Publications by authors named "Mehdi Birjandi"

27 Publications

  • Page 1 of 1

Association of gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran.

Arch Physiol Biochem 2020 Oct 6:1-6. Epub 2020 Oct 6.

Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: Adhesion molecules like E-selectin have important role in pathogenesis of atherosclerosis. and polymorphisms of gene and E-selectin serum level may affect the risk of coronary artery disease (CAD).

Methods: A total of 145 normal individuals and 154 patients diagnosed with CAD from the Lur population of Iran undergoing coronary angiography were enrolled. Genetic polymorphisms of were determined using PCR-RFLP. Serum level of soluble E-selectin was measured using Elisa.

Results: T allele in polymorphism was significantly associated with an increased risk of atherosclerosis ( = 0.018). No significant association was observed for polymorphism. The mean serum level of soluble E-selectin in the patient group was significantly higher than the control group ( < 0.001).

Conclusions: Allele type in polymorphism plays a role in increasing the risk of developing CAD. Furthermore, since serum E-selectin level is associated with systemic inflammation, it contributes to the increased risk of the disease.
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http://dx.doi.org/10.1080/13813455.2020.1828481DOI Listing
October 2020

Association between the FABP2 Ala54Thr and CRP+1059C/G polymorphisms and small dense LDL level in patients with atherosclerosis: a case-control study.

Arch Physiol Biochem 2020 Sep 24:1-7. Epub 2020 Sep 24.

Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: The polymorphisms of fatty acid-binding protein 2 (FABP2) and C-reactive protein (CRP) might act as genetic risk factors for atherosclerosis. The study aimed to investigate the relationship between FABP2 Ala54Thr and CRP+1059C/G polymorphisms and atherosclerosis as well as the association of Small dense-LDL (sd-LDL).

Methods: A total of 255 subjects (125 controls and 130 patients) were included. The FABP2 and CRP polymorphisms were determined by PCR-RFLP and AS-PCR methods, respectively. Sd-LDL was measured based on Hirano et al method.

Results: There were no significant distinctions between the patient and control groups concerning FABP2 and CRP polymorphisms ( > .05). No significant relationship was observed between studied polymorphisms and sd-LDL level in the patient group ( > .05). However, patients group had higher level of sd-LDL compared to controls ( < .05).

Conclusion: FABP2 Ala54Thr and CRP+1059G/C polymorphisms were not associated with atherosclerosis and sd-LDL level. However, the increased sd-LDL level was known as a risk factor for atherosclerosis.
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http://dx.doi.org/10.1080/13813455.2020.1817097DOI Listing
September 2020

Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide-induced type 2 diabetic rats.

Iran J Basic Med Sci 2020 Jun;23(6):714-723

Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objectives: The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.

Materials And Methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used as an animal model of type 2 diabetes. One group of rats received daily His (1000 mg/l) in drinking water for 8 weeks, whereas other groups (control and untreated diabetic groups) received only water. Different parameters such as glucose, insulin, insulin resistance, lipid profile, cardiac risk ratios, renal functional markers, and oxidative stress were determined in all groups. Moreover, renal histological alterations, mRNA expressions of anti-oxidant enzymes, and TNF-α were evaluated in the rats.

Results: His exhibited a protective effect on glucose, insulin, insulin resistance, lipid profile, cardiac risk ratios, renal functional markers, oxidative stress, and TNF-α. Furthermore, His restored the renal histological alterations and normalized the augmented mRNA expressions of renal anti-oxidant enzymes (glutathione peroxidase (GPX) and Cu-Zn superoxide dismutase (Cu-Zn SOD)) and TNF-α.

Conclusion: His could ameliorate diabetes complications related to oxidative stress, inflammation, dyslipidemia, hyperglycemia, insulin resistance, and nephropathy. Hence, the use of this amino acid is recommended for diabetic patients in order to reduce diabetes complications.
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http://dx.doi.org/10.22038/ijbms.2020.38553.9148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351437PMC
June 2020

Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.

Mol Biol Rep 2020 Jul 21;47(7):5137-5144. Epub 2020 Jun 21.

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

The oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays a pivotal role in the initiation and progression of atherosclerosis which is a complex and progressive disorder. Paraoxonase1 (PON1), which is required for lipid metabolism, is believed to protect LDL from oxidation. The relationship between PON1 gene Leusin55Methionin (L55M) and Glutamine192Arginine (Q192R) polymorphisms in western Iranians with atherosclerosis and its association with enzyme activity and oxidized low-density lipoprotein (oxLDL) were examined in the present study. In this study, blood specimens were collected from 145 healthy individuals and 154 patients with atherosclerosis proven by angiography referred to Shahid Madani Hospital, Khorramabad, Iran. Genomic deoxy ribonucleic acid (DNA) was extracted from whole blood. For all the subjects, restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) was carried out for the detection of L55M and Q192R polymorphisms. PON1 enzyme activity and the level of oxLDL were also evaluated. There was a 3.114-fold increase in the risk of developing atherosclerosis in the subjects presenting the PON1L55M, MM genotype compared to those with the LL genotype (OR 3.114; 95% CI 1.412-6.870). PON1Q192R polymorphism in the PON1 gene was not associated with atherosclerosis. Patients with atherosclerosis had significantly higher oxLDL and reduced PON1 enzyme activity (P < 0.05) compared to the controls. There was no association between the type of genotype, enzyme activity, and oxLDL level. It has been concluded that PON1L55M polymorphism and MM genotype are associated with an increased risk of coronary artery disease (CAD) in Iranian patients with atherosclerosis. We did not find any relationship between PON1Q192R polymorphism and atherosclerosis.
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http://dx.doi.org/10.1007/s11033-020-05585-2DOI Listing
July 2020

Comparison of the effects of Dexamethasone and Ondansetron on the Reduction of Postoperative Nausea and Vomiting following Cesarean Section under Spinal Anesthesia.

