Dr. Md Rashedunnabi Akanda,  Ph.D. - Sylhet Agricultural University - Associate Professor

Dr. Md Rashedunnabi Akanda

Ph.D.

Sylhet Agricultural University

Associate Professor

Sylhet | Bangladesh

Main Specialties: Neuropathology, Oncology, Pharmacology

ORCID logohttps://orcid.org/0000-0002-5464-9353

Dr. Md Rashedunnabi Akanda,  Ph.D. - Sylhet Agricultural University - Associate Professor

Dr. Md Rashedunnabi Akanda

Ph.D.

Introduction

Primary Affiliation: Sylhet Agricultural University - Sylhet , Bangladesh

Specialties:

Research Interests:

Education

Feb 2018
Chonbuk National University
PhD

Experience

Oct 2018
Chonnam National University Medical School
Post-Doctoral Researcher
Biomedical Research Center
Feb 2018
Sylhet Agricultural University
Associate Professor
Department of Pharmacology and Toxicology

Publications

13Publications

353Reads

3Profile Views

Caveolin-1 enhances brain metastasis of non-small cell lung cancer, potentially in association with the epithelial-mesenchymal transition marker SNAIL

Cancer Cell International

AbstractBackgroundCaveolin-1 (Cav-1) plays an important role in the development of various human cancers. We investigated the relationship between Cav-1 expression and non-small cell lung cancer (NSCLC) progression in the context of brain metastasis (BM).MethodsCav-1 expression was investigated in a series of 102 BM samples and 49 paired primary NSCLC samples, as well as 162 unpaired primary NSCLC samples with (63 cases) or without (99 cases) metastasis to distant organs. Human lung cancer cell lines were used for in vitro functional analysis.ResultsHigh Cav-1 expression in tumor cells was observed in 52% (38/73) of squamous cell carcinomas (SQCs) and 33% (45/138) of non-SQCs. In SQC, high Cav-1 expression was increased after BM in both paired and unpaired samples of lung primary tumors and BM (53% vs. 84% in paired samples, P = 0.034; 52% vs. 78% in unpaired samples, P = 0.020). Although the difference in median overall survival in patients NSCLC was not statistically significant, high Cav-1 expression in tumor cells (P = 0.005, hazard ratio 1.715, 95% confidence index 1.175–2.502) was independent prognostic factors of overall survival on multivariate Cox regression analyses, in addition to the presence of BM and non-SQC type. In vitro assays revealed that Cav-1 knockdown inhibited the invasion and migration of lung cancer cells. Genetic modulation of Cav-1 was consistently associated with SNAIL up- and down-regulation. These findings were supported by increased SNAIL and Cav-1 expression in BM samples of SQC.ConclusionsCav-1 plays an important role in the BM of NSCLC, especially in SQC. The mechanism may be linked to SNAIL regulation.KeywordsBrain metastasisCaveolin-1Epithelial-mesenchymal transitionNon-small cell lung cancerSNAIL

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July 2019

Impact Factor 3.439

6 Reads

Enhanced Expression and Functional Characterization of the Recombinant Putative Lysozyme-PMAP36 Fusion Protein.

Mol Cells 2019 Mar 19;42(3):262-269. Epub 2019 Feb 19.

Division of Biotechnology, College of Environmental & Bioresources Sciences, Chonbuk National University, Iksan 54596, Korea.

The porcine myeloid antimicrobial peptide (PMAP), one of the cathelicidin family members, contains small cationic peptides with amphipathic properties. We used a putative lysozyme originated from the bacteriophage P22 (P22 lysozyme) as a fusion partner, which was connected to the N-terminus of the PMAP36 peptide, to markedly increase the expression levels of recombinant PMAP36. The PMAP36-P22 lysozyme fusion protein with high solubility was produced in . The final purified yield was approximately 1.8 mg/L. The purified PMAP36-P22 lysozyme fusion protein exhibited antimicrobial activity against both Gram-negative and Gram-positive bacteria (, serovar Typhimurium, , and ). Furthermore, we estimated its hemolytic activity against pig erythrocytes as 6% at the high concentration (128 ?M) of the PMAP36-P22 lysozyme fusion protein. Compared with the PMAP36 peptide (12%), our fusion protein exhibited half of the hemolytic activity. Overall, our recombinant PMAP36-P22 lysozyme fusion protein sustained the antimicrobial activity with the lower hemolytic activity associated with the synthetic PMAP36 peptide. This study suggests that the PMAP36-P22 lysozyme fusion system could be a crucial addition to the plethora of novel antimicrobials.

