Publications by authors named "Mehmet Kola"

29 Publications

  • Page 1 of 1

The clinical use of ultra - Wide field imaging and intravenous fluorescein angiography in infants with retinopathy of prematurity.

Photodiagnosis Photodyn Ther 2021 Nov 26;37:102658. Epub 2021 Nov 26.

Department of Ophthalmology, Karadeniz Technical University, Faculty of Medicine, Tip Fakultesi, Goz Hastaliklari Klinigi, Farabi Caddesi, Trabzon 61080, Turkey.

Purpose: To investigate the potential benefits and practicality of ultra - wide field (UWF) imaging and intravenous UWF fluorescein angiography (IV UWF - FA) in infants with retinopathy of prematurity (ROP) using an Optos® California device.

Methods: This retrospective study involved 46 infants with a history of ROP who underwent UWF imaging with or without IV UWF - FA. ROP characteristics were identified using UWF color imaging. Retinal vascular findings following treatment were also assessed at IV UWF - FA analysis. All imaging sessions were performed under topical anesthesia without sedation. Main outcomes were the appearance of ROP at UWF color imaging and IV UWF-FA analysis, including status of ROP, neovascularizations, presence of plus disease, retinal vascular details, and resolution after treatment.

Results: Seven (three girls) of the 46 infants (22 girls) underwent IV UWF-FA. Twelve IV UWF-FA sessions were performed in total. The oldest infant during IV UWF-FA analysis was at 55 postmenstrual weeks. Clinical characteristics of disease were easily identified at UWF color imaging. IV UWF-FA images also clearly revealed non-perfused retinal areas, fluorescein leakage, macular edema, retinal vascular abnormalities, and the status of the peripheral vascular termini. Complications of IV UWF-FA occurred in one infant in the form of patchy yellow skin discoloration around the injection site which completely disappeared on the first day following the procedure.

Conclusions: Providing a high resolution panoramic view of the retina in a single image capture with no need for contact with the cornea appear to represent potential advantages of UWF imaging in infants with ROP. IV UWF-FA also seems to be a safe procedure which can be performed under topical anesthesia and that shows detailed retinal vascular alterations in patients with ROP.
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http://dx.doi.org/10.1016/j.pdpdt.2021.102658DOI Listing
November 2021

Infliximab therapy provides beneficial effects for choroidal thickness increase in patients with active ankylosing spondylitis: A possible mechanism mediating the suppressing of uveitis attacks.

Arch Rheumatol 2021 Mar 4;36(1):56-62. Epub 2020 Sep 4.

Department of Ophthalmology, Karadeniz Technical University Medical School, Trabzon, Turkey.

Objectives: This study aims to quantitatively assess the profile of the choroidal thickness (ChT) in patients with ankylosing spondylitis (AS) using optical coherence tomography (OCT), and to examine whether the posterior eye segment abnormalities in active AS patients are reversible by infliximab therapy.

Patients And Methods: October 2014 and March 2016 Thirty-one patients with AS (22 males, 9 females; mean age 39.6±12.3 years; range, 22 to 68 years) and 24 healthy controls (16 males, 8 females; mean age 40.8±8.9 years; range, 35 to 61 years) were enrolled. Patients' clinical and demographic characteristics were recorded. Using OCT, we performed retinal nerve fiber layer (RNFL) thickness, ganglion cell complex, and ChT measurements in AS patients before and six months after the initiation of infliximab therapy, and in healthy controls.

Results: At baseline, patients with AS had higher ChT (mean±standard deviation: 347.5±114.4 μm) compared to healthy controls (322.1±62.8 μm), although this did not reach statistical significance level (p=0.283). At six months after the first measurement, the mean ChT was significantly decreased (under infliximab therapy: 326.5±99.7 μm vs. before: 347.5±114.4 μm, p=0.018) in AS group, while no significant change was observed in the control group (p=0.102). RNFL thickness in the AS group was significantly decreased after six months of treatment with infliximab (p=0.008).

Conclusion: By evaluating the posterior eye segment of patients with AS using OCT, this study has demonstrated that active AS patients had higher ChT. The significant reduction in this ChT after infliximab therapy may be mediating the established effective suppressing action of infliximab on uveitis attacks.
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http://dx.doi.org/10.46497/ArchRheumatol.2021.7806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140873PMC
March 2021

Sedoanalgesia modality during laser photocoagulation for retinopathy of prematurity: Intraoperative complications and early postoperative follow-up.

Ulus Travma Acil Cerrahi Derg 2020 Sep;26(5):754-759

Department of Neonatology, Karadeniz Technical University Faculty of Medicine, Trabzon-Turkey.

Background: Laser photocoagulation (LPC) is a surgical procedure used in the treatment of premature retinopathy that may cause retinal detachment and blindness if not diagnosed and treated early. The anesthesia method used in LPC varies from sedoanalgesia to general anesthesia and airway management varies from spontaneous ventilation to endotracheal intubation. In this study, we aimed to evaluate the effectiveness of sedoanalgesia applications and this anesthesia procedure concerning intraoperative and postoperative complications by avoiding intubation and mechanical ventilation in premature infants with a fragile population.

