Publications by authors named "Mazhar Adli"

42Publications

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells.

Proc Natl Acad Sci U S A 2020 Oct 23. Epub 2020 Oct 23.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903;

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http://dx.doi.org/10.1073/pnas.2009899117DOI Listing
October 2020

Ethical Considerations in Therapeutic Clinical Trials Involving Novel Human Germline-Editing Technology.

CRISPR J 2020 02;3(1):18-26

Robert Lurie Comprehensive Cancer Center, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern, Chicago, Illinois.

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http://dx.doi.org/10.1089/crispr.2019.0051DOI Listing
February 2020

Mapping and Making Sense of Noncoding Mutations in the Genome.

Cancer Res 2019 09 6;79(17):4309-4314. Epub 2019 Aug 6.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0905DOI Listing
September 2019

The Biology and Application Areas of CRISPR Technologies.

Authors:
Mazhar Adli

J Mol Biol 2019 01 14;431(1):1-2. Epub 2018 Nov 14.

Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.11.012DOI Listing
January 2019

Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer.

Genome Biol 2018 11 7;19(1):190. Epub 2018 Nov 7.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, 1340 Jefferson Park Ave, Pinn Hall, Room: 6228, Charlottesville, VA, 22903, USA.

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http://dx.doi.org/10.1186/s13059-018-1572-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223090PMC
November 2018

Temporal and Spatial Epigenome Editing Allows Precise Gene Regulation in Mammalian Cells.

J Mol Biol 2019 01 9;431(1):111-121. Epub 2018 Aug 9.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.08.001DOI Listing
January 2019

CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool.

J Mol Biol 2019 01 7;431(1):88-101. Epub 2018 Jun 7.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.05.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286228PMC
January 2019

The CRISPR tool kit for genome editing and beyond.

Authors:
Mazhar Adli

Nat Commun 2018 05 15;9(1):1911. Epub 2018 May 15.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, 1340 Jefferson Park Ave, Pinn Hall, Rm: 640, Charlottesville, VA, 22902, USA.

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http://dx.doi.org/10.1038/s41467-018-04252-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953931PMC
May 2018

Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain.

Endocrinology 2018 01;159(1):132-144

Center for Human Health and the Environment and Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina.

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http://dx.doi.org/10.1210/en.2017-00730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761590PMC
January 2018

CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations.

Nat Methods 2017 Jul 5;14(7):710-712. Epub 2017 Jun 5.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

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http://www.nature.com/doifinder/10.1038/nmeth.4327
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http://dx.doi.org/10.1038/nmeth.4327DOI Listing
July 2017

Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9.

Nat Commun 2017 03 14;8:14725. Epub 2017 Mar 14.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA.

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http://www.nature.com/doifinder/10.1038/ncomms14725
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http://dx.doi.org/10.1038/ncomms14725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424063PMC
March 2017

CRISPR-Cas9-AID base editor is a powerful gain-of-function screening tool.

Nat Methods 2016 11;13(12):983-984

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1038/nmeth.4076DOI Listing
November 2016

Ethanolamine Signaling Promotes Salmonella Niche Recognition and Adaptation during Infection.

PLoS Pathog 2015 Nov 13;11(11):e1005278. Epub 2015 Nov 13.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643982PMC
November 2015

Cas9-chromatin binding information enables more accurate CRISPR off-target prediction.

Nucleic Acids Res 2015 Oct 1;43(18):e118. Epub 2015 Jun 1.

University of Virginia, School of Medicine, Department of Biochemistry and Molecular Genetics, 1340 Jefferson Park Ave, Jordan Hall, Room: 6240, Charlottesville, VA 22903, USA

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http://dx.doi.org/10.1093/nar/gkv575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605288PMC
October 2015

Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.

Cell Rep 2015 May 23;11(5):808-20. Epub 2015 Apr 23.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426023PMC
May 2015

Discovery of CTCF-sensitive Cis-spliced fusion RNAs between adjacent genes in human prostate cells.

PLoS Genet 2015 Feb 6;11(2):e1005001. Epub 2015 Feb 6.

Department of Pathology, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450057PMC
February 2015

Epigenetic States of nephron progenitors and epithelial differentiation.

J Cell Biochem 2015 Jun;116(6):893-902

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virgina.

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http://dx.doi.org/10.1002/jcb.25048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511265PMC
June 2015

Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds.

Endocrinology 2014 Aug 2;155(8):2770-80. Epub 2014 Jun 2.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908.

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http://dx.doi.org/10.1210/en.2014-1123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098001PMC
August 2014

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

Nat Biotechnol 2014 Jul 18;32(7):677-83. Epub 2014 May 18.

School of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1038/nbt.2916DOI Listing
July 2014

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.

J Exp Med 2013 Nov 11;210(12):2641-59. Epub 2013 Nov 11.

Human Oncology and Pathogenesis Program, 2 Leukemia Service, 3 Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, and 4 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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http://dx.doi.org/10.1084/jem.20131141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832937PMC
November 2013

Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq.

Nat Protoc 2011 Sep 29;6(10):1656-68. Epub 2011 Sep 29.

Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2011.402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493313PMC
September 2011

Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors.

Nat Methods 2010 Aug 11;7(8):615-8. Epub 2010 Jul 11.

Howard Hughes Medical Institute, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.1478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924612PMC
August 2010

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.

PLoS One 2010 Feb 25;5(2):e9428. Epub 2010 Feb 25.

Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009428PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828475PMC
February 2010

Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA.

Nat Methods 2010 Jan 29;7(1):47-9. Epub 2009 Nov 29.

Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://www.nature.com/doifinder/10.1038/nmeth.1404
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http://dx.doi.org/10.1038/nmeth.1404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862482PMC
January 2010

Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha.

Cancer Res 2007 Jul;67(13):6263-9

Lineberger Comprehensive Cancer Center, Department of Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1232DOI Listing
July 2007

IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation.

J Biol Chem 2006 Sep 13;281(37):26976-84. Epub 2006 Jul 13.

Lineberger Comprehensive Cancer Center, Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M603133200DOI Listing
September 2006

Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts.

Biofactors 2004 ;20(1):1-10

Sabanci University, 34956 Orhanli-Tuzla Istanbul, Turkey.

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http://dx.doi.org/10.1002/biof.5520200101DOI Listing
August 2004