Dr. Md Yousof Ali, PhD - University of Alberta - Postdoctoral fellow

Dr. Md Yousof Ali

PhD

University of Alberta

Postdoctoral fellow

Edmonton, Alberta | Canada

Main Specialties: Biology, Biotechnology, Cardiovascular Disease, Chemistry, Infectious Disease, Medical Toxicology, Neurology, Pharmacology

Additional Specialties: Pharmaceutical chemistry, diabetes and Alzheimer’s

Dr. Md Yousof Ali, PhD - University of Alberta - Postdoctoral fellow

Dr. Md Yousof Ali

PhD

Introduction

Primary Affiliation: University of Alberta - Edmonton, Alberta , Canada

Specialties:

Additional Specialties:

Research Interests:

Education

Sep 2016
Pukyong national university
PhD

Experience

Nov 2019
University of Alberta
Postdoc
Oct 2017
Concordia University
Post Doc
Oct 2017
Kung Hee university
Postdoctoral fellow

Publications

35Publications

1478Reads

13Profile Views

96PubMed Central Citations

Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidβ aggregation, and lipid peroxidation.

Bioorg Chem 2019 11 18;92:103293. Epub 2019 Sep 18.

Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103293DOI Listing
November 2019
2 Reads
2.152 Impact Factor

Angiotensin-I-Converting Enzyme Inhibitory Activity of Coumarins from .

Molecules 2019 Oct 31;24(21). Epub 2019 Oct 31.

Department of Food and Life Science, Pukyong National University, Busan 48513, Korea.

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http://dx.doi.org/10.3390/molecules24213937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864762PMC
October 2019
2.416 Impact Factor

Flavanone glycosides inhibit β-site amyloid precursor protein cleaving enzyme 1 and cholinesterase and reduce Aβ aggregation in the amyloidogenic pathway.

Chem Biol Interact 2019 Aug 11;309:108707. Epub 2019 Jun 11.

Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.06.020DOI Listing
August 2019
2 Reads
2.577 Impact Factor

Didymin, a dietary citrus flavonoid exhibits anti-diabetic complications and promotes glucose uptake through the activation of PI3K/Akt signaling pathway in insulin-resistant HepG2 cells.

Chem Biol Interact 2019 May 27;305:180-194. Epub 2019 Mar 27.

Department of Prescriptionology, College of Korean Medicine, Kyung Hee University, 26, Kyunghee Dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

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http://dx.doi.org/10.1016/j.cbi.2019.03.018DOI Listing
May 2019
16 Reads
2.577 Impact Factor

Correction to: Dihydroxanthyletin-type coumarins from Angelica decursiva that inhibits the formation of advanced glycation end products and human recombinant aldose reductase.

Arch Pharm Res 2019 04;42(4):379

Department of Food and Life Science, Pukyong National University, Busan, 48513, Republic of Korea.

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http://link.springer.com/10.1007/s12272-019-01113-4
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http://dx.doi.org/10.1007/s12272-019-01113-4DOI Listing
April 2019
6 Reads
1.751 Impact Factor

Kinetics and molecular docking of dihydroxanthyletin-type coumarins from Angelica decursiva that inhibit cholinesterase and BACE1.

Arch Pharm Res 2018 Jul 25;41(7):753-764. Epub 2018 Jul 25.

Department of Food and Life Science, Pukyong National University, Busan, 608-737, Republic of Korea.

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http://dx.doi.org/10.1007/s12272-018-1056-9DOI Listing
July 2018
12 Reads
1.751 Impact Factor

α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activity of Plastoquinones from Marine Brown Alga Sargassum serratifolium