Methods: This retrospective study included 89 patients who underwent laser photocoagulation under anesthesia for premature retinopathy. Patients' demographic characteristics, preoperative risk factors, anesthesia technique, especially airway management, changes in ventilation status during surgery, intraoperative complications, postoperative complications, and intensive care follow-up, were recorded and analyzed statistically.

Results: Two of the 89 patients who underwent laser photocoagulation were excluded from this study because they were followed up intubated. The number of patients who received mask ventilation due to intraoperative complications was 12 (13.8%). The mean operation time was 36.2±10.1 minutes. In 86.2% (n=75) of the patients, the surgical procedure was completed with sedoanalgesia while maintaining spontaneous ventilation.

Conclusion: Sedoanalgesia application during the surgical intervention of patients with Retinopathy of Prematurity (ROP) requiring early diagnosis and emergency treatment will minimize intraoperative and postoperative complications. We believe that sedoanalgesia as an anesthetic method can be applied as an effective alternative method while preserving spontaneous ventilation.
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http://dx.doi.org/10.14744/tjtes.2020.62378DOI Listing
September 2020

The role of simple inflammatory blood parameters in idiopathic epiretinal membrane patients.

Int Ophthalmol 2021 Jan 26;41(1):107-112. Epub 2020 Aug 26.

The State Hospital of Bayburt, Bayburt, Turkey.

Aim: To evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in idiopathic epiretinal membrane (IERM) patients, and their relations with visual acuity.

Method: Fifty-seven IERM and 51 control patients were included. All patients underwent comprehensive ophthalmological examination and complete blood count tests, and NLR and PLR values were calculated. Patients with IERM were compared with the control group, and associations with visual prognosis were evaluated. These ratios' cut-off values for IERM were also calculated RESULTS: NLR values were statistically significantly higher in the IERM group than in the control group (p = 0.001). No significant difference was observed between the IERM and control groups in terms of PLR (p = 0.43). No significant correlation was determined between visual acuity and NLR or PLR (r = 0.05, p = 0.66; and r = 0.18, p = 0.16, respectively). The cut-off value for NLR was 1.91.

Conclusion: Patients with IERM showed significantly increased NLR compared to control subjects suggesting that IERM patients may be prone to have high NLR values.
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http://dx.doi.org/10.1007/s10792-020-01557-4DOI Listing
January 2021

The efficacy of subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy.

Lasers Med Sci 2021 Jul 19;36(5):981-988. Epub 2020 Aug 19.

Department of Ophthalmology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.

Central serous chorioretinopathy (CSC) is a disease characterized by a well-defined serous detachment of the neurosensory retina. Therapeutic options in chronic cases are limited, and side effects can result in a limited response. The aim of this article is to assess the efficacy of subthreshold micropulse laser therapy in patients with chronic central serous chorioretinopathy. The study included 20 eyes of 19 patients who had a history of chronic or chronic recurrent CSC and who underwent subthreshold micropulse laser therapy between January 2015 and June 2018. Twenty eyes of 19 patients with a mean age of 48.9 ± 9.40 years were included. The mean visual acuity was 0.24 ± 0.28 logMAR before laser, 0.19 ± 0.25 logMAR 3 months after laser, and 0.18 ± 0.27 logMAR after 6 months. A statistically significant difference was determined in terms of visual acuity before and after treatment (p = 0.0001). The mean central retinal thickness was 308.10 ± 95.25 μm before laser, 233.65 ± 81.17 μm 3 months after laser, and 203.88 ± 72.79 μm at 6 months. A statistically significant relationship was present between visual acuity and the duration of disease (p = 0.001), between visual acuity and the outer nuclear layer thickness (p = 0.005), and between the outer nuclear layer thickness and the duration of disease in chronic cases (p = 0.008). There was no evidence of retinal pigment epithelium or retinal damage on optical coherence tomography or fundus autofluorescence secondary to subthreshold micropulse laser therapy. Visual acuity appears to be more associated with the duration of disease and with changes in the outer nuclear layer thickness in chronic CSC. Subthreshold micropulse laser therapy seems to be effective at treating chronic CSC, while it increases success during early period of the disease before the development of permanent retinal damage.
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http://dx.doi.org/10.1007/s10103-020-03129-5DOI Listing
July 2021

Wernicke`s encephalopathy manifesting with diplopia after ileojejunostomy: report of a pediatric case with Hirschsprung disease.

Turk J Pediatr 2020 ;62(2):310-314

Departments of Pediatric Neurology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.

Background: Wernicke`s encephalopathy (WE) is a coenzyme-induced disease with acute neuropsychiatric symptoms leading to high mortality and morbidity due to thiamine deficiency. WE is mostly caused by alcoholism in adult populations; however, it is often associated with gastrointestinal surgical procedures, recurrent vomiting, chronic diarrhea, cancer and chemotherapy treatment, systemic diseases, drugs, magnesium deficiency, and malnutrition in children. Although these predisposing factors are considered to be uncommon in children, they are actually highly frequent and can be fatal if not treated promptly.

Case: In this report, we present a patient who developed diplopia during total parenteral nutrition following surgical resection and was diagnosed with WE. The findings of the patient's cranial magnetic resonance imaging (MRI) findings were consistent with those of WE and the ocular findings of the patient resolved completely after thiamine treatment.

