Publications by authors named "Megan K Levings"

100Publications

A method for expansion and retroviral transduction of mouse regulatory T cells.

J Immunol Methods 2020 Nov 19:112931. Epub 2020 Nov 19.

Department of Surgery, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2020.112931DOI Listing
November 2020

Building a CAR-Treg: Going from the basic to the luxury model.

Cell Immunol 2020 Dec 28;358:104220. Epub 2020 Sep 28.

BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V5Z 4H4, Canada; Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2020.104220DOI Listing
December 2020

T-Cell Specificity Matters in IBD: Impaired IL10 Production Revealed by OmpC-Tetramers.

Cell Mol Gastroenterol Hepatol 2020 6;10(3):647-648. Epub 2020 Jul 6.

British Columbia Children's Hospital Research Institute, Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2020.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474152PMC
July 2020

Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function.

Eur J Immunol 2020 May 10. Epub 2020 May 10.

Department of Surgery, The University of British Columbia, Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/eji.201948435DOI Listing
May 2020

Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients.

Am J Transplant 2020 06 11;20(6):1562-1573. Epub 2020 Feb 11.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/ajt.15787DOI Listing
June 2020

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol.

Cytotherapy 2019 12 3;21(12):1216-1233. Epub 2019 Dec 3.

School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2019.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474528PMC
December 2019

Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease.

Cell Mol Gastroenterol Hepatol 2020 30;9(3):485-506. Epub 2019 Nov 30.

Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036547PMC
November 2019

Ectopic germline recombination activity of the widely used Foxp3-YFP-Cre mouse: a case report.

Immunology 2020 02 3;159(2):231-241. Epub 2019 Dec 3.

Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/imm.13153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954732PMC
February 2020

