Max S Topp

Max S Topp

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Max S Topp

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The use of bispecific antibodies to optimize the outcome of patients with acute leukemia, lymphoma and multiple myeloma after SCT.

Bone Marrow Transplant 2019 Aug;54(Suppl 2):721-726

Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1038/s41409-019-0596-zDOI Listing
August 2019

Coronary B-cell lymphoma infiltration causing myocardial infarction.

Eur Heart J 2019 Jul 31. Epub 2019 Jul 31.

Department of Internal Medicine I-Cardiology, University Hospital Würzburg, and Comprehensive Heart Failure Center (CHFC), University of Würzburg, Oberduerrbacher Str. 6, Würzburg, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz538DOI Listing
July 2019

Outcome of Patients With Early-Stage Infradiaphragmatic Hodgkin Lymphoma: A Comprehensive Analysis From the German Hodgkin Study Group.

J Clin Oncol 2018 09 10;36(25):2603-2611. Epub 2018 Jul 10.

Stephanie Sasse, Helen Goergen, Annette Plütschow, Boris Böll, Dennis A. Eichenauer, Michael Fuchs, Karolin Behringer, Christian Baues, Andreas Engert, Peter Borchmann, and Bastian von Tresckow, University Hospital of Cologne, Cologne; Max S. Topp, University Hospital of Würzburg, Würzburg; Julia Meissner, University of Heidelberg, Heidelberg; Andreas Neubauer, Philipps University, Marburg, Germany; Joseé M. Zijlstra, VU University Medical Center, Amsterdam, the Netherlands; Richard Greil, Paracelsus Medical University Salzburg, Salzburg Cancer Research Institute and Arbeitsgemeinschaft Medikamentöse Tumortherapie, Salzburg, Austria; and Jana Markova, Charles University in Prague and Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic.

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http://dx.doi.org/10.1200/JCO.2018.78.7192DOI Listing
September 2018

Incorporation of brentuximab vedotin into first-line treatment of advanced classical Hodgkin's lymphoma: final analysis of a phase 2 randomised trial by the German Hodgkin Study Group.

Lancet Oncol 2017 12 10;18(12):1680-1687. Epub 2017 Nov 10.

First Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany; German Hodgkin Study Group (GHSG), University Hospital of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30696-4DOI Listing
December 2017

Complete Hematologic and Molecular Response in Adult Patients With Relapsed/Refractory Philadelphia Chromosome-Positive B-Precursor Acute Lymphoblastic Leukemia Following Treatment With Blinatumomab: Results From a Phase II, Single-Arm, Multicenter Study.

J Clin Oncol 2017 Jun 29;35(16):1795-1802. Epub 2017 Mar 29.

Giovanni Martinelli and Cristina Papayannidis, Institute of Hematology and Medical Oncology "L. and A. Seràgnoli", Bologna; Alessandro Rambaldi, University of Milan Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; Nicolas Boissel, University Paris Diderot, Hôpital Saint-Louis, Paris; Patrice Chevallier, Centre Hospitalier Universitaire Nantes, Nantes, France; Oliver Ottmann, Cardiff University, Cardiff; Adele K. Fielding, University College London Cancer Institute, London, United Kingdom; Nicola Gökbuget, University Hospital, Goethe University, Frankfurt; Max S. Topp, Universitätsklinikum Würzburg, Würzburg, Germany; Ellen K. Ritchie, Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY; Lulu Ren Sterling, Amgen, San Francisco; Jonathan Benjamin, Amgen, Thousand Oaks; and Anthony Stein, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA.

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http://dx.doi.org/10.1200/JCO.2016.69.3531DOI Listing
June 2017

Blinatumomab for Acute Lymphoblastic Leukemia.

N Engl J Med 2017 06;376(23):e49

Universitätsklinikums Würzburg, Würzburg, Germany

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http://dx.doi.org/10.1056/NEJMc1704012DOI Listing
June 2017

Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia.

N Engl J Med 2017 03;376(9):836-847

From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen, Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University, University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and Medizinische Klinik und Poliklinik II, Universitätsklinikums Würzburg, Würzburg (M.S.T.) - all in Germany; Royal Free Hospital and University College London Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto (A.C.S.), and Centre Intégré Universitaire de Santé et de Services Sociaux de l'est de l'île de Montréal, Hôpital Maisonneuve-Rosemont, Montreal (J.B.) - all in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the Department of Medicine, Hospital Universitari i Politecnic La Fe, University of Valencia, Valencia, and Centro de Investigación Biomédica en Red de Cáncer, Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash University, Melbourne, VIC, Australia (A.W.); Institut Universitaire d'Hématologie, Hôpital Saint-Louis (Assistance Publique - Hôpitaux de Paris), Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia, Azienda Ospedaliera Policlinico Umberto I, Università Sapienza di Roma, Rome (R.F.), Azienda Unità Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo, Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Università Statale di Milano, Milan (A.R.) - all in Italy; Ankara Universitesi, Tip Fakültesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara (Ö.A.), and Dokuz Eylül Üniversitesi Tıp Fakültesi, İzmir (F.D.) - both in Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Kształcenia Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center, Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).

