Mehmet Toner

Mehmet Toner

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Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring.

Recent Results Cancer Res 2020 ;215:77-88

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/978-3-030-26439-0_4DOI Listing
January 2020

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping.

Cell Stem Cell 2019 Oct 3;25(4):570-583.e7. Epub 2019 Jul 3.

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114, USA; Harvard Stem Cell Institute, 7 Divinity Ave., Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193026
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http://dx.doi.org/10.1016/j.stem.2019.06.003DOI Listing
October 2019

Leveraging the zebrafish to model organ transplantation.

Curr Opin Organ Transplant 2019 Oct;24(5):613-619

Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School.

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http://dx.doi.org/10.1097/MOT.0000000000000696DOI Listing
October 2019

Supercooling extends preservation time of human livers.

Nat Biotechnol 2019 Oct 9;37(10):1131-1136. Epub 2019 Sep 9.

Center for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0223-yDOI Listing
October 2019

Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation.

Annu Rev Biomed Eng 2019 Jun 10;21:1-31. Epub 2018 Dec 10.

Center for Engineering in Medicine and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA; email: , ,

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052130DOI Listing
June 2019

Preface to the Interfaces and Biology 1: Cryobiology Special Issue.

Langmuir 2019 Jun;35(23):7335-7336

Guest Co-Editor, Helen Andrus Professor of Bioengineering , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts , United States.

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http://dx.doi.org/10.1021/acs.langmuir.9b01226DOI Listing
June 2019

Immunofunctional photodegradable poly(ethylene glycol) hydrogel surfaces for the capture and release of rare cells.

Colloids Surf B Biointerfaces 2019 Feb 20;174:483-492. Epub 2018 Nov 20.

Department of Chemical Engineering, University of Wyoming, Laramie, WY 82071, United States. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2018.11.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545105PMC
February 2019

Liquid biopsy: a perspective for probing blood for cancer.

Lab Chip 2019 02;19(4):548-549

Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://xlink.rsc.org/?DOI=C8LC90117A
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http://dx.doi.org/10.1039/c8lc90117aDOI Listing
February 2019

Rapid Isolation and Concentration of Pathogenic Fungi Using Inertial Focusing on a Chip-Based Platform.

Front Cell Infect Microbiol 2019 12;9:27. Epub 2019 Feb 12.

Rhode Island Hospital, Alpert Medical School and Brown University, Providence, RI, United States.

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http://dx.doi.org/10.3389/fcimb.2019.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379272PMC
February 2019

On-chip oocyte denudation from cumulus-oocyte complexes for assisted reproductive therapy.

Lab Chip 2018 12;18(24):3892-3902

BioMEMS Resource Center, The Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

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http://xlink.rsc.org/?DOI=C8LC01075G
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http://dx.doi.org/10.1039/c8lc01075gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335650PMC
December 2018

Role of synthetic antifreeze agents in catalyzing ice nucleation.

Cryobiology 2018 10 22;84:91-94. Epub 2018 Aug 22.

The Center for Engineering in Medicine and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, United States; Shriners Hospital for Children, Boston, MA, 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cryobiol.2018.08.010DOI Listing
October 2018

Janus-faced role of water in defining nanostructure of choline chloride/glycerol deep eutectic solvent.

Phys Chem Chem Phys 2018 Sep;20(35):22455-22462

BioMEMS Resource Center, The Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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http://xlink.rsc.org/?DOI=C8CP03882A
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http://dx.doi.org/10.1039/c8cp03882aDOI Listing
September 2018

Effect of Ice Nucleation and Cryoprotectants during High Subzero-Preservation in Endothelialized Microchannels.

ACS Biomater Sci Eng 2018 Aug 26;4(8):3006-3015. Epub 2018 Jun 26.

Center for Engineering in Medicine and BioMEMS Resource Center, Surgical Services, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.

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http://dx.doi.org/10.1021/acsbiomaterials.8b00648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753837PMC
August 2018

Anti-thrombotic strategies for microfluidic blood processing.

Lab Chip 2018 07;18(15):2146-2155

BioMEMS Resource Center, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c8lc00035bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082414PMC
July 2018

Oscillatory inertial focusing in infinite microchannels.

Proc Natl Acad Sci U S A 2018 07 10;115(30):7682-7687. Epub 2018 Jul 10.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1721420115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065022PMC
July 2018

Cryopreservation of infectious Cryptosporidium parvum oocysts.