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages William W Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Francesco Annunziato Achille Anselmo Petra Bacher Cosima T Baldari Sudipto Bari Vincenzo Barnaba Joana Barros-Martins Luca Battistini Wolfgang Bauer Sabine Baumgart Nicole Baumgarth Dirk Baumjohann Bianka Baying Mary Bebawy Burkhard Becher Wolfgang Beisker Vladimir Benes Rudi Beyaert Alfonso Blanco Dominic A Boardman Christian Bogdan Jessica G Borger Giovanna Borsellino Philip E Boulais Jolene A Bradford Dirk Brenner Ryan R Brinkman Anna E S Brooks Dirk H Busch Martin Büscher Timothy P Bushnell Federica Calzetti Garth Cameron Ilenia Cammarata Xuetao Cao Susanna L Cardell Stefano Casola Marco A Cassatella Andrea Cavani Antonio Celada Lucienne Chatenoud Pratip K Chattopadhyay Sue Chow Eleni Christakou Luka Čičin-Šain Mario Clerici Federico S Colombo Laura Cook Anne Cooke Andrea M Cooper Alexandra J Corbett Antonio Cosma Lorenzo Cosmi Pierre G Coulie Ana Cumano Ljiljana Cvetkovic Van Duc Dang Chantip Dang-Heine Martin S Davey Derek Davies Sara De Biasi Genny Del Zotto Gelo Victoriano Dela Cruz Michael Delacher Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing James P Di Santo Andreas Diefenbach Francesco Dieli Andreas Dolf Thomas Dörner Regine J Dress Diana Dudziak Michael Dustin Charles-Antoine Dutertre Friederike Ebner Sidonia B G Eckle Matthias Edinger Pascale Eede Götz R A Ehrhardt Marcus Eich Pablo Engel Britta Engelhardt Anna Erdei Charlotte Esser Bart Everts Maximilien Evrard Christine S Falk Todd A Fehniger Mar Felipo-Benavent Helen Ferry Markus Feuerer Andrew Filby Kata Filkor Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Britta Frehse Paul S Frenette Stefan Frischbutter Wolfgang Fritzsche David W Galbraith Anastasia Gangaev Natalio Garbi Brice Gaudilliere Ricardo T Gazzinelli Jens Geginat Wilhelm Gerner Nicholas A Gherardin Kamran Ghoreschi Lara Gibellini Florent Ginhoux Keisuke Goda Dale I Godfrey Christoph Goettlinger Jose M González-Navajas Carl S Goodyear Andrea Gori Jane L Grogan Daryl Grummitt Andreas Grützkau Claudia Haftmann Jonas Hahn Hamida Hammad Günter Hämmerling Leo Hansmann Goran Hansson Christopher M Harpur Susanne Hartmann Andrea Hauser Anja E Hauser David L Haviland David Hedley Daniela C Hernández Guadalupe Herrera Martin Herrmann Christoph Hess Thomas Höfer Petra Hoffmann Kristin Hogquist Tristan Holland Thomas Höllt Rikard Holmdahl Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Fang-Ping Huang Johanna E Huber Jochen Huehn Michael Hundemer Christopher A Hunter William Y K Hwang Anna Iannone Florian Ingelfinger Sabine M Ivison Hans-Martin Jäck Peter K Jani Beatriz Jávega Stipan Jonjic Toralf Kaiser Tomas Kalina Thomas Kamradt Stefan H E Kaufmann Baerbel Keller Steven L C Ketelaars Ahad Khalilnezhad Srijit Khan Jan Kisielow Paul Klenerman Jasmin Knopf Hui-Fern Koay Katja Kobow Jay K Kolls Wan Ting Kong Manfred Kopf Thomas Korn Katharina Kriegsmann Hendy Kristyanto Thomas Kroneis Andreas Krueger Jenny Kühne Christian Kukat Désirée Kunkel Heike Kunze-Schumacher Tomohiro Kurosaki Christian Kurts Pia Kvistborg Immanuel Kwok Jonathan Landry Olivier Lantz Paola Lanuti Francesca LaRosa Agnès Lehuen Salomé LeibundGut-Landmann Michael D Leipold Leslie Y T Leung Megan K Levings Andreia C Lino Francesco Liotta Virginia Litwin Yanling Liu Hans-Gustaf Ljunggren Michael Lohoff Giovanna Lombardi Lilly Lopez Miguel López-Botet Amy E Lovett-Racke Erik Lubberts Herve Luche Burkhard Ludewig Enrico Lugli Sebastian Lunemann Holden T Maecker Laura Maggi Orla Maguire Florian Mair Kerstin H Mair Alberto Mantovani Rudolf A Manz Aaron J Marshall Alicia Martínez-Romero Glòria Martrus Ivana Marventano Wlodzimierz Maslinski Giuseppe Matarese Anna Vittoria Mattioli Christian Maueröder Alessio Mazzoni James McCluskey Mairi McGrath Helen M McGuire Iain B McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Stephen D Miller Kingston H G Mills Hans Minderman Jenny Mjösberg Jonni Moore Barry Moran Lorenzo Moretta Tim R Mosmann Susann Müller Gabriele Multhoff Luis Enrique Muñoz Christian Münz Toshinori Nakayama Milena Nasi Katrin Neumann Lai Guan Ng Antonia Niedobitek Sussan Nourshargh Gabriel Núñez José-Enrique O'Connor Aaron Ochel Anna Oja Diana Ordonez Alberto Orfao Eva Orlowski-Oliver Wenjun Ouyang Annette Oxenius Raghavendra Palankar Isabel Panse Kovit Pattanapanyasat Malte Paulsen Dinko Pavlinic Livius Penter Pärt Peterson Christian Peth Jordi Petriz Federica Piancone Winfried F Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Zhiyong Poon Katharina Pracht Immo Prinz Carlo E M Pucillo Sally A Quataert Linda Quatrini Kylie M Quinn Helena Radbruch Tim R D J Radstake Susann Rahmig Hans-Peter Rahn Bartek Rajwa Gevitha Ravichandran Yotam Raz Jonathan A Rebhahn Diether Recktenwald Dorothea Reimer Caetano Reis e Sousa Ester B M Remmerswaal Lisa Richter Laura G Rico Andy Riddell Aja M Rieger J Paul Robinson Chiara Romagnani Anna Rubartelli Jürgen Ruland Armin Saalmüller Yvan Saeys Takashi Saito Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Inga Sandrock Angela Santoni Ramon Bellmàs Sanz Marina Saresella Catherine Sautes-Fridman Birgit Sawitzki Linda Schadt Alexander Scheffold Hans U Scherer Matthias Schiemann Frank A Schildberg Esther Schimisky Andreas Schlitzer Josephine Schlosser Stephan Schmid Steffen Schmitt Kilian Schober Daniel Schraivogel Wolfgang Schuh Thomas Schüler Reiner Schulte Axel Ronald Schulz Sebastian R Schulz Cristiano Scottá Daniel Scott-Algara David P Sester T Vincent Shankey Bruno Silva-Santos Anna Katharina Simon Katarzyna M Sitnik Silvano Sozzani Daniel E Speiser Josef Spidlen Anders Stahlberg Alan M Stall Natalie Stanley Regina Stark Christina Stehle Tobit Steinmetz Hannes Stockinger Yousuke Takahama Kiyoshi Takeda Leonard Tan Attila Tárnok Gisa Tiegs Gergely Toldi Julia Tornack Elisabetta Traggiai Mohamed Trebak Timothy I M Tree Joe Trotter John Trowsdale Maria Tsoumakidou Henning Ulrich Sophia Urbanczyk Willem van de Veen Maries van den Broek Edwin van der Pol Sofie Van Gassen Gert Van Isterdael René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Anouk von Borstel Konrad von Volkmann Ari Waisman Rachael V Walker Paul K Wallace Sa A Wang Xin M Wang Michael D Ward Kirsten A Ward-Hartstonge Klaus Warnatz Gary Warnes Sarah Warth Claudia Waskow James V Watson Carsten Watzl Leonie Wegener Thomas Weisenburger Annika Wiedemann Jürgen Wienands Anneke Wilharm Robert John Wilkinson Gerald Willimsky James B Wing Rieke Winkelmann Thomas H Winkler Oliver F Wirz Alicia Wong Peter Wurst Jennie H M Yang Juhao Yang Maria Yazdanbakhsh Liping Yu Alice Yue Hanlin Zhang Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky

