Mehdi Tafti

Mehdi Tafti

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Mehdi Tafti

Mehdi Tafti

Publications by authors named "Mehdi Tafti"

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Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons.

Proc Natl Acad Sci U S A 2019 Aug 2. Epub 2019 Aug 2.

Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland;

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http://dx.doi.org/10.1073/pnas.1902148116DOI Listing
August 2019

Kleine-Levin syndrome is associated with LMOD3 variants.

J Sleep Res 2019 Jun 19;28(3):e12718. Epub 2018 Jun 19.

Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1111/jsr.12718DOI Listing
June 2019

T cells in patients with narcolepsy target self-antigens of hypocretin neurons.

Nature 2018 10 19;562(7725):63-68. Epub 2018 Sep 19.

Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.

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http://dx.doi.org/10.1038/s41586-018-0540-1DOI Listing
October 2018

Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound.

Front Neurosci 2018 15;12:519. Epub 2018 Aug 15.

Faculty of Biology and Medicine, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.3389/fnins.2018.00519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104159PMC
August 2018

In vitro Cortical Network Firing is Homeostatically Regulated: A Model for Sleep Regulation.

Sci Rep 2018 Apr 19;8(1):6297. Epub 2018 Apr 19.

Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Génopode, 1015, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41598-018-24339-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908861PMC
April 2018

Rare missense mutations in P2RY11 in narcolepsy with cataplexy.

Brain 2017 Jun;140(6):1657-1668

Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1093/brain/awx093DOI Listing
June 2017

Measurement of narcolepsy symptoms: The Narcolepsy Severity Scale.

Neurology 2017 Apr 3;88(14):1358-1365. Epub 2017 Mar 3.

From CHU Montpellier (Y.D., S.B., C.P., R.L., L.B., B.C., M.B.), Hôpital Gui-de-Chauliac, Service de Neurologie, Unité du Sommeil, Centre National de Référence pour la Narcolepsie, Montpellier, France; Center for Integrative Genomics (G.L., M.T.), University of Lausanne; Centre Neuchâtelois de Psychiatrie (G.L.), Neuchâtel; Center for Investigation and Research in Sleep (M.T.), Lausanne University Hospital, Switzerland; Department of Psychology (C.M.M.), Université Laval, Quebec City, Quebec, Canada; Inserm (Y.D., S.B., C.P., R.L., I.J.), U1061; and Université Montpellier (Y.D., S.B., C.P., R.L., I.J.), France.

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http://dx.doi.org/10.1212/WNL.0000000000003787DOI Listing
April 2017

Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study.

Neurology 2017 01 30;88(5):463-469. Epub 2016 Dec 30.

From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000003557DOI Listing
January 2017

ERK signaling pathway regulates sleep duration through activity-induced gene expression during wakefulness.

Sci Signal 2017 01 24;10(463). Epub 2017 Jan 24.

Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/scisignal.aai9219DOI Listing
January 2017

The NoSAS score for screening of sleep-disordered breathing: a derivation and validation study.

Lancet Respir Med 2016 09 16;4(9):742-748. Epub 2016 Jun 16.

Center for Investigation and Research in Sleep, University Hospital of Lausanne, University of Lausanne, Lausanne, Switzerland; Pulmonary Department, University Hospital of Lausanne, University of Lausanne, Lausanne, Switzerland. Electronic address:

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http://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(
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http://linkinghub.elsevier.com/retrieve/pii/S221326001630075
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http://dx.doi.org/10.1016/S2213-2600(16)30075-3DOI Listing
September 2016

Age and gender variations of sleep in subjects without sleep disorders.

Ann Med 2015 29;47(6):482-91. Epub 2015 Jul 29.

a Center for Integrative Genomics (CIG), University of Lausanne , Lausanne , Switzerland.

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http://dx.doi.org/10.3109/07853890.2015.1074271DOI Listing
May 2016

Sleep Characteristics in Early Stages of Chronic Kidney Disease in the HypnoLaus Cohort.

Sleep 2016 Apr 1;39(4):945-53. Epub 2016 Apr 1.

Center for Investigation and Research in Sleep (CIRS), University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

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http://dx.doi.org/10.5665/sleep.5660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791628PMC
April 2016

Prevalence and determinants of periodic limb movements in the general population.

Ann Neurol 2016 Mar 12;79(3):464-74. Epub 2016 Feb 12.

Center for Investigation and Research in Sleep, Lausanne University Hospital, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/ana.24593DOI Listing
March 2016

Scoring criteria for portable monitor recordings: a comparison of four hypopnoea definitions in a population-based cohort.

Thorax 2015 Nov 20;70(11):1047-53. Epub 2015 Aug 20.