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http://dx.doi.org/10.14348/molcells.2019.2365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449713PMC
March 2019
9 Reads
3.533 Impact Factor

Protective efficacy of an inactivated vaccine candidate lysed by GI24 against brucellosis in Korean black goats.

Can J Vet Res 2019 Jan;83(1):68-74

Veterinary Public Health, College of Veterinary Medicine, Chonbuk National University, Gobong-ro 79, Iksan, Jeollabuk-do, Republic of Korea (Kim, Moon, Cho, Ochirkhuyag, Hur); Veterinary Histology, College of Veterinary Medicine, Chonbuk National University, Gobong-ro 79, Iksan, Jeollabuk-do, Republic of Korea (Akanda, Park).

The efficacy of GI24-lysed cells as a vaccine candidate against brucellosis in goats was evaluated on 2 groups of Korean black goats. Group A goats were immunized subcutaneously (SC) with sterile phosphate-buffered saline, whereas group B goats were immunized SC with approximately 3 × 10 lysed cells. Subcutaneous immunization with the lysed cells did not cause any negative impact on the overall clinical status, such as behavior and appetite, throughout the study period. The enzyme-linked immunosorbent assay (ELISA) optical densities values for lipopolysaccharide in serum were considerably higher in group B than those in group A. Also, the levels of the cytokines interleukin 4 (IL-4), tumor necrosis factor-alpha (TNF-?), and interferon gamma (IFN-?) were significantly elevated in group B compared with those in group A. Following intraconjunctival challenge with strain 544, the severity of brucellosis in terms of infection index and colonization of in tissues was significantly lower in group B than in group A. The present study concluded that 3 of 5 goats immunized with GI24-lysed bacteria were completely protected against challenge. Future investigations are required to improve the protective efficacy offered by lysed cells for practical applications in small ruminants.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318821PMC
January 2019
3 Reads
1.022 Impact Factor

The biological and pharmacological roles of polyphenol flavonoid tilianin.

Eur J Pharmacol 2019 Jan 31;842:291-297. Epub 2018 Oct 31.

College of Veterinary Medicine and Biosafety Research Institute, Chonbuk National University, Iksan 54596, Republic of Korea. Electronic address:

Archaeological evidence for phytomedicine has established the importance of plants as a source of biologically active molecules with beneficial effects. Related studies constitute significant tools for novel drug discovery. A major benefit of phytomedicine is that standard ethnopharmacological evidence regarding traditional uses can give indications for molecules that may be therapeutically significant. Tilianin is a polyphenol antioxidant commonly used as natural phytomedicine. At the molecular level, tilianin has been reported to modulate a number of key elements in cellular signal transduction pathways linked to oxidative stress-mediated inflammation, apoptosis, and angiogenesis. At present review, we address potential approaches for arbitrating novel tilianin biologics in medicinal applications, concentrating on the selection of personalized medicines and emphasizing tasks and prospects related to medical discoveries over the last few years. In particular, we highlight the major health benefits of tilianin, which comprise cardioprotective, neuroprotective, anti-atherogenic, anti-hypertensive, anti-diabetes, anti-inflammatory, antioxidant, anti-depressant, and miscellaneous aspects.

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183062
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http://dx.doi.org/10.1016/j.ejphar.2018.10.044DOI Listing
January 2019
16 Reads
2.896 Impact Factor

Regulation of JAK2/STAT3 and NF-κB signal transduction pathways; Veronica polita alleviates dextran sulfate sodium-induced murine colitis.

Biomed Pharmacother 2018 Apr 16;100:296-303. Epub 2018 Feb 16.

