Max Wicha

Max Wicha

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Max Wicha

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Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis.

Analyst 2019 Dec;144(24):7296-7309

Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA.

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http://dx.doi.org/10.1039/c9an01358jDOI Listing
December 2019

Co-culture of functionally enriched cancer stem-like cells and cancer-associated fibroblasts for single-cell whole transcriptome analysis.

Integr Biol (Camb) 2019 Dec 10. Epub 2019 Dec 10.

Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA.

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http://dx.doi.org/10.1093/intbio/zyz029DOI Listing
December 2019

Engineered Fibrillar Fibronectin Networks as Three-Dimensional Tissue Scaffolds.

Adv Mater 2019 Nov 30;31(46):e1904580. Epub 2019 Sep 30.

Biointerfaces Institute, Departments of Chemical Engineering, Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1002/adma.201904580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851443PMC
November 2019

Dietary polyunsaturated fatty acids modulate adipose secretome and is associated with changes in mammary epithelial stem cell self-renewal.

J Nutr Biochem 2019 Sep 24;71:45-53. Epub 2019 May 24.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2019.05.007DOI Listing
September 2019

Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.

Oncogene 2019 Jul;38(28):5749

Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA.

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http://dx.doi.org/10.1038/s41388-019-0838-yDOI Listing
July 2019

Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development.

Int J Mol Sci 2019 May 13;20(9). Epub 2019 May 13.

Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA.

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http://dx.doi.org/10.3390/ijms20092357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539898PMC
May 2019

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model.

Nat Commun 2019 03 29;10(1):1430. Epub 2019 Mar 29.

Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Augusta University, 1410 Laney Walker Blvd. CN2136, Augusta, GA, 30912, USA.

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http://dx.doi.org/10.1038/s41467-019-09015-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441000PMC
March 2019

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.

Oncogene 2019 01 30;38(4):469-482. Epub 2018 Aug 30.

Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA.

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http://dx.doi.org/10.1038/s41388-018-0472-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602794PMC
January 2019

Targeting Cancer Stem Cell Redox Metabolism to Enhance Therapy Responses.

Semin Radiat Oncol 2019 01;29(1):42-54

University of Michigan Rogel Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10534296183008
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http://dx.doi.org/10.1016/j.semradonc.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614864PMC
January 2019

Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer.

Cancer Lett 2018 12 15;438:165-173. Epub 2018 Sep 15.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA; Chemical Biology Program, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.09.022DOI Listing
December 2018

Morphology-based prediction of cancer cell migration using an artificial neural network and a random decision forest.

Integr Biol (Camb) 2018 12;10(12):758-767

Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA.

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http://xlink.rsc.org/?DOI=C8IB00106E
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http://dx.doi.org/10.1039/c8ib00106eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329292PMC
December 2018

Modeling of Interactions between Cancer Stem Cells and their Microenvironment: Predicting Clinical Response.

Methods Mol Biol 2018 ;1711:333-349

Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1007/978-1-4939-7493-1_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322404PMC
October 2018

Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.

Dev Cell 2018 10 27;47(2):145-160.e6. Epub 2018 Sep 27.

Division of Molecular Medicine and Genetics, University of Michigan, 5000 LSI, 210 Washtenaw, Ann Arbor, MI 48109-2216, USA; Department of Internal Medicine, University of Michigan, 5000 LSI, 210 Washtenaw, Ann Arbor, MI 48109-2216, USA; Life Sciences Institute, University of Michigan, 5000 LSI, 210 Washtenaw, Ann Arbor, MI 48109-2216, USA; Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183069
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http://dx.doi.org/10.1016/j.devcel.2018.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317358PMC
October 2018

Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations.

J Glob Oncol 2018 10;4:1-8

Evelyn Jiagge, Carlos Murga-Zamalloa, Celina G. Kleer, Mark Hoenerhoff, Kathy Toy, Sofia Merajver, Barbara Salem, and Max Wicha, University of Michigan, Ann Arbor; George Divine, Jessica Bensenhaver, Henry Ford Health System, Detroit, MI; Evelyn Jiagge, Baffour Awuah, Joseph Oppong, and Ernest Adjei, Komfo Anokye Teaching Hospital, Kumasi, Ghana; and Aisha Souleiman Jibril, St. Paul's Hospital, Millenium Medical Center, Addis Ababa, Ethiopia; Lisa Newman, Melissa Davis, and Kofi Gyan, Weill Cornell Medicine, New York, NY.

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http://ascopubs.org/doi/10.1200/JGO.18.00056
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http://dx.doi.org/10.1200/JGO.18.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818279PMC
October 2018

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer.

Cell Metab 2018 Jul 24;28(1):87-103.e6. Epub 2018 May 24.