Centre for Investigation and Research in Sleep (CIRS), Lausanne University Hospital (CHUV), Lausanne, Switzerland Pulmonary Department (CHUV), Lausanne University Hospital, Lausanne, Vaud, Switzerland.

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http://dx.doi.org/10.1136/thoraxjnl-2014-205982DOI Listing
November 2015

Bad sleep? Don't blame the moon! A population-based study.

Sleep Med 2015 Nov 18;16(11):1321-1326. Epub 2015 Aug 18.

Center for Investigation and Research in Sleep (CIRS), Lausanne University Hospital (CHUV), Lausanne, Switzerland; Pulmonary Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2015.08.002DOI Listing
November 2015

Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2".

Sci Transl Med 2015 Nov;7(314):314le2

Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/scitranslmed.aad2353DOI Listing
November 2015

Catechol-O-methyltransferase, dopamine, and sleep-wake regulation.

Sleep Med Rev 2015 Aug 27;22:47-53. Epub 2014 Oct 27.

Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland; Zürich Center for Interdisciplinary Sleep Research, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.smrv.2014.10.006DOI Listing
August 2015

Cytokine-induced sleep: Neurons respond to TNF with production of chemokines and increased expression of Homer1a in vitro.

Brain Behav Immun 2015 Jul 1;47:186-92. Epub 2014 Dec 1.

Institute of Experimental Immunology, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2014.11.008DOI Listing
July 2015

Association of socioeconomic status with sleep disturbances in the Swiss population-based CoLaus study.

Sleep Med 2015 Apr 7;16(4):469-76. Epub 2015 Feb 7.

Center For Investigation and Research In Sleep, Lausanne University Hospital, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.sleep.2014.12.014DOI Listing
April 2015

Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus Study.

Sleep 2015 Mar 1;38(3):391-400. Epub 2015 Mar 1.

Center for Investigation and Research in Sleep (CIRS), Lausanne University Hospital (CHUV), Lausanne, Switzerland.

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http://dx.doi.org/10.5665/sleep.4496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335515PMC
March 2015

Effect of transnasal insufflation on sleep-disordered breathing in acute stroke.

Sleep Breath 2015 Mar 28;19(1). Epub 2014 Oct 28.

Centre d'Investigation et de Recherche sur le Sommeil, Centre Hospitalier Universitaire Vaudois and Université de Lausanne, Lausanne, Switzerland,

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http://dx.doi.org/10.1007/s11325-012-0794-zDOI Listing
March 2015

Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy.

Lancet Neurol 2015 Mar 16;14(3):318-28. Epub 2015 Feb 16.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; Center for Investigation and Research in Sleep, Vaud University Hospital, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(14)70218-2DOI Listing
March 2015

Central and peripheral metabolic changes induced by gamma-hydroxybutyrate.

Sleep 2015 Feb 1;38(2):305-13. Epub 2015 Feb 1.

Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.5665/sleep.4420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288612PMC
February 2015

HLA-DQ allele competition in narcolepsy: where is the evidence?

Authors:
Mehdi Tafti

Sleep 2015 Jan 1;38(1):153-4. Epub 2015 Jan 1.

Center for Integrative Genomics (CIG) University of Lausanne, Lausanne, Switzerland; Center for Investigation and Research in Sleep (CIRS), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

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http://dx.doi.org/10.5665/sleep.4344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262949PMC
January 2015

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.

PLoS Genet 2014 Jul 31;10(7):e1004508. Epub 2014 Jul 31.

Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1004508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117451PMC
July 2014

Electroencephalogram paroxysmal θ characterizes cataplexy in mice and children.

Brain 2013 May;136(Pt 5):1592-608

Centre for Integrative Genomics, Université de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1093/brain/awt069DOI Listing
May 2013

Kleine-Levin syndrome: functional imaging correlates of hypersomnia and behavioral symptoms.

Neurology 2012 Oct 17;79(18):1927-9. Epub 2012 Oct 17.

Center for Investigation and Research in Sleep, University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e318271f85
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http://dx.doi.org/10.1212/WNL.0b013e318271f85aDOI Listing
October 2012

Effect of transnasal insufflation on sleep disordered breathing in acute stroke: a preliminary study.

Sleep Breath 2012 Sep 19;16(3):759-64. Epub 2011 Aug 19.

Center for Investigation and Research in Sleep, Centre Hospitalier Universitaire Vaudois and Université de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s11325-011-0572-3DOI Listing
September 2012

Dreaming without REM sleep.

Conscious Cogn 2012 Sep 29;21(3):1129-40. Epub 2012 May 29.

