Publications by authors named "Md Amirul Islam"

15 Publications

  • Page 1 of 1

Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.

Biomed Pharmacother 2021 Aug 12;140:111732. Epub 2021 Jun 12.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti-spasmodic, anthelmintic, and anti-arrhythmias. This study aims to evaluate its hepatoprotective effect against paracetamol-induced liver toxicity in a rat model. Five groups of rats (n = 7) were orally treated (once daily) with 0.05% tween 80 dissolved in 0.9% NaCl solution (vehicle), paracetamol 640 mg/kg (negative control), 50 mg/kg silymarin (positive control), or nerol (50 and 100 mg/kg) for 14 days, followed by the hepatotoxicity induction using paracetamol (PCM). The blood samples and livers of the animals were collected and subjected to biochemical and microscopical analysis. The histological findings suggest that paracetamol caused lymphocyte infiltration and marked necrosis, whereas maintenance of the normal hepatic structural was observed in group pre-treated with silymarin and nerol. The rats pre-treated with nerol significantly and dose-dependently reduced the hepatotoxic markers in animals. Nerol at 100 mg/kg significantly reversed the paracetamol-induced altered situations, including the liver enzymes, plasma proteins, antioxidant enzymes and serum bilirubin, lipid peroxidation (LPO) and cholesterol [e.g., total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c)] levels in animals. Taken together, nerol exerted significant hepatoprotective activity in rats in a dose-dependent manner. PCM-induced toxicity and nerol induced hepatoprotective effects based on expression of inflammatory and apoptosis factors will be future line of work for establishing the precise mechanism of action of nerol in Wistar albino rats.
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http://dx.doi.org/10.1016/j.biopha.2021.111732DOI Listing
August 2021

Zingiber roseum Rosc. rhizome: A rich source of hepatoprotective polyphenols.

Biomed Pharmacother 2021 Jul 6;139:111673. Epub 2021 May 6.

Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address:

Zingiber roseum is native to Bangladesh and widely used in folk medicine. This present study was designed to assess the ameliorative potential of Zingiber roseum rhizome extract in carbon tetrachloride (CCl) induced hepatotoxicity in mice model. Seven phenolic compounds were identified and quantified by HPLC analysis in the plant extract, including quercetin, myricetin, catechin hydrate, trans-ferulic acid, trans-cinnamic acid, (-) epicatechin, and rosmarinic acid. Hepatotoxicity was induced by administrating a single intraperitoneal injection of CCl (10 mL/kg) on 7th day of treatment. The results revealed that plant extract at all doses (100, 200 and 400 mg/kg) significantly reduced (p < 0.05) the elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) concentrations, and these effects were comparable to that of standard drug silymarin. Histopathological examination also revealed the evidence of recovery from CCL induced cellular damage when pretreated with Z. roseum rhizome extract. The in-vivo hepatoprotective effects were further investigated by the in-silico study of the aforementioned compounds with liver-protective enzymes such as superoxide dismutase (SOD), peroxiredoxin, and catalase. The strong binding affinities (ranging from -7.3359 to -9.111 KCal/mol) between the phenolic compounds (except trans-cinnamic acid) and oxidative stress enzymes inhibit ROS production during metabolism. The compounds were also found non-toxic in computational prediction, and a series of biological activities like antioxidant, anticarcinogen, cardio-protectant, hepato-protectant have been detected.
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http://dx.doi.org/10.1016/j.biopha.2021.111673DOI Listing
July 2021

Virulence Determinants and Multidrug Resistance of Isolated from Migratory Birds.

Antibiotics (Basel) 2021 Feb 15;10(2). Epub 2021 Feb 15.

Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.

