Megan D Hoban

Megan D Hoban

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Megan D Hoban

Megan D Hoban

Publications by authors named "Megan D Hoban"

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11Publications

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Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates.

Mol Ther 2019 Aug 24;27(8):1389-1406. Epub 2019 May 24.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697408PMC
August 2019

Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM Syndrome.

Cell Rep 2018 05;23(9):2606-2616

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Division of Hematology & Oncology, Department of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.celrep.2018.04.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181643PMC
May 2018

Analyzing CRISPR genome-editing experiments with CRISPResso.

Nat Biotechnol 2016 07;34(7):695-7

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242601PMC
July 2016

A genome editing primer for the hematologist.

Blood 2016 05 6;127(21):2525-35. Epub 2016 Apr 6.

Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA; and Department of Pediatrics, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-01-678151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882802PMC
May 2016

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.

Blood 2016 Feb 12;127(7):839-48. Epub 2016 Jan 12.

Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA; and.

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http://dx.doi.org/10.1182/blood-2015-09-618587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760089PMC
February 2016

Delivery of Genome Editing Reagents to Hematopoietic Stem/Progenitor Cells.

Curr Protoc Stem Cell Biol 2016 Feb 3;36:5B.4.1-10. Epub 2016 Feb 3.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1002/9780470151808.sc05b04s36DOI Listing
February 2016

The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells.

Mol Ther Methods Clin Dev 2015 22;2:15012. Epub 2015 Apr 22.

Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California, USA ; Department of Pediatrics, UCLA Children's Discovery and Innovation Institute David Geffen School of Medicine, University of California , Los Angeles, California, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23290501163002
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http://dx.doi.org/10.1038/mtm.2015.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445009PMC
June 2015

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.

Blood 2015 Apr 2;125(17):2597-604. Epub 2015 Mar 2.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA; Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, University of California, Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1182/blood-2014-12-615948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408287PMC
April 2015

Dissecting the mechanism of histone deacetylase inhibitors to enhance the activity of zinc finger nucleases delivered by integrase-defective lentiviral vectors.

Hum Gene Ther 2014 Jul 2;25(7):599-608. Epub 2014 Apr 2.

Department of Microbiology, Immunology, and Molecular Genetics; and Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research; University of California , Los Angeles, Los Angeles, CA 90095.

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http://dx.doi.org/10.1089/hum.2013.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098962PMC
July 2014