Maximilian Heeg

A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS.

J Exp Med 2021 Feb;218(2)

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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February 2021

Seletalisib for Activated PI3Kδ Syndromes: Open-Label Phase 1b and Extension Studies.

J Immunol 2020 Dec 28;205(11):2979-2987. Epub 2020 Oct 28.

Imagine Institute, University of Paris, 75015 Paris, France.

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December 2020

Early-onset autoimmunity associated with SOCS1 haploinsufficiency.

Nat Commun 2020 10 21;11(1):5341. Epub 2020 Oct 21.

Université de Paris, Imagine institute, laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, 24 boulevard du Montparnasse, 75015, Paris, France.

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October 2020

Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis.

J Clin Immunol 2020 08 7;40(6):901-916. Epub 2020 Jul 7.

CHU Sainte-Justine, Department of Pediatrics, Department of Microbiology, Infectious Diseases and Immunology, University of Montreal, Montreal, QC, H3T 1C5, Canada.

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August 2020

Comprehensive infectious disease screening in a cohort of unaccompanied refugee minors in Germany from 2016 to 2017: A cross-sectional study.

Authors:

Ales Janda Kristin Eder Roland Fressle Anne Geweniger Natalie Diffloth Maximilian Heeg Nadine Binder Ana-Gabriela Sitaru Jan Rohr Philipp Henneke Markus Hufnagel Roland Elling

PLoS Med 2020 03 31;17(3):e1003076. Epub 2020 Mar 31.

Department of Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Freiburg, Germany.

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March 2020

Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity.

Clin Immunol 2020 01 23;210:108316. Epub 2019 Nov 23.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany. Electronic address:

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January 2020

Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies.

J Allergy Clin Immunol 2020 01 14;145(1):434-437.e4. Epub 2019 Sep 14.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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January 2020

The German National Registry of Primary Immunodeficiencies (2012-2017).

Authors:

Sabine M El-Helou Anika-Kerstin Biegner Sebastian Bode Stephan R Ehl Maximilian Heeg Maria E Maccari Henrike Ritterbusch Carsten Speckmann Stephan Rusch Raphael Scheible Klaus Warnatz Faranaz Atschekzei Renata Beider Diana Ernst Stev Gerschmann Alexandra Jablonka Gudrun Mielke Reinhold E Schmidt Gesine Schürmann Georgios Sogkas Ulrich H Baumann Christian Klemann Dorothee Viemann Horst von Bernuth Renate Krüger Leif G Hanitsch Carmen M Scheibenbogen Kirsten Wittke Michael H Albert Anna Eichinger Fabian Hauck Christoph Klein Anita Rack-Hoch Franz M Sollinger Anne Avila Michael Borte Stephan Borte Maria Fasshauer Anja Hauenherm Nils Kellner Anna H Müller Anett Ülzen Peter Bader Shahrzad Bakhtiar Jae-Yun Lee Ursula Heß Ralf Schubert Sandra Wölke Stefan Zielen Sujal Ghosh Hans-Juergen Laws Jennifer Neubert Prasad T Oommen Manfred Hönig Ansgar Schulz Sandra Steinmann Klaus Schwarz Gregor Dückers Beate Lamers Vanessa Langemeyer Tim Niehues Sonu Shai Dagmar Graf Carmen Müglich Marc T Schmalzing Eva C Schwaneck Hans-Peter Tony Johannes Dirks Gabriele Haase Johannes G Liese Henner Morbach Dirk Foell Antje Hellige Helmut Wittkowski Katja Masjosthusmann Michael Mohr Linda Geberzahn Christian M Hedrich Christiane Müller Angela Rösen-Wolff Joachim Roesler Antje Zimmermann Uta Behrends Nikolaus Rieber Uwe Schauer Rupert Handgretinger Ursula Holzer Jörg Henes Lothar Kanz Christoph Boesecke Jürgen K Rockstroh Carolynne Schwarze-Zander Jan-Christian Wasmuth Dagmar Dilloo Brigitte Hülsmann Stefan Schönberger Stefan Schreiber Rainald Zeuner Tobias Ankermann Philipp von Bismarck Hans-Iko Huppertz Petra Kaiser-Labusch Johann Greil Donate Jakoby Andreas E Kulozik Markus Metzler Nora Naumann-Bartsch Bettina Sobik Norbert Graf Sabine Heine Robin Kobbe Kai Lehmberg Ingo Müller Friedrich Herrmann Gerd Horneff Ariane Klein Joachim Peitz Nadine Schmidt Stefan Bielack Ute Groß-Wieltsch Carl F Classen Jessica Klasen Peter Deutz Dirk Kamitz Lisa Lassay Klaus Tenbrock Norbert Wagner Benedikt Bernbeck Bastian Brummel Eusebia Lara-Villacanas Esther Münstermann Dominik T Schneider Nadine Tietsch Marco Westkemper Michael Weiß Christof Kramm Ingrid Kühnle Silke Kullmann Hermann Girschick Christof Specker Elisabeth Vinnemeier-Laubenthal Henriette Haenicke Claudia Schulz Lothar Schweigerer Thomas G Müller Martina Stiefel Bernd H Belohradsky Veronika Soetedjo Gerhard Kindle Bodo Grimbacher

