various functional groups enabled the reduction of silver ions onto the AuNRs and stabilization of the resultant NPs without using any surfactant, reducing agent, and seed material. The shape and growth model of the [email protected] nanostructures was manipulated by simply tuning the amount of silver ions. This procedure created different NP morphologies ranging from concentric to acentric/island shape core-shell nanostructures. Also, even at the highest Ag deposition, the PLDOPA layer is still conformally present onto the [email protected] core-shell NRs. The unique properties of NP systems provided remarkable characteristics in surface-enhanced Raman spectroscopy, catalytic activity, and cell viability tests.
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http://dx.doi.org/10.1088/1361-6528/abf9c7DOI Listing
May 2021

Hyperkalemia in chronic heart failure with renal dysfunction or diabetes mellitus: Results from the TREAT HF study.

Turk Kardiyol Dern Ars 2021 Apr;49(3):198-205

Dokuz Eylül Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye.

Objective: Chronic kidney disease (CKD) and diabetes mellitus (DM) are common comorbidities in heart failure (HF). Patients with HF are at a high risk of hyperkalemia, and are therefore undertreated with respect to disease-modifying therapies. The Turkish Research Team-Heart Failure (TREAT HF) data were analyzed for the evaluation of hyperkalemia in real-life clinical practice in HF patients with CKD or DM.

Methods: The TREAT HF is a multicenter, national, observational registry. In this study, potassium levels of 1028 patients with HF were analyzed. Hyperkalemia is defined as blood potassium levels >5 mEq/L and evaluated based on the CKD, DM, HF medications, and New York Heart Association (NYHA) classes.

Results: Overall, 14.3% of patients (n=147) were found to have hyperkalemia. Hyperkalemia was more prevalent in patients with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 than those with eGFR ≥60 mL/min/1.73 m2 (17.7% and 12%, respectively, p=0.010). Hyperkalemia was present in 10.9% (n=23) of patients with stage 1, 12.6% (n=50) with stage 2, 17.0% (n=52) with stage 3, and 19.5% (n=22) with stage 4-5 CKD. Hyperkalemia was higher in patients with DM (20.5% vs 12.3%, p=0.001). Furthermore, hyperkalemia was much higher in patients with DM with eGFR <60 mL/min/1.73 m2 (25.2%). The rate of hyperkalemia increased across NYHA categories (NYHA-I: 9.8%, NYHA-II: 12.8%, NYHA-III: 14.4%, and NYHA-IV: 23.4%, p=0.030). In patients with stage 4-5 CKD who were receiving renin-angiotensin-aldosterone system (RAAS) inhibitor therapy, more patients had hyperkalemia than those not receiving RAAS inhibitor therapy (23.4% and 12.5%, respectively).

Conclusion: In clinical practice, 14.3% of all patients with HF, 17.7% of all patients with CKD, and 20.5% of all patients with DM have hyperkalemia. The risk of hyperkalemia increases with advanced stages of CKD or NYHA and the risk is higher in patients receiving RAAS inhibitor therapy.
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http://dx.doi.org/10.5543/tkda.2021.58675DOI Listing
April 2021

Second Look Ultrasonography-Guided Breast Biopsy with Magnetic Resonance Imaging Confirmation by Intralesional Contrast Injection.

Eur J Breast Health 2021 Jan 24;17(1):1-9. Epub 2020 Dec 24.

Clinic of Radiology, Memorial Hospital, İstanbul, Turkey.

Objective: This study aimed to introduce an alternative pre-biopsy confirmation technique that combines sonography-guided intra-lesional contrast injections and single non-enhanced magnetic resonance imaging (MRI) pulse sequence in order to identify sonographic correlates of incidentally detected breast MRI lesions which were occult on primary ultrasonography (USG) and mammography examination.

