Publications by authors named "Maurizio Simmaco"

98Publications

Increased kynurenine-to-tryptophan ratio in the serum of patients infected with SARS-CoV2: An observational cohort study.

Biochim Biophys Acta Mol Basis Dis 2020 Dec 16;1867(3):166042. Epub 2020 Dec 16.

Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University, Rome, Italy; Laboratory of Clinical Biochemistry, Advanced Molecular Diagnostic Unit, Sant'Andrea University Hospital, Rome, Italy. Electronic address:

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December 2020

Evidence for treatment with estradiol for women with SARS-CoV-2 infection.

BMC Med 2020 11 25;18(1):369. Epub 2020 Nov 25.

Department Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health Augustenburger Platz 1, 13353, Berlin, Germany.

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November 2020

Gut microbiota composition in children with obstructive sleep apnoea syndrome: a pilot study.

Sleep Med 2020 Dec 17;76:140-147. Epub 2020 Oct 17.

Pediatric Sleep Disease Center, Child Neurology, NESMOS Dept, School of Medicine and Psychology, Sapienza University of Rome, S. Andrea Hospital, Rome, Italy. Electronic address:

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December 2020

Inter-individual variation in CYP2A6 activity and chronic obstructive pulmonary disease in smokers: Perspectives for an early predictive marker.

Biochim Biophys Acta Mol Basis Dis 2021 Jan 19;1867(1):165990. Epub 2020 Oct 19.

Laboratory of Clinical Biochemistry, Sant'Andrea Hospital, Rome, Italy; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University, Rome, Italy. Electronic address:

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January 2021

Impact of COVID-19 prevention measures on risk of health care-associated Clostridium difficile infection.

Am J Infect Control 2020 Oct 5. Epub 2020 Oct 5.

Internal Medicine and Emergency Medicine Unit, Sant'Andrea University Hospital and "Sapienza" University of Rome, Rome, Italy; Emergency Medicine CoViD-19 Unit, Sant'Andrea University Hospital and "Sapienza" University of Rome, Rome, Italy; Department of Neurosciences, Mental Health, and Sensory Organs, "Sapienza" University of Rome, Rome, Italy.

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October 2020

Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms.

Int J Environ Res Public Health 2020 09 9;17(18). Epub 2020 Sep 9.

Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University, 00185 Rome, Italy.

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September 2020

Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2.

Int J Environ Res Public Health 2020 08 2;17(15). Epub 2020 Aug 2.

Laboratory of Clinical Biochemistry, University Hospital Sant'Andrea, Department of Neurosciences, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, via di Grottarossa 1035, 00189 Rome, Italy.

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August 2020

The effect of dexmedetomidine on status epilepticus in a patient with anti-NMDA receptor encephalitis.

Can J Anaesth 2020 Nov 15;67(11):1677-1679. Epub 2020 Jul 15.

Unit of Anesthesia and Intensive Care Medicine, Sant'Andrea University Hospital, Rome, Italy.

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November 2020

Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome.

Biol Chem 2020 03;401(4):497-503

Institute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), Via Paolo Gaifami 18, I-95126 Catania, Italy.

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March 2020

The future of pharmacogenetics in the treatment of migraine.

Pharmacogenomics 2019 11 22;20(16):1159-1173. Epub 2019 Oct 22.

Department of Neurosciences, Mental Health & Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.

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November 2019

Urinary and exhaled biomarkers of exercise-induced bronchoconstriction in atopic asthmatic children.

Pediatr Pulmonol 2019 09 19;54(9):1447-1456. Epub 2019 Jun 19.

Pediatric Unit Sant'Andrea Hospital, NESMOS Department, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.

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September 2019

Intensive first-line FIr-C/FOx-C association of triplet chemotherapy plus cetuximab in wild-type metastatic colorectal cancer patients: preliminary phase II data and prediction of individual limiting toxicity syndromes by pharmacogenomic biomarkers.

Ther Adv Med Oncol 2019 10;11:1758835919846421. Epub 2019 May 10.