Conclusion: Although WE is rare in children it can be prevented by early diagnosis and treatment and oculomotor findings such as diplopia can be a warning sign.
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http://dx.doi.org/10.24953/turkjped.2020.02.019DOI Listing
August 2021

Characteristics and Seasonal Variations of Rhegmatogenous Retinal Detachment in the Eastern Black Sea Region of Turkey: 8-Year Results.

Turk J Ophthalmol 2020 04;50(2):94-98

Karadeniz Technical University Faculty of Medicine, Department of Ophthalmology, Trabzon, Turkey.

Objectives: To assess seasonal variations in the incidence of rhegmatogenous retinal detachment (RRD) in the Eastern Black Sea region of Turkey.

Materials And Methods: Patients presenting due to primary RRD to a university hospital operating as a reference clinic in the region between 2011 and 2018 were evaluated retrospectively. Patients' ages, sex, affected eye, and presentation times were recorded. Years were divided into months, quarters, seasons, and half-year periods, and these periods were analyzed in terms of differences in patient numbers.

Results: Two hundred eighty-one eyes of 276 patients meeting the study criteria were included. The patients' mean age was 60.2 years, and the male:female ratio was 1.35:1. Right and left eye rates were similar. Detachments were most common (49.4%) in the upper temporal quadrant. Eighty-nine patients (31.6%) had undergone uncomplicated phacoemulsification surgery a mean 2.7 years previously. The mean annual case number was 35.13±5.43, and no statistically significant variation was determined in case numbers by year (p=0.558). Analysis of all years revealed a monthly mean case number of 23.42±4.4, with the highest number of cases, 29 (10.3%), being seen in September and the lowest number, 13 (4.7%), in December. No statistically significant monthly variation was determined (p=0.613). Similarly, no statistically significant variation was observed in case numbers analyzed by quarter, season, or half-year (p>0.05).

Conclusion: The incidence of cases of uncomplicated RRD does not exhibit seasonal variation in our region. We also think that since 31.6% had a history of cataract surgery, patients undergoing phacoemulsification surgery, even if uncomplicated, should be periodically assessed for detachment.
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http://dx.doi.org/10.4274/tjo.galenos.2019.59140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204898PMC
April 2020

Repeatability and Agreement of Macular Thickness Measurements Obtained with Two Different Scan Modes of the Optovue RTVue Optical Coherence Tomography Device

Turk J Ophthalmol 2019 Apr;49(2):78-83

Karadeniz Technical University Faculty of Medicine, Department of Ophthalmology, Trabzon, Turkey

Objectives: To evaluate the repeatability and agreement of macular thickness measurements obtained with E-MM5 and MM6, two different scan modes, on the Optovue RTVue optic coherence tomography (OCT) device.

Materials And Methods: Three consecutive macular thickness measurements in 30 healthy volunteers were taken using the OCT device E-MM5 and MM6 scan modes. The repeatability and agreement of these measurements obtained from the two scan modes and divided into nine anatomical regions based on early treatment diabetic retinopathy study were subjected to statistical analysis.

Results: The mean age of the participants was 29.7±6.39 years. Intraclass correlation (all ICC values ≥0.86) and coefficient of variation (all coefficient of variation values ≤2%) analyses of consecutive OCT measurements in the nine regions of the macula obtained in both E-MM5 and MM6 scan modes gave high repeatability rates. Mean macular thickness values in the foveal region were 243.76±21.79 μm in E-MM5 mode and 247.04±19.83 μm in MM6 mode (p=0.543). Values for measurements obtained in E-MM5 and MM6 scan modes in parafoveal macular regions were also statistically similar (p>0.05 for all). However, a statistically significant difference was observed between the two modes in perifoveal macular measurements, except in the superior region.

Conclusion: The Optovue RTVue OCT device gives highly repeatable measurement results for macular thicknesses in both E-MM5 and MM6 scan modes. However, it should be considered that measurements performed in E-MM5 and MM6 modes give different results in perifoveal regions.
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http://dx.doi.org/10.4274/tjo.galenos.2018.88972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517858PMC
April 2019

ACCIDENTAL DUPLICATION: Investigation of the effect of hemoglobin F and A levels on development of retinopathy of prematurity.

J AAPOS 2017 Jun 3. Epub 2017 Jun 3.

Karadeniz Technical University, Faculty of Medicine, Department of Pediatric Disease, Trabzon, TURKEY.

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.jaapos.2017.03.006. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
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http://dx.doi.org/10.1016/j.jaapos.2017.02.007DOI Listing
June 2017

Evaluation of the effects on choroidal thickness of bimatoprost 0.03% versus a brinzolamide 1.0%/timolol maleate 0.5% fixed combination.

Cutan Ocul Toxicol 2017 Dec 25;36(4):397-403. Epub 2017 Apr 25.

a Faculty of Medicine , Department of Ophthalmology, Karadeniz Technical University , Trabzon , Turkey.

Objective: To investigate the effects of two different medical treatment options on choroidal thickness (CT) in cases of open-angle glaucoma (OAG).