Nat Commun 2018 07 23;9(1):2883. Epub 2018 Jul 23.

Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, 01536, USA.

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http://dx.doi.org/10.1038/s41467-018-05240-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056504PMC
July 2018

Molecular Dynamics at the Interface between Ice and Poly(vinyl alcohol) and Ice Recrystallization Inhibition.

Langmuir 2018 05 13;34(17):5116-5123. Epub 2017 Dec 13.

Center for Engineering in Medicine and BioMEMS Resource Center , Massachusetts General Hospital, Harvard Medical School , Boston , Massachusetts 02129 , United States.

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http://dx.doi.org/10.1021/acs.langmuir.7b03243DOI Listing
May 2018

Ultra-fast vitrification of patient-derived circulating tumor cell lines.

PLoS One 2018 23;13(2):e0192734. Epub 2018 Feb 23.

BioMEMS Resource Center, Center for Engineering in Medicine & Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192734PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825040PMC
April 2018

Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity.

Cold Spring Harb Symp Quant Biol 2016 7;81:269-274. Epub 2017 Apr 7.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1101/sqb.2016.81.031120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501288PMC
February 2018

A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability.

Lab Chip 2017 11;17(23):4077-4088

The Center for Engineering in Medicine, BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1039/c7lc00883jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702951PMC
November 2017

Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells.

Sci Rep 2017 09 7;7(1):10936. Epub 2017 Sep 7.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-11119-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589885PMC
September 2017

Clusters of Circulating Tumor Cells: a Biophysical and Technological Perspective.

Curr Opin Biomed Eng 2017 Sep 10;3:13-19. Epub 2017 Aug 10.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.

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http://dx.doi.org/10.1016/j.cobme.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720146PMC
September 2017

Non-equilibrium Inertial Separation Array for High-throughput, Large-volume Blood Fractionation.

Sci Rep 2017 08 30;7(1):9915. Epub 2017 Aug 30.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-10295-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577162PMC
August 2017

Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions.

Sci Rep 2017 07 18;7(1):5658. Epub 2017 Jul 18.

BioMEMS Resource Center, Center for Engineering in Medicine, & Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-05978-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515929PMC
July 2017

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry.

Sci Rep 2017 05 26;7(1):2433. Epub 2017 May 26.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-01150-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446400PMC
May 2017

Controlled ice nucleation using freeze-dried Pseudomonas syringae encapsulated in alginate beads.

Cryobiology 2017 04 14;75:1-6. Epub 2017 Mar 14.

Center for Engineering in Medicine and BioMEMS Resource Center, Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, United States; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States; Shriners Hospital for Children, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cryobiol.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501296PMC
April 2017

Cryopreservation of human spermatozoa with minimal non-permeable cryoprotectant.

Cryobiology 2016 10 4;73(2):162-7. Epub 2016 Aug 4.

Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cryobiol.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519348PMC
October 2016

Single-step electrical field strength screening to determine electroporation induced transmembrane transport parameters.

Biochim Biophys Acta 2016 09 3;1858(9):2041-2049. Epub 2016 Jun 3.

The Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.

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http://dx.doi.org/10.1016/j.bbamem.2016.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509163PMC
September 2016

Bacterial Ice Nucleation in Monodisperse D2O and H2O-in-Oil Emulsions.

Langmuir 2016 09 18;32(36):9229-36. Epub 2016 Aug 18.

Shriners Hospital for Children, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acs.langmuir.6b02212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501280PMC
September 2016

Deformability-based cell selection with downstream immunofluorescence analysis.

Integr Biol (Camb) 2016 05 21;8(5):654-64. Epub 2016 Mar 21.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1039/c5ib00284bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868639PMC
May 2016

Clusters of circulating tumor cells traverse capillary-sized vessels.

Proc Natl Acad Sci U S A 2016 May 18;113(18):4947-52. Epub 2016 Apr 18.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Shriners Hospital for Children, Boston, MA 02114

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http://dx.doi.org/10.1073/pnas.1524448113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983862PMC
May 2016

Engineered Trehalose Permeable to Mammalian Cells.

PLoS One 2015 26;10(6):e0130323. Epub 2015 Jun 26.

The Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130323PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482662PMC
April 2016

Flexible Octopus-Shaped Hydrogel Particles for Specific Cell Capture.

Small 2016 Apr 1;12(15):2001-2008. Epub 2016 Mar 1.

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1002/smll.201600163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903076PMC
April 2016

The Role of Physical Stabilization in Whole Blood Preservation.