College of Veterinary Medicine and Biosafety Research Institute, Chonbuk National University, Iksan 54596, Republic of Korea. Electronic address:

Ulcerative colitis (UC) is a major inflammatory bowel disease (IBD) has become a worldwide emergent disease. Veronica polita (VP) is a medicinal herb that has strong antioxidant and anti-inflammatory properties. In the present study, we studied the protective effect of VP on dextran sulfate sodium (DSS)-induced experimental colitis in mice. Phytochemical screening of VP extract demonstrated the presence of high total phenolic and flavonoid contents. Compared with the DSS group, VP significantly reduced clinical symptoms with less weight loss, bloody stool, shortening of the colon, and the severity of colitis was considerably inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in the colon and spleen. Also, treatment with VP considerably decreased the nitric oxide (NO) and malondialdehyde (MDA) level. VP remarkably downregulated the expression of tumor necrosis factor-? (TNF-?), interleukin-1? (IL-1?), interleukin-6 (IL-6), inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) in the colon tissue. Likewise, activation of the signal transducer and activator of transcription 3 (STAT3) and nuclear factor-kappa B (NF-?B) was effectively blocked by VP. Taken together, these results demonstrate that VP has an ameliorative effect on colonic inflammation mediated by modulation of oxidative stress and inflammatory mediators by suppressing the JAK2/STAT3 and NF-?B signaling pathways.

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http://dx.doi.org/10.1016/j.biopha.2018.01.168DOI Listing
April 2018
3 Reads
3.457 Impact Factor

Neuroprotective Effects of Sigesbeckia pubescens Extract on Glutamate-Induced Oxidative Stress in HT22 Cells via Downregulation of MAPK/caspase-3 Pathways.

Cell Mol Neurobiol 2018 Mar 5;38(2):497-505. Epub 2017 May 5.

College of Veterinary Medicine and Biosafety Research Institute, Chonbuk National University, Iksan, 54596, Republic of Korea.

Sigesbeckia pubescens (SP) is a traditional Chinese medicine, possessing antioxidant and anti-inflammatory activities. In this study, we evaluate the neuroprotective activities of SP extract on glutamate-induced oxidative stress in HT22 cells and the molecular mechanism underlying neuroprotection. We applied 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), crystal violet, reactive oxygen species (ROS), lactate dehydrogenase (LDH), quantitative real-time polymerase chain reaction (qPCR), and western blot analyses for assessing the neuroprotective effects of SP extract. The experimental study revealed that SP considerably increased the cell viability, and reduced the oxidative stress promoted ROS and LDH generation in HT22 cells in a dose-dependent manner. Additionally, the morphology of HT22 cells was effectively improved by SP. Upregulated gene expressions of mitogen-activated protein kinase (MAPK) were markedly attenuated by SP. Similarly, SP notably suppressed the ROS-mediated phosphorylation of MAPK (pERK1/2, pJNK, and pp38) cascades and activation of apoptotic factor caspase-3 signaling pathway that overall contributed to the neuroprotection. Taken together, SP may exert neuroprotective effects via alteration of MAPK and caspase-3 pathways under oxidative stress condition. Therefore, SP is a potential agent for preventing oxidative stress-mediated neuronal cell death.

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http://dx.doi.org/10.1007/s10571-017-0496-yDOI Listing
March 2018
103 Reads
3.895 Impact Factor

Anti-Inflammatory and Gastroprotective Roles of Rabdosia inflexa through Downregulation of Pro-Inflammatory Cytokines and MAPK/NF-κB Signaling Pathways.

Int J Mol Sci 2018 Feb 16;19(2). Epub 2018 Feb 16.

College of Veterinary Medicine and Bio-safety Research Institute, Chonbuk National University, Iksan 54596, Korea.