Methods: Sixty-seven eyes newly diagnosed with OAG and 52 healthy eyes constituting the control group were included in the study. Glaucomatous eyes were randomly divided into two subgroups; Group I was started on bimatoprost 0.03% and Group II on a brinzolamide 1.0%/timolol maleate 0.5% fixed combination (BTFC). Intraocular pressure (IOP), ocular pulse amplitude (OPA) and subfoveal CT measurements were performed in all eyes in the study before treatment and on weeks 2, 4 and 8 after treatment.

Results: Mean initial IOP values in groups I and II and the control group were 25.5 ± 4.7, 25.1 ± 5.2 and 16.1 ± 2.9 mmHg, mean OPA values were 3.7 ± 1, 3.6 ± 1.4 and 2.4 ± 0.6 mmHg and mean CT values were 269.4 ± 83, 264.5 ± 84.4 and 320.1 ± 56.6 μm, respectively. Eight weeks after treatment, mean IOP values in Groups I and II and the control group were 18.3 ± 2.6, 18.1 ± 3.4 and 15.7 ± 2.9 mmHg, mean OPA values were 2.9 ± 1.2, 2.8 ± 1.5 and 2.3 ± 0.8 mmHg and mean CT values were 290.2 ± 87.3, 271.8 ± 82.5 and 319.3 ± 56.8 μm, respectively. No significant difference was determined in terms of the decrease in IOP and OPA obtained after treatment in Group I and Group II. However, a significant difference was observed between the two groups in terms of choroidal thickening after treatment.

Conclusion: The use of topical ocular hypotensive medication in eyes with OAG results in an increase in CT. This increase is relatively greater with bimatoprost 0.03% therapy compared to BTFC.
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http://dx.doi.org/10.1080/15569527.2017.1315128DOI Listing
December 2017

Investigation of the effect of hemoglobin F and A levels on development of retinopathy of prematurity.

J AAPOS 2017 Apr 10;21(2):136-140. Epub 2017 Mar 10.

Department of Pediatric Disease, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Purpose: To investigate the effect of hemoglobin F (HbF) and hemoglobin A (HbA) levels on development of retinopathy of prematurity (ROP) in premature infants.

Methods: In this prospective study, blood samples were collected from the side of the heel of 49 premature infants at postnatal months 0, 1, 2, and 3. HbF and HbA levels were measured in all samples and analyzed statistically. Furthermore, correlation analysis was performed regarding development of ROP, blood transfusion, and HbF and HbA levels.

Results: A total of 49 infants were included. The mean gestational age of the premature infants was 30.9 ± 2.7 weeks (range, 25-35 weeks); mean birth weight, 1542 ± 582 g (range, 520-3240 g). Of the 49 premature infants, stage 1 ROP or above developed in 26 (53%). Mean HbF levels were lower at postnatal months 1 and 2 in premature infants with ROP compared to those without ROP (P = 0.013 and 0.02, respectively); however, mean HbA levels were higher in the infants with ROP than the others (P = 0.034 and 0.029, respectively). Analysis of covariance that ignored transfusion revealed no difference between the means of Hb variants in the infants with and without ROP (P = 0.572 and 0.486).

Conclusions: Blood transfusion significantly altered the levels of HbF and HbA in premature infants, and Hb variants have no direct effect on development of ROP.
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http://dx.doi.org/10.1016/j.jaapos.2017.03.006DOI Listing
April 2017

Evaluation of Retinal Changes Using Optical Coherence Tomography in a Pediatric Case of Susac Syndrome.

Turk J Ophthalmol 2017 Jan 17;47(1):59-62. Epub 2017 Jan 17.

Karadeniz Technical University Faculty of Medicine, Department of Ophthalmology, Trabzon, Turkey.

Susac syndrome is a rare occlusive vasculopathy affecting the retina, inner ear and brain. The cause is unknown, although it generally affects young women. This syndrome can be difficult to diagnose because its signs can only be revealed by detailed examination. These signs are not always concomitant, but may appear at different times. This report describes a pediatric case who was diagnosed with Susac syndrome when retinal lesions were identified in the inactive period with the help of optical coherence tomography (OCT). The purpose of this case report is to emphasize the importance of OCT in clarifying undefined retinal changes in Susac syndrome.
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http://dx.doi.org/10.4274/tjo.27482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282545PMC
January 2017

Bilateral acute angle closure developing due to use of ipratropium bromide and salbutamol.

Int Ophthalmol 2018 Feb 6;38(1):385-388. Epub 2017 Feb 6.

Department of Ophthalmology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.

Acute angle closure can be seen as a side effect of some medications that can be used systemically. In this article, clinical characteristics of 54-year-old female patient who applied to our clinic with bilateral acute angle closure and has been received nebulized form of salbutamol and ipratropium bromide due to asthma for 4 days was evaluated. Right and left eye IOP were measured as 50 and 48 mmHg. IOP was reduced with anti-glaucomatous treatment. and peripheral iridectomy was done, and then the patient was discharged. It is necessary to be careful to prevent contact with the eye of nebulized form of these drugs which may result in angle closure glaucoma when used systemically.
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http://dx.doi.org/10.1007/s10792-017-0458-xDOI Listing
February 2018

Determination of regional screening criteria for retinopathy ofprematurity in the Eastern Black Sea region of Turkey.

Turk J Med Sci 2016 Feb 17;46(2):381-7. Epub 2016 Feb 17.

