Maya Topf

Maya Topf

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Maya Topf

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Cryo-electron microscopy targets in CASP13: Overview and evaluation of results.

Proteins 2019 Dec 23;87(12):1128-1140. Epub 2019 Oct 23.

Institute of Structural and Molecular Biology, Birkbeck, University College London, London, UK.

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http://dx.doi.org/10.1002/prot.25817DOI Listing
December 2019

Critical assessment of methods of protein structure prediction (CASP)-Round XIII.

Proteins 2019 Dec 23;87(12):1011-1020. Epub 2019 Oct 23.

Institute for Bioscience and Biotechnology Research, Rockville, Maryland.

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http://dx.doi.org/10.1002/prot.25823DOI Listing
December 2019

Modelling structures in cryo-EM maps.

Curr Opin Struct Biol 2019 Oct 5;58:105-114. Epub 2019 Aug 5.

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2019.05.024DOI Listing
October 2019

Conserved Central Intraviral Protein Interactome of the Family.

mSystems 2019 Oct 1;4(5). Epub 2019 Oct 1.

Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, United Kingdom

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http://dx.doi.org/10.1128/mSystems.00295-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774017PMC
October 2019

Structural transitions during the scaffolding-driven assembly of a viral capsid.

Nat Commun 2019 Oct 24;10(1):4840. Epub 2019 Oct 24.

Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London, WC1E 7HX, UK.

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http://dx.doi.org/10.1038/s41467-019-12790-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813328PMC
October 2019

Exome sequencing identifies variants in FKBP4 that are associated with recurrent fetal loss in humans.

Hum Mol Genet 2019 Aug 22. Epub 2019 Aug 22.

Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1093/hmg/ddz203DOI Listing
August 2019

Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships.

PLoS Biol 2019 Jun 14;17(6):e3000316. Epub 2019 Jun 14.

Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.3000316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594648PMC
June 2019

Mapping Aldehyde Dehydrogenase 1A1 Activity using an [ F]Substrate-Based Approach.

Chemistry 2019 Feb 14;25(9):2345-2351. Epub 2019 Jan 14.

Centre for Advanced Biomedical Imaging, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.

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http://doi.wiley.com/10.1002/chem.201805473
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http://dx.doi.org/10.1002/chem.201805473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379060PMC
February 2019

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.

Nat Commun 2018 12 14;9(1):5316. Epub 2018 Dec 14.

Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1038/s41467-018-07653-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294249PMC
December 2018

Jwalk and MNXL web server: model validation using restraints from crosslinking mass spectrometry.

Bioinformatics 2018 10;34(20):3584-3585

Institute for Structural and Molecular Biology, Birkbeck College, University of London, London, UK.

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https://academic.oup.com/bioinformatics/article/34/20/3584/4
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http://dx.doi.org/10.1093/bioinformatics/bty366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184817PMC
October 2018

Modeling Protein Complexes Using Restraints from Crosslinking Mass Spectrometry.

Structure 2018 07 24;26(7):1015-1024.e2. Epub 2018 May 24.

Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039719PMC
July 2018

Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties.

Nat Commun 2018 03 6;9(1):957. Epub 2018 Mar 6.

Department of Neuroscience, Physiology & Pharmacology UCL, Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1038/s41467-018-02927-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840332PMC
March 2018

Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.

Mol Pharmacol 2018 02 1;93(2):128-140. Epub 2017 Dec 1.

Departments of Chemistry (J.N., T.D.S.) and Neuroscience, Physiology and Pharmacology (A.C., N.S.M.), University College London, London, United Kingdom; and Institute of Structural and Molecular Biology, Birkbeck, University of London, London, United Kingdom (J.N., M.T.)

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http://dx.doi.org/10.1124/mol.117.110551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767682PMC
February 2018

Clinical and molecular characterization of -related severe early-onset epilepsy.

Neurology 2018 01 1;90(1):e55-e66. Epub 2017 Dec 1.