Globally, gastric ulcer is a vital health hazard for a human. (RI) has been used in traditional medicine for inflammatory diseases. The present study aimed to investigate the protective effect and related molecular mechanism of RI using lipopolysaccharide (LPS)-induced inflammation in RAW 246.7 cells and HCl/EtOH-induced gastric ulcer in mice. We applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde (MDA), quantitative real-time polymerase chain reaction (qPCR), immunohistochemistry (IHC), and Western blot analyses to evaluate the protective role of RI. Study revealed that RI effectively attenuated LPS-promoted NO and ROS production in RAW 246.7 cells. In addition, RI mitigated gastric oxidative stress by inhibiting lipid peroxidation, elevating NO, and decreasing gastric inflammation. RI significantly halted elevated gene expression of pro-inflammatory cytokines such as tumor necrosis factor-? (), interleukin-1? (), interleukin-6 (), inducible nitric oxide synthetase (), and cyclooxygenase-2 () in gastric tissue. Likewise, RI markedly attenuated the mitogen-activated protein kinases (MAPKs) phosphorylation, COX-2 expression, phosphorylation and degradation of inhibitor kappa B (I?B?) and activation of nuclear factor kappa B (NF-?B). Thus, experimental findings suggested that the anti-inflammatory and gastroprotective activities of RI might contribute to regulating pro-inflammatory cytokines and MAPK/NF-?B signaling pathways.

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http://www.mdpi.com/1422-0067/19/2/584
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http://dx.doi.org/10.3390/ijms19020584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855806PMC
February 2018
4 Reads
4.183 Impact Factor

Brucella abortus lysed cells using GI24 induce robust immune response and provide effective protection in Beagles.

Pathog Dis 2018 02;76(1)

College of Veterinary Medicine, Chonbuk National University Special Campus, Iksan, 54596, Republic of Korea.

The aim of the present study is to estimate the protective efficacy of Brucella abortus lysed cells by GI24 against brucellosis in Beagles. Group A was subcutaneously (sc) immunized with sterile phosphate-buffered saline, and group B was sc immunized with approximately 3 × 109 of the lysed cells. Brucella-LPS-specific serum IgG titers and IL-4, TNF-? and IFN-? concentrations were investigated by enzyme linked immunosorbent assay. All dogs were intraconjunctivally challenged with B. abortus strain 544 at 6 weeks post-prime immunization. The serum IgG titers were considerably higher in group B than in group A. The levels of IL-4, TNF-? and IFN-? in group B than in group A were significantly higher. Following challenge, no challenge strain was observed from all tissues of three dogs of group B. However, challenge strain was detected from spleen, uterus (except one Beagle) and inguinal and retropharyngeal lymph nodes of all group A Beagles. The results of this study demonstrated that sc immunization with the lysed cells induced robust antibody and cell-mediated immune responses in Beagles. The lysed cells also conferred protection against infection with B. abortus. These results suggest that sc immunization with B. abortus lysed cells by GI24 is a good vaccine candidate against brucellosis in dogs.

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http://dx.doi.org/10.1093/femspd/ftx124DOI Listing
February 2018
112 Reads
2.182 Impact Factor

The Anti-Stress Effect of Mentha arvensis in Immobilized Rats.

Int J Mol Sci 2018 Jan 25;19(2). Epub 2018 Jan 25.

College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Iksan 54596, Korea.

Stress can lead to inflammation, accelerated aging, and some chronic diseases condition. (MA) is a traditional medicine having antioxidant and anti-inflammatory activities. The present study investigated the anti-stress role of MA and fermented MA (FMA) extract in immobilized rats. We studied the lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells and rats were immobilized for 2 h per day for 14 days using a restraining cage. MA (100 mg/kg) and FMA (100 mg/kg) were orally administered to rats 1 h prior to immobilization. Using high-performance liquid chromatography (HPLC) analysis, we determined the rosmarinic acid content of MA and FMA. The generation of malondialdehyde (MDA) and nitric oxide (NO) in RAW 246.7 cells were suppressed by both MA and FMA. In rats, MA and FMA notably improved the body weight, daily food intake, and duodenum histology. MDA and NO level were gradually decreased by MA and FMA treatment. MA and FMA significantly controlled the stress-related hormones by decreasing corticosterone and ?-endorphin and increasing serotonin level. Moreover, protein expression levels of mitogen activated protein kinases (MAPK) and cyclooxygenase-2 (COX-2) were markedly downregulated by MA and FMA. Taken together, MA and FMA could ameliorate immobilized-stress by reducing oxidative stress, regulating stress-related hormones, and MAPK/COX-2 signaling pathways in rats. Particularly, FMA has shown greater anti-stress activities than MA.