Department of Pediatric Disease, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Background/aim: To establish a regional screening protocol for retinopathy of prematurity (ROP).

Materials And Methods: Data were analyzed from the hospital records of 1241 infants with gestational age (GA) at birth ≤36 weeks and birth weight (BW) of ≤3600 g.

Results: The mean GA of the infants was 32.05 ± 2.7 weeks and the mean BW was 1780.5 ± 576 g. ROP at any stage was detected in 703 of the 1241 infants (555 female). Eleven infants with type 1 ROP were treated with 810 nm diode laser photocoagulation. No treatment was needed in infants born after 33 weeks of gestation and weighing over 1760 g. Logistic regression analysis showed a significant relationship between the development of ROP and GA, BW, number of deliveries, respiratory distress syndrome, and treatment with oxygen or mechanical ventilation. Receiver operating characteristic curve analysis showed that a GA of 33 weeks or a BW of 1770 g appears to be an appropriate criterion for identifying infants who may require ROP treatment.

Conclusion: GA ≤ 33 weeks and BW ≤ 1770 g can be used as screening criteria in terms of ROP in infants for the Eastern Black Sea region.
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http://dx.doi.org/10.3906/sag-1410-97DOI Listing
February 2016

Comparison of brimonidine-timolol and dorzolamide-timolol in the management of intraocular pressure increase after phacoemulsification.

Int J Ophthalmol 2015 18;8(5):945-9. Epub 2015 Oct 18.

Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey.

Aim: To compare the effectiveness of brimonidine/timolol fixed combination (BTFC) and dorzolamide/timolol fixed combination (DTFC) in the management of short-term intraocular pressure (IOP) increase after phacoemulsification surgery.

Methods: Eighty eyes of 80 patients undergoing phacoemulsification and intraocular lens (IOL) implantation were randomly assigned into three groups. Group 1 consisted of 28 eyes and represented the control group. Group 2 consisted of 25 eyes undergoing phacoemulsification surgery and BTFC was instilled at the end of surgery. Group 3 consisted of 27 eyes undergoing phacoemulsification surgery and DTFC was instilled at the end of surgery. IOP was measured preoperatively and 6, 24h and 1wk postoperatively.

Results: There was no statistically significant difference in preoperative baseline IOP among the three groups (P=0.84). However, IOP was significantly lower in groups 2 and 3 compared to the control group (P<0.05 for all comparisons) at all postoperative visits. There was no significant difference between groups 2 and 3 at any visit. Eight eyes (28.6%) in the control group, two (8%) in Group 2 and one (3.7%) in Group 3 had IOP >25 mm Hg at 6h after surgery (P=0.008). However, IOP decreased and was >25 mm Hg in only one eye in each group at 24h after surgery.

Conclusion: BTFC and DTFC have similar effects in reducing increases in IOP after phacoemulsification surgery and can both be recommended for preventing IOP spikes after such surgery.
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http://dx.doi.org/10.3980/j.issn.2222-3959.2015.05.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631018PMC
November 2015

Chiasmal optic neuritis may be secondary to pneumococcal meningitis: a child with acute monocular vision loss.

Neurol Sci 2016 Jan 5;37(1):139-141. Epub 2015 Sep 5.

Department of Ophthalmology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.

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http://dx.doi.org/10.1007/s10072-015-2377-9DOI Listing
January 2016

The effectiveness and reliability of posterior sub-Tenon triamcinolone acetonide injection in branch retinal vein occlusion-related macular edema.

Cutan Ocul Toxicol 2016 Sep 12;35(3):185-9. Epub 2015 Aug 12.

a Department of Ophthalmology, Faculty of Medicine , Karadeniz Technical University , Trabzon , Turkey.

Objective: To investigate the effectiveness and reliability of posterior sub-Tenon triamcinolone acetonide (PSTA) application in branch retinal vein occlusion (BRVO)-related macular edema.

Methods: Patients with confirmed BRVO-related macular edema were enrolled in the study. Patients were injected with a single, therapeutic dose of 40 mg PSTA. Detailed ophthalmic examination was performed at baseline and at 1, 3 and 6 months after the treatment. Best corrected visual acuity (BCVA), intraocular pressure (IOP), cataractogenic change (CC) and macular optical coherence tomography (OCT) analysis results were evaluated. The results were compared statistically.

Results: Forty-one eyes of 41 patients with a mean age of 63.49 ± 10.99 (55-86) years, 15 (36.6%) females, were included in the study. BCVA in LogMAR values at 1 and 3 months were significantly better than at baseline, while no significant difference from baseline was observed in sixth month values (p < 0.001, p < 0.001 and p = 0.846, respectively). Central macular thickness values obtained using OCT were significantly lower at the first, third and sixth months compared to baseline (p < 0.001 for all). IOP elevation was determined in only two eyes (4.8%) at the end of the study period, and no CC was detected in any case.

Conclusion: PSTA application is an effective and safe option in BRVO-related macular edema.
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http://dx.doi.org/10.3109/15569527.2015.1074586DOI Listing
September 2016

[Primary Neisseria meningitidis conjunctivitis in a 14-month-old child].