Eur J Immunol 2019 Oct;49(10):1457-1973

Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201970107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350392PMC
October 2019

Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells.

Gastroenterology 2019 12 10;157(6):1584-1598. Epub 2019 Sep 10.

BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada; Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.09.002DOI Listing
December 2019

A New Mechanism of Action in Human and Mouse Treg Cells: The Ke(y)to Suppression.

Immunity 2019 05;50(5):1122-1124

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, University of British Columbia, Vancouver, BC, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193018
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http://dx.doi.org/10.1016/j.immuni.2019.04.008DOI Listing
May 2019

Cancer immunotherapies repurposed for use in autoimmunity.

Nat Biomed Eng 2019 04;3(4):259-263

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.nature.com/articles/s41551-019-0359-6
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http://dx.doi.org/10.1038/s41551-019-0359-6DOI Listing
April 2019

Innate Control of Tissue-Reparative Human Regulatory T Cells.

J Immunol 2019 04 8;202(8):2195-2209. Epub 2019 Mar 8.

Department of Surgery, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada;

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http://dx.doi.org/10.4049/jimmunol.1801330DOI Listing
April 2019

Treg gene signatures predict and measure type 1 diabetes trajectory.

JCI Insight 2019 03 21;4(6). Epub 2019 Mar 21.

Department of Surgery, University of British Columbia (UBC), and BC Children's Hospital Research Institute (BCCHRI), Vancouver, British Columbia, Canada.

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http://insight.jci.org/articles/view/123879
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http://dx.doi.org/10.1172/jci.insight.123879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483004PMC
March 2019

Characterization of regulatory T cells in obese omental adipose tissue in humans.