Sleep Disorders Unit, Pitié-Salpêtrière Hospital, APHP, Paris, France.

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http://dx.doi.org/10.1016/j.concog.2012.04.010DOI Listing
September 2012

Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory.

Sleep 2012 Aug 1;35(8):1071-83. Epub 2012 Aug 1.

Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.5665/sleep.1992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397788PMC
August 2012

Positional therapy for obstructive sleep apnea: an objective measurement of patients' usage and efficacy at home.

Sleep Med 2012 Apr 18;13(4):425-8. Epub 2012 Jan 18.

Centre for Investigation and Research in Sleep, Lausanne University Hospital, CHUV, 1011 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.sleep.2011.11.004DOI Listing
April 2012

Age-related changes in sleep in inbred mice are genotype dependent.

Neurobiol Aging 2012 Jan 9;33(1):195.e13-26. Epub 2010 Jul 9.

Center for Integrative Genomics, University of Lausanne, Genopode Building, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.05.010DOI Listing
January 2012

Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues.

Anal Bioanal Chem 2011 May 1;400(4):1105-12. Epub 2011 Apr 1.

Swiss Laboratory for Doping Analyses, University Center of Legal Medecine, Geneva and Lausanne, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland.

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http://link.springer.com/10.1007/s00216-011-4891-9
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http://dx.doi.org/10.1007/s00216-011-4891-9DOI Listing
May 2011

Pulse wave amplitude drops during sleep are reliable surrogate markers of changes in cortical activity.

Sleep 2010 Dec;33(12):1687-92

Centre d'Investigation et de Recherche sur le Sommeil, Département de Médecine interne, Service de Neurologie, CHUV and Université de Lausanne, Lausanne, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982739PMC
http://dx.doi.org/10.1093/sleep/33.12.1687DOI Listing
December 2010

Genetic aspects of normal and disturbed sleep.

Authors:
Mehdi Tafti

Sleep Med 2009 Sep 5;10 Suppl 1:S17-21. Epub 2009 Aug 5.

Center for Integrative Genomics, University of Lausanne, Génopode, 1015 Lausanne, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S13899457090024
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http://dx.doi.org/10.1016/j.sleep.2009.07.002DOI Listing
September 2009

Physiology. How much sleep do we need?

Science 2009 Aug;325(5942):825-6

Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/science.1178713DOI Listing
August 2009

How to keep the brain awake? The complex molecular pharmacogenetics of wake promotion.

Neuropsychopharmacology 2009 Jun 4;34(7):1625-40. Epub 2009 Feb 4.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/npp.2009.3DOI Listing
June 2009

Genetics of sleep.

Annu Rev Genet 2008 ;42:361-88

The Neuroscience Institute, San Diego, California 92121, USA.

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http://dx.doi.org/10.1146/annurev.genet.42.110807.091541DOI Listing
February 2009

The genetic basis of sleep disorders.

Curr Pharm Des 2008 ;14(32):3386-95

Department of Neurology, Hôpital Gui de Chauliac, CHU Montpellier, Inserm U888, 34295 Montpellier, France.

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http://dx.doi.org/10.2174/138161208786549308DOI Listing
January 2009

Quantitative genetics of sleep in inbred mice.

Authors:
Mehdi Tafti

Dialogues Clin Neurosci 2007 ;9(3):273-8

Center for Integrative Genomics (CIG), University of Lausanne, Génopode Bldg, 1015 Dorigny-Lausanne, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202492PMC
January 2008

Functional implication of the vitamin A signaling pathway in the brain.

Arch Neurol 2007 Dec;64(12):1706-11

Center for Integrative Genomics, University of Lausanne, 1015, Lausanne, Switzerland.

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http://dx.doi.org/10.1001/archneur.64.12.1706DOI Listing
December 2007

Homer1a is a core brain molecular correlate of sleep loss.

Proc Natl Acad Sci U S A 2007 Dec 6;104(50):20090-5. Epub 2007 Dec 6.

Center for Integrative Genomics and Lausanne DNA Array Facility, University of Lausanne, Génopode, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1073/pnas.0710131104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148427PMC
December 2007

Narcolepsy and familial advanced sleep-phase syndrome: molecular genetics of sleep disorders.

Curr Opin Genet Dev 2007 Jun 27;17(3):222-7. Epub 2007 Apr 27.

Center for Integrative Genomics (CIG) and Center for Investigation and Research in Sleep (CIRS), University of Lausanne and Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S0959437X0700072
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http://dx.doi.org/10.1016/j.gde.2007.04.007DOI Listing
June 2007

Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans'.