Mikrobiyol Bul 2015 Jul;49(3):467-72

Karadeniz Technical University Faculty of Medicine, Department of Medical Microbiology, Trabzon, Turkey.

Meningococcal conjunctivitis is a rare but important infection since it can lead to severe complications and can threaten public health. It may emerge in two forms, either primary or secondary type which is developed after a systemic infection. Accurate diagnosis of primary meningococcal conjunctivitis is very important in addition to ocular complications which can result in loss of vision, the condition can also lead to severe complications like systemic meningococcal disease. However, the lack of specific symptoms which can distinguish meningococcal conjunctivitis from other forms of bacterial conjunctivitis, initiation of empiric antibiotic therapy without performing culture and nonaccurate differentiation of Neisseria gonorrhoeae and Neisseria meningitidis with commercial kits/systems used in laboratories cause problematic situations. This report describes a case of primary unilateral conjunctivitis in a 14-month-old girl caused by non-groupable N.meningitidis that was resolved without sequelae following treatment. A pre-healthy 14-month-old girl was brought to the pediatric emergency department with redness, crusts and discharge in the left eye that had begun two days earlier. Ocular examination revealed hyperemia and purulent discharge in the left conjunctiva. Purulent conjunctivitis was diagnosed. A conjunctival swab specimen was taken for culture, and the patient was started on topical netilmicin (4x1), topical fusidic acid (2x1) and artificial tears. Microscopic examination of the conjunctival swab revealed polymorphonuclear leukocytes and no visible bacteria. Catalase and oxidase positive, gram-negative diplococci grew purely in culture. The first Gram stain preparation was evaluated again after the growth and small numbers of gram-negative diplococci were observed. The cultivated bacteria were identified as N.meningitidis using MALDI-TOF MS (Bruker Daltonics, Germany), but as N.gonorrhoeae with BBL Crystal N/H (Neisseria/Haemophilus) (BD Diagnostic Systems, MD) identification system. The isolate was identified as N.meningitidis by polymerase chain reaction method. The isolate was sent to the Public Health Institution of Turkey for confirmation and serotyping. It was confirmed as non-groupable N.meningitidis. This is the first report of conjunctivitis caused by non-groupable N.meningitidis from Turkey. We wish to emphasize the importance of Gram staining and differentiation of the species by automatized systems in diagnosis, netilmicin may be one of the options for empiric treatment and in terms of public health the most appropriate approach may be evaluation of the severity of conjunctivitis and causative serogroup which depends on case-based approach.
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http://dx.doi.org/10.5578/mb.9362DOI Listing
July 2015

Regarding Comments by Yolcu et al. on "Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography".

Ocul Immunol Inflamm 2015 11;23(6):465-6. Epub 2015 Mar 11.

c Department of Physiology , Karadeniz Technical University, Faculty of Medicine , Trabzon , Turkey.

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http://dx.doi.org/10.3109/09273948.2014.999379DOI Listing
March 2016

Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy.

Turk J Med Sci 2014 ;44(3):524-9

Department of Ophthalmology, Karadeniz Technical University, Trabzon, Turkey.

Background/aim: To prospectively assess the effects of panretinal photocoagulation (PRP) treatment on pulsatile ocular blood flow (POBF) in patients with proliferative diabetic retinopathy (PDRP).

Materials And Methods: The study included 40 eyes with PDRP in 27 patients. The PRP treatments were completed in 3 sessions with 3-week intervals. The intraocular pressure (IOP), pulse amplitude (PA), pulse volume (PV), and POBF changes that arose during the sessions were recorded using a blood flow analyzer.

Results: The average age of the patients was 57.37 ± 11.14 years. The pre-PRP basal IOP, PA, PV, and POBF values were 20.44 ± 4.13 mmHg, 4.23 ± 1.73 mmHg, 6.89 ± 2.28 μL, and 21.86 ± 5.83 μL/s, respectively. One month after the completion of the PRP sessions, the values were 18.49 ± 4.44 mmHg, 2.78 ± 1.13 mmHg, 5.27 ± 2.08 μL, and 15.89 ± 5.05 μL/s, respectively, and the differences were significant (P = 0.001, P < 0.0001, P < 0.0001, and P < 0.0001, respectively).

Conclusion: PRP treatment reduces the choroidal blood flow and consequently causes significant decreases in IOP, PA, PV, and POBE .
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http://dx.doi.org/10.3906/sag-1303-87DOI Listing
March 2015

Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults.

Arq Bras Oftalmol 2014 Aug;77(4):228-32

Department of Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey.

Purpose: To investigate the effects of topically applied 1% cyclopentolate hydrochloride on anterior segment parameters obtained with a Pentacam rotating Scheimpflug camera in healthy young adults.

Methods: Anterior segment analyses of 25 eyes from 25 young adults (Group 1), before and after 45 min of 1% cyclopentolate hydrochloride application, were performed. For a control group (cycloplegia-free, Group 2), 24 eyes of 24 age- and sex-matched healthy cases were evaluated twice at 45 min intervals. The results obtained from the groups were compared statistically.