Eur J Immunol 2019 02 8;49(2):336-347. Epub 2019 Jan 8.

Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/eji.201847570DOI Listing
February 2019

Taking regulatory T-cell therapy one step further.

Curr Opin Organ Transplant 2018 10;23(5):509-515

British Columbia Children's Hospital Research Institute.

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http://Insights.ovid.com/crossref?an=00075200-900000000-9910
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http://dx.doi.org/10.1097/MOT.0000000000000566DOI Listing
October 2018

An optimized method to measure human FOXP3 regulatory T cells from multiple tissue types using mass cytometry.

Eur J Immunol 2018 08 16;48(8):1415-1419. Epub 2018 May 16.

BC Children's Hospital Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/eji.201747407DOI Listing
August 2018

Engineering therapeutic T cells to suppress alloimmune responses using TCRs, CARs, or BARs.

Am J Transplant 2018 06 21;18(6):1305-1311. Epub 2018 Apr 21.

Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/ajt.14747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992079PMC
June 2018

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells.

Front Immunol 2017 3;8:1460. Epub 2017 Nov 3.

BC Children's Hospital Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fimmu.2017.01460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675854PMC
November 2017

Guiding regulatory T cells to the allograft.

Curr Opin Organ Transplant 2018 02;23(1):106-113

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/MOT.0000000000000483DOI Listing
February 2018

Biomarker-guided stratification of autoimmune patients for biologic therapy.

Curr Opin Immunol 2017 Dec 17;49:56-63. Epub 2017 Oct 17.

Department of Surgery, University of British Columbia, Canada; BC Children's Hospital Research Institute, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2017.09.006DOI Listing
December 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Mübeccel Akdis Immanuel Andrä Francesco Annunziato Petra Bacher Vincenzo Barnaba Luca Battistini Wolfgang M Bauer Sabine Baumgart Burkhard Becher Wolfgang Beisker Claudia Berek Alfonso Blanco Giovanna Borsellino Philip E Boulais Ryan R Brinkman Martin Büscher Dirk H Busch Timothy P Bushnell Xuetao Cao Andrea Cavani Pratip K Chattopadhyay Qingyu Cheng Sue Chow Mario Clerici Anne Cooke Antonio Cosma Lorenzo Cosmi Ana Cumano Van Duc Dang Derek Davies Sara De Biasi Genny Del Zotto Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing Andreas Diefenbach James Di Santo Francesco Dieli Andreas Dolf Vera S Donnenberg Thomas Dörner Götz R A Ehrhardt Elmar Endl Pablo Engel Britta Engelhardt Charlotte Esser Bart Everts Anita Dreher Christine S Falk Todd A Fehniger Andrew Filby Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Paul S Frenette David Galbraith Natalio Garbi Maria Dolores García-Godoy Jens Geginat Kamran Ghoreschi Lara Gibellini Christoph Goettlinger Carl S Goodyear Andrea Gori Jane Grogan Mor Gross Andreas Grützkau Daryl Grummitt Jonas Hahn Quirin Hammer Anja E Hauser David L Haviland David Hedley Guadalupe Herrera Martin Herrmann Falk Hiepe Tristan Holland Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Christopher A Hunter Anna Iannone Hans-Martin Jäck Beatriz Jávega Stipan Jonjic Kerstin Juelke Steffen Jung Toralf Kaiser Tomas Kalina Baerbel Keller Srijit Khan Deborah Kienhöfer Thomas Kroneis Désirée Kunkel Christian Kurts Pia Kvistborg Joanne Lannigan Olivier Lantz Anis Larbi Salome LeibundGut-Landmann Michael D Leipold Megan K Levings Virginia Litwin Yanling Liu Michael Lohoff Giovanna Lombardi Lilly Lopez Amy Lovett-Racke Erik Lubberts Burkhard Ludewig Enrico Lugli Holden T Maecker Glòria Martrus Giuseppe Matarese Christian Maueröder Mairi McGrath Iain McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Kingston Mills David Mirrer Jenny Mjösberg Jonni Moore Barry Moran Alessandro Moretta Lorenzo Moretta Tim R Mosmann Susann Müller Werner Müller Christian Münz Gabriele Multhoff Luis Enrique Munoz Kenneth M Murphy Toshinori Nakayama Milena Nasi Christine Neudörfl John Nolan Sussan Nourshargh José-Enrique O'Connor Wenjun Ouyang Annette Oxenius Raghav Palankar Isabel Panse Pärt Peterson Christian Peth Jordi Petriz Daisy Philips Winfried Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Carlo Pucillo Sally A Quataert Timothy R D J Radstake Bartek Rajwa Jonathan A Rebhahn Diether Recktenwald Ester B M Remmerswaal Katy Rezvani Laura G Rico J Paul Robinson Chiara Romagnani Anna Rubartelli Beate Ruckert Jürgen Ruland Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Birgit Sawitzki Alexander Scheffold Matthias Schiemann Frank Schildberg Esther Schimisky Stephan A Schmid Steffen Schmitt Kilian Schober Thomas Schüler Axel Ronald Schulz Ton Schumacher Cristiano Scotta T Vincent Shankey Anat Shemer Anna-Katharina Simon Josef Spidlen Alan M Stall Regina Stark Christina Stehle Merle Stein Tobit Steinmetz Hannes Stockinger Yousuke Takahama Attila Tarnok ZhiGang Tian Gergely Toldi Julia Tornack Elisabetta Traggiai Joe Trotter Henning Ulrich Marlous van der Braber René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Konrad von Volkmann Ari Waisman Rachael Walker Michael D Ward Klaus Warnatz Sarah Warth James V Watson Carsten Watzl Leonie Wegener Annika Wiedemann Jürgen Wienands Gerald Willimsky James Wing Peter Wurst Liping Yu Alice Yue Qianjun Zhang Yi Zhao Susanne Ziegler Jakob Zimmermann