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http://dx.doi.org/10.3390/ijms19020355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855577PMC
January 2018
34 Reads
4.183 Impact Factor

Involvement of MAPK/NF-κB signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer.

Biomed Pharmacother 2017 Nov 6;95:1139-1146. Epub 2017 Oct 6.

College of Veterinary Medicine and Biosafety Research Institute, Chonbuk National University, Iksan 54596, South Korea. Electronic address:

Gastric ulcer is an important risk factor for human health globally. Camellia japonica (CJ) is a plant of which the fruits are used as traditional phytomedicine for inflammatory and immunomodulatory diseases; however, the underlying molecular mechanism has not been clarified. The present study aimed to investigate the immunopharmacological activities of Camellia japonica and validate its pharmacological targets. To evaluate the protective roles of Camellia japonica on LPS-induced inflammation in RAW 264.7 cells and HCl/EtOH-induced gastric ulcer in mice; we applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde (MDA), quantitative real-time polymerase chain reaction (qPCR), immunohistochemistry (IHC), and western blot analyses. We also determined the total phenolic and flavonoid content of Camellia japonica which might possess antioxidant and anti-inflammatory properties. We found the production of NO and ROS in RAW 246.7 cells were both suppressed by Camellia japonica. Moreover, Camellia japonica mitigated the HCl/EtOH-induced oxidative stress in gastric mucosa via the reduction of lipid peroxidation and elevation of NO production. Gastric mucosal damages were prominently improved by Camellia japonica, as confirmed by the histopathological evaluation. The gene expression of inflammatory cytokines and enzymes TNF-?, IL-6, IL-1?, iNOS, and COX-2 was notably downregulated by Camellia japonica. In addition, Camellia japonica markedly attenuated the MAPKs (ERK1/2, JNK, and p38) phosphorylation, COX-2 expression, and activation of transcription factor NF-?B and as well as phosphorylation and degradation of I?B? in gastric mucosa. Taken together, the intimated anti-inflammatory and gastroprotective mechanism of Camellia japonica is mediated by modulation of oxidative stress, inflammatory cytokines, and enzymes via suppression of MAPK/NF-?B signaling pathways.

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http://dx.doi.org/10.1016/j.biopha.2017.09.031DOI Listing
November 2017
4 Reads
3.456 Impact Factor

Hair growth promoting activity of discarded biocomposite keratin extract.

J Biomater Appl 2017 08 29;32(2):230-241. Epub 2017 Jun 29.

1 College of Veterinary Medicine and Biosafety Research Institute, Chonbuk National University, Republic of Korea.

Keratin biomaterial has been used in regenerative medicine owing to its in-vivo and in-vitro biocompatibility. The present study was aimed to investigate the hair growth promoting activity of keratin extract and its mechanism of action. Keratin extract was topically applied on the synchronized depilated dorsal skin of telogenic C57BL/6 mice and promoted hair growth by inducing the anagen phase. The histomorphometric observation indicated significantly increases the number, shaft of hair follicles and deep subcutis area in the keratin extract treated group in contrast to the control group, which was considered an indication of anagen phase induction. Subsequently, the quantitative real-time polymerase chain reaction analysis revealed that fibroblast growth factor-10, vascular endothelial growth factor, insulin-like growth factor-1, ?-catenin, and Shh were expressed earlier in the keratin extract-treated group than in the control group. Besides, keratin extract has been observed to be biocompatible when analyzed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and 4',6-diamidino-2-phenylindole staining using immortalized human keratinocyte cells, showing more than 90% cell viability. Our study demonstrated that keratin extract stimulating hair follicle growth by inducing the growth phase; anagen in telogenic C57BL/6 mice and thus the topical application of keratin extract may represent a promising biomaterial for the management and applications of hair follicle disorder.

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http://dx.doi.org/10.1177/0885328217717076DOI Listing
August 2017
6 Reads
2.764 Impact Factor

Hepatoprotective Role of Hydrangea macrophylla against Sodium Arsenite-Induced Mitochondrial-Dependent Oxidative Stress via the Inhibition of MAPK/Caspase-3 Pathways.

Int J Mol Sci 2017 Jul 10;18(7). Epub 2017 Jul 10.