Curr Clin Pharmacol 2020 Mar 2. Epub 2020 Mar 2.

Department of medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: Postoperative nausea and vomiting (PONV) is a common complication associated with the use of anesthesia. Several antiemetics are used to reduce the incidence and severity of PONV. The aim of this study is to investigate the role of dexamethasone and ondansetron to treat PONV in patients undergoing cesarean section (c-section) under spinal anesthesia.

Methods: This double-blind clinical trial study was performed on patients who were referred to the operating room of Haji Karim Asali Hospital of Khorramabad for elective cesarean section in 2016-17. Upon meeting the inclusion criteria, patients were allotted into two groups (n=60). Group A received 8mg of dexamethasone and group B received 4mg of ondansetron after spinal anesthesia. The Visual Analog Scale (VAS) questionnaire and Depression-Anxiety-Stress Scale (DASS) questionnaire was used for the analysis. Patients with mild to moderate stress, anxiety, and depression were included in the study. Data were analyzed using SPSS 16 software.

Results: There was no difference in the demographic data of the two groups. The mean severity of nausea in group A was significantly higher than in group B. The frequency of vomiting in group A was 20 times higher than group B, which was found to be statistically significant, p = 0.018. Concerning the type of delivery with the frequency of nausea, the results showed that the frequency of nausea in group A was 3.24 times higher than group B, however, this difference was not statistically significant, p = 0.106.

Conclusion: Based on the results of this study, ondansetron had a significant effect on the alleviation of postoperative nausea and vomiting, as compared to dexamethasone in c-section surgical candidates.
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http://dx.doi.org/10.2174/1574884715666200302122800DOI Listing
March 2020

The effect of inspiratory muscle training on fatigue and dyspnea in patients with heart failure: A randomized, controlled trial.

Jpn J Nurs Sci 2020 Apr 19;17(2):e12290. Epub 2019 Aug 19.

Department of Biostatistics and Epidemiology, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.

Aim: Fatigue and dyspnea are debilitating symptoms in patients with heart failure (HF). The purpose of this study was to evaluate the effects of inspiratory muscle training (IMT) on dyspnea, fatigue and the New York Heart Association (NYHA) functional classification in patients with HF.

Methods: In this prospective, randomized, controlled trial, 84 patients with HF (NYHA classes II-III/IV) with a mean age of 56.62 ± 9.56 years were randomly assigned to a 6-week IMT (n = 42) or a sham IMT (n = 42) program. The IMT was performed at 40% of the maximal inspiratory pressure (MIP) in the IMT group and at 10% in the sham group. The main outcomes were assessed at baseline and after the intervention and included dyspnea severity scale (Modified Medical Research Council [MMRC], Fatigue Severity Scale [FSS] and the NYHA functional classification (based on the presenting symptoms).

Results: The between-group analysis showed significant improvements in dyspnea, fatigue and the NYHA functional classification in the IMT group compared to the sham group (P < .05). The within-group analysis showed significant improvements in dyspnea (from 2.63 ± 0.79 to 1.38 ± 0.66, P < .001), fatigue (from 43.36 ± 8.5 to 28.95 ± 9.11, P < .001) and the NYHA functional classification (from 2.73 ± 0.5 to 2.1 ± 0.6, P = .001) in the IMT group, while fatigue and dyspnea increased significantly in the sham group.

Conclusions: The 6-week home-based IMT was found to be an effective and safe tool for reducing dyspnea and fatigue and improving the NYHA functional classification.
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http://dx.doi.org/10.1111/jjns.12290DOI Listing
April 2020

Study of angiotensin-converting enzyme insertion/deletion polymorphism, enzyme activity and oxidized low density lipoprotein in Western Iranians with atherosclerosis: a case-control study.

BMC Cardiovasc Disord 2019 08 1;19(1):184. Epub 2019 Aug 1.

Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: It has been indicated that Angiotensin-Converting Enzyme Insertion/Deletion (ACE I/D) polymorphism (rs4646994) could be regarded as a genetic factor that raises the risk of CAD through its impact on the activity of Angiotensin-Converting Enzyme (ACE) and angiotensin II level. The present study seeks to examine the relationship between ACE I/D polymorphism with the risk of atherosclerosis. Moreover, its potential effects on ACE activity and oxLDL level are investigated.

Methods: In this study, 145 healthy individuals and 154 patients (143 males and 156 females) were selected among the subjects referred to Shahid Madani Hospital. Atherosclerosis was determined in all subjects with gold standard angiography. Blood samples were collected, used to isolate white blood cells (WBC) and serum separation. The DNA was extracted and the polymorphism was determined by polymerase chain reaction (PCR). The enzyme activity was measured using high-performance liquid chromatography (HPLC).

Results: This study indicated that patients with atherosclerosis had higher levels of oxidized Low-Density Lipoprotein (oxLDL) and ACE activity (P < 0.05) as compared to controls. Although we found a significant association between ACE I/D polymorphism genotype and the allele with atherosclerosis in the male group, there were no association when the entire patient group was compared to the entire control group.