Eur J Immunol 2017 10;47(10):1584-1797

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse, Bern.

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http://doi.wiley.com/10.1002/eji.201646632
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http://dx.doi.org/10.1002/eji.201646632DOI Listing
October 2017

Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk.

Eur J Immunol 2017 11 20;47(11):1867-1874. Epub 2017 Sep 20.

Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1002/eji.201646739DOI Listing
November 2017

Antigen-specific regulatory T cells: are police CARs the answer?

Transl Res 2017 09 19;187:53-58. Epub 2017 Jun 19.

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2017.06.009DOI Listing
September 2017

Thymic progenitors of TCRαβ CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development.

J Exp Med 2017 Aug 26;214(8):2421-2435. Epub 2017 Jun 26.

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada

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http://dx.doi.org/10.1084/jem.20170844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551581PMC
August 2017

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation.

Transplantation 2017 10;101(10):2277-2287

1 Department of Surgery, University of British Columbia and British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1097/TP.0000000000001757DOI Listing
October 2017

Circulating gluten-specific FOXP3CD39 regulatory T cells have impaired suppressive function in patients with celiac disease.

J Allergy Clin Immunol 2017 Dec 8;140(6):1592-1603.e8. Epub 2017 Mar 8.

Immunovirology and Pathogenesis Program, The Kirby Institute, UNSW Sydney, Sydney, Australia; St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, Australia.

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http://dx.doi.org/10.1016/j.jaci.2017.02.015DOI Listing
December 2017

The role of FOXP3 in autoimmunity.

Curr Opin Immunol 2016 12 19;43:16-23. Epub 2016 Aug 19.

Department of Surgery, University of British Columbia, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.07.004DOI Listing
December 2016

Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells.

Transplant Direct 2015 Feb;1(1):1-7

Columbia Center for Translational Immunology, Columbia University Medical Center, 650 West 168 Street, Black Building 15 Floor, New York, NY 10032,

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http://dx.doi.org/10.1097/TXD.0000000000000511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806341PMC
February 2015

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes.