From Molecular Neurosciences (A.M., E.M., A., A.N., M.A.K.), Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health; Department of Neurology (A.M., A., A.N., C.E., J.H.C., M.A.K.) and Neuroradiology (W.K.C.), Great Ormond Street Hospital for Children, London, UK; Florey Institute of Neuroscience and Mental Health (U.N., E.V.G., I.E.S., S.P.), Melbourne, Australia; Department of Biological Sciences (S.M., M.T.), Institute of Structural and Molecular Biology, Birkbeck College, University of London; Regional Molecular Genetics Laboratory (N.T., R.H.S.), North East Thames Regional Genetics Service, and Department of Clinical Genetics (A.V.K., R.H.S.), Great Ormond Street Hospital, London, UK; Department of Paediatric Neurology (S.A.), Red Cross War Memorial Children's Hospital, Cape Town, South Africa; Department of Paediatric Neurology (G.A.), Addenbrooke's Hospital, Cambridge; Roald Dahl EEG Unit (R.A.), Department of Neurology, and Department of Neurology (R.K.), Alder Hey Children's Hospital, Liverpool; Department of Paediatric Neurology (A.D.), Sheffield Children's Hospital; Clinical Neurosciences (C.E., J.H.C.), Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London; Institute of Infection and Global Health (R.K.), University of Liverpool; Department of Paediatric Neurology (K.L.), Evelina Children's Hospital, Guys and St. Thomas' NHS Foundation Trust, London; Department of Clinical Genetics (T.M.), Northern Genetics Service; Department of Pediatric Neurology (V.R.), Great North Children's Hospital, Newcastle Upon Tyne; Department of Paediatric Neurology (R.S.), University Hospital Leicester Children's Hospital; Department of Paediatric Neurology (J.T.), Royal Manchester Children's Hospital; Department of Paediatric Neurology (W.W.), Nottingham University Hospitals NHS Trust, UK; Epilepsy Genetics Program (A. Poduri), Department of Neurology, Boston Children's Hospital; Department of Neurology (A. Poduri), Harvard Medical School, Boston, MA; University of Melbourne (I.E.S.), Austin Health and Royal Children's Hospital, Australia; and Department of Medicine (S.P.), Royal Melbourne Hospital, University of Melbourne, Australia. Dr. Malhotra is currently at the Department of Biochemistry, University of Cambridge, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754647PMC
January 2018

Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes.

Viruses 2017 12 31;10(1). Epub 2017 Dec 31.

Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, University of London, London WC1E 7HT, UK.

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http://dx.doi.org/10.3390/v10010016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795429PMC
December 2017

Structural basis of human kinesin-8 function and inhibition.

Proc Natl Acad Sci U S A 2017 11 23;114(45):E9539-E9548. Epub 2017 Oct 23.

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, London, WC1E 7HX, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1712169114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692573PMC
November 2017

Integrative modelling of cellular assemblies.

Curr Opin Struct Biol 2017 10 20;46:102-109. Epub 2017 Jul 20.

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683902PMC
October 2017

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

Sci Adv 2017 08 4;3(8):e1701726. Epub 2017 Aug 4.

Department of Crystallography, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.

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http://dx.doi.org/10.1126/sciadv.1701726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544394PMC
August 2017

Improved metrics for comparing structures of macromolecular assemblies determined by 3D electron-microscopy.

J Struct Biol 2017 07 25;199(1):12-26. Epub 2017 May 25.

Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479444PMC
July 2017

HVint: A Strategy for Identifying Novel Protein-Protein Interactions in Herpes Simplex Virus Type 1.

Mol Cell Proteomics 2016 09 6;15(9):2939-53. Epub 2016 Jul 6.

From the: ‡Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK;

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http://dx.doi.org/10.1074/mcp.M116.058552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013309PMC
September 2016

The Importance of Non-accessible Crosslinks and Solvent Accessible Surface Distance in Modeling Proteins with Restraints From Crosslinking Mass Spectrometry.

Mol Cell Proteomics 2016 07 5;15(7):2491-500. Epub 2016 May 5.