Department of Surgery, University of Michigan School of Medicine, BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-0669, USA; University of Michigan Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI, USA; Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA; Graduate Programs in Immunology and Tumor Biology, University of Michigan School of Medicine, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238219PMC
July 2018

Heterogeneity of Human Breast Stem and Progenitor Cells as Revealed by Transcriptional Profiling.

Stem Cell Reports 2018 05 29;10(5):1596-1609. Epub 2018 Mar 29.

Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995162PMC
May 2018

Asparagine and Glutamine: Co-conspirators Fueling Metastasis.

Cell Metab 2018 05;27(5):947-949

University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.04.012DOI Listing
May 2018

FGFR signaling regulates resistance of head and neck cancer stem cells to cisplatin.

Oncotarget 2018 May 18;9(38):25148-25165. Epub 2018 May 18.

Department of Cariology, Restorative Science & Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

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http://www.oncotarget.com/fulltext/25358
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http://dx.doi.org/10.18632/oncotarget.25358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982758PMC
May 2018

Tamoxifen and ERα36: Fertilizing the seeds of breast cancer metastasis.

Cell Res 2018 04;28(4):391-392

University of Michigan Comprehensive Cancer Center, Michigan Medicine, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41422-018-0028-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939042PMC
April 2018

IL6 blockade potentiates the anti-tumor effects of γ-secretase inhibitors in Notch3-expressing breast cancer.

Cell Death Differ 2018 02 13;25(2):330-339. Epub 2017 Oct 13.

Key Laboratory of Breast Cancer in Shanghai, Cancer Institute, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

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http://dx.doi.org/10.1038/cdd.2017.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762847PMC
February 2018

Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer.

Mol Cancer 2018 02 23;17(1):65. Epub 2018 Feb 23.

Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200032, China.

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http://dx.doi.org/10.1186/s12943-018-0809-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824475PMC
February 2018

Dendritic-cell-based immunotherapy evokes potent anti-tumor immune responses in CD105+ human renal cancer stem cells.

Mol Carcinog 2017 Nov 14;56(11):2499-2511. Epub 2017 Sep 14.

State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.

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http://dx.doi.org/10.1002/mc.22697DOI Listing
November 2017

Algorithm for cellular reprogramming.

Proc Natl Acad Sci U S A 2017 11 24;114(45):11832-11837. Epub 2017 Oct 24.

Department of Computational Medicine and Bioinformatics, Medical School, University of Michigan, Ann Arbor, MI 48109;

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http://dx.doi.org/10.1073/pnas.1712350114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692574PMC
November 2017

Development and Application of Cancer Stem Cell-Targeted Vaccine in Cancer Immunotherapy.

J Vaccines Vaccin 2017 31;8(6). Epub 2017 Oct 31.

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

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http://dx.doi.org/10.4172/2157-7560.1000371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800506PMC
October 2017

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy.

Nat Rev Immunol 2017 Sep 30;17(9):559-572. Epub 2017 May 30.

Department of Surgery, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/nri.2017.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731833PMC
September 2017

High-Throughput Microfluidic Labyrinth for the Label-free Isolation of Circulating Tumor Cells.

Cell Syst 2017 09 20;5(3):295-304.e4. Epub 2017 Sep 20.

Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Translational Oncology Program, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.08.012DOI Listing
September 2017

Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells.

Cancer Lett 2017 05 27;394:52-64. Epub 2017 Feb 27.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, Husson University, Bangor, ME 04401, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.02.023DOI Listing
May 2017

Selective Photomechanical Detachment and Retrieval of Divided Sister Cells from Enclosed Microfluidics for Downstream Analyses.

ACS Nano 2017 05 8;11(5):4660-4668. Epub 2017 May 8.

Department of Electrical Engineering and Computer Science, University of Michigan , 1301 Beal Avenue, Ann Arbor, Michigan 48109-2122, United States.

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http://dx.doi.org/10.1021/acsnano.7b00413DOI Listing
May 2017

Microfluidic continuum sorting of sub-populations of tumor cells via surface antibody expression levels.

Lab Chip 2017 03;17(7):1349-1358

Department of Chemical Engineering, University of Michigan, 2300 Hayward St, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1039/c6lc01496hDOI Listing
March 2017

Single Amino Acid Variant Profiles of Subpopulations in the MCF-7 Breast Cancer Cell Line.

J Proteome Res 2017 02 20;16(2):842-851. Epub 2017 Jan 20.

Department of Surgery, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718353PMC
February 2017

RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.

Clin Cancer Res 2017 Jan 29;23(2):514-522. Epub 2016 Dec 29.

Innovation Center for Cell Signaling Network and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1348DOI Listing
January 2017

Breast Cancer and African Ancestry: Lessons Learned at the 10-Year Anniversary of the Ghana-Michigan Research Partnership and International Breast Registry.