Diabetes 2016 04 19;65(4):1031-9. Epub 2016 Jan 19.

Department of Surgery, The University of British Columbia, and Child & Family Research Institute, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.2337/db15-0572DOI Listing
April 2016

CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance.

Cell Transplant 2015 ;24(10):2143-54

Department of Pathology and Laboratory Medicine, University of British Columbia and Child and Family Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.3727/096368914X685249DOI Listing
August 2016

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.

J Immunol 2015 Jul 8;195(2):488-97. Epub 2015 Jun 8.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada V5Z 1M9; Child and Family Research Institute, Vancouver, British Columbia, Canada V5Z 4H4;

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http://dx.doi.org/10.4049/jimmunol.1403225DOI Listing
July 2015

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance.

J Immunol 2015 May 13;194(10):4777-83. Epub 2015 Apr 13.

Department of Surgery, University of British Columbia and Child and Family Research Institute, Vancouver, British Columbia V5Z 4H4, Canada

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http://dx.doi.org/10.4049/jimmunol.1500020DOI Listing
May 2015

The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome.

Front Immunol 2015 18;6:61. Epub 2015 Feb 18.

Department of Surgery, Child and Family Research Institute, University of British Columbia , Vancouver, BC , Canada.

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http://dx.doi.org/10.3389/fimmu.2015.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332351PMC
March 2015

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis.

J Allergy Clin Immunol 2015 Apr 10;135(4):946-.e9. Epub 2015 Feb 10.

Department of Medicine, University of British Columbia, and the Child and Family Research Institute, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1932DOI Listing
April 2015

Control of tissue-localized immune responses by human regulatory T cells.

Eur J Immunol 2015 Feb 8;45(2):333-43. Epub 2014 Dec 8.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada; Child & Family Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/eji.201344205DOI Listing
February 2015

Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity.

J Immunol 2014 Jan 9;192(2):623-9. Epub 2013 Dec 9.

Department of Surgery, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1302181
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http://dx.doi.org/10.4049/jimmunol.1302181DOI Listing
January 2014

The role of FOXP3 in regulating immune responses.

Int Rev Immunol 2014 Mar 15;33(2):110-28. Epub 2013 Aug 15.

Department of Surgery, University of British Columbia and Child & Family Research Institute , Vancouver, British Columbia , Canada.

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http://dx.doi.org/10.3109/08830185.2013.811657DOI Listing
March 2014

Immune regulation in obesity-associated adipose inflammation.

J Immunol 2013 Jul;191(2):527-32

Department of Surgery, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

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http://dx.doi.org/10.4049/jimmunol.1301035DOI Listing
July 2013

Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.

J Immunol 2013 Mar 28;190(5):2001-8. Epub 2013 Jan 28.

Department of Surgery, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

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http://dx.doi.org/10.4049/jimmunol.1201379DOI Listing
March 2013

In vitro generation of human T regulatory cells: generation, culture, and analysis of FOXP3-transduced T cells.

Methods Mol Biol 2013 ;946:115-32

Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

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May 2013

ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation.

Eur J Immunol 2012 Dec 26;42(12):3310-21. Epub 2012 Oct 26.

Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/eji.201142213DOI Listing
December 2012

The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function.

Front Immunol 2012 13;3:245. Epub 2012 Aug 13.

Department of Surgery, Child and Family Research Institute, The University of British Columbia Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fimmu.2012.00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417165PMC
August 2012

T regulatory cell therapy in transplantation: stability, localization and functional specialization.

Curr Opin Organ Transplant 2012 Aug;17(4):343-8

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/MOT.0b013e328355aaafDOI Listing
August 2012

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

Front Immunol 2012 4;3:129. Epub 2012 Jun 4.

Department of Pathology and Laboratory Medicine, University of British Columbia Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fimmu.2012.00129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366440PMC
August 2012

Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers.