Front Immunol 2019 19;10:1272. Epub 2019 Jul 19.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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October 2020

Profound immunodeficiency with severe skin disease explained by concomitant novel CARMIL2 and PLEC1 loss-of-function mutations.

Authors:

Maria E Maccari Carsten Speckmann Maximilian Heeg Antonia Reimer Federica Casetti Cristina Has Stephan Ehl Carla N Castro

Clin Immunol 2019 11 10;208:108228. Epub 2019 Jun 10.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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November 2019

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in .

Front Immunol 2019 19;10:297. Epub 2019 Mar 19.

Faculty of Medicine, Center for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, Freiburg, Germany.

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May 2020

Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease.

Authors:

Maximilian Heeg Sandra Ammann Christian Klemann Marcus Panning Valeria Falcone Harmut Hengel Kai Lehmberg Udo Zur Stadt Katharina Wustrau Gritta Janka Stephan Ehl

Pediatr Blood Cancer 2018 11 1;65(11):e27344. Epub 2018 Aug 1.

Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, Freiburg, Germany.

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November 2018

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry.

Authors:

Maria Elena Maccari Hassan Abolhassani Asghar Aghamohammadi Alessandro Aiuti Olga Aleinikova Catherine Bangs Safa Baris Federica Barzaghi Helen Baxendale Matthew Buckland Siobhan O Burns Caterina Cancrini Andrew Cant Pascal Cathébras Marina Cavazzana Anita Chandra Francesca Conti Tanya Coulter Lisa A Devlin J David M Edgar Saul Faust Alain Fischer Marina Garcia-Prat Lennart Hammarström Maximilian Heeg Stephen Jolles Elif Karakoc-Aydiner Gerhard Kindle Ayca Kiykim Dinakantha Kumararatne Bodo Grimbacher Hilary Longhurst Nizar Mahlaoui Tomas Milota Fernando Moreira Despina Moshous Anna Mukhina Olaf Neth Benedicte Neven Alexandra Nieters Peter Olbrich Ahmet Ozen Jana Pachlopnik Schmid Capucine Picard Seraina Prader William Rae Janine Reichenbach Stephan Rusch Sinisa Savic Alessia Scarselli Raphael Scheible Anna Sediva Svetlana O Sharapova Anna Shcherbina Mary Slatter Pere Soler-Palacin Aurelie Stanislas Felipe Suarez Francesca Tucci Annette Uhlmann Joris van Montfrans Klaus Warnatz Anthony Peter Williams Phil Wood Sven Kracker Alison Mary Condliffe Stephan Ehl

Front Immunol 2018 16;9:543. Epub 2018 Mar 16.

Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany.

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May 2019

Hemophagocytic lymphohistiocytosis as presenting manifestation of profound combined immunodeficiency due to an ORAI1 mutation.

Authors:

Christian Klemann Sandra Ammann Miriam Heizmann Sebastian Fuchs Sebastian F Bode Maximilian Heeg Hans Fuchs Kai Lehmberg Udo Zur Stadt Claudia Roll Thomas Vraetz Carsten Speckmann Myriam Ricarda Lorenz Klaus Schwarz Jan Rohr Stefan Feske Stephan Ehl

J Allergy Clin Immunol 2017 12 19;140(6):1721-1724. Epub 2017 Jun 19.

Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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December 2017