Migratory birds are carriers of multidrug resistant pathogenic . However, their roles in the dissemination of these resistant pathogens are still being neglected in Bangladesh. The present study was therefore carried out to detect multidrug resistant . In addition, these isolates were also screened for the presence of avian pathogenic (APEC)-associated virulence genes. A total of 66 fecal matter samples of migratory birds were screened. were isolated and identified by culturing and biochemical tests followed by polymerase chain reaction (PCR). APEC-associated virulence genes were detected by PCR. Disk diffusion assays were employed to investigate antibiogram profiles. Bivariate analysis was performed to assess correlations in resistance patterns between antimicrobials and to assess associations between virulence genes of . Among the 66 samples assessed by PCR, 55 (83.33%) were found positive for Of these 55 isolates, the APEC-associated virulence gene was detected in 67.27% of the isolates, which was significantly higher than in the cases of (29.09%) and (5.45%) genes. In addition, three isolates were found positive for all three virulence genes, while 23 and 12 isolates were positive for one and two virulence genes respectively. In the bivariate analysis, significant associations were detected between and virulence genes. Using the antibiogram, all isolates were found to be multidrug resistant (MDR). The isolates exhibited 100% resistance against ampicillin and erythromycin in addition to varying percentages of resistance against streptomycin, tetracycline, ciprofloxacin, and chloramphenicol. Highly positive correlations between tetracycline and ciprofloxacin, chloramphenicol and ciprofloxacin, chloramphenicol and tetracycline were observed by bivariate analysis. To the best of our knowledge, this is the first study that reports APEC-associated virulence genes of MDR from migratory birds in Bangladesh. Results indicate that migratory birds are reservoirs of MDR isolates carrying APEC-associated virulence genes, which can seriously contribute to the development of human and animal diseases.
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http://dx.doi.org/10.3390/antibiotics10020190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919266PMC
February 2021

Molecular Phylogenetics and Biological Potential of Fungal Endophytes From Plants of the Sundarbans Mangrove.

Front Microbiol 2020 13;11:570855. Epub 2020 Nov 13.

Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.

The Sundarbans forest in Bangladesh is the world's largest mangrove. It is a unique ecosystem where living organisms face extreme challenges to compete for survival. Such competition results in the production of bioactive molecules which are useful for agriculture and human health. In this study, eighty fungal endophytes from nine mangrove plants growing in a region, as yet unexplored, of the Sundarbans were isolated by surface sterilisation and pure culture techniques. Among the eighty isolates subjected to a preliminary antimicrobial screening using an agar plug diffusion assay, only fifteen showed some promising activity. These were subsequently identified by polymerase chain reaction of their ITS gene. Extracts prepared from the identified isolates were screened for antimicrobial, antioxidant, cytotoxic and α-glucosidase inhibitory activities. Their total polyphenol and flavonoid content and their FRAP value were also determined. All endophytes are reported for the first time in the plants under investigation.
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http://dx.doi.org/10.3389/fmicb.2020.570855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691279PMC
November 2020

Antidiabetic and hepatoprotective potential of whole plant extract and isolated compounds of Aeginetia indica.

Biomed Pharmacother 2020 Dec 1;132:110942. Epub 2020 Nov 1.

Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh. Electronic address:

Background: Aeginetia indica, a perennial herb from the Orobanchaceae family, generally grows as a root parasite and is widely distributed in the forests of South and South-Asian countries. The plant has valuable uses in herbal medicine against various diseases, such as diabetes, liver diseases, and arthritis.

Aim Of The Study: The present study was designed to investigate the antidiabetic and hepatoprotective effects of the methanol extract of the whole plant of A. indica in a mouse model followed by the isolation of bioactive compounds and their in-silico studies.

Methods: The hepatoprotective effects were evaluated in a paracetamol-induced hepatotoxicity mouse model. The antidiabetic effects were examined by an oral glucose tolerance test and in an alloxan-induced diabetes mouse model.

Results: The plant extract, at a dose of 400 mg/kg, caused a significant reduction (p < 0.001) in liver enzyme concentrations, including alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase, similar to the effects of standard drug silymarin. The plant extract, at 400 mg/kg, also significantly reduced (p < 0.001) the fasting blood glucose concentration by 27.33 % after 3 h, compared with a reduction of 45.31 % in response to glibenclamide. In the alloxan-induced diabetes model mice, significant reductions (p < 0.05) in elevated glucose concentrations were observed on days 10 and 20 in mice treated with plant extract and glibenclamide. Chromatographic analyses and nuclear magnetic resonance (NMR) studies identified the presence of β-sitosterol, stigmasterol, and oleic acid in the extract. The possible mechanism underlying the antidiabetic effects was revealed by molecular docking analyses examining the binding of β-sitosterol and stigmasterol with sirtuin 4, an NAD-dependent deacylase enzyme that downregulates leucine-induced and glutamate dehydrogenase-induced insulin secretion. The binding affinities between sirtuin 4 and β-sitosterol, stigmasterol, and NAD were found to be -8.6 kcal/mol, -7.2 kcal/mol and -9.5 kcal/mol, respectively, indicating the probable competition between NAD and the isolated components for sirtuin 4.