Materials And Methods: From May 2014 through May 2015, a total of 37 incidental breast lesions of 37 patients, which were detected by breast MRI, were evaluated with targeted second look ultrasound (SLUS). The suspected lesion on USG was marked with a gadolinium-based contrast agent under USG guidance. After a single non-enhanced T1 weighted control MR sequence, positively correlated lesions with initial MRI were sampled by USG guided core biopsy.

Results: Of the 37 lesions evaluated, 32 (86%) lesions showed a correlation between MRI and SLUS findings. On SLUS core biopsy, there were eight (25%) malignant and 11 (34.4%) high-risk lesions among these 32 cases with correlated MRI findings; while the remaining 13 (40.6%) cases had benign histopathology. Eleven (34.4%) of the SLUS-discovered lesions were focus, 11 (34.4%) were non-mass enhancements, and the remaining 10 (31.2%) were mass lesions. Of the five lesions (13.5%) that showed no correlations on MRI and SLUS examinations, four were non-mass enhancements and one was focus.

Conclusion: SLUS represents a method for identifying MRI-detected lesions and provides a bridge to ultrasound-guided biopsy for histopathological diagnosis. There is a need for confirmation of biopsies to avoid false negative results. We describe a cheap, safe, and easy-to-apply USG-guided pre-biopsy lesions marking method in order to ensure definite correlation.
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http://dx.doi.org/10.5152/ejbh.2020.5663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006787PMC
January 2021

Targeted locus amplification to detect molecular markers in mantle cell and follicular lymphoma.

Hematol Oncol 2021 Mar 20. Epub 2021 Mar 20.

Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Torino, Torino, Italy.

Minimal residual disease (MRD) monitoring by PCR methods is a strong and standardized predictor of clinical outcome in mantle cell lymphoma (MCL) and follicular lymphoma (FL). However, about 20% of MCL and 40% of FL patients lack a reliable molecular marker, being thus not eligible for MRD studies. Recently, targeted locus amplification (TLA), a next-generation sequencing (NGS) method based on the physical proximity of DNA sequences for target selection, identified novel gene rearrangements in leukemia. The aim of this study was to test TLA in MCL and FL diagnostic samples lacking a classical, PCR-detectable, t(11; 14) MTC (BCL1/IGH), or t(14; 18) major breakpoint region and minor cluster region (BCL2/IGH) rearrangements. Overall, TLA was performed on 20 MCL bone marrow (BM) or peripheral blood (PB) primary samples and on 20 FL BM, identifying a novel BCL1 or BCL2/IGH breakpoint in 16 MCL and 8 FL patients (80% and 40%, respectively). These new breakpoints (named BCL1-TLA and BCL2-TLA) were validated by ASO primers design and compared as MRD markers to classical IGH rearrangements in eight MCL: overall, MRD results by BCL1-TLA were superimposable (R Pearson = 0.76) to the standardized IGH-based approach. Moreover, MRD by BCL2-TLA reached good sensitivity levels also in FL and was predictive of a primary refractory case. In conclusion, this study offers the proof of principle that TLA is a promising and reliable NGS-based technology for the identification of novel molecular markers, suitable for further MRD analysis in previously not traceable MCL and FL patients.
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http://dx.doi.org/10.1002/hon.2864DOI Listing
March 2021

Morphometric Analysis of Cavitas Glenoidalis with Multidedector CT.

Turk J Med Sci 2021 Mar 12. Epub 2021 Mar 12.

Background: The glenoid cavity is a sliced egg-shaped joint surface located on the lateral margin of the scapula to form the shoulder joint. Antero-superior notch affects the morphology of the glenoid cavity. Recognition of variations in shape and dimensions of the glenoid cavity is important for better comprehension of joint-associated diseases, especially in total shoulder arthroplasty procedures. The aim of this study was to perform morphometric measurements on the glenoid cavity through Multi-detector Computed Tomography images.