From the ‡Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet street, London, WC1E 7HX, UK;

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http://dx.doi.org/10.1074/mcp.M116.058560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937519PMC
July 2016

Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.

Methods 2016 05 14;100:42-9. Epub 2016 Mar 14.

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854230PMC
May 2016

Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B.

Proc Natl Acad Sci U S A 2016 Apr 24;113(15):4176-81. Epub 2016 Mar 24.

Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1523234113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839410PMC
April 2016

γ-TEMPy: Simultaneous Fitting of Components in 3D-EM Maps of Their Assembly Using a Genetic Algorithm.

Structure 2015 Dec 19;23(12):2365-2376. Epub 2015 Nov 19.

Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671957PMC
December 2015

: a Python library for assessment of three-dimensional electron microscopy density fits.

J Appl Crystallogr 2015 Aug 27;48(Pt 4):1314-1323. Epub 2015 Jun 27.

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London , Malet street, London WC1E 7HX, UK.

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http://dx.doi.org/10.1107/S1600576715010092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520291PMC
August 2015

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

PLoS Biol 2015 Feb 5;13(2):e1002049. Epub 2015 Feb 5.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Australia; The ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, Australia; Department of Microbiology, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1371/journal.pbio.1002049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318580PMC
February 2015

Collaborative computational project for electron cryo-microscopy.

Acta Crystallogr D Biol Crystallogr 2015 Jan 1;71(Pt 1):123-6. Epub 2015 Jan 1.

Scientific Computing Department, Science and Technology Facilities Council, Daresbury Laboratory, Warrington WA4 4AD, England.

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http://journals.iucr.org/d/issues/2015/01/00/gm5035/gm5035.p
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http://www.ccpem.ac.uk/documents/Winn_CommunityMeeting_Feb13
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http://scripts.iucr.org/cgi-bin/paper?S1399004714018070
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http://dx.doi.org/10.1107/S1399004714018070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304692PMC
January 2015

Allosteric signalling in the outer membrane translocation domain of PapC usher.

Elife 2014 Oct 28;3. Epub 2014 Oct 28.

Institute of Structural and Molecular Biology, Birkbeck College and University College London, London, United Kingdom.

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http://dx.doi.org/10.7554/eLife.03532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356140PMC
October 2014

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.

Elife 2014 Sep 10;3:e03680. Epub 2014 Sep 10.

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, London, United Kingdom.

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http://dx.doi.org/10.7554/eLife.03680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358365PMC
September 2014

Photo-antagonism of the GABAA receptor.

Nat Commun 2014 Jul 29;5:4454. Epub 2014 Jul 29.

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1038/ncomms5454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124873PMC
July 2014

Combined approaches to flexible fitting and assessment in virus capsids undergoing conformational change.

J Struct Biol 2014 Mar 12;185(3):427-39. Epub 2013 Dec 12.

Institute of Structural and Molecular Biology, Department of Biological Sciences/Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2013.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988922PMC
March 2014

Distinct phenotypes in zebrafish models of human startle disease.

Neurobiol Dis 2013 Dec 9;60:139-51. Epub 2013 Sep 9.

Department of Biology and Physics, 1000 Chastain Rd, #1202, Kennesaw State University, Kennesaw, GA 30144 USA.

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http://dx.doi.org/10.1016/j.nbd.2013.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972633PMC
December 2013

Conformational States of macromolecular assemblies explored by integrative structure calculation.

Structure 2013 Sep;21(9):1500-8

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.str.2013.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988990PMC
September 2013

Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems.

Mol Microbiol 2013 Jul 14;89(2):324-33. Epub 2013 Jun 14.

Institute of Structural and Molecular Biology, UCL and Birkbeck, Malet Street, London, WC1E 7HX, UK.

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http://dx.doi.org/10.1111/mmi.12275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912908PMC
July 2013

Changes in Apaf-1 conformation that drive apoptosome assembly.