J Glob Oncol 2016 Oct 27;2(5):302-310. Epub 2016 Jul 27.

, , , , , , , , , , , , , , , and , Komfo Anokye Teaching Hospital; , Kwame Nkrumah University of Science and Technology, Kumasi; , University of Ghana Medical School and Korle-Bu, Accra, Ghana; , , , , , , , , , and , University of Michigan Medical School, Ann Arbor; , , , , and , Henry Ford Health System International Center for the Study of Breast Cancer Subtypes, Detroit, MI; and , Sisters Network, Houston, TX.

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http://dx.doi.org/10.1200/JGO.2015.002881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493263PMC
October 2016

Promise of cancer stem cell vaccine.

Hum Vaccin Immunother 2015 ;11(12):2796-9

a Comprehensive Cancer Center; University of Michigan ; Ann Arbor , MI USA.

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http://dx.doi.org/10.1080/21645515.2015.1083661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054775PMC
September 2016

Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling.

Adv Sci (Weinh) 2016 Sep 18;3(9):1600063. Epub 2016 Apr 18.

Department of Chemical Engineering3074 H.H. Dow Building2300 Hayward St.Ann ArborMI48109-2136USA; Biointerfaces InstituteNorth Campus Research Complex2800 Plymouth Road, Bldg. 90Ann ArborMI48109-2800USA.

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http://dx.doi.org/10.1002/advs.201600063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039969PMC
September 2016

Single cell dual adherent-suspension co-culture micro-environment for studying tumor-stromal interactions with functionally selected cancer stem-like cells.

Lab Chip 2016 08 6;16(15):2935-45. Epub 2016 Jul 6.

Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA.

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http://dx.doi.org/10.1039/c6lc00062bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977365PMC
August 2016

Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention.

Breast Cancer Res Treat 2016 07 15;158(1):29-41. Epub 2016 Jun 15.

Department of Environmental Health Sciences, University of Michigan School of Public Health, 6630 SPH Tower, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1007/s10549-016-3854-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831404PMC
July 2016

Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response.

PLoS One 2015 23;10(9):e0135797. Epub 2015 Sep 23.

University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135797PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580445PMC
June 2016

High-Throughput Single-Cell Derived Sphere Formation for Cancer Stem-Like Cell Identification and Analysis.

Sci Rep 2016 06 13;6:27301. Epub 2016 Jun 13.

Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA.

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http://dx.doi.org/10.1038/srep27301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904376PMC
June 2016

Transdifferentiation-Induced Neural Stem Cells Promote Recovery of Middle Cerebral Artery Stroke Rats.

PLoS One 2015 9;10(9):e0137211. Epub 2015 Sep 9.

Affiliated Bayi Brain Hospital, General Hospital of Beijing Military Region, P.L.A, Beijing, 100700, PR China; Neurosurgery Institute of Beijing Military Region, Beijing, 100700, PR China.

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https://pdfs.semanticscholar.org/0cb2/faa2a8dda9ff09aff6b1bc
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137211PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564190PMC
May 2016

IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence.

Neoplasia 2016 05 15;18(5):273-281. Epub 2016 Apr 15.

*Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Otolaryngology, University of Michigan School of Medicine, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI, USA; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887598PMC
May 2016

Breast cancer stem cells: current advances and clinical implications.

Methods Mol Biol 2015 ;1293:1-49

Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, 026 NCRC 335S, Ann Arbor, MI, 49108, USA.

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http://link.springer.com/10.1007/978-1-4939-2519-3_1
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http://dx.doi.org/10.1007/978-1-4939-2519-3_1DOI Listing
February 2016

Clinical predictors of long-term survival in HER2-positive metastatic breast cancer.

Breast Cancer Res Treat 2016 Feb 13;155(3):589-95. Epub 2016 Feb 13.

Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, Ann Arbor, MI, 48109-5843, USA.

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http://dx.doi.org/10.1007/s10549-016-3705-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895232PMC
February 2016

Leptin and Adiponectin Modulate the Self-renewal of Normal Human Breast Epithelial Stem Cells.

Cancer Prev Res (Phila) 2015 Dec 20;8(12):1174-83. Epub 2015 Oct 20.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan. Department of Internal Medicine Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. VA Medical Center, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670788PMC
December 2015

A quantitative proteomics analysis of MCF7 breast cancer stem and progenitor cell populations.

Proteomics 2015 Nov 7;15(22):3772-83. Epub 2015 Oct 7.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1002/pmic.201500002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715579PMC
November 2015

Metabolic plasticity of cancer stem cells.

Oncotarget 2015 Nov;6(34):35141-2

University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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http://www.oncotarget.com/fulltext/6177
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http://dx.doi.org/10.18632/oncotarget.6177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742088PMC
November 2015

Epithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistance.