Methods: Glenoid cavities of 391 individuals (197 males (50.4%), 194 females (49.6%)) were reviewed by using Multi-detector Computed Tomography. CT images were examined from January 2014 to April 2016 by scanning files. The average age of men was 60.28 ± 15.43, while the average age of women was 58.82 ± 16.38. The maximum length and maximum width of glenoid cavities, the width, depth and circumference at the notch level were measured, and the index value was calculated. The glenoid cavity shapes were typed as pear, inverted comma and oval type. Furthermore, metric values which provide the best differentiation between genders were found through ROC analysis.

Results: The pear GC type was detected by 53.2%, inverted comma type was detected by 28.4%, and oval type was detected by 18.4%. In all of our morphometric measurements, male values were higher than female values, and there was no significant difference between them. Furthermore, significant differences were found for width at the notch level and circumference lengths between the right and left sides; however, there was not any significant difference between maximum length, maximum width, depth and the index (p<0.05). Results of ROC analysis revealed significant measurements for the maximum length and maximum width measurements of the glenoid for gender determination.

Conclusions: It was reported in the literature that morphometric information of the glenoid cavity is useful to increase clinical success in case of different pathological conditions such as Bankart lesion, rotator cuff disease, and osteochondral defect. Recognition of different shapes and dimensions of the glenoid cavity is essential for the design of the glenoid component especially for total shoulder arthroplasty procedure. We believe that the data obtained in our study would be useful for prosthesis designers and orthopaedic surgeons.
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http://dx.doi.org/10.3906/sag-2011-106DOI Listing
March 2021

Medium Cut-Off Membrane Can Be a New Treatment Tool in Amanita phalloides Poisoning.

Wilderness Environ Med 2021 Jun 4;32(2):192-197. Epub 2021 Mar 4.

Department of Internal Medicine, Faculty of Medicine, Mugla University, Mugla, Turkey.

Mushroom poisoning is a common health problem that can be seen seasonally and geographically. Most mushroom poisoning requiring treatment worldwide is due to Amanita phalloides. Although liver failure and kidney injury are frequent, poisoning can also lead to more serious clinical situations, such as shock, pancreatitis, encephalopathic coma, cardiac failure, disseminated intravascular coagulation, and multiple organ dysfunction syndrome, and may cause death. In addition, when standard treatment approaches fail, extracorporeal treatment methods are often used. We report 2 cases in which hemodialysis with medium cut-off membrane was performed. We observed an improvement in liver and kidney function in both of our cases. The first case recovered, but the second case proved fatal owing to Acinetobacter sepsis, despite an improvement in renal function. Medium cut-off membrane hemodialysis may be an alternative option in the treatment of Amanita phalloides poisoning.
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http://dx.doi.org/10.1016/j.wem.2020.12.002DOI Listing
June 2021

Time interval between E and E' waves can predict complicated clinical course in patients with acute pulmonary embolism.

J Clin Ultrasound 2021 Jul 3;49(6):580-585. Epub 2021 Mar 3.

Department of Cardiology, Kartal Koşuyolu Heart and Vascular Disease Research and Training Hospital, Istanbul, Turkey.

Purpose: Acute pulmonary embolism is a life-threatening cardiothoracic emergency leading to right ventricle systolic and diastolic dysfunction. In the present study, we investigated the right ventricle diastolic function and its predictive value in patients with acute pulmonary embolism.

Material And Methods: Were prospectively recruited in this study 621 patients diagnosed with acute pulmonary embolism between December 2015 and June 2019. Among them, 173 were excluded, leaving 448 patients for follow-up. Transthoracic echocardiography was performed for the evaluation of the right ventricle systolic and diastolic indices. At 30-day follow-up, the patients were allocated either into the benign or in the complicated clinical course group.