Marine Drugs

Abstract:Sargassum serratifoliumC. Agardh (Phaeophyceae, Fucales)is a marine brown alga thatbelongs to the family Sargassaceae. It is widely distributed throughout coastal areas of Korea andJapan.S. serratifoliumhas been found to contain high concentrations of plastoquinones, which havestrong anti-cancer, anti-inflammatory, antioxidant, and neuroprotective activity. This study aimsto investigate the anti-diabetic activity ofS. serratifoliumand its major constituentsthroughinhibition of protein tyrosine phosphatase 1B (PTP1B),α-glucosidase, and ONOO−-mediatedalbumin nitration.S. serratifoliumethanolic extract and fractions exhibited broad PTP1B andα-glucosidase inhibitory activity (IC50, 1.83~7.04 and 3.16~24.16μg/mL for PTP1B andα-glucosidase,respectively). In an attempt to identify bioactivecompounds, three plastoquinones (sargahydroquinoicacid, sargachromenol and sargaquinoic acid) were isolated from the activen-hexane fraction ofS.serratifolium. All three plastoquinones exhibited dose-dependent inhibitory activity against PTP1B inthe IC50range of 5.14–14.15μM, while sargachromenol and sargaquinoic acid showed dose-dependentinhibitory activity againstα-glucosidase (IC5042.41±3.09 and 96.17±3.48μM, respectively).In the kinetic study of PTP1B enzyme inhibition, sargahydroquinoic acid and sargaquinoic acidled to mixed-type inhibition, whereas sargachromenol displayed noncompetitive-type inhibition.Moreover, plastoquinones dose-dependently inhibited ONOO−-mediated albumin nitration. Dockingsimulations of these plastoquinones demonstrated negative binding energies and close proximityto residues in the binding pocket of PTP1B andα-glucosidase, indicating that these plastoquinoneshave high affinity and tight binding capacity towards the active site of the enzymes. These resultsdemonstrate thatS.serratifoliumand its major plastoquinones may have the potential as functionalfood ingredients for the prevention and treatment of type 2 diabetes. α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activity of Plastoquinones from Marine Brown Alga Sargassum serratifolium. Available from: https://www.researchgate.net/publication/321429627_a-Glucosidase_and_Protein_Tyrosine_Phosphatase_1B_Inhibitory_Activity_of_Plastoquinones_from_Marine_Brown_Alga_Sargassum_serratifolium [accessed Feb 18 2018].

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February 2018
8 Reads

Dihydroxanthyletin-type coumarins from Angelica decursiva that inhibits the formation of advanced glycation end products and human recombinant aldose reductase

Archives of Pharmacal Research

The formation of advanced glycation end-products (AGE) and aldose reductase activity have been implicated in the development of diabetic complications. The present study was aimed to evaluate human recombinant aldose reductase (HRAR) and AGE inhibitory activity of seven natural dihydroxanthyletin-type coumarins, 4-hydroxy Pd-C-III (1), 40 -methoxy Pd-C-I (2), Pd-C-I (3), Pd-C-II (4), Pd-C-III (5), decursidin (6), and (?)-transdecursidinol (7) from Angelica decursiva. Coumarins 1–7 showed potent HRAR and AGE inhibitory activities with ranges of IC50 values of 1.03–21.31 and 0.41–5.56 lM, respectively. In the kinetic study for HRAR enzyme inhibition, coumarins 1, 3, 4, and 7 were competitive-type inhibitors, 6 was a mixed-type inhibitor, whereas 2 and 5 were noncompetitive-type inhibitors. Furthermore, we also predicted the docking interactions of HRAR with coumarins 1–7 using AutoDock Vina, and as a result, the simulated enzyme-inhibitor complexes exhibited negative binding energies (Autodock Vina = - 9.6 to - 8.1 kcal/mol for HRAR), indicating a high affinity and tight binding capacity for the HRAR active site. Our results clearly indicate the potential HRAR and AGE formation inhibitory activities of dihydroxanthyletin-type coumarins, which could be further explored to develop therapeutic modalities for the treatment of diabetes and related complications.

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December 2017
16 Reads

α-Methyl artoflavanocoumarin from Juniperus chinensis exerts anti-diabetic effects by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant HepG2 cells

Archives of Pharmacal Research

Diabetes mellitus is one of the greatest global health issues and much research effort continues to be directed toward identifying novel therapeutic agents. Insulin resistance is a challenging integrally related topic and molecules capable of overcoming it are of considerable therapeutic interest in the context of type 2 diabetes mellitus (T2DM). Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling transduction and is regarded a novel therapeutic target in T2DM. Here, we investigated the inhibitory effect of α-methyl artoflavanocoumarin (MAFC), a natural flavanocoumarin isolated from Juniperus chinensis, on PTP1B in insulin-resistant HepG2 cells. MAFC was found to potently inhibit PTP1B with an IC50 of 25.27 ± 0.14 µM, and a kinetics study revealed MAFC is a mixed type PTP1B inhibitor with a Ki value of 13.84 µM. Molecular docking simulations demonstrated MAFC can bind to catalytic and allosteric sites of PTP1B. Furthermore, MAFC significantly increased glucose uptake and decreased the expression of PTP1B in insulin-resistant HepG2 cells, down-regulated the phosphorylation of insulin receptor substrate (IRS)-1 (Ser307), and dose-dependently enhanced the protein levels of IRS-1, phosphorylated phosphoinositide 3-kinase (PI3K), Akt, and ERK1. These results suggest that MAFC from J. chinensis has therapeutic potential in T2DM by inhibiting PTP1B and activating insulin signaling pathways.