Conclusion: Our study revealed the ACE I/D polymorphism of the ACE gene may not be an independent risk factor in the development of atherosclerosis and evaluation of ACE activity level is more important in evaluating the risk of disease. The researchers found no relation between ACE I/D polymorphism and atherosclerosis and also between types of genotype, ACE activity, and OxLDL level.
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http://dx.doi.org/10.1186/s12872-019-1158-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676562PMC
August 2019

The Relation between Polymorphisms in Exon 5 and Exon 6 of GSTP1 Gene and the Risk of Lung Cancer in Iranian People

Asian Pac J Cancer Prev 2019 May 25;20(5):1503-1509. Epub 2019 May 25.

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: The GSTP1 gene, which is located on chromosome 11q13, consists of 7 exons and 6 introns. There are two polymorphisms in GSTP1 that have been exposed to a transposition for codon 105 (Ile/Val) and 114 (Ala/Val) in exons 5 and 6, which have been studied previously in relation to lung cancer. Since the level of GSTP1 expression in lung tissues and other human epithelial tissues is high, GSTP1Val-105 polymorphism is recognized as a sensitive factor for tobacco-related cancers, especially lung cancer. Methods: One hundred and twenty tissue block samples of patients with lung cancers and 120 peripheral blood samples of the control group were obtained from two referral cancer centers in Tehran, Iran, from 2011 to 2016. Genomic DNA was extracted from tissue blocks and buffy coat of study cases to detect SNP of GSTP1 gene using Tetra-primer ARMS-PCR. Results: There was a notable correlation between the incidence of lung cancer and variant Val105 (P-value=0.001; OR=2/6; 95% CI=1.49-4.53) and Ile105 (P-value=0.003; OR=0.41; 95% CI=0.23-0.73). The odds ratio for lung cancer in the homozygous Ile105/Ile105 genotype was 3.56 times higher than that of individual with heterozygous Ile105/Val105 (P-value<0.001; OR=3/56; 95% CI=1.826-6.934) genotype, that was statistically significant. Furthermore, the results showed that there was no significant correlation between Ala114/Val114 genotypes and lung cancer. The BC (P-value=0.007; OR=0.16; 95% CI=0.04-0.61) and AA (P=0.001) genotypes were statistically significant (P-value <0.05); and for those who had AA genotype, the odds ratio was almost six times higher than those with BC genotype. Conclusions: The study of GSTP1 polymorphisms indicated that unlike the polymorphism in exon 5, the GSTP1 exon 6 polymorphism correlated with the lung cancer risk in the select group of Iranian people. Likewise, the potential use of this genetic polymorphism as a lung cancer predictor is confirmed.
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http://dx.doi.org/10.31557/APJCP.2019.20.5.1503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857866PMC
May 2019

Pectin/Chitosan/Tripolyphosphate Nanoparticles: Efficient Carriers for Reducing Soil Sorption, Cytotoxicity, and Mutagenicity of Paraquat and Enhancing Its Herbicide Activity.

J Agric Food Chem 2019 May 9;67(20):5736-5745. Epub 2019 May 9.

Environmental Health Research Center, Research Institute for Health Development , Kurdistan University of Medical Sciences , Sanandaj , Iran.

As a potent herbicide capable of contaminating water and soil environments, paraquat, which is still widely used worldwide, is toxic to mammals, algae, aquatic animals, etc. Paraquat was loaded on novel nanoparticles composed of pectin, chitosan, and sodium tripolyphosphate (PEC/CS/TPP). The size, polydispersity index, and ζ potential of nanoparticles were characterized. Further assessments were carried out by SEM, AFM, FT-IR, and DSC. The encapsulation was highly efficient, and there was a delayed release pattern of paraquat. The encapsulated herbicide was less toxic to alveolar and mouth cell lines. Moreover, the mutagenicity of the formulation was significantly lower than those of pure or commercial forms of paraquat in a Salmonella typhimurium strain model. The soil sorption of paraquat and the deep soil penetration of the nanoparticle-associated herbicide were also decreased. The herbicidal activity of paraquat for maize or mustard was not only preserved but also enhanced after encapsulation. It was concluded that paraquat encapsulation with PEC/CS/TPP nanoparticles is highly efficient and the formulation has significant herbicide activity. It is less toxic to human environment and cells, as was evidenced by less soil sorption, cytotoxicity, and mutagenicity. Hence, paraquat-loaded PEC/CS/TPP nanoparticles have potential advantages for future use in agriculture.
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http://dx.doi.org/10.1021/acs.jafc.9b01106DOI Listing
May 2019

Serum insulin level, HOMA-IR and prostate cancer risk: A systematic review and meta-analysis.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):110-115. Epub 2018 Aug 29.

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address:

Aims: This meta-analysis study was performed to assess serum insulin level and insulin resistance status in prostate cancer patients in observational studies.

Materials And Methods: A systematic literature search was performed for observational studies in Scopus, PubMed, Ovid and ISI Web of Science up to July 2017.