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http://dx.doi.org/10.1056/NEJMoa1609783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881572PMC
March 2017

Epileptic seizures and rhinocerebral mucormycosis during blinatumomab treatment in a patient with biphenotypic acute leukemia.

Ann Hematol 2017 Jan 3;96(1):151-153. Epub 2016 Oct 3.

Department of Medicine A/Hematology and Oncology, University of Muenster, Albert-Schweitzer-Campus 1, D-48149, Muenster, Germany.

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http://dx.doi.org/10.1007/s00277-016-2837-1DOI Listing
January 2017

Hsp90 inhibition ameliorates CD4 T cell-mediated acute Graft versus Host disease in mice.

Immun Inflamm Dis 2016 12 10;4(4):463-473. Epub 2016 Oct 10.

Institute for Virology and Immunobiology University of Würzburg Würzburg Germany.

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http://dx.doi.org/10.1002/iid3.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134726PMC
December 2016

Correction regarding data on blinatumomab-associated seizures.

Nat Rev Clin Oncol 2016 10 23;13(10):650. Epub 2016 Aug 23.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Unit 428, PO Box 301402, 1515 Holcombe Boulevard, Houston, Texas 77030-1402, USA.

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http://dx.doi.org/10.1038/nrclinonc.2016.133DOI Listing
October 2016

Targeting polo-like kinase 1 suppresses essential functions of alloreactive T cells.

Immunol Res 2016 06;64(3):687-98

Division of Hematology and Oncology, Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1007/s12026-015-8778-2DOI Listing
June 2016

Bispecific T-Cell Engager (BiTE) Antibody Construct Blinatumomab for the Treatment of Patients With Relapsed/Refractory Non-Hodgkin Lymphoma: Final Results From a Phase I Study.

J Clin Oncol 2016 Apr 16;34(10):1104-11. Epub 2016 Feb 16.

Maria-Elisabeth Goebeler, Stefan Knop, Max S. Topp, Hermann Einsele, and Ralf C. Bargou, Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg; Andreas Viardot, University Ulm; Peter Kufer, Gerhard Zugmaier, Matthias Klinger, Andreas Wolf, Margit Schmidt, and Patrick A. Baeuerle, Amgen Research (Munich); Brigitte Dorsch, Metronomia Clinical Research, Munich; Richard Noppeney, University of Essen Medical Center, Essen; Georg Hess, Johannes Gutenberg-University, Mainz; Stefan Kallert and Andreas Mackensen, University of Erlangen Medical Center, Erlangen; Kathrin Rupertus and Lothar Kanz, University of Tübingen Medical Center, Tübingen; Martin Libicher, Diakoniekrankenhaus Schwäbisch-Hall, Schwäbisch-Hall; Jürgen Scheele, University of Freiburg Medical Center; Eugen Leo, LEOConsulting, Freiburg, Germany; and Dirk Nagorsen and Beate D. Quednau, Amgen, Thousand Oaks, CA.

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http://dx.doi.org/10.1200/JCO.2014.59.1586DOI Listing
April 2016

Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.

J Leukoc Biol 2015 Dec 11;98(6):1091-105. Epub 2015 Aug 11.

*Department of Internal Medicine II, Division of Hematology and Oncology, and Comprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Würzburg, Germany; Medical Department, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; and Laboratory of Infection Biology, Division of Infectious Diseases and Hospital Epidemiology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1189/jlb.5A0814-413RDOI Listing
December 2015

Multispecific Aspergillus T cells selected by CD137 or CD154 induce protective immune responses against the most relevant mold infections.

J Infect Dis 2015 Apr 2;211(8):1251-61. Epub 2014 Nov 2.

Infection Biology Laboratory, Department of Biomedicine Division of Infectious Diseases and Hospital Epidemiology, Departments of Biomedicine and Clinical Research.

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http://dx.doi.org/10.1093/infdis/jiu607DOI Listing
April 2015

Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia.

J Clin Oncol 2014 Dec 10;32(36):4134-40. Epub 2014 Nov 10.