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November 2017
8 Reads

Hepatoprotective effect of Cassia obtusifolia seed extract and constituents against oxidative damage induced by tert‐butyl hydroperoxide in human hepatic HepG2 cells

Journal of Food Biochemistry

The aim of the present study was to investigate the hepatoprotective effects of different soluble fractions of methanolic derived Cassia obtusifolia seeds extract (COE) and its active components in tert-butyl hydroperoxide (t-BHP)-induced oxidative stress in HepG2 cells. Among the tested fractions, the ethyl acetate (EtOAc) fraction was the most active hepatoprotective fraction. From the active EtOAc fraction, six anthraquinones (alaternin, emodin, aloe emodin, 2-hydroxyemodin 1-methyl ether, chryso-obtusin-2-O-β-d-glucoside, and questin) and one naphthopyrone glycoside (cassiaside) were isolated. The cytotoxic effect in 200 µM t-BHP-induced HepG2 cells was inhibited by COE and their bioactive compounds. The protective effect of COE in 200 µM t-BHP-induced HepG2 cells may be associated with positive regulation of glutathione (GSH) and decreased in reactive oxygen species (ROS) formation of their bioactive compounds. The increased ROS and decreased GSH levels observed in t-BHP-treated HepG2 cells were ameliorated by pretreatment with cassiaside, alaternin, and aloe emodin, indicating that the hepatoprotective effects of these major constituents are mediated by induction of cellular defense against oxidative stress. Overall, COE displayed a significant cytoprotective effect against oxidative stress, which may most likely be because of active compounds like cassiaside, alaternin, and aloe emodin in COE, which leads to maintenance of the normal redox status of cells.

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September 2017
9 Reads

Kinetics and Molecular Docking Studies of 6-Formyl Umbelliferone Isolated from Angelica decursiva as an Inhibitor of Cholinesterase and BACE1

Molecules

Coumarins, which have low toxicity, are present in some natural foods, and are used in various herbal remedies, have attracted interest in recent years because of their potential medicinal properties. In this study, we report the isolation of two natural coumarins, namely umbelliferone (1) and 6-formyl umbelliferone (2), from Angelica decursiva, and the synthesis of 8-formyl umbelliferone (3) from 1. We investigated the anti-Alzheimer disease (anti-AD) potential of these coumarins by assessing their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1). Among these coumarins, 2 exhibited poor inhibitory activity against AChE and BChE, and modest activity against BACE1. Structure–activity relationship analysis showed that 2 has an aldehyde group at the C-6 position, and exhibited strong anti-AD activity, whereas the presence or absence of an aldehyde group at the C-8 position reduced the anti-AD activity of 3 and 1, respectively. In addition, 2 exhibited concentration-dependent inhibition of peroxynitrite-mediated protein tyrosine nitration. A kinetic study revealed that 2 and 3 non-competitively inhibited BACE1. To confirm enzyme inhibition, we predicted the 3D structures of AChE and BACE1, and used AutoDock 4.2 to simulate binding of coumarins to these enzymes. The blind docking studies demonstrated that these molecules could interact with both the catalytic active sites and peripheral anionic sites of AChE and BACE1. Together, our results indicate that 2 has an interesting inhibitory activity in vitro, and can be used in further studies to develop therapeutic modalities for the treatment of AD.