Results: From 2070 publication were searched firstly, only 10 studies with 9 and 6 arms included for the meta-analysis assessing serum insulin level and HOMA-IR status in prostate cancer patients, respectively. Pooled effects analysis showed that the Fasting insulin level was significantly higher in men with prostate cancer compared to control group (WMD = 2.12 μ IU/ml, 95%CI; 0.26, 3.99; P = 0.02). Sub-group analysis showed that the elevation in serum insulin level takes place only in patients with ages more than 65 years old (WMD = 3.88 μ IU/ml, 95%CI; 2.28, 5.48; P < 0.001). HOMA-IR was no significantly different between study groups. However, the difference got statistically significant after sub-grouping patients based on their age (WMD = 1.37, 95% CI; 0.61, 2.12; P < 0.001).

Conclusion: In conclusion, the results of this meta-analysis study showed higher fasting serum insulin and HOMA-IR levels especially in patients with ages more than 65 years..
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http://dx.doi.org/10.1016/j.dsx.2018.08.031DOI Listing
May 2019

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) Polymorphisms and Lung Cancer Risk among a Select Group of Iranian People

Asian Pac J Cancer Prev 2018 10 26;19(10):2921-2927. Epub 2018 Oct 26.

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective(s): Lung cancer, caused primarily by smoking, is one of the leading determinants of mortality throughout the world. Here we investigated the effects of polymorphisms in two enzymes, i.e., GSTT1 and GSTM1, related to the antioxidant defense line against carcinogens associated with lung cancer among a select group of Iranian people. Materials and Methods: One hundred and twenty lung cancer patients from two referral centers in Tehran, Iran, were recruited for comparison with 120 healthy controls. Genomic DNA was extracted from the FFPE tumor tissues of the select cases and peripheral blood buffy coats of healthy controls. The polymorphisms of GSTT1 and GSTM1 were investigated by multiplex polymerase chain reaction. Results: With the 240 samples studied, no specific relationship with lung cancer was discerned for the GSTM1 (P=0.35; OR=1/33; 95% CI=0.79-2.25) polymorphism, but the GSTT1 (P=0.005; OR=2.4; CI=1.32-4.35) gene polymorphism revealed a notable association on logistic regression, taking into account age and sex factors. Furthermore, the GSTT1 genotype distribution in patients with LSCC was different from that of healthy cases (P=0.006; OR=3.11; CI=1.38-7.04). The risk of developing lung cancer with the T0M1 genotype was 3.46 times higher than with T1M1 genotype (P=0.002; OR=3.46; CI=1.61-7.46). Moreover, the risk of developing LSCC cancer in people with T0M1 genotypes was significantly elevated (P=0.004; OR=4.5; CI=1.62-12.52). Conclusion: Unlike GSTM1, the GSTT1 genotype distribution is associated with the incidence of lung cancer in Iranian people. Different types of lung cancer appear to show various correlations with GST polymorphisms in this regard.
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http://dx.doi.org/10.22034/APJCP.2018.19.10.2921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291040PMC
October 2018

Effect of Vitamin E Supplementation on Plasma and Urine Levels of Isoprostane F2α in Randomized Controlled Clinical Trials: A Systematic Review and Meta-Analysis.

Int J Vitam Nutr Res 2017 Sep 16;87(5-6):314-321. Epub 2018 Jul 16.

1 Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Vitamin E can reduce the level of lipid peroxidation and the related markers such as urine and plasma levels of isoprostanes. However, effects of vitamin E supplementation on plasma and urine level of isoprostane F2α as markers of lipid peroxidation were conflicting in various clinical trials. The current meta-analysis was carried out to determine the effects of vitamin E supplementation on plasma and urine levels of isoprostanes F2α in randomized clinical trials. A systematic search of RCTs was carried out in PubMed, Scopus, Science Direct and Cochrane Library databases. OF 889 relevantly founded articles, only four articles with five arms met the criteria for meta-analysis of plasma level of isoprostanes F2α. For the urine level of isoprostane F2α, three studies with 14 arms were included in the meta-analysis. After pooled analyzing, a significant reduction of 6.98 ng / l was seen in plasma level of isoprostane F2α in vitamin E receiving group (95% CI = -11.2, -2.76; 0.001) while no significant heterogeneity was seen between the studies included in this meta-analysis ( 0.81 and I2 = 0.0%). However, the pooled effect of vitamin E supplementation on urine level of isoprostane F2α was not statistically significant (-11.31 pg / mg creatinine (95% CI = -26.4, 3.78; 0.88). Results of this meta-analysis have shown that vitamin E supplementation can only reduce plasma level of isoprostane F2α and has no significant effect on reducing urine level of this biomarker.
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http://dx.doi.org/10.1024/0300-9831/a000488DOI Listing
September 2017

Antagonistic effect of isolated probiotic bacteria from natural sources against intestinal pathotypes.

Electron Physician 2018 Mar 25;10(3):6534-6539. Epub 2018 Mar 25.

Nephrology Fellowship, Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: Probiotics are live microorganisms which are beneficial bacteria that are normal flora of the digestive system which, in determined amounts, show beneficial effects on host health, and can balance gastrointestinal microflora. Digestive tract diseases such as diarrhea are one of the major causes of child mortality in developing countries. Different pathotypes of cause diarrhea that affects children, therefore reduction of these colonization strains in humans or animals can decline gastrointestinal disorders such as diarrhea.

Objective: The aim of this study was to determine the antimicrobial effect of probiotic bacterial strains isolated from different natural sources against 4 pathotypes of pathogenic using disk and well diffusion methods.