Results: The mean ages of the groups were 23.04 ± 3.42 (range, 18-29) and 22.4 ± 2.05 (range, 18-27) years for Groups 1 and 2, respectively (p=0.259). In Group 1, measurements between the two analyses were significantly different for the values of anterior chamber depth (ACD), anterior chamber angle (ACA), and anterior chamber volume (ACV) (p<0.05), whereas no statistical difference was found for the central corneal thickness (CCT) and keratometry (K1, K2) measurements. In Group 2, none of these parameters were statistically different between the two analyses.

Conclusions: Topically applied 1% cyclopentolate hydrochloride caused an increase in the ACD and ACV values, and a decrease in the ACA value. However, it had no significant effect on the CCT and keratometry measurements. It is important to consider these effects when using the Pentacam device on young adults with cycloplegia and when applying it for various reasons.
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http://dx.doi.org/10.5935/0004-2749.20140059DOI Listing
August 2014

The effect of topical 1% cyclopentolate on IOLMaster biometry.

Optom Vis Sci 2014 Nov;91(11):1343-7

*MD Department of Ophthalmology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey (CA); Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey (AT, MK); and Department of Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey (OMC).

Purpose: To investigate the effects of topical cyclopentolate on ocular biometry parameters in healthy young adults.

Methods: Ocular biometry measurements were performed twice with 45-minute intervals by use of the IOLMaster. Effects of topical application of 1% cyclopentolate were examined in 25 eyes from 25 young adults (group 1) before and after its application. As a control (cyclopentolate-free, group 2), 30 eyes from 30 age- and sex-matched healthy subjects were evaluated within the same period.

Results: There was no difference between the groups with respect to mean (±SD) ages (group 1: 23 [±3.19] years [range, 18 to 28 years] vs. group 2: 22.6 [±2.7] years [range, 18 to 28 years], p = 0.616). In group 1, the anterior chamber depth and horizontal iris width (white-to-white distance) measurements between the two sessions were significantly different, whereas the axial length was not. In group 2, none of these parameters were different between the two sessions.

Conclusions: Topical application of 1% cyclopentolate caused an increase in the anterior chamber depth and white-to-white distance values without any significant effect on axial length measurement. It is necessary to consider these effects on measurements taken with an IOLMaster in young adults in whom 1% cyclopentolate has been applied.
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http://dx.doi.org/10.1097/OPX.0000000000000388DOI Listing
November 2014

Evaluation of the Repeatability and the Reproducibility of AL-Scan Measurements Obtained by Residents.

J Ophthalmol 2014 22;2014:739652. Epub 2014 Jul 22.

Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.

Purpose. To assess the repeatability and reproducibility of ocular biometry and intraocular lens (IOL) power measurements obtained by ophthalmology residents using an AL-Scan device, a novel optical biometer. Methods. Two ophthalmology residents were instructed regarding the AL-Scan device. Both performed ocular biometry and IOL power measurements using AL-Scan, three times on each of 128 eyes, independently of one another. Corneal keratometry readings, horizontal iris width, central corneal thickness, anterior chamber depth, pupil size, and axial length values measured by both residents were recorded together with IOL power values calculated on the basis of four different IOL calculation formulas (SRK/T, Holladay, and HofferQ). Repeatability and reproducibility of the measurements obtained were analyzed using the intraclass correlation coefficient (ICC). Results. Repeatability (ICC, 0.872-0.999 for resident 1 versus 0.905-0.999 for resident 2) and reproducibility (ICC, 0.916-0.999) were high for all biometric measurements. Repeatability (ICC, 0.981-0.983 for resident 1 versus 0.995-0.996 for resident 2) and reproducibility were also high for all IOL power measurements (ICC, 0.996 for all). Conclusions. The AL-Scan device exhibits good repeatability and reproducibility in all biometric measurements and IOL power calculations, independent of the operator concerned.
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http://dx.doi.org/10.1155/2014/739652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129666PMC
August 2014

Ischemia-modified albumin (IMA): a novel marker of vascular involvement in Behçet's disease?

Joint Bone Spine 2015 Jan 30;82(1):68-9. Epub 2014 Jul 30.

Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.

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http://dx.doi.org/10.1016/j.jbspin.2014.06.007DOI Listing
January 2015

Evaluation of choroidal thickness in ankylosing spondylitis using optical coherence tomography.

Ocul Immunol Inflamm 2014 Dec 2;22(6):434-8. Epub 2014 Jul 2.

Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University , Trabzon , Turkey .

Unlabelled: Abstract Purpose: To investigate posterior segment (PS) findings in the eye in patients with ankylosing spondylitis (AS).

Methods: Eighty-four patients with AS and 63 healthy controls were enrolled. PS evaluations were performed using optical coherence tomography (OCT). Foveal thickness, peripapillary retinal nerve fiber layer thickness, macular volume, ganglion cell complex, and choroidal thickness (CT) values were compared between the groups.

Results: Mean CT was higher in patients with AS (326.5 ± 71.5 µm) than in the healthy controls (286.2 ± 59.5 µm) (p = 0.001). There was no significant difference between patients with AS and the healthy control group in terms of other OCT parameters. There was also no significant correlation between CT, AS activity index, and disease duration.

Conclusions: This is the first study to evaluate effects of AS on CT. CT was high in patients with AS compared to healthy controls.
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http://dx.doi.org/10.3109/09273948.2014.928734DOI Listing
December 2014

Serum anti-carbonic anhydrase antibodies and oxidant-antioxidant balance in patients with acute anterior uveitis.

