Max Holzer

Max Holzer

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Max Holzer

Max Holzer

Publications by authors named "Max Holzer"

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Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.

Front Neuroanat 2019 16;13:69. Epub 2019 Jul 16.

Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.3389/fnana.2019.00069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646461PMC
July 2019

TDP-43 and Cytoskeletal Proteins in ALS.

Mol Neurobiol 2018 Apr 2;55(4):3143-3151. Epub 2017 May 2.

Department for Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, University of Leipzig, Liebigstraße 19, 04103, Leipzig, Germany.

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http://dx.doi.org/10.1007/s12035-017-0543-1DOI Listing
April 2018

TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole.

Sci Rep 2018 02 2;8(1):2248. Epub 2018 Feb 2.

Department for Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, University of Leipzig, Liebigstraße 19, 04103, Leipzig, Germany.

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http://dx.doi.org/10.1038/s41598-018-20565-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797228PMC
February 2018

Tau and tauopathies.

Brain Res Bull 2016 09 9;126(Pt 3):238-292. Epub 2016 Sep 9.

Paul Flechsig Institute of Brain Research, Universität Leipzig, Liebigstrasse 19, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.brainresbull.2016.08.018DOI Listing
September 2016

Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

PLoS One 2015 23;10(3):e0119423. Epub 2015 Mar 23.

Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119423PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370497PMC
March 2016

Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters.

Hippocampus 2016 Mar 13;26(3):301-18. Epub 2015 Oct 13.

Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1002/hipo.22522DOI Listing
March 2016

Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimer's disease pathology.

J Neural Transm (Vienna) 2015 Apr 6;122(4):531-9. Epub 2014 Dec 6.

Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109, Leipzig, Germany,

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http://dx.doi.org/10.1007/s00702-014-1342-8DOI Listing
April 2015

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease.

Neuropathol Appl Neurobiol 2014 Dec;40(7):815-32

Department for Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, Paul Flechsig Institute of Brain Research, Leipzig, Germany.

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http://dx.doi.org/10.1111/nan.12163DOI Listing
December 2014

Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan.

Philos Trans R Soc Lond B Biol Sci 2014 Oct;369(1654):20140046

Zentrum für Molekulare Neurobiologie, Universitätsklinikum Hamburg - Eppendorf, Martinistr. 52, 20246 Hamburg, Germany Center for Neuroscience, Shantou University Medical College, 22 Xin Ling Road, Shantou 515041, People's Republic of China Keck Center for Collaborative Neuroscience and Department of Cell Biology, Rutgers University, 604 Allison Road, Piscataway, NJ 08554, USA

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http://dx.doi.org/10.1098/rstb.2014.0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173296PMC
October 2014

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

Biochim Biophys Acta 2014 Sep 4;1842(9):1527-38. Epub 2014 Jun 4.

Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, 04109 Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311138PMC
September 2014

Tau oligomers impair artificial membrane integrity and cellular viability.

J Biol Chem 2012 Dec 5;287(52):43223-33. Epub 2012 Nov 5.

Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, Faculty of Medicine, Jahnallee 59, University of Leipzig, 04109 Leipzig, Germany.

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http://dx.doi.org/10.1074/jbc.M112.396176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527910PMC
December 2012

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.

Bioorg Med Chem Lett 2012 Nov 13;22(22):6914-8. Epub 2012 Sep 13.

Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X1201150
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http://dx.doi.org/10.1016/j.bmcl.2012.09.006DOI Listing
November 2012

Expression of the embryonal isoform (0N/3R) of the microtubule-associated protein tau in the adult rat central nervous system.

J Comp Neurol 2010 Jul;518(13):2538-53

Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany.

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http://dx.doi.org/10.1002/cne.22351DOI Listing
July 2010

Pattern of tau isoforms expression during development in vivo.

Int J Dev Neurosci 2009 Oct 18;27(6):591-7. Epub 2009 Jun 18.

Paul Flechsig Institute of Brain Research, Department of Cellular and Molecular Mechanisms of Neurodegeneration, University of Leipzig, Jahnallee 59, 04019 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.ijdevneu.2009.06.001DOI Listing
October 2009

A putative role for cell cycle-related proteins in microtubule-based neuroplasticity.

Eur J Neurosci 2009 Mar;29(6):1096-107

Paul Flechsig Institute for Brain Research, Department for Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1111/j.1460-9568.2009.06661.xDOI Listing
March 2009

Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy.

Am J Pathol 2008 Jan 13;172(1):123-31. Epub 2007 Dec 13.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, UK.

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http://dx.doi.org/10.2353/ajpath.2008.070627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189621PMC
January 2008

Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus.

Hippocampus 2007 ;17(2):98-102

Department of Neuroanatomy, Paul-Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1002/hipo.20255DOI Listing
March 2007

Tau gene (MAPT) sequence variation among primates.

Gene 2004 Oct;341:313-22

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1016/j.gene.2004.07.013DOI Listing
October 2004

Neuronal activation of Ras regulates synaptic connectivity.

Eur J Neurosci 2004 Jun;19(11):2953-66

Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, D-04109 Leipzig, Germany.

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http://dx.doi.org/10.1111/j.0953-816X.2004.03409.xDOI Listing
June 2004

Constitutive expression of p21H-Ras(Val12) in neurons induces increased axonal size and dendritic microtubule density in vivo.

J Neurosci Res 2003 Dec;74(6):868-74

Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1002/jnr.10838DOI Listing
December 2003

Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus.

Acta Neuropathol 2002 Nov 3;104(5):471-81. Epub 2002 Jul 3.

Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany.

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http://dx.doi.org/10.1007/s00401-002-0581-1DOI Listing
November 2002

Dephosphorylation of tau protein by calcineurin triturated into neural living cells.

Cell Mol Neurobiol 2002 Feb;22(1):13-24

Department of Biochemistry and Molecular Biology, Beijing Normal University, People's Republic of China.

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http://dx.doi.org/10.1023/a:1015385527187DOI Listing
February 2002