Methods: This cross-sectional study was conducted from December 2013 to July 2014 on Martyr Chamran University in Ahwaz city. A total of 13 probiotic colonies isolated from 20 samples of traditional dairy products including yogurt, cheese and milk, and 20 samples of vegetables including carrots and cabbages (red and white), of which 5 isolates were selected to determine the antimicrobial effect against 4 pathotypes, randomly. The antimicrobial effect was evaluated using two methods: disk diffusion and well diffusion tests and measuring growth inhibition zones of probiotics against 4 pathotypes of pathogenic

Results: Obtained results showed growth inhibition effects of all 5 probiotic strains against Escherichia coli pathotypes in both used methods. But in comparison had higher growth inhibitory effects in both methods.

Conclusion: results of this study demonstrated high antimicrobial effect of probiotic bacteria against pathogenic strains. It indicated a positive and beneficial role of probiotics in human health and prevention of illness.
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http://dx.doi.org/10.19082/6534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942575PMC
March 2018

The effect of progressive muscle relaxation on the management of fatigue and quality of sleep in patients with chronic obstructive pulmonary disease: A randomized controlled clinical trial.

Complement Ther Clin Pract 2018 May 6;31:64-70. Epub 2018 Feb 6.

School of Nursing and Midwifery, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address:

Objective: To assess the effect of progressive muscle relaxation (PMR) on fatigue and sleep quality of patients with chronic obstructive pulmonary disease (COPD) stages 3 and 4.

Materials And Methods: The pretest posttest clinical trial recruited 91 patients COPD grades 3 and 4. Following random assignment of subjects, the treatment group (n = 45) performed PMR for eight weeks and the control group (n = 46) received routine cares. At baseline and after the intervention, fatigue and sleep quality was assessed. Data obtained were analyzed in SPSS.

Results: It was determined that PMR decreased patients' fatigue level and improved some sleep quality subscales including subjective sleep quality, sleep latency, sleep duration and habitual sleep efficiency, but no improvement was found in global sleep quality and other sleep subscales.

Conclusion: An eight-week home-based PMR program can be effective in reducing fatigue and improving certain subscales of sleep quality in patients with COPD stages 3,4. (IRCT2016080124080N3).
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http://dx.doi.org/10.1016/j.ctcp.2018.01.010DOI Listing
May 2018

Effect of vitamin D supplementation on anthropometric indices among overweight and obese women: A double blind randomized controlled clinical trial.

Diabetes Metab Syndr 2018 Jul 27;12(4):537-541. Epub 2018 Mar 27.

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Islamic Republic of Iran. Electronic address:

Aims: The aim of this study was to investigate effect of vitamin D supplementation on anthropometric indices among women with overweight and obesity.

Methods: This double blind randomize clinical trial was conducted on 66 overweight and obese women. Those in intervention group received oral supplement of vitamin D 50,000 IU (1250 mcg) per 25 day and in control group participants received placebo for 3 months. Anthropometric indices were measured before and after 3 months intervention. Before the intervention a 24-h dietary recall (3 days) were used to assess dietary intake of individuals. Independent t test and multivariate repeated measure were used to data analysis.

Results: The mean difference of anthropometric indices, serum calcium, 25 (OH) D and serum PTH between the intervention and control groups were significant (P < 0/05). However, no significant differences in serum phosphorus between the intervention and control groups were seen.

Conclusion: Supplementation with vitamin D 50 μg for each day for 3 months resulted in a significant reduction in anthropometric indices in women with obesity and overweight with normal primary 25(OH) D serum levels.
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http://dx.doi.org/10.1016/j.dsx.2018.03.022DOI Listing
July 2018

Seroepidemiological study of Q fever in Lorestan province, western Iran, 2014.

Iran J Microbiol 2017 Aug;9(4):213-218

Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.

Background And Objectives: Q fever is a zoonotic disease and farm animals serve as the main reservoir of the disease. The aim of this study was to evaluate the seroprevalence of Q fever in sheep, in Lorestan province in western Iran.

Materials And Methods: In this cross-sectional study, 330 blood samples were collected from sheep, from each county in Lorestan province. The samples were tested by ELISA for the presence of immunoglobulin (IgG) against .

Results: Among the samples tested, 45 samples (13.64%) were seropositive. Of 35 studied herds, 21 (60%) had a history of infection. In terms of number of positive samples, there was no significant difference between the three geographical regions (central, west and east) (p=0.687). There was no statistically significant difference between age groups (p =0.604). Gender also had no effect on infection rates, in female and male sheep (p =0.814). No significant difference was observed between the number of lactation and positive serology (p =0.376). The rate of infection with Q fever and abortion also had no statistically significant difference (p =0.152).

Conclusion: The findings of this study showed that sheep in Lorestan were infected by Q fever and the cycle of disease transmission had been established between animals and ticks.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723973PMC
August 2017

The concentration data of heavy metals in Iranian grown and imported rice and human health hazard assessment.

Data Brief 2018 Feb 21;16:453-459. Epub 2017 Nov 21.

Department of Biostatistics, School of Health and Nutrition, Lorestan University of medical sciences, Khorramabad, Iran.