Results: The group with complicated clinical course had higher value of pulmonary artery systolic pressure (PASP), right/left ventricle diameter ratio, E-wave velocity, E/A ratio, A' wave velocity, E/E' ratio, and time interval between E and E' waves (P < .05), but lower values of tricuspid annular plane systolic excursion, A-wave velocity, isovolumetric relaxation time, deceleration time, E', and E'/A' (P < .05). Complicated clinical course was associated with shorter isovolumetric relaxation time (r = .564, P < .001), E/E' (r = .495, P < .001), and TE-E' (r = .596, P < .001). Receiver operator characteristic curve analysis showed that TE-E' had the largest area under curve (TE-E' 0.82, IVRT 0.77, E/E' 0.72). A cut-off value of TE-E' = 70 milliseconds had an 81.1% sensitivity and 71.4% specificity for the prediction of the complicated clinical course.

Conclusion: The assessment of the right ventricle diastolic function could predict the complicated clinical course in patients with acute pulmonary embolism.
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http://dx.doi.org/10.1002/jcu.22995DOI Listing
July 2021

Marital status and outcomes in chronic heart failure: Does it make a difference of being married, widow or widower?

North Clin Istanb 2021 29;8(1):63-70. Epub 2021 Jan 29.

Department of Cardiology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Objective: We aimed to compare the outcomes of chronic heart failure (HF) patients with reduced ejection fraction (CHFrEF) in the Turkish Research Team in HF (TREAT-HF) registry according to marital status with a specific focus on being the widowed (widow/widower) versus the married.

Methods: TREAT-HF is a network, enrolling CHFrEF with a follow up for HF-related hospitalization (HFrH) and all-cause mortality (ACM). In this cohort, the widowed patients were compared with patients who were married before and after propensity score (PS) matching analysis.

Results: There were 723 cHFrEF patients with a complete dataset, including reported marital status at baseline for this analysis. Out of 723 patients with HF, 37 "never-married" and "divorced" patients were excluded from the analysis. Then, out of 686 remaining patients with HF, who had at least one reported marriage in the database, widowed patients with HF (n=124) were compared with married patients (n=562). The mean follow up period was 21±12 months up to 48 months. The widowed patients had a higher risk of HFrH (p=0.047), although ACM remained similar compared to married patients (p=0.054). After PS matching, HFrH remained more frequent among the widowed compared with the married (p=0.039) although ACM yielded similar rates. Of note, it was shown that being a widower (p=0.419) was not linked to increased risk of HFrH during follow up contrary to being a widow (p=0.037) despite similar age, ejection fraction, creatinine, NYHA functional class distribution and a similar rate of life-saving medications.

Conclusion: PS matching analysis yielded that the widowed had increased the risk for HFrH. Of note, widowers did not seem to have an increased risk for HFrH, contrary to widows.
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http://dx.doi.org/10.14744/nci.2020.88003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881434PMC
January 2021

Monitoring chemically and green-synthesized silver nanoparticles in maize seedlings via surface-enhanced Raman spectroscopy (SERS) and their phytotoxicity evaluation.

Talanta 2021 Apr 13;225:121952. Epub 2020 Dec 13.

Department of Biology, Ataturk University, 25240, Erzurum, Turkey. Electronic address:

The emergence of nanomaterials in consumer products has increased concern for their potential hazards in the environment and biological systems. Therefore, the monitoring of nanoparticles in biological systems is of great importance. Despite the numerous attempts, the methods to evaluate the uptake, translocation, and accumulation of nanomaterials inside the plant tissue are still limited. In this study, for the first time, we proposed the monitoring of the silver nanoparticles (AgNPs) in different tissues of the plant through surface-enhanced Raman spectroscopy (SERS) approach. For this, chemically (Che-AgNPs) and green-synthesized AgNPs (Gr-AgNPs) were prepared properly and their surfaces were functionalized with Raman-active molecule. With the contribution of electromagnetic enhancement, our NP systems provided high signal-to-noise SERS spectra. After exposure to NPs to maize seedlings as a model plant, we detected that AgNPs were accumulated mainly in the epidermis and cortex of the root and phloem parts of the shoot. Highly distinctive SERS spectra were collected from the root and shoot cross-section of each NP system. Also, the accumulation of the AgNPs was furtherly confirmed through inductively-coupled mass spectrometry and scanning electron microscopy analysis. Moreover, the exposure of AgNPs to maize seedlings led to remarkable alterations in both phytotoxic and biomolecular indicators including chlorophyll, protein and, antioxidant enzymes.
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http://dx.doi.org/10.1016/j.talanta.2020.121952DOI Listing
April 2021

Synthesis and characterization of piperazine-substituted dihydrofuran derivatives viaMn(OAc) mediated radical cyclizations.