Immunology 2012 Jun;136(2):115-22

Department of Surgery, University of British Columbia & Child and Family Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/j.1365-2567.2012.03572.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403270PMC
June 2012

Suppression assays with human T regulatory cells: a technical guide.

Eur J Immunol 2012 Jan 12;42(1):27-34. Epub 2011 Dec 12.

Child and Family Research Institute & Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/eji.201141651DOI Listing
January 2012

Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci.

J Immunol 2011 Dec 2;187(11):5615-26. Epub 2011 Nov 2.

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

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http://dx.doi.org/10.4049/jimmunol.1101058DOI Listing
December 2011

Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice.

Inflamm Bowel Dis 2012 Jan 29;18(1):85-93. Epub 2011 Oct 29.

Department of Surgery, University of British Columbia and Immunity in Health & Disease, Child and Family Research Institute, British Columbia Children's Hospital, Vancouver, Canada.

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http://dx.doi.org/10.1002/ibd.21738DOI Listing
January 2012

CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation.

Eur J Immunol 2011 Dec 10;41(12):3455-66. Epub 2011 Nov 10.

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1002/eji.201141814DOI Listing
December 2011

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.

J Clin Invest 2011 Aug;121(8):3024-8

Departments of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1172/JCI43048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148722PMC
August 2011

Moving to tolerance: clinical application of T regulatory cells.

Semin Immunol 2011 Aug 28;23(4):304-13. Epub 2011 May 28.

Department of Surgery, University of British Columbia, Canada.

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http://dx.doi.org/10.1016/j.smim.2011.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836227PMC
August 2011

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells.

J Immunol 2011 May 15;186(10):5533-7. Epub 2011 Apr 15.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4E3.

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http://dx.doi.org/10.4049/jimmunol.1002126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015973PMC
May 2011

Environmental influences on T regulatory cells in inflammatory bowel disease.

Semin Immunol 2011 Apr 3;23(2):130-8. Epub 2011 Feb 3.

Department of Surgery, University of British Columbia and Immunity in Health & Disease, Child and Family Research Institute, British Columbia Children's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.smim.2011.01.012DOI Listing
April 2011

Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils.

Eur J Immunol 2011 Feb 11;41(2):306-12. Epub 2011 Jan 11.

Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/eji.201040459DOI Listing
February 2011

Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production.

Cancer Immunol Immunother 2011 Mar 14;60(3):381-8. Epub 2010 Dec 14.

Department of Surgery, Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 950 West 28th Ave, Vancouver, BC V5Z4H4, Canada.

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http://dx.doi.org/10.1007/s00262-010-0948-4DOI Listing
March 2011

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells.

J Allergy Clin Immunol 2010 Dec 30;126(6):1242-51. Epub 2010 Oct 30.

Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jaci.2010.09.001DOI Listing
December 2010

Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells.

J Immunol 2010 Nov 29;185(9):5011-22. Epub 2010 Sep 29.

Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4049/jimmunol.1000541DOI Listing
November 2010

Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells.

Blood 2010 Dec 23;116(25):5748-51. Epub 2010 Sep 23.

Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1182/blood-2010-07-295436DOI Listing
December 2010

Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes.

J Immunol 2010 Oct 1;185(7):3814-8. Epub 2010 Sep 1.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1001860
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October 2010

The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells.

Inflamm Bowel Dis 2011 Jan 18;17(1):319-33. Epub 2010 Aug 18.

Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/ibd.21428DOI Listing
January 2011

Inflammatory effects of ex vivo human Th17 cells are suppressed by regulatory T cells.

J Immunol 2010 Sep 18;185(6):3199-208. Epub 2010 Aug 18.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4049/jimmunol.1000557DOI Listing
September 2010

3rd Keystone Symposium on T regulatory cells.

Immunotherapy 2009 Jul;1(4):529-37

Department of Surgery, University of British Columbia & Immunity & Infection Research Centre, Vancouver Coastal Heath Research Institute, 2660 Oak Street, Vancouver, B.C., V6K 4H8, Canada.