The aim of this study was to review the prevalence of rice contamination to heavy metals in Iranian grown and imported rice brands by conducting a systematic review and assess the related human health risk. Multiple keywords such as "rice, heavy metals, and Iran" were used to search in related databases. The average concentration of Cd, Pb, As, Cu, Zn, Cr, Ni and Co for Iranian grown/imported rice were calculated as 0.16±0.08/0.13±0.05, 0.196±0.16/0.55±0.56, 0.046±0.002/0.057±0.0035,0.29±0.05/0.61±0.31, 26.13±10.3/3.46±2.49, 0.22±0.04/0.76±0.101, 16±7.3/2.08±0.34 and 0.29±0.047/0.29±0.07 mg kg, respectively. Except Co, there were significant differences between Iranian and imported rice brands. Estimated weekly intake for none of the metals exceeds the provisional tolerable weekly intake value. Accordingly, the rice types consumed in Iran have no health hazard for consumers.
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http://dx.doi.org/10.1016/j.dib.2017.11.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723357PMC
February 2018

Effects of geranium aroma on anxiety among patients with acute myocardial infarction: A triple-blind randomized clinical trial.

Complement Ther Clin Pract 2017 Nov 16;29:201-206. Epub 2017 Oct 16.

School of Nursing & Midwifery, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective: The is study examined the effects of geranium aroma on anxiety among patients with AMI.

Methods: This randomized, triple-blind, placebo-controlled clinical trial recruited 80 patients with AMI through convenience sampling. The patients were allocated to geranium and placebo groups (n = 40 each) using stratified block randomization. On the second day of admission three drops of geranium essential oil and placebo were poured on absorbing patches attached inside the oxygen masks of the geranium and placebo groups, respectively. The patients were asked to inhale the aroma for 20 min a day on two consecutive days.

Results: all stages of the intervention, the two groups had a significant difference in anxiety scores, i.e. geranium aroma caused significantly greater reductions in the anxiety scores (P < 0.001).

Conclusion: Inhalation aromatherapy with geranium essential oil is recommended as an easy-to-use, intervention to reduce anxiety among patients with AMI.
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http://dx.doi.org/10.1016/j.ctcp.2017.10.005DOI Listing
November 2017

Parkinson's disease and Toxoplasma gondii infection: Sero-molecular assess the possible link among patients.

Acta Trop 2017 Sep 9;173:97-101. Epub 2017 Jun 9.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

We investigated the possible association between Parkinson's disease (PD), the second most common neurodegenerative disorder and Toxoplasma gondii infection, the most common neurotropic protozoan parasitic infection, using serological and molecular techniques. One hundred and fifteen patients with confirmed PD and 115 healthy subjects in the same age and sex distribution were enrolled in this study. Blood samples were taken from each participant and the sera was screened for anti-Toxoplasma antibodies (IgG and IgM). PCR assay was performed in duplicate using the primer pair targeting the B1 gene of Toxoplasma. Amplicons were directly sequenced to conduct the phylogenetic analysis. The prevalence of Toxoplasma infection based on IgG titer was 53% in case and 55.6% in the control groups, revealing no statistically significant association between Toxoplasma seropositivity and PD (OR=0.90; 95% CI=0.54-1.51; P=0.691). According to PCR assay, the prevalence of Toxoplasma infections was 19.3% in the case and 10.4% in control groups which the difference was statistically significant (OR=3.02; 95% CI=1.46-6.27; P=0.002). Multiple sequence alignment of Toxoplasma gondii isolates manifested a common haplotype by the identity: 93.6-100% and divergence: 0-6.7%. We concluded that T. gondii infection not only could not be a risk factor to PD, but even it could be concluded that patients with PD are in more risk to acquisition of infection. These results provide fresh insights into the ambiguous association between T. gondii infection and PD.
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http://dx.doi.org/10.1016/j.actatropica.2017.06.002DOI Listing
September 2017

Prediction and Diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD) and Identification of Its Associated Factors Using the Classification Tree Method.

Iran Red Crescent Med J 2016 Nov 9;18(11):e32858. Epub 2016 Aug 9.

Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease in many parts of the world.

Objectives: The aim of the present study was to identify the most important factors influencing NAFLD using a classification tree (CT) to predict the probability of NAFLD.

Patients And Methods: This cross-sectional study was conducted in Kavar, a town in the south of Fars province, Iran. A total of 1,600 individuals were selected for the study via the stratified method and multiple-stage cluster random sampling. A total of 30 demographic and clinical variables were measured for each individual. Participants were divided into two datasets: testing and training. We used the training dataset (1,120 individuals) to build the CT and the testing dataset (480 individuals) to assess the CT. The CT was also used to estimate class and to predict fatty liver occurrence.

Results: NAFLD was diagnosed in 22% of the individuals in the sample. Our findings revealed that the following variables, based on univariate analysis, had a significant association with NAFLD: marital status, history of hepatitis B vaccine, history of surgery, body mass index (BMI), waist-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), triglycerides (TG), alanine aminotransferase (ALT), cholesterol (CHO0, aspartate aminotransferase (AST), glucose (GLU), albumin (AL), and age (P < 0.05). The main affecting variables for predicting NAFLD based on the CT and in order of importance were as follows: BMI, WHR, triglycerides, glucose, SBP, and alanine aminotransferase. The goodness of fit model based on the training and testing datasets were as follows: prediction accuracy (80%, 75%), sensitivity (74%, 73%), specificity (83%, 77%), and the area under the receiver operating characteristic (ROC) curve (78%, 75%), respectively.

Conclusions: The CT is a suitable and easy-to-interpret approach for decision-making and predicting NAFLD.
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http://dx.doi.org/10.5812/ircmj.32858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292777PMC
November 2016

The Reliability of Classification of Terminal Nodes in GUIDE Decision Tree to Predict the Nonalcoholic Fatty Liver Disease.