Turk J Chem 2020 26;44(5):1303-1313. Epub 2020 Oct 26.

Department of Chemistry, Faculty of Arts and Sciences, Kocaeli University, 41380 Umuttepe, Kocaeli Turkey.

The aim of this study is to synthesize novel piperazine-containing dihydrofuran compounds (3a-n)from radical additions and cyclizations of diacyl and alkyl-acyl piperazine derivatives (1a-h) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc) for the first time. From the reactions of 1a-c with dimedone (2a);1a, 1c, and 1d with acetylacetone (2b); and 1a with ethylacetoacetate(2c) ,the dihydrofuran-piperazine compounds 3a-c, 3d-f, and 3g were obtained in medium to high yields (31%-81%), respectively. In addition, dihydrofuran-piperazine compounds 3h-j and 3k-n were prepared at low to medium yields (20%-40%) from the reactions of with and with , respectively.
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http://dx.doi.org/10.3906/kim-2003-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751941PMC
October 2020

Comparison of outcomes of Holmium enucleation of the prostate for small- and moderate-sized prostates.

Andrologia 2021 Apr 11;53(3):e13970. Epub 2021 Jan 11.

Department of Urology, Gazi University Faculty of Medicine, Ankara, Turkey.

There is an ongoing discussion in the literature on the surgical treatment option for small prostate size benign prostate hyperplasia (BPH) patients. This study aimed to evaluate the efficacy of Holmium laser enucleation of the prostate (HoLEP) surgery in small (<30 ml) and moderate (30-80 ml) prostate size as accepted in European Association of Urology guideline. We retrospectively analysed our database between May 2016 and May 2019 and patients who underwent HoLEP surgery. Patients who have prostate size <80 ml were included the study. These patients were divided into two group: group 1 with prostate size <30 ml (n: 64) and group 2 with prostate size 30-80 ml (n: 101). Enucleation time (ET), morcellation time (MT), total operation time (OT), enucleation efficiency (EE), morcellation efficiency (ME), intra- and post-operative complications were analysed. While EE and Hb drop were better in favour of group 2; PSA drop, ET, MT, OT and ME were superior in favour of group 1. In group 1, intra-operative complications were higher (6 vs. 2; p < .05) and post-operative complications did not differ statistically between groups (p = .14). No statistically significant finding was found between groups regarding incontinence. In conclusion, HoLEP is a reliable method in terms of its results in patients with small prostates.
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http://dx.doi.org/10.1111/and.13970DOI Listing
April 2021

Transposition of brachiobasilic arteriovenous fistulas: One-stage or two-stage technique and factors affecting the early maturation.

Ther Apher Dial 2020 Nov 26. Epub 2020 Nov 26.

Department of Cardiovascular Surgery, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Tibbiye Cd No 13, Istanbul, Turkey.