College of Veterinary Medicine and Biosafety Research Institute, Chonbuk National University, Iksan 54596, Korea.

Sodium arsenite (NaAsO?) has been recognized as a worldwide health concern. (HM) is used as traditional Chinese medicine possessing antioxidant activities. The study was performed to investigate the therapeutic role and underlying molecular mechanism of HM on NaAsO?-induced toxicity in human liver cancer (HepG2) cells and liver in mice. The hepatoprotective role of HM in HepG2 cells was assessed by using 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), and lactate dehydrogenase (LDH) assays. Histopathology, lipid peroxidation, serum biochemistry, quantitative real-time polymerase chain reaction (qPCR) and Western blot analyses were performed to determine the protective role of HM against NaAsO? intoxication in liver tissue. In this study, we found that co-treatment with HM significantly attenuated the NaAsO?-induced cell viability loss, intracellular ROS, and LDH release in HepG2 cells in a dose-dependent manner. Hepatic histopathology, lipid peroxidation, and the serum biochemical parameters alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were notably improved by HM. HM effectively downregulated the both gene and protein expression level of the mitogen-activated protein kinase (MAPK) cascade. Moreover, HM well-regulated the Bcl-2-associated X protein (Bax)/B-cell lymphoma-2 (Bcl-2) ratio, remarkably suppressed the release of cytochrome , and blocked the expression of the post-apoptotic transcription factor caspase-3. Therefore, our study provides new insights into the hepatoprotective role of HM through its reduction in apoptosis, which likely involves in the modulation of MAPK/caspase-3 signaling pathways.

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http://www.mdpi.com/1422-0067/18/7/1482
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http://dx.doi.org/10.3390/ijms18071482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535972PMC
July 2017
53 Reads
4.183 Impact Factor

In Vivo and In Vitro Hepatoprotective Effects of Methanolic Extract via Downregulation of MAPK/Caspase-3 Pathway.

Evid Based Complement Alternat Med 2017 5;2017:8137627. Epub 2017 Jul 5.

College of Veterinary Medicine and Biosafety Research Institute, Chonbuk National University, Iksan 54596, Republic of Korea.

(GK) is an indigenous Chinese herbal medicine widely used for the treatment of various inflammation and liver disorders. However, the exact mechanism of action of GK remains unknown. This study aimed to investigate the protective effect and related molecular mechanism of GK on NaAsO-induced cytotoxicity in HepG2 cells and liver damage in mice. The cytoprotective role of GK was assessed on HepG2 cells using MTT assay. Oxidative stress and lactate dehydrogenase levels were measured with ROS and LDH assay. Histopathology and serum enzymes levels were estimated. The molecular mechanism was evaluated by qPCR and immunoblotting to ensure the hepatoprotective role of GK against NaAsO intoxication in mice. We found cotreatment with GK significantly attenuated NaAsO-induced cell viability loss, intracellular ROS, and LDH release. Hepatic histopathology and serum biochemical parameters, ALT, and AST were notably improved by cotreatment with GK. Beside, GK markedly altered both mRNA and protein expression level of MAPK. The proapoptotic and antiapoptotic protein Bax/Bcl-2 ratio was significantly regulated by GK. Moreover, GK remarkably suppressed the postapoptotic transcription protein cleaved caspase-3 expression. The present study reveals that GK possesses hepatoprotective activity which is probably involved in the modulation of the MAPK/caspase-3 pathway.

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http://dx.doi.org/10.1155/2017/8137627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516716PMC
July 2017
6 Reads
2.064 Impact Factor

Top co-authors

Byung-Yong Park
Byung-Yong Park

College of Veterinary Medicine

11
Hyun-Jin Tae
Hyun-Jin Tae

National Institute on Aging

6
Dongchoon Ahn
Dongchoon Ahn

College of Veterinary Medicine

6
In-shik Kim
In-shik Kim

College of Veterinary Medicine

6
Weishun Tian
Weishun Tian

College of Veterinary Medicine and Biosafety Research Institute

4
Jin Hur
Jin Hur

Yonsei University College of Medicine

3
Anowarul Islam
Anowarul Islam

Case Western Reserve University

3
Byung Yong Park
Byung Yong Park

College of Veterinary Medicine

1