Ocul Immunol Inflamm 2014 Apr 24;22(2):127-32. Epub 2013 Sep 24.

Department of Ophthalmology, Karadeniz Technical University, School of Medicine , Trabzon , Turkey .

Purpose: To study the existence of anti-carbonic anhydrase antibodies (anti-CA-I&II) in acute anterior uveitis (AAU) patients and to analyze the relationship between the levels of these antibodies and the total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), and malondialdehyde (MDA) level.

Methods: Forty-five AAU cases and 43 healthy controls were enrolled in this prospective study.

Results: The average anti-CA I and II antibody levels were 0.433 ± 0.306 and 0.358 ± 0.261 IU/mL, respectively, in the AAU group and 0.275 ± 0.147 and 0.268 ± 0.108 IU/mL, respectively, in the control group (p = 0.004 and p = 0.036, respectively). In addition, it was found that the TOC, OSI, and MDA levels in the AAU subjects were statistically significantly higher than those of the control subjects.

Conclusions: These results suggest that autoimmune responses against CA I and CA II and an altered serum oxidant-antioxidant balance may be involved in the pathogenesis of AAU.
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http://dx.doi.org/10.3109/09273948.2013.830753DOI Listing
April 2014

Effects of phacoemulsification surgery on ocular hemodynamics.

Int J Ophthalmol 2013 18;6(4):537-41. Epub 2013 Aug 18.

Department of Ophthalmology, School of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey.

Aim: To evaluate the possible effects of phacoemulsification cataract surgery on ocular hemodynamics.

Methods: In this prospective study, intraocular pressure (IOP), pulsatile ocular blood flow (POBF), and ocular pulse amplitude (OPA) were measured pre-operatively (baseline) and at 1 week and 3 weeks postoperation in 52 eyes of 26 patients (mean age 63.15±10.25 years) scheduled for unilateral phacoemulsification cataract surgery with intraocular lens implantation. In all of the eyes, a blood flow analyzer (Paradigm DICON; Paradigm Medical Industries Inc.; USA) was used to obtain measurements of IOP, POBF, and OPA. The data obtained from operated eyes were compared statistically to untreated fellow phakic eyes of the patients.

Results: For operated eyes, the mean baseline IOP, POBF, and OPA values were 15.9±4.64mmHg, 17.41±4.84µL/s, and 2.91±1.12mmHg, respectively. The IOP, POBF, and OPA values were 17.19±4.34mmHg, 17.56±6.46µL/s, and 3.12±1.1mmHg, respectively, in the nonoperated control eyes. Statistically significant differences from baseline measurements were not observed 1 week and 3 weeks postoperation for the operated or nonoperated eyes. There were also no statistically significant differences in any measurements between the operated and nonoperated eyes in all the examination periods (P>0.05 for all).

Conclusion: Uncomplicated phacoemulsification surgery does not affect ocular hemodynamics in normotensive eyes with cataracts.
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http://dx.doi.org/10.3980/j.issn.2222-3959.2013.04.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755318PMC
August 2013

Bilateral Optic Nerve Aplasia in a Child.

J Pediatr Ophthalmol Strabismus 2009 Jun 25. Epub 2009 Jun 25.

An 3-month-old female infant was admitted to the authors' clinic because of abnormal gaze position. On examination, the eyes were in the down gaze position. The left eye had a partial iris and lens coloboma. On funduscopic examination, the optic nerve and retinal vessels could not be detected. Optic nerve and optic chiasm were not observed on magnetic resonance imaging.
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http://dx.doi.org/10.3928/01913913-20090616-02DOI Listing
June 2009

The effect of the aspiration of pericardial effusion on intraocular pressure.

Acta Cardiol 2003 Oct;58(5):385-8

Department of Ophthalmology, Medical School, Karadeniz Technical University, Trabzon, Turkey.

Objective: To assess the effect of pericardial effusion on intraocular pressure (IOP).

Patients And Methods: Twenty-two patients with pericardial effusion were enrolled into the study. The average pericardial effusion was 2245 +/- 257 cc, and the mean IOP was 26.1 +/- 2.1 mm Hg in the initial examination. Pericardial effusion was aspirated via canula under topical anaesthesia at two or three-day intervals. IOP was measured after every aspiration of pericardial fluid. We statistically compared the changes in the mean IOP after every aspiration (one-way ANOVA), and calculated the correlation (regression analysis) between the amount of fluid and the changes in IOP.

Results: An average of 400 ml of fluid was aspirated at two or three-day intervals. The mean IOP decreased to 23.3, 21.2, 19.1 and 16.3 mm Hg after aspirations, respectively. These decreases in the mean IOP were statistically significant (p < 0.01). In regression analysis, we observed a meaningful relationship between the changes in IOP and the amount of pericardial effusion (p < 0.001).

Conclusion: We found that pericardial effusion affected IOP due to increased episcleral venous pressure. Therefore, patients with pericardial effusion should be referred for an ophthalmological examination with IOP measurement. IOP-lowering medication can eventually be started or adjusted by the ophthalmologist.
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http://dx.doi.org/10.2143/AC.58.5.2005301DOI Listing
October 2003
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