The brachiobasilic transposition (BBT) arteriovenous fistula (AVF) is a valuable option especially for dialysis patients with previously failed vascular access. We aim to report factors affecting the maturation of BBT-AVF created with either one-stage or two-stage technique. BBT-AVF procedures between January 2015 and May 2019 by a dedicated vascular access team were investigated retrospectively. A total of 122 patients (63 males, 59 females), with 6 to 12 weeks of follow-up after the BBT-AVF procedure were included in the study. Patients of one-stage and two-stage techniques were compared for maturation rates. Patients with successful and failed maturation were compared for baseline characteristics and anatomic factors. Of 122 BBT-AVF procedures, 54 were created with the one-stage and 68 were created with the two-stage technique. The mean age of the patients was 58.2 ± 13.8, the mean brachial artery and basilic vein diameters were 3.91 ± 1.02 mm, and 3.39 ± 1.16 mm. Of 122 included patients, 88 (72.1%) had mature AVFs at follow-up. The AVF maturation rates were similar between the one- and two-stage groups (70.4% vs 73.5%; P = .699). Lower age (62.8 ± 12.5 vs 56.5 ± 13.9; P = .023) and greater brachial artery diameter (3.09 ± 0.84 mm vs 4.23 ± 1.76 mm; P < .048) were the only factors affecting the AVF maturation in univariate analysis. Gender, extremity side, diabetes mellitus, hypertension, and targeted vein diameter were not found to affect the AVF maturation (P = .301, P = .084, P = .134, P = .858, P = .127). Target artery diameter (P = .049) was the only significant factor affecting BBT-AVF maturation in multivariate analysis. One-stage and two-stage BBT-AVFs are similar in terms of maturation rates. Targeted artery diameter was the only factor important in BBT-AVF maturation in our study group. The two-stage technique can be preferred considering smaller incision size and lower complication rate in patients with suitable anatomy.
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http://dx.doi.org/10.1111/1744-9987.13610DOI Listing
November 2020

Transport mechanisms and emission of landfill gas through various cover soil configurations in an MSW landfill using a static flux chamber technique.

J Environ Manage 2021 Feb 24;280:111677. Epub 2020 Nov 24.

Environmental Engineering, University of Colorado at Boulder, Boulder, CO, USA. Electronic address:

This study evaluated the transport mechanisms and emission rates of landfill gas (LFG) from 200- (vegetated with short grass), 300- (vegetated with short grass), and 450-mm-thick (non-vegetated) interim cover soils within a municipal solid waste landfill. LFG emission and diffusion mechanisms were evaluated using static flux chambers and laboratory-scale diffusion columns. Overall, the greatest CH and CO emissions were consistently observed from the 200-mm-thick cover soil with an average flux rate of 39.2 mg m h and 3.07 × 10 mg m h, respectively. In addition to CH and CO, HS migration through a 450-mm interim cover soil was also evaluated. The HS emission rate was relatively more uniform at an average of 2.47 × 10 mg m h. Long-term LFG emission was predicted using an emission model based on a first-order decomposition rate equation and compared with the static flux chamber method. The field-measured CO, CH and HS emissions were less than the estimated emissions from the emission model, by 22%, 85%, and 91%, respectively. Further, the diffusion coefficients of CH, CO, and HS for the interim cover soils were determined using a laboratory-scale diffusion column test and compared with a three-parameter diffusion model. The measured and estimated diffusion coefficients for the three landfill gases were within the 10% variation limits. Based on these findings, the LFG emission rate varied depending on the physical-chemical properties of the cover soil (e.g., cover thickness, moisture content, compaction ratio, uneven distribution of soil), organic material content and age of buried refuse, and seasonal environmental conditions (such as temperature). Test results showed that fugitive CH emissions can be reduced one fourth by utilizing an appropriate cover soil (300-mm to 450-mm, CL) compared to cases with a thinner cover soil.
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http://dx.doi.org/10.1016/j.jenvman.2020.111677DOI Listing
February 2021

Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.

N Engl J Med 2021 01 13;384(2):105-116. Epub 2020 Nov 13.