Conclusion: The present study revealed that A. indica exerted protective effects against alloxan-induced diabetes and paracetamol-induced hepatotoxicity in mice, which supports the findings regarding the use of A. indica during traditional medical practice.
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http://dx.doi.org/10.1016/j.biopha.2020.110942DOI Listing
December 2020

Migratory birds as the potential source for the transmission of and other fungus to Bangladesh.

J Adv Vet Anim Res 2020 Jun 7;7(2):338-344. Epub 2020 May 7.

Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Objectives: Migratory birds play a major role in the transmission of pathogens globally, but still their role in the transmission of fungi in Bangladesh is not known. The present study was carried out for the isolation and molecular detection of fungi including from migratory birds traveling to Bangladesh.

Materials And Methods: A total of 50 fecal samples were collected from BaojaniBaor, Magura, and areas close to Jahangirnagar University, Savar. The isolation of fungus was based on culture on Potato Dextrose Agar (PDA), followed by staining, morphology, and molecular detection using polymerase chain reaction (PCR).

Results: Among 50 samples, 40 showed positive for fungal growth on PDA, of which 30 yield only yeast-like colonies, five only molds, and five yielded both yeast and molds. The isolated molds produced various pigmented colonies, namely, black, whitish, grayish, olive green, and yellow. Among 10 molds, six were confirmed as fungi by PCR using genus-specific primers such as ITS1 and ITS4. Later, of these six fungi, five were confirmed as by PCR with primers such as ASAP1 and ASAP2 specific for genus. Therefore, the overall occurrence of was 10% (5/50). PCR specific for and failed to produce specific PCR amplicon, suggesting that the isolated belongs to other groups.

Conclusion: This is the first report describing the isolation and molecular detection of from fecal samples of migratory birds in Bangladesh. The present findings confirm that migratory birds are potential source for and other fungus in Bangladesh.
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http://dx.doi.org/10.5455/javar.2020.g427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320803PMC
June 2020

Relative Saliency and Ranking: Models, Metrics, Data and Benchmarks.

IEEE Trans Pattern Anal Mach Intell 2021 Jan 4;43(1):204-219. Epub 2020 Dec 4.

Salient object detection is a problem that has been considered in detail and many solutions have been proposed. In this paper, we argue that work to date has addressed a problem that is relatively ill-posed. Specifically, there is not universal agreement about what constitutes a salient object when multiple observers are queried. This implies that some objects are more likely to be judged salient than others, and implies a relative rank exists on salient objects. Initially, we present a novel deep learning solution based on a hierarchical representation of relative saliency and stage-wise refinement. Further to this, we present data, analysis and baseline benchmark results towards addressing the problem of salient object ranking. Methods for deriving suitable ranked salient object instances are presented, along with metrics suitable to measuring algorithm performance. In addition, we show how a derived dataset can be successively refined to provide cleaned results that correlate well with pristine ground truth in its characteristics and value for training and testing models. Finally, we provide a comparison among prevailing algorithms that address salient object ranking or detection to establish initial baselines providing a basis for comparison with future efforts addressing this problem. The source code and data are publicly available via our project page: ryersonvisionlab.github.io/cocosalrank.
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http://dx.doi.org/10.1109/TPAMI.2019.2927203DOI Listing
January 2021

Antioxidant and hepatoprotective activity of against Paracetamol-induced hepatotoxicity in Sprague-Dawley rat.

Nat Prod Res 2020 Nov 19;34(22):3219-3225. Epub 2019 Jan 19.

Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.

