Meggan Mackay

Meggan Mackay

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Meggan Mackay

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Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort.

J Rheumatol 2019 May 15;46(5):492-500. Epub 2019 Jan 15.

From the Rheumatology/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Medicine, Unit of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm; Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund; Unit for Clinical Therapy Research (ClinTRID), Karolinska University, Stockholm, Sweden; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, Ontario; Division of Rheumatology, Centre Hospitalier Universitaire (CHU) de Québec - Université Laval, Quebec City, Quebec; Division of Rheumatology, Cumming School of Medicine - University of Calgary, Calgary, Alberta; Division of Rheumatology, Department of Medicine, McGill University Health Centre, Montreal, Quebec; Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia; Department of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea; Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham; Centre for Rheumatology Research, University College, London; Lupus Research Unit, The Rayne Institute, St. Thomas' Hospital, King's College London School of Medicine, London; Lanarkshire Centre for Rheumatology, Hairmyres Hospital, East Kilbride, Scotland; Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, The University of Manchester and UK National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK; Cedars-Sinai/David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California; Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma; Department of Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, New York; Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Feinstein Institute for Medical Research, Manhasset, New York; Division of Rheumatology and Immunology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina; Autoimmunity Institute, Allegheny Health Network, Pittsburgh, Pennsylvania; Northwestern University and Feinberg School of Medicine, Chicago, Illinois; Division of Rheumatology, Emory University School of Medicine, Atlanta, Georgia; University of California San Diego School of Medicine, La Jolla, California; Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina; Division of Rheumatology, Columbia University Medical Center, New York, New York, USA; Department of Rheumatology, Center for Rheumatology Research Fossvogur Landspitali University Hospital, Reyjkavik, Iceland; Autoimmune Disease Unit, Department of Internal Medicine, Hospital Universitario Cruces, BioCruces Health Research Institute, University of the Basque Country, Barakaldo; Josep Font Autoimmune Diseases Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Spain; Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey; Copenhagen Lupus and Vasculitis Clinic, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Rheumatology, Kantousspital, Schaffhausen, Switzerland.

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http://dx.doi.org/10.3899/jrheum.180713DOI Listing
May 2019

Patterns of ANA+ B cells for SLE patient stratification.

JCI Insight 2019 May 2;4(9). Epub 2019 May 2.

Center of Autoimmune Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.

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https://insight.jci.org/articles/view/127885
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http://dx.doi.org/10.1172/jci.insight.127885DOI Listing
May 2019

Loss of an IgG plasma cell checkpoint in patients with lupus.

J Allergy Clin Immunol 2019 Apr 13;143(4):1586-1597. Epub 2018 Nov 13.

Center of Autoimmune Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183158
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http://dx.doi.org/10.1016/j.jaci.2018.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451885PMC
April 2019

Construction of a frailty index as a novel health measure in systemic lupus erythematosus.

J Rheumatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Medicine, Division of Rheumatology, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Community Health & Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada; Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea;Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Instituto Nacional de Ciencias Medicas y Nutrición, Mexico City, Mexico; Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Divisions of Rheumatology and Clinical Epidemiology, Department of Medicine, McGill University, Montreal, Quebec, Canada; Division of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA; Division of Rheumatology, CHU de Québec et Université Laval, Quebec City, Canada; Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, ON, Canada; Arthritis Research UK Epidemiology Unit, Faculty of Biology Medicine and Health, Manchester Academic Health Sciences Center, The University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Center Manchester, UK; Center for Rheumatology, Department of Medicine, University College London, UK; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, King's College London School of Medicine, UK, London, UK; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Northwestern University and Feinberg School of Medicine, Chicago, IL, USA; Lupus Center of Excellence, Allegheny Health Network, Pittsburgh, PA, USA; Lanarkshire Center for Rheumatology, Hairmyres Hospital, East Kilbride, Scotland UK; Feinstein Institute for Medical Research, Manhasset, NY, USA; Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain; Emory University School of Medicine, Division of Rheumatology, Atlanta, Georgia, USA Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey; Unit for clinical therapy research (ClinTRID), Karolinska Institute, Stockholm, Sweden; Department of Clinical Sciences Lund, Rheumatology, Lund University, Lund, Sweden. Josep Font Autoimmune Diseases Laboratory, IDIBAPS, Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Spain; Medical University of South Carolina, Charleston, South Carolina, USA; UCSD School of Medicine, La Jolla, CA, USA; Copenhagen Lupus and Vasculitis Clinic, 4242, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; University of Manitoba, Winnipeg, Manitoba, Canada; Hospital for Joint Diseases, NYU, Seligman Center for Advanced Therapeutics, New York NY; Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada. Funding for this work was provided by the Nova Scotia Health Authority Research Fund. Dr. Sang-Cheol Bae's work was supported in part by NRF-2017M3A9B4050335, Republic of Korea. Dr. Caroline Gordon's work was supported by Lupus UK and the NIHR /Wellcome Trust Clinical Research Facility. The Montreal General Hospital Lupus Clinic is partially supported by the Singer Family Fund for Lupus Research. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Paul R. Fortin presently holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases at Université Laval, and part of this work was done while he was still holding a Distinguished Senior Investigator of The Arthritis Society. Dr. Bruce is a National Institute for Health Research (NIHR) Senior Investigator and is supported by Arthritis Research UK, the NIHR Manchester Biomedical Centre and the NIHR/Wellcome Trust Manchester Clinical Research Facility. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. Dr Isenberg and Dr Rahman are supported by and supported by the National Institute for Health, Research University College London Hospitals Biomedical Research Center. The Hopkins Lupus Cohort is supported by the NIH (grant AR43727 and 69572). Dr. Mary Anne Dooley's work was supported by the NIH (grant RR00046). Dr. Ramsey-Goldman's work was supported by the NIH (grants 5UL1TR001422-02, formerly 8UL1TR000150 and UL-1RR-025741, K24-AR-02318, and P60AR064464 formerly P60-AR- 48098). Dr. Ruiz-Irastorza is supported by the Department of Education, Universities and Research of the Basque Government. Dr. Soren Jacobsen is supported by the Danish Rheumatism Association (A3865) and the Novo Nordisk Foundation (A05990). Dr. John G. Hanly is supported by the Canadian Institutes of Health Research (grant MOP-88526). Address Correspondence to: Dr. John G Hanly, Division of Rheumatology, Nova Scotia Rehabilitation Centre (2nd Floor), 1341 Summer Street, Halifax, Nova Scotia, Canada, B3H 4K4.Email:

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.181338
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April 2019

Metabolic and microstructural alterations in the SLE brain correlate with cognitive impairment.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Center for Neurosciences, Feinstein Institute for Medical Research and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York, USA.

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https://insight.jci.org/articles/view/124002
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http://dx.doi.org/10.1172/jci.insight.124002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485360PMC
January 2019

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.

Sci Rep 2017 03 21;7(1):270. Epub 2017 Mar 21.

Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, 11030, USA.

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http://www.nature.com/articles/s41598-017-00290-w
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http://dx.doi.org/10.1038/s41598-017-00290-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412647PMC
March 2017

Lupus brain fog: a biologic perspective on cognitive impairment, depression, and fatigue in systemic lupus erythematosus.

Authors:
Meggan Mackay

Immunol Res 2015 Dec;63(1-3):26-37

Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs12026-015-87
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http://link.springer.com/10.1007/s12026-015-8716-3
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http://dx.doi.org/10.1007/s12026-015-8716-3DOI Listing
December 2015

A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: data from the MAINTAIN Nephritis Trial.

Lupus Sci Med 2015 12;2(1):e000123. Epub 2015 Nov 12.

Rheumatology Department , Cliniques Universitaires Saint-Luc, Pôle de Pathologies Rhumatismales Inflammatoires et Systémiques, Université catholique de Louvain , Bruxelles , Belgium.