Sci Rep 2016 Feb 15;6:21023. Epub 2016 Feb 15.

BioMEMS Resource Center, Center for Engineering in Medicine, &Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/srep21023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753451PMC
February 2016

Live pups from evaporatively dried mouse sperm stored at ambient temperature for up to 2 years.

PLoS One 2014 12;9(6):e99809. Epub 2014 Jun 12.

Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, Massachusetts, United States of America; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099809PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055687PMC
December 2015

Deformability of Tumor Cells versus Blood Cells.

Sci Rep 2015 Dec 18;5:18542. Epub 2015 Dec 18.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1038/srep18542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683468PMC
December 2015

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition.

Trends Cancer 2015 Sep 28;1(1):44-52. Epub 2015 Sep 28.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02129, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2015.07.006DOI Listing
September 2015

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

Science 2015 Sep;349(6254):1351-6

Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/science.aab0917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872391PMC
September 2015

A computational study of circulating large tumor cells traversing microvessels.

Comput Biol Med 2015 Aug 10;63:187-95. Epub 2015 Jun 10.

Department of Surgery and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.compbiomed.2015.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819961PMC
August 2015

A microfluidic device for label-free, physical capture of circulating tumor cell clusters.

Nat Methods 2015 Jul 18;12(7):685-91. Epub 2015 May 18.

1] Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490017PMC
July 2015

Continuous Flow Microfluidic Bioparticle Concentrator.

Sci Rep 2015 Jun 10;5:11300. Epub 2015 Jun 10.

1] BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA [2] Shriners Hospital for Children, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.1038/srep11300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462155PMC
June 2015

MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.

Mol Cancer Res 2015 May 12;13(5):934-43. Epub 2015 Feb 12.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts. Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433453PMC
May 2015

Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.

Adv Mater 2015 Mar 15;27(9):1593-9. Epub 2015 Jan 15.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA, 02129, USA; Shriners Hospital for Children, Harvard Medical School, 51 Blossom Street, Boston, MA, 02114, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School 55, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1002/adma.201404677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492283PMC
March 2015

"Universal" vitrification of cells by ultra-fast cooling.

Technology (Singap World Sci) 2015 Mar;3(1):64-71

BioMEMS Resource Center, Mass achusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, MA.

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http://dx.doi.org/10.1142/S2339547815500053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404302PMC
March 2015

Fast sorting of CD4+ T cells from whole blood using glass microbubbles.

Technology (Singap World Sci) 2015 Mar;3(1):38-44

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1142/S2339547815500016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493921PMC
March 2015

Bioengineered implantable scaffolds as a tool to study stromal-derived factors in metastatic cancer models.

Cancer Res 2014 Dec 22;74(24):7229-38. Epub 2014 Oct 22.

Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts. Harvard Stem Cell Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267901PMC
December 2014

Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering.

Nat Nanotechnol 2014 Dec;9(12):969-80

Department of Computer and Electrical Engineering, University of Toronto, Toronto, Ontario M5S 1A4, Canada.

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http://dx.doi.org/10.1038/nnano.2014.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472305PMC
December 2014

Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.

Nat Commun 2014 Dec 9;5:5662. Epub 2014 Dec 9.

1] Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts 02114, USA [2] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/ncomms6662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261930PMC
December 2014

Collective and individual migration following the epithelial-mesenchymal transition.

Nat Mater 2014 Nov 17;13(11):1063-71. Epub 2014 Aug 17.

BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nmat4062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209198PMC
November 2014

Brain tumor cells in circulation are enriched for mesenchymal gene expression.

Cancer Discov 2014 Nov 19;4(11):1299-309. Epub 2014 Aug 19.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221467PMC
November 2014

A Raman microspectroscopy study of water and trehalose in spin-dried cells.

Biophys J 2014 Nov;107(10):2253-62

The Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts. Electronic address:

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http://www.cell.com/cms/attachment/2022827986/2043284002/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S000634951401006
Publisher Site
http://dx.doi.org/10.1016/j.bpj.2014.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241435PMC
November 2014

Inertial focusing in microfluidics.

Annu Rev Biomed Eng 2014 Jul 29;16:371-96. Epub 2014 May 29.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, Massachusetts 02114; email:

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http://dx.doi.org/10.1146/annurev-bioeng-121813-120704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467210PMC
July 2014

Supercooling enables long-term transplantation survival following 4 days of liver preservation.