U.O.S.D. Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, L'Aquila 67100, Italy.

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May 2019

Migraine and cluster headache show impaired neurosteroids patterns.

J Headache Pain 2019 May 27;20(1):61. Epub 2019 May 27.

Department of Clinical and Molecular Medicine, Sapienza University and Regional Referral Headache Centre, Sant'Andrea Hospital, via di Grottarossa 1035-1039, 00189, Rome, Italy.

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May 2019

Optimising migraine treatment: from drug-drug interactions to personalized medicine.

J Headache Pain 2019 May 17;20(1):56. Epub 2019 May 17.

Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

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May 2019

DHA Oral Supplementation Modulates Serum Epoxydocosapentaenoic Acid (EDP) Levels in Breast Cancer Patients.

Oxid Med Cell Longev 2019 5;2019:1280987. Epub 2019 Mar 5.

Department of Translational and Precision Medicine, Sapienza University of Rome, v.le dell'Università 37, 00185 Rome, Italy.

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July 2019

Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.

Schizophr Res 2019 06 2;208:465-466. Epub 2019 Mar 2.

International Mood & Psychotic Disorders Research Consortium, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

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June 2019

Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD).

Curr Neuropharmacol 2019 ;17(8):710-736

Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University, Unit of Psychiatry, Sant'Andrea University Hospital, Rome, Italy.

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January 2020

Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?

J Transl Med 2018 08 6;16(1):219. Epub 2018 Aug 6.

Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035-1037, 00189, Rome, Italy.

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August 2018

Changing the Approach to Anticoagulant Therapy in Older Patients with Multimorbidity Using a Precision Medicine Approach.

Int J Environ Res Public Health 2018 08 2;15(8). Epub 2018 Aug 2.

Department of Clinical and Molecular Medicine, Azienda Ospedaliera Universitaria S. Andrea, via di Grottarossa 1035/1039, 00189 Rome, Italy.

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August 2018

Tailoring Treatment in Polymorbid Migraine Patients through Personalized Medicine.

CNS Drugs 2018 06;32(6):559-565

Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.

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June 2018

Maternal exposure to endocrine disruptors and placental transmission: a pilot study.

Gynecol Endocrinol 2018 Nov 29;34(11):1001-1004. Epub 2018 May 29.

d NESMOS Department , S. Andrea Hospital, University of Rome Sapienza , Rome , Italy.

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November 2018

Stable Remission of Multiple Chemical Sensitivity Syndrome and Major Depression With Citalopram and 1-Month Deep Transcranial Magnetic Stimulation: A Case Report.

J ECT 2017 09;33(3):e27-e29

Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University and Unit of Psychiatry, Sant'Andrea Hospital, Rome and Department of Psychiatric Rehabilitation, P. Alberto Mileno Onlus Foundation, San Francesco Institute, Vasto, Chieti, Italy, Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University, Rome, Italy. Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University and Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University and Advanced Molecular Diagnostics Unit (DiMA), Sant'Andrea Hospital, Rome, Italy Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University and Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy Department of Neurology and Psychiatry, Sapienza University, Rome, Italy Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University and Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University and Advanced Molecular Diagnostics Unit (DiMA), Sant'Andrea Hospital, Rome, Italy Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University and Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy.

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September 2017

Changes in serum levels of kynurenine metabolites in paediatric patients affected by ADHD.

Eur Child Adolesc Psychiatry 2017 Dec 19;26(12):1433-1441. Epub 2017 May 19.

NESMOS Department, School of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University, Via di Grottarossa 1035-1039, 00189, Rome, Italy.

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December 2017

A nomogram to predict 5-fluorouracil toxicity: when pharmacogenomics meets the patient.

Anticancer Drugs 2017 06;28(5):551-556

Departments of aClinical and Molecular Medicine bRadiological Oncological and Pathological Sciences cNeurosciences, Mental Health and Sensory Organs (NESMOS), 'Sapienza' University of Rome dDepartment of Medical Oncology, Sant'Andrea Hospital eLaboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute fIstituto Dermopatico dell'Immacolata-IRCCS, Rome, Italy.