Biochemistry 2013 Apr 22;52(13):2319-27. Epub 2013 Mar 22.

Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1021/bi301721gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645920PMC
April 2013

RIBFIND: a web server for identifying rigid bodies in protein structures and to aid flexible fitting into cryo EM maps.

Bioinformatics 2012 Sep 12;28(18):2391-3. Epub 2012 Jul 12.

Department of Crystallography/Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, UK.

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http://dx.doi.org/10.1093/bioinformatics/bts446DOI Listing
September 2012

ATP-triggered conformational changes delineate substrate-binding and -folding mechanics of the GroEL chaperonin.

Cell 2012 Mar 22;149(1):113-23. Epub 2012 Mar 22.

Crystallography and Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK.

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http://dx.doi.org/10.1016/j.cell.2012.02.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326522PMC
March 2012

Finding rigid bodies in protein structures: Application to flexible fitting into cryoEM maps.

J Struct Biol 2012 Feb 7;177(2):520-31. Epub 2011 Nov 7.

Institute of Structural and Molecular Biology, Crystallography/Department of Biological Sciences, Birkbeck College, University of London, London WC1E 7HX, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S10478477110031
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http://dx.doi.org/10.1016/j.jsb.2011.10.011DOI Listing
February 2012

Scoring functions for cryoEM density fitting.

J Struct Biol 2011 May 4;174(2):333-43. Epub 2011 Feb 4.

Institute of Structural and Molecular Biology, Crystallography, Department of Biological Sciences, Birkbeck College, University of London, London WC1E7HX, UK.

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http://dx.doi.org/10.1016/j.jsb.2011.01.012DOI Listing
May 2011

Exploring the spatial and temporal organization of a cell's proteome.

J Struct Biol 2011 Mar 19;173(3):483-96. Epub 2010 Nov 19.

European Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jsb.2010.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784337PMC
March 2011

Structure of the Drosophila apoptosome at 6.9 å resolution.

Structure 2011 Jan;19(1):128-40

Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.str.2010.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053581PMC
January 2011

CHOYCE: a web server for constrained homology modelling with cryoEM maps.

Bioinformatics 2010 Jul 5;26(13):1673-4. Epub 2010 May 5.

Institute of Structural and Molecular Biology, Crystallography, Department of Biological Sciences, Birkbeck College, University of London, London, UK.

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http://dx.doi.org/10.1093/bioinformatics/btq237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887048PMC
July 2010

A fast mathematical programming procedure for simultaneous fitting of assembly components into cryoEM density maps.

Bioinformatics 2010 Jun;26(12):i261-8

Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btq201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881386PMC
June 2010

Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.

J Biol Chem 2010 May 31;285(20):14848-51. Epub 2010 Mar 31.

Department of Biochemistry, Gene Center and Center for Integrated Protein Science (CiPS), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse, Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C109.096057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865328PMC
May 2010

Structure of an apoptosome-procaspase-9 CARD complex.

Structure 2010 May;18(5):571-83

Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118-2526, USA.

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http://dx.doi.org/10.1016/j.str.2010.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874686PMC
May 2010

Comprehensive molecular structure of the eukaryotic ribosome.

Structure 2009 Dec;17(12):1591-1604

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology and Department of Biological Sciences, Columbia University, New York, NY 10032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126090041
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http://dx.doi.org/10.1016/j.str.2009.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814252PMC
December 2009

Inferential optimization for simultaneous fitting of multiple components into a CryoEM map of their assembly.

J Mol Biol 2009 Apr 20;388(1):180-94. Epub 2009 Feb 20.

Blavatnik School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel-Aviv 69978, Israel.

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http://dx.doi.org/10.1016/j.jmb.2009.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680734PMC
April 2009

Mapping a molecular link between allosteric inhibition and activation of the glycine receptor.

Nat Struct Mol Biol 2008 Oct 21;15(10):1084-93. Epub 2008 Sep 21.

Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1038/nsmb.1492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685790PMC
October 2008

Integrating diverse data for structure determination of macromolecular assemblies.