Nat Med 2014 Jul 29;20(7):790-3. Epub 2014 Jun 29.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141719PMC
July 2014

Inertio-elastic focusing of bioparticles in microchannels at high throughput.

Nat Commun 2014 Jun 18;5:4120. Epub 2014 Jun 18.

Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/ncomms5120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476514PMC
June 2014

Isolation and molecular characterization of circulating melanoma cells.

Cell Rep 2014 May 18;7(3):645-53. Epub 2014 Apr 18.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Howard Hughes Medical Institute, Bethesda, MD 20815, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00217-4.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400217
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http://dx.doi.org/10.1016/j.celrep.2014.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079008PMC
May 2014

Discontinuous nanoporous membranes reduce non-specific fouling for immunoaffinity cell capture.

Small 2013 Dec 13;9(24):4207-14. Epub 2013 Jun 13.

BioMEMS Resource Center, Center for Engineering in Medicine and Department of Surgery, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://doi.wiley.com/10.1002/smll.201300977
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http://dx.doi.org/10.1002/smll.201300977DOI Listing
December 2013

Magnetic barcode assay for genetic detection of pathogens.

Nat Commun 2013 ;4:1752

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncomms2745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635151PMC
November 2013

Nanotechnology: emerging tools for biology and medicine.

Genes Dev 2013 Nov;27(22):2397-408

Center for Biomedical Engineering, School of Engineering.

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http://dx.doi.org/10.1101/gad.226837.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841729PMC
November 2013

Mitochondrial localization and the persistent migration of epithelial cancer cells.

Biophys J 2013 May;104(9):2077-88

Harvard-MIT Division of Health-Science Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.bpj.2013.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647149PMC
May 2013

3D multi-isotope imaging mass spectrometry reveals penetration of 18O-trehalose in mouse sperm nucleus.

PLoS One 2012 27;7(8):e42267. Epub 2012 Aug 27.

National Resource for Imaging Mass Spectrometry, Division of Genetics, Harvard Medical School, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042267PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428319PMC
February 2013

Metabolic preconditioning of mammalian cells: mimetic agents for hypoxia lack fidelity in promoting phosphorylation of pyruvate dehydrogenase.

Cell Tissue Res 2013 Jan 9;351(1):99-106. Epub 2012 Nov 9.

Department of Biological Sciences, Division of Cellular, Developmental and Integrative Biology, Louisiana State University, Baton Rouge, LA 70803, USA.

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http://dx.doi.org/10.1007/s00441-012-1517-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537919PMC
January 2013

Inertial focusing cytometer with integrated optics for particle characterization.

Technology (Singap World Sci) 2013;1(1):27-36

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA 02114, USA.

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http://dx.doi.org/10.1142/S233954781350009XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206911PMC
January 2013

Late embryogenesis abundant proteins protect human hepatoma cells during acute desiccation.

Proc Natl Acad Sci U S A 2012 Dec 26;109(51):20859-64. Epub 2012 Nov 26.

Division of Cellular, Developmental, and Integrative Biology, Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.

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http://dx.doi.org/10.1073/pnas.1214893109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529014PMC
December 2012

Nanoporous micro-element arrays for particle interception in microfluidic cell separation.

Lab Chip 2012 Sep 5;12(17):3159-67. Epub 2012 Jul 5.

BioMEMS Resource Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1039/c2lc40109fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005922PMC
September 2012

Visualization of microscale particle focusing in diluted and whole blood using particle trajectory analysis.

Lab Chip 2012 Jun 1;12(12):2199-210. Epub 2012 Mar 1.

Electrical Engineering and Computer Science Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c2lc21100aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211080PMC
June 2012

Biopolymer system for cell recovery from microfluidic cell capture devices.

Anal Chem 2012 Apr 3;84(8):3682-8. Epub 2012 Apr 3.

Harvard-MIT Division of Health Sciences and Technology, Massachussets Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/ac300190jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328665PMC
April 2012

Inertial focusing dynamics in spiral microchannels.

Phys Fluids (1994) 2012 Mar 6;24(3):32001. Epub 2012 Mar 6.

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http://dx.doi.org/10.1063/1.3681228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311666PMC
March 2012

Antibody-functionalized fluid-permeable surfaces for rolling cell capture at high flow rates.

Biophys J 2012 Feb 21;102(4):721-30. Epub 2012 Feb 21.

BioMEMS Resource Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.bpj.2011.12.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283808PMC
February 2012