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June 2017

Clinical Applications of Personalized Medicine: A New Paradigm and Challenge.

Curr Pharm Biotechnol 2017 ;18(3):194-203

Malzoni Clinical-Scientific Institute (MaCSI), Via Carmelo Errico 2, 83100 Avellino, Italy.

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December 2017

Personalised Healthcare: The DiMA Clinical Model.

Curr Pharm Biotechnol 2017 ;18(3):242-252

DiMA (Advanced Molecular Diagnosis), Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital - Sapienza University of Rome, Via di Grottarossa, 00189 Rome. Italy.

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December 2017

Integrated OMICS tools for personalised medicine.

J Headache Pain 2015 Dec;16(Suppl 1):A9

Advanced Molecular Diagnostics Unit, Sant'Andrea Hospital, Sapienza University of Roma, Rome, Italy.

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December 2015

5-Fluorouracil degradation rate could predict toxicity in stages II-III colorectal cancer patients undergoing adjuvant FOLFOX.

Anticancer Drugs 2017 03;28(3):322-326

Departments of aClinical and Molecular Medicine bNeurosciences, Mental Health and Sensory Organs (NESMOS), 'Sapienza' University of Rome Departments of cMedical Oncology dGeneral Surgery, Sant'Andrea Hospital eIstituto Dermopatico dell'Immacolata-IRCCS, Rome, Italy.

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March 2017

Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner.

Addict Biol 2016 11 26;21(6):1072-1085. Epub 2015 May 26.

International Associated Laboratory (LIA) 'Prenatal Stress and Neurodegenerative Diseases', UMR8576 University Lille 1/CNRS, France.

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November 2016

The TYMS-TSER polymorphism is associated with toxicity of low-dose capecitabine in patients with advanced gastrointestinal cancer.

Anticancer Drugs 2016 11;27(10):1044-9

aClinical and Molecular Medicine Department bAdvanced Molecular Diagnostics Unit cDepartment of Neurosciences, Mental Health and Sensory Organs, Sant'Andrea Hospital, Sapienza University dGenetic Epidemiology Unit, National Centre for Epidemiology, Surveillance and Health Promotion, National Institute of Health, Rome, Italy.

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November 2016

Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study.

Mult Scler 2017 Mar 11;23(3):442-446. Epub 2016 Jul 11.

Center for Experimental Neurological Therapies, Sant'Andrea Hospital, Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

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March 2017

Altered kynurenine pathway metabolites in serum of chronic migraine patients.

J Headache Pain 2015 29;17:47. Epub 2016 Apr 29.

Department of Molecular Medicine, Sant'Andrea Medical Center, Sapienza University, Via di Grottarossa 1035-1039, Rome, 00189, Italy.

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September 2016

CYP19A1 Genetic Polymorphisms rs4646 and Osteoporosis in Patients Treated with Aromatase Inhibitor-Based Adjuvant Therapy.

Eurasian J Med 2016 Feb 7;48(1):10-4. Epub 2015 Jul 7.

Department of Clinical Oncology, Sant'Andrea Hospital, School of Medicine and Psychology, University of Rome La Sapienza, Rome, Italy.

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February 2016

Altered serum levels of kynurenine metabolites in patients affected by cluster headache.

J Headache Pain 2015 22;17:27. Epub 2016 Mar 22.

Department of Molecular Medicine, Sant'Andrea Medical Center, Sapienza University of Rome, Via di Grottarossa 1035-1039, Rome, 00189, Italy.

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September 2016

Personalized Cancer Therapy Considering Cytochrome P450 Variability.

Adv Pharmacol 2015 11;74:113-30. Epub 2015 May 11.

Structural Bioinformatics Group, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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April 2016

Effect of MTHFR Polymorphisms on Gastrointestinal Cancer Risk in Italy.

World J Oncol 2015 Aug 27;6(4):394-397. Epub 2015 Aug 27.