From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California; Estudios Clínicos Latino América, Rosario, Argentina (R.D.); the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina; the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom; Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.); the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.); the University of Minnesota, Minneapolis (I.A.); Instituto Nacional de Cardiología, Mexico City (A.A.-M.); the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.); Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.); Medical University of Vienna, Vienna (D.B.); Pontificia Universidad Católica de Chile, Santiago (R.C.); Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.); the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.); Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.); University of Utah, Salt Lake City (J.C.F.); National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.); Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.); Commenius University, Bratislava, Slovakia (E.G.); the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.); Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada; the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.); the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.); Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.); St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.); University Clinic of Lomonosov, Moscow State University, Moscow (V.M.); Saitama Citizens Medical Center, Saitama, Japan (S.M.); Institute of Cardiology, Kyiv, Ukraine (A.P.); Wroclaw Medical University, Wroclaw, Poland (P.P.); Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.); Vilnius University, Vilnius, Lithuania (P.S.); the University of Cape Town, Cape Town, South Africa (K.S.); the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.); the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.); St. John of God Hospital, Budapest, Hungary (J.T.); AZ Sint-Lucas, Ghent, Belgium (H.V.); the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.); the University of Groningen, Groningen, the Netherlands (A.A.V.); Dokuz Eylul University, Izmir, Turkey (M.B.Y.); and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France.

Background: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown.

Methods: We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes.

Results: During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups.

Conclusions: Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016-002299-28.).
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http://dx.doi.org/10.1056/NEJMoa2025797DOI Listing
January 2021

HoLEP after prostate biopsy: does it have any impact?

World J Urol 2020 Nov 13. Epub 2020 Nov 13.

Department of Urology, Gazi University School of Medicine, Ankara, Turkey.

Purpose: Holmium laser enucleation of the prostate (HoLEP) has recently become the recommended treatment for prostate in all sizes in benign prostate hyperplasia surgery. A recent prostate biopsy performed prior to the HoLEP procedure can make surgeons concerned about the surgery. We aimed to investigate the per- and postoperative outcomes of the HoLEP procedure in patients who underwent prostate biopsy and to evaluate the most appropriate surgery time after biopsy.

Methods: The data of 160 patients who underwent HoLEP by a single surgeon between March 2017 and December 2019 were retrospectively reviewed. The patients were divided into two groups, Group 1 consisted of 80 patients without prostate biopsy and Group 2 consisted of 80 patients with prior prostate biopsy. All HOLEP procedures in group 2 were performed at least 2 weeks following biopsy. Per- and postoperative outcomes, complications were evaluated.

Results: No significant differences were found between groups in terms of by enucleation time, efficiency of laser, efficiency of enucleation, hospitalization time, and catheterization removal time. Only morcellation time was shorter in biopsy naïve patients. There were no statistical differences in postoperative outcomes. Previous prostate biopsy did not affect the continence status in our study group. There were not any Clavien grade 4 or higher complications. Urinary tract infection was higher in early post-biopsy period, there was no difference among the groups. CONCLUSıON: Our study confirms that HoLEP is a safe and efficient surgical procedure for the patients with prior prostate biopsy. We believe that it can be safely performed 2nd week following prostate biopsy.
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http://dx.doi.org/10.1007/s00345-020-03518-zDOI Listing
November 2020

De Ritis ratio: how effectively can we use in bladder cancer management?

Biomark Med 2020 10 5;14(15):1453-1460. Epub 2020 Nov 5.

Department of Urology, University of Health Sciences, Bagcilar Training & Research Hospital, Istanbul, Turkey.

This study aims to determine the relationship between the pre-operative De Ritis ratio (DRR) and bladder cancer (BCa) pathological subtypes. A total of 248 patients with primary BCa were included. Univariate and multivariate analyses were performed to identify whether DRR can be a risk factor for the presence of carcinoma (C). There was a statistically significant difference between the nonmuscle invasive BCa risk groups and the muscle-invasive BCa group according to the median DRR levels (p < 0.001). DRR was an independent risk factor for the presence of C in multivariate analysis (OR: 1.909; 95% CI: 0.030-0.196; p = 0.008). DRR can be considered as an independent risk factor for the presence of C in patients with primary BCa.
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http://dx.doi.org/10.2217/bmm-2020-0212DOI Listing
October 2020