Authors:
Mehdi Tafti

Nat Med 2007 May;13(5):525-6; author reply 526

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http://dx.doi.org/10.1038/nm0507-525DOI Listing
May 2007

Molecular genetics and treatment of narcolepsy.

Ann Med 2006 ;38(4):252-62

Service de Neurologie B, Hôpital Gui-de-Chauliac and INSERM E0361, Montpellier-France, and Center for Integrative Genomics, University of Lausanne, Lausanne-Dorigny, Switzerland.

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http://dx.doi.org/10.1080/07853890500489700DOI Listing
December 2006

Daytime sleepiness with and without cataplexy in Chinese-Taiwanese patients.

Sleep Med 2006 Aug 3;7(5):454-7. Epub 2006 Jul 3.

Sleep Disorders Clinic, Chang-Gung University Hospital, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.sleep.2006.05.009DOI Listing
August 2006

Genes for normal sleep and sleep disorders.

Ann Med 2005 ;37(8):580-9

Center for Integrative Genomics, University of Lausanne, 1015 Lausanne-Dorigny, Switzerland.

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http://dx.doi.org/10.1080/07853890500372047DOI Listing
March 2006

Genetics of narcolepsy and other major sleep disorders.

Swiss Med Wkly 2005 Nov;135(45-46):662-5

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerand.

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http://dx.doi.org/2005/45/smw-11162DOI Listing
November 2005

Retinoic acid signaling affects cortical synchrony during sleep.

Science 2005 Oct;310(5745):111-3

Center for Integrative Genomics, University of Lausanne, Génopode, 1015 Lausanne-Dorigny, Switzerland.

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http://dx.doi.org/10.1126/science.1117623DOI Listing
October 2005

Genetics of normal and pathological sleep in humans.

Sleep Med Rev 2005 Apr;9(2):91-100

Service de Neurologie B, Gui-de-Chauliac Hospital, Montpellier, France.

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http://dx.doi.org/10.1016/j.smrv.2004.06.001DOI Listing
April 2005

Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset.

Ann Neurol 2004 Dec;56(6):905-8

Service de Neurologie B, Hôpital Gui-de-Chauliac, Montpellier, France.

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http://dx.doi.org/10.1002/ana.20339DOI Listing
December 2004

A narcolepsy susceptibility locus maps to a 5 Mb region of chromosome 21q.

Ann Neurol 2004 Sep;56(3):382-8

Service de Neurologie B, Hôpital Gui-de-Chauliac, Montpellier, France.

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http://dx.doi.org/10.1002/ana.20208DOI Listing
September 2004

The loss of circadian PAR bZip transcription factors results in epilepsy.

Genes Dev 2004 Jun 2;18(12):1397-412. Epub 2004 Jun 2.

Department of Molecular Biology, National Center of Competence Research Frontiers in Genetics, Sciences III, University of Geneva, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1101/gad.301404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC423191PMC
June 2004

Month of birth as a risk factor for narcolepsy.

Sleep 2003 Sep;26(6):663-5

Service de Neurologie B, Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac Montpellier, France.

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http://dx.doi.org/10.1093/sleep/26.6.663DOI Listing
September 2003

Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep.

Nat Genet 2003 Jul;34(3):320-5

Biochemistry and Genetics Unit, Department of Psychiatry, University of Geneva and Geneva University Hospitals, Chemin du Petit-Bel-Air 2, 1225 Chêne-Bourg, Switzerland.

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http://dx.doi.org/10.1038/ng1174DOI Listing
July 2003

Immunogenetics and sleep disorders.

Authors:
Mehdi Tafti

Pharmacogenomics 2003 Jul;4(4):365-7

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http://dx.doi.org/10.1517/phgs.4.4.365.22750DOI Listing
July 2003

Genetics of sleep and sleep disorders.

Front Biosci 2003 May 1;8:e381-97. Epub 2003 May 1.

Department of Biological Sciences, Stanford University, Stanford, California 94305-5356, USA.

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May 2003

Pharmacogenomics in the treatment of narcolepsy.

Pharmacogenomics 2003 Jan;4(1):23-33

Biochemistry and Genetics Unit, Department of Psychiatry, Geneva University Hospitals, 2 Chemin du Petit-Bel-Air, CH-1225 Chêne-Bourg, Switzerland.

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http://dx.doi.org/10.1517/phgs.4.1.23.22590DOI Listing
January 2003

Invited review: genetic dissection of sleep.

J Appl Physiol (1985) 2002 Mar;92(3):1339-47

Biochemistry and Clinical Neurophysiology Unit, Department of Psychiatry, University of Geneva, CH-1225 Geneva, Switzerland.

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http://dx.doi.org/10.1152/japplphysiol.00834.2001DOI Listing
March 2002