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http://dx.doi.org/10.1136/lupus-2015-000123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654096PMC
December 2015

Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-D-Aspartate Receptor.

EBioMedicine 2015 Jul 30;2(7):755-64. Epub 2015 May 30.

Autoimmune & Musculoskeletal Disease Center, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA ; Department of Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY 11030, USA.

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http://dx.doi.org/10.1016/j.ebiom.2015.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534689PMC
July 2015

Cognitive and emotional abnormalities in systemic lupus erythematosus: evidence for amygdala dysfunction.

Neuropsychol Rev 2012 Sep 11;22(3):252-70. Epub 2012 Aug 11.

The Graduate Center and Queens College, City University of New York, Flushing, NY, USA.

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http://link.springer.com/10.1007/s11065-012-9213-2
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September 2012

Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study.

Arthritis Res Ther 2009 28;11(5):R143. Epub 2009 Sep 28.

Division of Rheumatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1186/ar2816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787265PMC
February 2010

The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus.

PLoS One 2010 Feb 16;5(2):e9193. Epub 2010 Feb 16.

Division of Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, Manhasset, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009193PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821911PMC
February 2010

Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus.

Rheum Dis Clin North Am 2010 Feb;36(1):187-201, x-xi

Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0889857X0900128
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http://dx.doi.org/10.1016/j.rdc.2009.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837540PMC
February 2010

Development, impact, and measurement of enhanced physical diagnosis skills.

Adv Health Sci Educ Theory Pract 2009 Oct 22;14(4):547-56. Epub 2008 Oct 22.

Division of Infectious Disease-Staff house rm. 226, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, Lakeville Rd., New Hyde Park, NY 11042, USA.

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http://dx.doi.org/10.1007/s10459-008-9137-zDOI Listing
October 2009

Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus.

PLoS One 2009 Jun 2;4(6):e5776. Epub 2009 Jun 2.

The Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685013PMC
June 2009

Identification of DNA-reactive B cells in patients with systemic lupus erythematosus.

J Immunol Methods 2008 Sep 17;338(1-2):79-84. Epub 2008 Aug 17.

Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York 11030, USA.

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http://dx.doi.org/10.1016/j.jim.2008.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577778PMC
September 2008

Neuropsychiatric systemic lupus erythematosus reconsidered.

Nat Clin Pract Rheumatol 2008 Mar;4(3):112-3

Department of Immunology and Rheumatology, Instituto Nacional Nutrición, Mexico City, Mexico.

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http://dx.doi.org/10.1038/ncprheum0726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734405PMC
March 2008

Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis.

Arthritis Rheum 2007 Jun;56(6):1894-903

Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1002/art.22594DOI Listing
June 2007

Urinary TWEAK and the activity of lupus nephritis.

J Autoimmun 2006 Dec 24;27(4):242-50. Epub 2007 Jan 24.

Division of Rheumatology, Forchheimer 701N, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.jaut.2006.12.003DOI Listing
December 2006

Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE.

J Exp Med 2006 Sep 21;203(9):2157-64. Epub 2006 Aug 21.

Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1084/jem.20051503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118390PMC
September 2006

Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays.

J Clin Invest 2005 Dec;115(12):3428-39

Department of Internal Medicine-Rheumatology, Center for Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8884, USA.

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http://dx.doi.org/10.1172/JCI23587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297234PMC
December 2005

Systemic lupus erythematosus presenting with features suggestive of human immunodeficiency virus infection.

J Rheumatol 2005 Jul;32(7):1365-8

Department of Medicine and Microbiology, Columbia University Medical Center, New York, New York 10032, USA.

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July 2005

Renal tubular acidosis, Sjögren syndrome, and bone disease.

Arch Intern Med 2004 Apr;164(8):905-9

Department of Medicine, Albert Einstein College of Medicine, Belfer Building, Room 1008, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1001/archinte.164.8.905DOI Listing
April 2004