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September 2017
10 Reads

BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium

Bioorganic & Medicinal Chemistry

A wide range of pharmacological properties of Sargassum spp. extracts and isolated components have been recognized. Although individual meroterpenoids of Sargassum species have been reported to possess strong activity against Alzheimer’s disease (AD), the active compounds of Sargassum serratifolium have not been fully explored. Therefore, we evaluated the anti-AD activity of S. serratifolium extract through enzyme inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1). Three meroterpenoids (sargahydroquinoic acid (1), sargachromenol (2) and sargaquinoic acid (3)) were isolated from S. serratifolium. These compounds showed moderate AChE inhibitory activity, but exhibited potent inhibitory activity against BChE and BACE1 (15.1, 9.4, and 10.4 µM for BChE; 4.3, 6.9, and 12.5 µM for BACE1, respectively). Kinetic study and molecular docking simulation of these compounds demonstrated that 1 and 3 interacted with both catalytic aspartyl residues and allosteric sites of BACE1, whereas 2 interacted with the allosteric site of BACE1. The results of the present study demonstrate that meroterpenoids from S. serratifolium might be beneficial in the treatment of AD

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May 2017
9 Reads

Molecular Docking Study and Evaluation of the Anti-diabetic Complications of Dihydroxanthyletin-type Coumarins from Angelica decursiva

The FASEB Journal

Diabetes is a very common disease that has assumed epidemic proportions, affecting 5.9% of the worldwide adult population. As the disease develops, a parallel increase has been seen in the prevalence of complications like cataract, nephropathy, retinopathy, neuropathy, and heart diseases. Various mechanistic explanations have been proposed as the cause of these complications, where the formation of advanced glycation end products (AGE) and the aldose reductase (AR)-related polyol pathway are generally accepted mechanisms, which represent potential targets for the treatment of these complications. Angelica decursiva Fr. et Sav is a perennial herb that is widely distributed in China, Japan, and Korea. This plant has been long been used in traditional Korean medicine as an antitussive, analgesic, antipyretic, and cough remedy. In traditional Chinese medicine, it is used as a remedy for thick phlegm, asthma, and upper respiratory tract infections. The plant is a rich source of different coumarins, which have been reported to possess a wide range of biological activities, including anti-inflammatory, antioxidant, and anti-diabetic activities. Recently, we reported the potential anti-diabetic activity of MeOH extracts and their constituents through the inhibition of protein tyrosine phosphatase 1B and α-glucosidase. However, no detailed investigations are available on the major constituents of dihydroxanthyletin-type coumarins from A. decursiva regarding the possibility of developing anti-diabetic complications drugs. Therefore, we investigated the anti-diabetic complications potential of seven natural dihydroxanthyletin-type coumarins, 4-hydroxy Pd-C-III (1), 4′-methoxy Pd-C-I (2), Pd-C-I (3), Pd-C-II (4), Pd-C-III (5), decursidin (6), and (+)-trans-decursidinol (7) isolated from Angelica decursiva and evaluated their inhibitory activities against AGE formation and human recombinant aldose reductase (HRAR) activity. Coumarins 1–7 exhibited dose-dependent inhibitory activities on AGE and HRAR with IC50 values ranging of 0.41–5.56 μM and 1.03–21.31 μM, respectively. Kinetic analysis of HRAR inhibition showed that 1, 3, 4, and 7 were competitive-type inhibitors, 6 was a mixed-type inhibitor, whereas 2 and 5 were noncompetitive-type inhibitors. To further understand the mechanisms of action of the coumarins with inhibitory activity against HRAR with coumarins 1–7, we performed molecular docking simulations using AutoDock Vina. As a result, the simulated enzyme-inhibitor complexes exhibited negative binding energies (Autodock Vina = −9.6 to −8.1 kcal/mol for HRAR), indicating a high affinity and tight binding capacity for the HRAR active site. In conclusion, these results suggest that the dihydroxanthyletin-type coumarins from A. decursiva are potential major compounds that can be used in the prevention and/or treatment of diabetic complications.

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April 2017
10 Reads

Hepatoprotective effects of different combinations of sweet orange, Unshiu mikan, and mini tomato juice powders against tert‐butyl hydroperoxide‐induced oxidative stress in HepG2 cells