Comput Math Methods Med 2016 7;2016:3874086. Epub 2016 Dec 7.

Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Tree structured modeling is a data mining technique used to recursively partition a dataset into relatively homogeneous subgroups in order to make more accurate predictions on generated classes. One of the classification tree induction algorithms, GUIDE, is a nonparametric method with suitable accuracy and low bias selection, which is used for predicting binary classes based on many predictors. In this tree, evaluating the accuracy of predicted classes (terminal nodes) is clinically of special importance. For this purpose, we used GUIDE classification tree in two statuses of equal and unequal misclassification cost in order to predict nonalcoholic fatty liver disease (NAFLD), considering 30 predictors. Then, to evaluate the accuracy of predicted classes by using bootstrap method, first the classification reliability in which individuals are assigned to a unique class and next the prediction probability reliability as support for that are considered.
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http://dx.doi.org/10.1155/2016/3874086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174753PMC
March 2017

The effect of berberis vulgaris extract on transaminase activities in non-alcoholic Fatty liver disease.

Hepat Mon 2015 Feb 5;15(2):e25067. Epub 2015 Feb 5.

Department of Biostatistics, School of Public Health, Lorestan University of Medical Sciences, Khoramabad, IR Iran.

Background: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disorder in western countries and an important cause of liver cirrhosis, as well as liver failure. Up to now, 20‒40% of the individuals suffer from this disorder and its prevalence is estimated around 5‒30% in Asia. The NAFLD is one of the most prevalent causes for increases in liver enzymes and has a close relationship with obesity, dyslipidemia, hypertension, and type II diabetes. However, no definite treatment has been identified for it yet.

Objectives: The present study aimed to investigate the effect of berberis vulgaris extract in inducing changes in liver enzymes levels.

Patients And Methods: The present clinical trial was conducted on 80 patients, including 32 males (40%) and 48 females (60%), who were randomly assigned into two groups of case and control. All the patients had ultrasound evidence of lipid accumulation in the liver and increases in liver enzymes. The case group received two capsules (750 mg) containing berberis vulgaris extract every day for 3 months, while the control group was treated with placebo. The weight, liver transaminases levels and lipid profiles of the two groups were assessed before, during, and after the study.

Results: In the case group, the mean serum levels of alanine transaminase (ALT) and aspartate transaminase (AST) decreased from 49 to 27.48 and 48.22 to 29.8 u/L, respectively, which was statistically significant compared to the control group (P < 0.001, P < 0.001). In the control group, the mean of ALT and AST decreased from 50.4 to 46.8 and 45.7 to 44.9 u/L, respectively. The difference was not statistically significant. In addition, a significant decrease was observed in weight, triglycerides, and cholesterol, while no significant change was found in fasting blood sugar, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL).

Conclusions: Considering the significant decrease in the liver enzymes, triglycerides and cholesterol after using berberis vulgaris extract, further studies with larger sample sizes will identify the accurate dose as well as duration of consumption for this extract, to recommend in the treatment of patients with NAFLD.
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http://dx.doi.org/10.5812/hepatmon.25067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350248PMC
February 2015

Comparison of designed slippers splints with the splints available on the market in the treatment of hallux valgus.

Acta Med Iran 2012 ;50(2):107-12

Department of Orthopedic Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran.

Hallux valgus or the lateral deviation of the great toe is a complex disease. If it is not treated, it will cause the deviation of other toes. Hallux valgus is three times more common in females and may cause uncomfortable deformity of the foot, problems in putting on unsuitable and narrow toe box shoes, and pain on the medial side of the first metatarsophalangeal joint; therefore, patients seek medical services. Untreated hallux valgus may cause the hammer toe deformity of the second toe. In this cohort study, 30 patients referring to the Orthopedic Clinic of Shohada Ashayer Hospital of Khorramabad, Iran, with a complaint of hallux valgus were randomly divided into two groups. The splints designed by the researches (slippers splints) were given to the case group, and the splints on the market including night splints and interdigital pads were given to the control group. The patients were followed every three months for a year and every time the weight bearing anteroposterior radiography of both feet were taken and hallux valgus and inter-metatarsal angles were measured. The data was analyzed by the SPSS software using repeated measure tests. In the case group that used the designed splints regularly, hallux valgus angles decreased more dramatically than in the control group (P<0.001). This study showed that, despite controversies over the nonoperative treatment of hallux valgus, if hallux valgus angle in patient is mild to moderate, the splint can be used as a nonoperative treatment.
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June 2012

Frequency of epididymo-orchitis in hospitalized patients with acute scrotum at Shohadaye Ashayer Hospital, Khorramabad, Iran.

J Pak Med Assoc 2012 Jan;62(1):44-6

Department of Urology, Urology and Nephrology Research Center (UNRC), Lorestan Unversity of Medical Sciences, Lorestan, Islamic Republic of Iran.

Objective: To investigate the frequency of epididymo-orchitis in patients with acute scrotum.

Methods: In this five-year cross sectional study from March 2004 to June 2009, 83 patients who were hospitalized for acute scrotal pain at Shohadaye Ashayer Hospital in Khorramabad were investigated. First, urine analysis and urine culture tests were carried out followed by sonography if necessary. In cases of suspicious sexual activities, serologic tests and urethral secretion culture were also carried out. In patients whose response to treatment was unsatisfactory after 48 hours, brucellosis and tuberculosis were investigated.