Annu Rev Biochem 2008 ;77:443-77

Department of Biopharmaceutical Sciences, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158-2330, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.biochem.77.
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http://dx.doi.org/10.1146/annurev.biochem.77.060407.135530DOI Listing
September 2008

The genetics of hyperekplexia: more than startle!

Trends Genet 2008 Sep 15;24(9):439-47. Epub 2008 Aug 15.

Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, UK.

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http://dx.doi.org/10.1016/j.tig.2008.06.005DOI Listing
September 2008

A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.

Nat Struct Mol Biol 2008 Sep;15(9):910-5

Institut für Medizinische Physik und Biophysik, Charite-Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117-Berlin, Germany.

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http://dx.doi.org/10.1038/nsmb.1469DOI Listing
September 2008

Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT.

Nat Struct Mol Biol 2008 Jul 8;15(7):746-53. Epub 2008 Jun 8.

Graduate Program in Structural and Computational Biology and Molecular Biophysics, One Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nsmb.1436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546500PMC
July 2008

Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel.

Proc Natl Acad Sci U S A 2008 Jul 10;105(28):9610-5. Epub 2008 Jul 10.

National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0803189105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474495PMC
July 2008

Structure of the mammalian 80S ribosome at 8.7 A resolution.

Structure 2008 Apr;16(4):535-48

Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.str.2008.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775484PMC
April 2008

Protein structure fitting and refinement guided by cryo-EM density.

Structure 2008 Feb;16(2):295-307

School of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom.

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http://dx.doi.org/10.1016/j.str.2007.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409374PMC
February 2008

Crystallographic conformers of actin in a biologically active bundle of filaments.

J Mol Biol 2008 Jan 16;375(2):331-6. Epub 2007 Oct 16.

National Center for Macromolecular Imaging and Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680129PMC
January 2008

Refinement of protein structures by iterative comparative modeling and CryoEM density fitting.

J Mol Biol 2006 Apr 2;357(5):1655-68. Epub 2006 Feb 2.

Department of Biopharmaceutical Sciences, California Institute for Quantitative Biomedical Research, QB3, 1700 4th Street, Suite 503B, University of California at San Francisco, San Francisco, CA 94143-2552, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.01.062DOI Listing
April 2006

Combining electron microscopy and comparative protein structure modeling.

Curr Opin Struct Biol 2005 Oct;15(5):578-85

Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.sbi.2005.08.001DOI Listing
October 2005

Structural characterization of components of protein assemblies by comparative modeling and electron cryo-microscopy.

J Struct Biol 2005 Feb;149(2):191-203

Department of Biopharmaceutical Sciences, California Institute for Quantitative Biomedical Research, Mission Bay Genentech Hall, 600 16th Street, Suite N472D, University of California, San Francisco, CA 94143, USA.

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February 2005

Theoretical studies on the deacylation step of serine protease catalysis in the gas phase, in solution, and in elastase.

J Am Chem Soc 2004 Nov;126(44):14631-41

Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, OX1 3QZ, United Kingdom.

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November 2004

The unusual bifunctional catalysis of epimerization and desaturation by carbapenem synthase.

J Am Chem Soc 2004 Aug;126(32):9932-3

School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia.

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http://pubs.acs.org/doi/abs/10.1021/ja047899v
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August 2004

Crystal structure of carbapenem synthase (CarC).

J Biol Chem 2003 Jun 28;278(23):20843-50. Epub 2003 Feb 28.

Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, South Parks Road, Oxford OX1 3QZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M213054200DOI Listing
June 2003

Ab initio QM/MM dynamics simulation of the tetrahedral intermediate of serine proteases: insights into the active site hydrogen-bonding network.

J Am Chem Soc 2002 Dec;124(49):14780-8

Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, OX1 3QZ, United Kingdom.

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http://dx.doi.org/10.1021/ja026219qDOI Listing
December 2002

Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases.

Proteins 2002 May;47(3):357-69

Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/prot.10097DOI Listing
May 2002