Curr Pharm Des 2015 ;21(10):1301-10

University of Michigan Comprehensive Cancer Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498673PMC
http://dx.doi.org/10.2174/1381612821666141211120604DOI Listing
October 2015

Chemokines and cellular plasticity of ovarian cancer stem cells.

Oncoscience 2015 25;2(7):615-6. Epub 2015 Jul 25.

Department of Surgery, Graduate Programs in Immunology and Tumor Biology, University of Michigan Comprehensive Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549357PMC
http://dx.doi.org/10.18632/oncoscience.181DOI Listing
September 2015

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer.

Cell Stem Cell 2015 Sep;17(3):260-71

Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560840PMC
September 2015

Concise Review: Targeting Cancer Stem Cells Using Immunologic Approaches.

Stem Cells 2015 Jul 13;33(7):2085-92. Epub 2015 May 13.

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/stem.2039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478204PMC
July 2015

Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating γ-Secretase-Mediated Notch1 Activation in Caveolae.

Neoplasia 2015 Jun;17(6):497-508

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586150007
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http://dx.doi.org/10.1016/j.neo.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719004PMC
June 2015

Tumor twitter: cellular communication in the breast cancer stem cell niche.

Cancer Discov 2015 May;5(5):469-71

Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422104PMC
May 2015

Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.

PLoS One 2013 23;8(12):e82821. Epub 2013 Dec 23.

Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Columbus, Ohio, United States of America ; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871589PMC
March 2015

Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity.

Mol Cancer Ther 2015 Mar 11;14(3):779-787. Epub 2015 Feb 11.

Georgia Regents University Cancer Center, Department of Biochemistry and Molecular Biology 1410 Laney Walker Blvd. CN2136 Augusta, GA 30912.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456218PMC
March 2015

A nomogram for predicting the benefit of adjuvant cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma.

Sci Rep 2015 Mar 17;5:9202. Epub 2015 Mar 17.

1] Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China [2] Department of Biotherapy, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1038/srep09202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361845PMC
March 2015

Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells.

Oncotarget 2015 Feb;6(6):3709-21

Innovation Center for Cell Biology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science & Technology of China, Hefei, Anhui, China.

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http://dx.doi.org/10.18632/oncotarget.2888DOI Listing
February 2015

Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor.

Nat Commun 2015 Jan 23;6:5988. Epub 2015 Jan 23.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100190, China.

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http://dx.doi.org/10.1038/ncomms6988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354030PMC
January 2015

A radial flow microfluidic device for ultra-high-throughput affinity-based isolation of circulating tumor cells.

Small 2014 Dec 29;10(23):4895-904. Epub 2014 Jul 29.

Department of Chemical Engineering, University of Michigan, 3074 H.H. Dow, 2300 Hayward St. Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1002/smll.201400719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455044PMC
December 2014

Biological and clinical significance of cancer stem cell plasticity.

Clin Transl Med 2014 Dec 7;3(1):32. Epub 2014 Oct 7.

University of Michigan Comprehensive Cancer Center, 1500 E. Medical Center Dr., Ann Arbor, 48109, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883980PMC
December 2014

Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model.

Oncotarget 2014 Dec;5(23):12383-97

Department of Chemical Engineering, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109. Translational Oncology Program, University of Michigan, Ann Arbor, MI 48109.

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http://dx.doi.org/10.18632/oncotarget.2592DOI Listing
December 2014

MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

Cancer Res 2014 Nov 12;74(22):6648-60. Epub 2014 Sep 12.

Innovation Center for Cell Biology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370193PMC
November 2014

Characterization of a novel transgenic mouse tumor model for targeting HER2+ cancer stem cells.

Int J Biol Sci 2013 6;10(1):25-32. Epub 2013 Dec 6.

2. University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879588PMC
August 2014

Regulatory roles of miRNA in the human neural stem cell transformation to glioma stem cells.

J Cell Biochem 2014 Aug;115(8):1368-80

Department of Neurosurgery, Navy General Hospital PLA, Beijing, 100048, China.

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August 2014

KRAS and cancer stem cells in APC-mutant colorectal cancer.

J Natl Cancer Inst 2014 Feb;106(2):djt444

Affiliations of authors: Department of Internal Medicine (ERF, MSW), Department of Human Genetics (ERF), Department of Pathology (ERF), and the Cancer Center (ERF, MSW), University of Michigan Medical School, Ann Arbor, MI.

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February 2014

Targeting self-renewal, an Achilles' heel of cancer stem cells.

Authors:
Max S Wicha

Nat Med 2014 Jan;20(1):14-5

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA.

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January 2014

The thyroid cancer PAX8-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype.

Endocr Relat Cancer 2013 Oct 11;20(5):725-39. Epub 2013 Sep 11.

Cellular and Molecular Biology Graduate Program, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839064PMC
October 2013