Results: Out of 83 patients with epididymo-orchitis, there were positive urine cultures in 69 patients. In 52 (62.7%) of these patients, 30 were infected with E. Coli, 9 with Klebsiella, 8 with Pseudomonas, and 5 cases with Proteus, respectively. In 17 cases, tuberculosis and ischaemic orchitis were observed.

Conclusion: Among common causes of epididymo-orchitis, rare causes such as tumour, tuberculosis, and brucellosis must be taken into consideration. In all these cases sufficient time for the follow-up should be taken into account.
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January 2012

The effect of Olanzapine and Sertraline on personality disorder in patients with methadone maintenance therapy.

Psychiatr Danub 2010 Dec;22(4):544-7

Lorestan University of Medical Sciences, Tehran, Iran.

Background: Various drugs have been suggested for treatment of Borderline Personality Disorder (BPD)-a disabling disease affecting two percent of the general population. If a drug could alleviate a wide range of symptoms, it would be more suitable. In these disorders drug addiction is very common. This fact makes the symptoms complicated and the treatment more difficult.

Subjects And Methods: This study is designed to evaluate the effect of Olanzapine and Sertraline in patients suffering from personality disorders who are on methadone maintenance therapy. This study is a clinical trial. 120 males and females were chosen for methadone maintenance therapy through interview by a psychiatrist based on DSM-IV-TR diagnostic criteria for BPD. Afterwards they were randomly divided into two groups. These groups separately received Olanzapine (5-10 mg daily) and Sertraline (50-100 mg daily) therapy. The SCL-90 questionnaire was filled by all participants before treatment and at the 4th, 8th and 12th weeks of treatment.

Results: According to this clinical trial, Olanzapine and Sertraline are effective in ameliorating symptoms of depression, anxiety and aggression, reducing sensitivity in interpersonal relationships and alleviating obsessive symptoms, pessimistic behaviors and somatization disorders in patients with personality disorders on methadone maintenance therapy.

Conclusion: As result of this study it appears that Olanzapine and Sertraline are definitely effective in alleviating symptoms of patients with personality disorder, prescribing theses drugs are recommended for these patients.
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December 2010

Assessment of clonidine effect as premedicative drug on kidney function.

J Pak Med Assoc 2010 Jul;60(7):570-2

Lorestan University of Medical Sciences, Lorestan.

Objective: To assess the effect of oral clonidine as a premedicative drug on 24-hour urine output, urine specific gravity, plasma renin activity as well as serum and urine electrolytes levels.

Methods: This prospective study was carried out on 60 women aged 20-40 years old undergoing repair of cystocoele-rectocoele perineorraphy under general anaesthesia in Asali Hospital in 2004 in Khorramabad, Iran. Subjects were randomly divided into two equal groups of 30 each. Group I and group II received clonidine tablet at the dose of 5 microg/kg and placebo tablet, respectively, 90 minutes before induction of general anesthesia. In this study, blood and urine samples were taken for laboratory measurements prior as well as 6 hours after taking the tablets. Differences between the two groups were compared through Mann-Whitney u-test, chi2 test and t-student test. P-value < 0.05 was considered statistically significant.

Results: There were no significant changes before and after receiving tablets in urine and blood Na and K as well as urine specific gravity in group II (P > 0.05). Group I had higher urine Na and K level (P = 0.001), however, no differences had been shown in blood Na and K level (P > 0.05). Urine specific gravity was lower in group I after receiving tablet (P < 0.009). A significant increase in 24-hour urine output (P = 0.001) and a marked decrease in plasma renin activity was seen in group I (P = 0.001).

Conclusion: This study suggests that clonidine is a safe premedicative drug in anaesthesia and does not change the serum electrolytes levels.
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July 2010

Effect of saffron on semen parameters of infertile men.

Urol J 2008 ;5(4):255-9

Department of Urology, Lorestan University of Medical Sciences, Khorramabad, Iran.

Introduction: We conducted this study to determine the effects of saffron (Crocus sativus) on the results of semen analysis in men with idiopathic infertility.

Materials And Methods: In this clinical trial, 52 nonsmoker infertile men whose problem could not be solved surgically were enrolled. They were treated by saffron for 3 months. Saffron, 50 mg, was solved in drinking milk and administered 3 times a week during the study course. Semen analysis was done before and after the treatment and the results were compared.

Results: The mean percentage of sperm with normal morphology was 26.50 +/- 6.44% before the treatment which increased to 33.90 +/- 10.45%, thereafter (P < .001). The mean percentage of sperm with Class A motility was 5.32 +/- 4.57% before and 11.77 +/- 6.07% after the treatment (P < .001). Class B and C motilities were initially 10.09 +/- 4.20% and 19.79 +/- 9.11% which increased to 17.92 +/- 6.50% (P < .001) and 25.35 +/- 10.22% (P < .001), respectively. No significant increase was detected in sperm count; the mean sperm count was 43.45 +/- 31.29 x 106/mL at baseline and 44.92 +/- 28.36x 106/mL after the treatment period (P = .30).

Conclusion: Saffron, as an antioxidant, is positively effective on sperm morphology and motility in infertile men, while it does not increase sperm count. We believe further studies on larger sample sizes are needed to elucidate the potential role and mechanism of action of saffron and its ingredient in the treatment of male infertility.
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April 2009