Department of Clinical Oncology, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Azienda Ospedaliera Sant'Andrea, Via di Grottarossa, 1035/39, 00189 Roma, Italy.

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August 2015

Intestinal permeability in children with recurrent respiratory and gastrointestinal symptoms.

J Paediatr Child Health 2015 Dec 4;51(12):1214-20. Epub 2015 Jun 4.

Pediatric Unit Sant'Andrea Hospital, NESMOS Department, Faculty of Medicine and Psychology, 'Sapienza' University, Rome, Italy.

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December 2015

Mitochondrial myopathy and comorbid major depressive disorder: effectiveness of dTMS on gait and mood symptoms.

Gen Hosp Psychiatry 2015 May-Jun;37(3):274.e7-9. Epub 2015 Mar 13.

NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University of Rome School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy; Villa Rosa, Suore Hospitaliere of the Sacred Heart of Jesus, Viterbo, Italy.

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February 2016

Single nucleotide polymorphisms related to vitamin B12 serum levels in autoimmune gastritis patients with or without pernicious anaemia.

Dig Liver Dis 2015 Apr 22;47(4):285-90. Epub 2015 Jan 22.

Digestive and Liver Disease Unit, Department of Medical and Surgery Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University Rome, Rome, Italy. Electronic address:

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April 2015

Lack of association between oxidative stress-related gene polymorphisms and chronic migraine in an Italian population.

Expert Rev Neurother 2015 Feb 14;15(2):215-25. Epub 2015 Jan 14.

Advanced Molecular Diagnostics Unit, Sant'Andrea Hospital, Rome, Italy.

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February 2015

Urinary concentration of 8-isoprostane as marker of severity of pediatric OSAS.

Sleep Breath 2014 Dec 17;18(4):723-9. Epub 2014 Jan 17.

Neuroscience, Mental Health and Sense Organs Department, Sleep Disorder Centre, Faculty of Medicine and Psychology, "La Sapienza" University, Rome, Italy,

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December 2014

The omics in migraine.

J Headache Pain 2013 Jul 1;14:55. Epub 2013 Jul 1.

Sant'Andrea Hospital, Advanced Molecular Diagnostics Unit, Via di Grottarossa 1035 - 1039, Rome 00189, Italy.

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July 2013

Pharmacokinetic evaluation of almotriptan for the treatment of migraines.

Expert Opin Drug Metab Toxicol 2013 May 9;9(5):637-44. Epub 2013 Apr 9.

Sapienza University of Rome and Regional Referral Headache Centre, Sant'Andrea Hospital, Department of Clinical and Molecular Medicine, Rome, Italy.

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May 2013

Sumatriptan succinate : pharmacokinetics of different formulations in clinical practice.

Expert Opin Pharmacother 2012 Nov 26;13(16):2369-80. Epub 2012 Sep 26.

NESMOS Department, Advanced Molecular Diagnostic Unit, Sapienza University, Sant'Andrea Hospital, Via di Grottarossa 1035,Rome, Italy.

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November 2012

Emerging treatment for chronic migraine and refractory chronic migraine.

Expert Opin Emerg Drugs 2012 Sep 3;17(3):393-406. Epub 2012 Aug 3.

Sapienza University and Advanced Molecular Diagnostic Unit, Sant'Andrea Hospital, NESMOS Department, Rome, Italy.

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September 2012

Pharmacokinetic evaluation of zolmitriptan for the treatment of migraines.

Expert Opin Drug Metab Toxicol 2012 Aug 5;8(8):1043-50. Epub 2012 Jul 5.

Sapienza University, Sant'Andrea Hospital, Advanced Molecular Diagnostic Unit, NESMOS Department, Rome, Italy.

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August 2012

Treatment of perimenstrual migraine with triptans: an update.

Curr Pain Headache Rep 2012 Oct;16(5):445-51

Sapienza University, Advanced Molecular Diagnostic Unit, NESMOS Department, Sant'Andrea Hospital, Rome, Italy.

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October 2012