Journal of Food Biochemistry

The aim of the present study was to evaluate the ability of raw mini tomato (Solanum lycopersicum L.) juice powder to attenuate cytotoxicity in combination with juice powders from two orange species [Citrus sinensis (L.) Osbeck and Citrus unshiu Marcow]. To this end, the hepatoprotective activities of these combinations against tert-butyl hydroperoxide (t-BHP)-induced oxidative stress in HepG2 cells were evaluated, and the most suitable ratios for optimal flavonoid availability were identified. The levels of intracellular reactive oxygen species (ROS) and glutathione (GSH) and the extent of upregulation of phase-ІІ proteins such as heme oxygenase-1 (HO-1) were quantified to assess the hepatoprotective effects of four different ratios of these powders. Three main compounds–hesperidin, narirutin, and rutin were analyzed by simultaneous high-performance liquid chromatography. The total phenolic and flavonoid contents of the 2:1:3 powder mixture were 8.69 mg/g GAE and 2.56 mg/g QE, respectively. The levels of these contents were correlated with the decrease in ROS, increase in GSH level, and restoration of HO-1. Furthermore, the hepatoprotective efficacy of each of the four ratios was attributed to its flavonoid content. These results indicate that combinations of juice powders, particularly at a ratio of 2:1:3, are a potentially useful therapeutic source of phenolic compounds for the treatment of oxidative stress-related hepatotoxicity.

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March 2017
12 Reads

Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells.

Arch Pharm Res 2017 Jan 31;40(1):37-48. Epub 2016 Oct 31.

Department of Food and Life Science, Pukyong National University, Busan, 608-737, Republic of Korea.

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http://dx.doi.org/10.1007/s12272-016-0852-3DOI Listing
January 2017
94 Reads
1 Citation
1.751 Impact Factor

Promising Inhibitory Effects of Anthraquinones, Naphthopyrone, and Naphthalene Glycosides, from Cassia obtusifolia on α-Glucosidase and Human Protein Tyrosine Phosphatases 1B.

Molecules 2016 Dec 27;22(1). Epub 2016 Dec 27.

Department of Food and Life Science, Pukyong National University, Busan 608-737, Korea.

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http://dx.doi.org/10.3390/molecules22010028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155831PMC
December 2016
93 Reads
4 Citations
2.420 Impact Factor

Protective Effects of Sweet Orange, Unshiu Mikan, and Mini Tomato Juice Powders on -BHP-Induced Oxidative Stress in HepG2 Cells.

Prev Nutr Food Sci 2016 Sep 30;21(3):208-220. Epub 2016 Sep 30.

Department of Food and Life Science, Pukyong National University, Busan 48513, Korea.

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http://www.dbpia.co.kr/Journal/ArticleDetail/NODE07018386
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http://dx.doi.org/10.3746/pnf.2016.21.3.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063206PMC
September 2016
17 Reads

Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases.

J Ethnopharmacol 2016 Sep 15;191:152-160. Epub 2016 Jun 15.

Department of Food and Life Science, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2016.06.037DOI Listing
September 2016
86 Reads
7 Citations
3.000 Impact Factor

BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides.

J Ethnopharmacol 2016 Aug 5;190:219-30. Epub 2016 Jun 5.

Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2016.06.013DOI Listing
August 2016
80 Reads
4 Citations
3.000 Impact Factor

PTP1B, α-glucosidase, and DPP-IV inhibitory effects for chromene derivatives from the leaves of Smilax china L.

Chem Biol Interact 2016 Jun 6;253:27-37. Epub 2016 Apr 6.

College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.04.012DOI Listing
June 2016
132 Reads
5 Citations
2.580 Impact Factor

Coumarins from Angelica decursiva inhibit α-glucosidase activity and protein tyrosine phosphatase 1B.

Chem Biol Interact 2016 May 13;252:93-101. Epub 2016 Apr 13.

Department of Food and Life Science, Pukyong National University, Busan, 608-737, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.04.020DOI Listing
May 2016
34 Reads
4 Citations
2.580 Impact Factor

Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera.

Food Chem Toxicol 2016 Mar 26;89:104-11. Epub 2016 Jan 26.

Department of Food and Life Science, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2016.01.014DOI Listing
March 2016
68 Reads
4 Citations
2.900 Impact Factor

Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis.

Asian Pac J Trop Med 2016 Feb 11;9(2):103-11. Epub 2016 Jan 11.

Department of Food and Life Science, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.apjtm.2016.01.014DOI Listing
February 2016
51 Reads
4 Citations
0.930 Impact Factor

Anti-diabetic and anti-Alzheimer's disease activities of Angelica decursiva.

Arch Pharm Res 2015 Dec 8;38(12):2216-27. Epub 2015 Jul 8.