The ethanol extracts of were investigated for antioxidant and hepatoprotective activity. Hepatoprotective activity against paracetamol-induced acute hepatotoxicity was estimated in Sprague-Dawley rat. In DPPH free radical assay the root and stem extracts showed IC values at 133 and 91 µg/mL, respectively, while ascorbic acid at 14 µg/mL. Extracts also exhibited hydroxyl radical scavenging activity and reducing power. HPLC-DAD analysis indicated the presence of some polyphenolic compounds. Treatment of extracts significantly reduced the elevated serum levels of GPT ( < 0.01), GOT ( < 0.01) and bilirubin ( < 0.001). Both extracts restored the reduced level of total proteins and albumin. A significant increase in HDL-c but decrease in LDL-c level was observed compared to induced control. In histopathological study of liver sections, both extracts showed minimal to mild multifocal and diffuse granular degeneration and mild to moderate lobular disarray compared to control group. Results suggest that both extracts can prevent paracetamol induced hepatotoxicity.
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http://dx.doi.org/10.1080/14786419.2018.1550768DOI Listing
November 2020

Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.

Biomed Pharmacother 2018 Oct 29;106:1686-1695. Epub 2018 Jul 29.

Laboratório de Toxicidade Genética do Programa de Pós-graduação em Ciências Farmacêuticas da Universidade Federal do Piauí, CEP: 64.049-550, Teresina Brazil; Programa de Pós-Graduação em Biotecnologia (RENORBIO) da Universidade Federal do Piauí, Teresina, Brazil.

Epilepsy is a neurological disease affecting people of all ages worldwide. Side effects of antiepileptic drugs and their association with oxidative stress stimulate the search for new drugs, which would be more affordable with fewer adverse effects. Accordingly, the aim of the present work is to evaluate the anticonvulsant effect of anacardic acid (AA), a natural compound extracted from cashew liquid (Anacardium occidentalis), in murine models, as well as its antioxidant actions in Saccharomyces cerevisiae. AA (>90% purity) was tested, in vivo, in male Swiss mice (25-30 g) with four convulsive models, (1) pentylenetetrazole, (2) pilocarpine, (3) electroshock, and (4) kainic acid, at doses of 25, 50, and 100 mg/kg, body weight (B.W.) Additionally, the effective dose, toxic dose, and protective index studies were also performed. Results revealed that AA exhibits anticonvulsive effects in models 1, 3, and 4, with a mean effective dose (ED) of 39.64 (model 1) >100 mg/kg, B.W. (model 2), and 38.36 (model 3); furthermore, AA displays a protection index of 1.49 (model 1), <0.6 (model 2, and 1.54 (model 3). In addition, AA showed antioxidant activities in S. cerevisiae mutated for superoxide dismutases (SOD). In conclusion, these results show that AA exhibits significant anticonvulsant and antioxidant activities and may be used as a promising natural product for the treatment of epilepsy.
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http://dx.doi.org/10.1016/j.biopha.2018.07.121DOI Listing
October 2018

Phytol: A review of biomedical activities.

Food Chem Toxicol 2018 Nov 18;121:82-94. Epub 2018 Aug 18.

King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia; Novel Global Community Educational Foundation, Australia.

Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
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http://dx.doi.org/10.1016/j.fct.2018.08.032DOI Listing
November 2018

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer.

Cancer Lett 2018 04 14;420:129-145. Epub 2018 Feb 14.

King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia; Novel Global Community Educational Foundation, Australia. Electronic address:

The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been proven to possess several important protective biological activities, including antioxidant, anti-inflammatory, immunomodulatory, antiseptic, antimicrobial, cytotoxic, hypolipidemic, cardioprotective, hepatoprotective, and neuroprotective effects. In addition, it has been reported to play a therapeutic role in the treatment of major human diseases, such as Parkinson's disease, rheumatoid arthritis, and colitis. This systematic review aims to highlight andrographolide as a promising agent in cancer treatment. To this purpose, a number of databases were used to search for the cytotoxic/anticancer effects of andrographolide in pre-clinical and clinical studies. Among 1703 identified literature articles, 139 were included in this review; 109 were investigated as non-clinical, whereas 24, 3, and 3 were pre-clinical, clinical, and non-pre-clinical trials, respectively. Among the model systems, cultured cell lines appeared as the most frequently (79.14%) used, followed by in vivo models using rodents, among others. Furthermore, andrographolide was found to exert cytotoxic/anticancer effects on almost all types of cell lines with the underlying mechanisms involving oxidative stress, cell cycle arrest, anti-inflammatory and immune system mediated effects, apoptosis, necrosis, autophagy, inhibition of cell adhesion, proliferation, migration, invasion, anti-angiogenic activity, and other miscellaneous actions. After careful consideration of the relevant evidence, we suggest that andrographolide can be one of the potential agents in the treatment of cancer in the near future.
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http://dx.doi.org/10.1016/j.canlet.2018.01.074DOI Listing
April 2018

Chemical composition and pharmacological activities of Pisum sativum.