Max S. Topp, Hermann Einsele, and Ralf C. Bargou, Universitätsklinikum Würzburg, Würzburg; Nicola Gökbuget, Goethe University; Dieter Hoelzer, Onkologikum, Frankfurt; Gerhard Zugmaier, Petra Klappers, and Noemi Mergen, Amgen Research; Dorothea Wessiepe, Metronomia, Munich; Matthias Stelljes, University of Münster, Münster; Svenja Neumann, Heinz-August Horst, and Monika Brüggemann, University Schleswig Holstein, City Hospital, Kiel; Andreas Viardot, University of Ulm, Ulm; Reinhard Marks, Universitätsklinikum Freiburg, Freiburg; Helmut Diedrich, Medizinische Hochschule Hannover, Hannover; Christoph Faul, Universitätsklinikum Tübingen, Tübingen; Albrecht Reichle, Universitätsklinikum Regensburg, Regensburg, Germany; and Chris Holland and Shilpa Alekar, Amgen, Rockville, MD.

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http://dx.doi.org/10.1200/JCO.2014.56.3247DOI Listing
December 2014

Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice.

Immunol Cell Biol 2014 Sep 13;92(8):659-70. Epub 2014 May 13.

Department of Internal Medicine II, Division of Hematology, Universitätsklinikum Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/icb.2014.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168117PMC
September 2014

Generation of a multipathogen-specific T-cell product for adoptive immunotherapy based on activation-dependent expression of CD154.

Blood 2011 Jul 3;118(4):1121-31. Epub 2011 Jun 3.

Department of Biomedicine and Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-12-32
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http://dx.doi.org/10.1182/blood-2010-12-322610DOI Listing
July 2011

The worst case: giant exulcerating seminoma.

Urol Int 2010 17;84(1):113-5. Epub 2010 Feb 17.

Department of Urology and Pediatric Urology, Julius Maximilians University Medical School, Oberdürrbacher Strasse 6, DE-97080 Würzburg, Germany.

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http://dx.doi.org/10.1159/000273478DOI Listing
October 2010

Selective depletion of alloreactive T cells by targeted therapy of heat shock protein 90: a novel strategy for control of graft-versus-host disease.

Blood 2009 Sep 5;114(13):2829-36. Epub 2009 Aug 5.

Department of Internal Medicine II, Division of Hematology, University Hospital of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1182/blood-2009-06-224600DOI Listing
September 2009

Processing of two latent membrane protein 1 MHC class I epitopes requires tripeptidyl peptidase II involvement.

J Immunol 2009 Aug 8;183(3):1587-97. Epub 2009 Jul 8.

Medical Clinic und Policlinic II, Julius-Maximilian University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.0803441DOI Listing
August 2009

Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom).

Blood 2009 Apr 30;113(18):4137-43. Epub 2009 Jan 30.

Department of Internal Medicine II, Division of Hematology and Medical Oncology, University Hospital Wuerzburg and Early Clinical Development Unit of Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany.

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http://dx.doi.org/10.1182/blood-2008-10-184135DOI Listing
April 2009

Genetically engineered attenuated measles virus specifically infects and kills primary multiple myeloma cells.

J Gen Virol 2009 Mar;90(Pt 3):693-701

Medizinische Klinik und Poliklinik II, Universitätsklinik Würzburg, Josef-Schneider-Str. 2, 97078 Würzburg, Germany.

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http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/vir.0.007302-0DOI Listing
March 2009

Human CD4+ T cells displaying viral epitopes elicit a functional virus-specific memory CD8+ T cell response.

J Immunol 2007 May;178(9):5465-72

Medical Clinic and Polyclinic II, Julius-Maximilian University of Würzburg, Röntgernring 11, D-97070 Würzburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.178.9.5465DOI Listing
May 2007

Effect of serum and CTL on focal growth of human cytomegalovirus.

J Clin Virol 2007 Feb 3;38(2):112-9. Epub 2007 Jan 3.

Institute of Medical Virology, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.jcv.2006.11.009DOI Listing
February 2007

Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus.

Blood 2006 Mar 1;107(6):2562-9. Epub 2005 Dec 1.

Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.1182/blood-2005-04-1660DOI Listing
March 2006

Enhanced transgene expression in quiescent and activated human CD8+ T cells.

Hum Gene Ther 2004 Jul;15(7):648-58

Pediatric Oncology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://labs.fhcrc.org/pgreenberg/Publications/15242525.pdf
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http://www.liebertonline.com/doi/abs/10.1089/104303404136121
Publisher Site
http://dx.doi.org/10.1089/1043034041361217DOI Listing
July 2004

Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production.

J Exp Med 2003 Sep 8;198(6):947-55. Epub 2003 Sep 8.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1084/jem.20021288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194206PMC
September 2003

Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells.

Blood 2002 Dec 8;100(12):3960-7. Epub 2002 Aug 8.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1182/blood-2002-05-1359DOI Listing
December 2002

Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus.

J Clin Invest 2002 Aug;110(4):537-48

Department of Medicine, Department of Laboratory Medicine, and. Department of Pathobiology, University of Washington, Seattle, Washington 98104, USA.

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http://dx.doi.org/10.1172/JCI15537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150419PMC
August 2002