Department of Food Science and Nutrition, Pukyong National University, Busan, 608-737, Republic of Korea.

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http://dx.doi.org/10.1007/s12272-015-0629-0DOI Listing
December 2015
97 Reads
3 Citations
1.751 Impact Factor

Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways.

Arch Pharm Res 2015 Dec 29;38(12):2153-62. Epub 2015 Jun 29.

Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju, 561-756, Republic of Korea.

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http://dx.doi.org/10.1007/s12272-015-0626-3DOI Listing
December 2015
27 Reads
4 Citations
1.751 Impact Factor

Chemical Constituents of Euonymus alatus (Thunb.) Sieb. and Their PTP1B and α-Glucosidase Inhibitory Activities.

Phytother Res 2015 Oct 14;29(10):1540-8. Epub 2015 Jul 14.

College of Pharmacy, Catholic University of Daegu, Gyeongsan, 712-702, Korea.

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http://dx.doi.org/10.1002/ptr.5411DOI Listing
October 2015
97 Reads
2 Citations
2.400 Impact Factor

Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies.

J Ethnopharmacol 2015 Aug 28;171:28-36. Epub 2015 May 28.

Department of Food and Life Science, Pukyong National University, Busan 608-737, Republic of Korea.

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http://dx.doi.org/10.1016/j.jep.2015.05.020DOI Listing
August 2015
81 Reads
6 Citations
3.000 Impact Factor

Isolation of cholinesterase and β-secretase 1 inhibiting compounds from Lycopodiella cernua.

Bioorg Med Chem 2015 Jul 6;23(13):3126-34. Epub 2015 May 6.

College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.04.080DOI Listing
July 2015
54 Reads
3 Citations
2.793 Impact Factor

Protein tyrosine phosphatase 1B (PTP1B) inhibitory constituents from the aerial parts of Tradescantia spathacea Sw.

Fitoterapia 2015 Jun 22;103:113-21. Epub 2015 Mar 22.

College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2015.03.017DOI Listing
June 2015
25 Reads
1 Citation
2.220 Impact Factor

Insulin-mimetic selaginellins from Selaginella tamariscina with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.

J Nat Prod 2015 Jan 6;78(1):34-42. Epub 2015 Jan 6.

College of Pharmacy, Catholic University of Daegu , Gyeongsan 712-702, Republic of Korea.

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http://dx.doi.org/10.1021/np5005856DOI Listing
January 2015
33 Reads
6 Citations
3.800 Impact Factor

The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities.

Arch Pharm Res 2014 Oct 24;37(10):1354-63. Epub 2014 Mar 24.

Department of Food Science and Nutrition, Pukyong National University, Pusan, 608-737, Republic of Korea,

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http://dx.doi.org/10.1007/s12272-014-0351-3DOI Listing
October 2014
38 Reads
5 Citations
1.751 Impact Factor

Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ.

Fitoterapia 2014 Oct 12;98:199-208. Epub 2014 Aug 12.

Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2014.08.006DOI Listing
October 2014
43 Reads
10 Citations
2.220 Impact Factor

Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin.

Food Chem Toxicol 2014 Feb 27;64:27-33. Epub 2013 Nov 27.

Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2013.11.020DOI Listing
February 2014
76 Reads
13 Citations
2.900 Impact Factor

Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ.

Fitoterapia 2014 Jan 12;92:260-9. Epub 2013 Dec 12.

Department of Food and Life Science, Pukyong National University, 608-737, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2013.12.003DOI Listing
January 2014
202 Reads
10 Citations
2.220 Impact Factor

Top co-authors

Jae Sue Choi
Jae Sue Choi

College of Pharmacy

20
Hyun Ah Jung
Hyun Ah Jung

Pukyong National University

19
Susoma Jannat
Susoma Jannat

Pukyong National University

8
Byung-Sun Min
Byung-Sun Min

College of Pharmacy

6
Ran Joo Choi
Ran Joo Choi

Seoul National University

5
Hee Jin Jung
Hee Jin Jung

Pukyong National University

4
Mi-Hee Woo
Mi-Hee Woo

Korea Research Institute of Bioscience and Biotechnology

3
Hae Young Chung
Hae Young Chung

College of Pharmacy

3
Hyong Oh Jeong
Hyong Oh Jeong

College of Pharmacy

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