BMC Complement Altern Med 2017 Mar 27;17(1):171. Epub 2017 Mar 27.

Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh.

Background: Consumption of vegetables has been proven to be effective in the prevention of different diseases. Traditionally edible aerial part of Pisum sativum L. subsp. sativum (Fabaceae) is used to treat diabetes, heart diseases and as blood purifier. Present study was aimed to explore the traditional use of aerial parts of P. sativum as a source of antidiabetic agent. In addition, antioxidant activity and chemical composition was carried out.

Methods: Total polyphenol content was spectrophotometrically determined using Folin Chiocalteu's reagent while the flavonoids by aluminum chloride colorimetric assay. Identification of compounds of the extract was made through HPLC and LCMS. Antihyperglycemic activity was assessed by oral glucose tolerance test in mice. Antioxidant activity was determined by DPPH free radical scavenging and reducing power assay.

Results: Total polyphenol and total flavonoids content were found to be 51.23 mg gallic acid equivalent and 30.88 mg quercetin equivalent per gram of dried plant extract respectively. Ellagic acid and p-coumeric acid were detected through HPLC. A total of eight compounds including naringenin, β-sitosterol were indentified through LCMS. In OGTT, extract (200 mg/kg bw) showed a 30.24% decrease (P< 0.05) in blood glucose levels at 30 min compared to the normal control. The extract showed IC value of 158.52 μg/mL in DPPH scavenging assay and also showed comparable reducing power.

Conclusion: Along with other compounds ellagic acid and β-sitosterol present in the extract may be responsible for its antioxidant as well as antihyperglycemic activities. Altogether these results rationalize the use of this vegetable in traditional medicine.
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http://dx.doi.org/10.1186/s12906-017-1699-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368943PMC
March 2017

Synthesis of the Natural Product Marthiapeptide A.

Org Lett 2015 Nov 15;17(21):5149-51. Epub 2015 Oct 15.

School of Chemistry, The University of New South Wales , Gate 2 High Street, Sydney 2052, Australia.

The first total synthesis of marthiapeptide A is reported. Two synthetic procedures are described: the first, which was unsuccessful, attempts to close the ring at position I, and the second, which was successful, closes the ring at position II. It appears that the first route was unsuccessful because it required cyclization next to the rigid thiazole moiety, whereas the second route closed next to the more flexible thiazoline ring.
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http://dx.doi.org/10.1021/acs.orglett.5b02574DOI Listing
November 2015

The fungal natural product (1S,3S)-austrocortirubin induces DNA damage in HCT116 cells via a mechanism unique from other DNA damaging agents.

Bioorg Med Chem Lett 2015 Jan 29;25(2):249-53. Epub 2014 Nov 29.

Department of Chemistry, University of New South Wales, Kensington, NSW 2052, Australia. Electronic address:

Screening a series of natural product-based tetrahydroanthraquinones led to the identification of a novel molecule, (1S,3S)-austrocortirubin (2), which acts via inducing DNA damage. Compound 2 has a GI50 of 3μM against HCT116 and induces apoptosis. Mechanism of action studies indicate that it causes significant DNA damage during G0/G1, S, and G2 cell cycle phases. Cells are stopped at the G2/M phase checkpoint, and do not reach mitosis due to large amounts of DNA damage. Thus, compound 2 exhibits a unique mechanism of action, one that is distinct from doxorubicin, despite the high degree of structural homology between these two quinone-based structures.
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http://dx.doi.org/10.1016/j.bmcl.2014.11.055DOI Listing
January 2015

Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.

Bioorg Med Chem Lett 2013 Sep 3;23(17):4862-6. Epub 2013 Jul 3.

Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40-80μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor.
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http://dx.doi.org/10.1016/j.bmcl.2013.06.082DOI Listing
September 2013