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http://dx.doi.org/10.2217/imt.09.33DOI Listing
July 2009

Deconvolution and chromatic aberration corrections in quantifying colocalization of a transcription factor in three-dimensional cellular space.

Micron 2010 Aug 20;41(6):633-40. Epub 2010 Mar 20.

The James Hogg Research Centre, Heart+Lung Institute at St. Paul's Hospital - University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.micron.2010.03.005DOI Listing
August 2010

ATG-induced expression of FOXP3 in human CD4(+) T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells.

Blood 2009 Dec 12;114(24):5003-6. Epub 2009 Oct 12.

Department of Medicine, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1182/blood-2009-04-214437DOI Listing
December 2009

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis.

Inflamm Bowel Dis 2010 Mar;16(3):401-9

Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/ibd.21097DOI Listing
March 2010

Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.

Blood 2009 Nov 8;114(19):4138-41. Epub 2009 Sep 8.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 58-20132 Milan, Italy.

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http://dx.doi.org/10.1182/blood-2009-04-214593DOI Listing
November 2009

SHIP regulates the reciprocal development of T regulatory and Th17 cells.

J Immunol 2009 Jul 19;183(2):975-83. Epub 2009 Jun 19.

Department of Surgery, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4049/jimmunol.0803749DOI Listing
July 2009

The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells.

Eur J Immunol 2009 Jun;39(6):1480-93

Department of Surgery, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Centre, Vancouver, Canada.

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http://dx.doi.org/10.1002/eji.200838908DOI Listing
June 2009

Molecular regulation of cellular immunity by FOXP3.

Adv Exp Med Biol 2009 ;665:30-46

Department of Surgery, University of British Columbia, Vancouver, Canada.

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May 2010

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3.

Eur J Immunol 2008 Dec;38(12):3282-9

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/eji.200838373DOI Listing
December 2008

Graft-versus-host disease: suppression by statins.

Nat Med 2008 Nov;14(11):1155-6

Department of Medicine, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nm1108-1155DOI Listing
November 2008

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease.

Immunology 2008 Oct;125(2):145-53

Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, Canada.

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http://dx.doi.org/10.1111/j.1365-2567.2008.02939.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561137PMC
October 2008

CD4+ T-regulatory cells: toward therapy for human diseases.

Immunol Rev 2008 Jun;223:391-421

Department of Surgery, Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00634.xDOI Listing
June 2008

Pro-tolerogenic effects of photodynamic therapy with TH9402 on dendritic cells.

J Clin Apher 2008 ;23(2):82-91

Department of Medicine, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/jca.20162DOI Listing
June 2008

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

Int Immunol 2008 Mar 12;20(3):421-31. Epub 2008 Feb 12.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1093/intimm/dxn002DOI Listing
March 2008

Isolation, expansion, and characterization of human natural and adaptive regulatory T cells.

Methods Mol Biol 2007 ;380:83-105

San Raffaele Telethon Institute for Gene Therapy, Milan, Italy.

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http://dx.doi.org/10.1007/978-1-59745-395-0_6DOI Listing
April 2008

Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells.

J Immunol Methods 2007 Jul 11;324(1-2):92-104. Epub 2007 Jun 11.

Department of Surgery, University of British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jim.2007.05.008DOI Listing
July 2007

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.

Int Immunol 2007 Apr 27;19(4):345-54. Epub 2007 Feb 27.

Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada.

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http://dx.doi.org/10.1093/intimm/dxm014DOI Listing
April 2007

Functional dynamics of naturally occurring regulatory T cells in health and autoimmunity.

Adv Immunol 2006 ;92:119-55

Department of Surgery, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver V6H 3Z6, Canada.

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http://dx.doi.org/10.1016/S0065-2776(06)92003-3DOI Listing
December 2006

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells.

Blood 2007 Mar 24;109(5):2014-22. Epub 2006 Oct 24.

Department of Surgery, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1182/blood-2006-07-035279DOI Listing
March 2007