Maurice Dickins

Maurice Dickins

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Maurice Dickins

Maurice Dickins

Publications by authors named "Maurice Dickins"

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24Publications

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Application of PBPK modelling in drug discovery and development at Pfizer.

Xenobiotica 2012 Jan 30;42(1):94-106. Epub 2011 Oct 30.

Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Sandwich, Kent, UK.

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http://dx.doi.org/10.3109/00498254.2011.627477DOI Listing
January 2012

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.

Xenobiotica 2012 Jan 11;42(1):28-45. Epub 2011 Nov 11.

Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Sandwich, Kent, UK.

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http://dx.doi.org/10.3109/00498254.2011.626464DOI Listing
January 2012

An evaluation of ondansetron binding interactions with human cytochrome P450 enzymes CYP3A4 and CYP2D6.

Drug Metab Lett 2010 Jan;4(1):25-30

Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

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http://dx.doi.org/10.2174/187231210790980408DOI Listing
January 2010

Maraviroc: in vitro assessment of drug-drug interaction potential.

Br J Clin Pharmacol 2008 Oct 10;66(4):498-507. Epub 2008 Apr 10.

Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, UK.

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http://dx.doi.org/10.1111/j.1365-2125.2008.03198.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561101PMC
October 2008

Quantitative structure-activity relationships (QSARs) in inhibitors of various cytochromes P450: the importance of compound lipophilicity.

J Enzyme Inhib Med Chem 2007 Feb;22(1):1-6

School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.

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http://www.tandfonline.com/doi/full/10.1080/1475636060095218
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http://dx.doi.org/10.1080/14756360600952183DOI Listing
February 2007

Lipophilicity relationships in inhibitors of CYP2C9 and CYP2C19 enzymes.

J Enzyme Inhib Med Chem 2006 Aug;21(4):385-9

School of Biomedical and Molecular Sciences University of Surrey, Guildford, Surrey, GU2 XH, UK.

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http://www.tandfonline.com/doi/full/10.1080/1475636060070331
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http://dx.doi.org/10.1080/14756360600703313DOI Listing
August 2006

Quantitative structure-activity relationships (QSars) in CYP3A4 inhibitors: the importance of lipophilic character and hydrogen bonding.

J Enzyme Inhib Med Chem 2006 Apr;21(2):127-32

School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.

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http://dx.doi.org/10.1080/14756360500532747DOI Listing
April 2006

Substrates of human cytochromes P450 from families CYP1 and CYP2: analysis of enzyme selectivity and metabolism.

Drug Metabol Drug Interact 2004 ;20(3):111-42

School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK.

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http://dx.doi.org/10.1515/dmdi.2004.20.3.111DOI Listing
March 2005

Induction of cytochromes P450.

Authors:
Maurice Dickins

Curr Top Med Chem 2004 ;4(16):1745-66

Pharmacokinetics, Dynamics and Metabolism, Pfizer Central Research, Sandwich, Kent CT13 9NJ, UK.

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http://dx.doi.org/10.2174/1568026043387115DOI Listing
March 2005

Compound lipophilicity for substrate binding to human P450s in drug metabolism.

Drug Discov Today 2004 Jun;9(12):530-7

School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK.

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http://ac.els-cdn.com/S1359644604031150/1-s2.0-S135964460403
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http://linkinghub.elsevier.com/retrieve/pii/S135964460403115
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http://dx.doi.org/10.1016/S1359-6446(04)03115-0DOI Listing
June 2004

A molecular model of CYP2D6 constructed by homology with the CYP2C5 crystallographic template: investigation of enzyme-substrate interactions.

Drug Metabol Drug Interact 2003 ;19(3):189-210

School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK.

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http://www.degruyter.com/dg/viewarticle.fullcontentlink:pdfe
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http://dx.doi.org/10.1515/dmdi.2003.19.3.189DOI Listing
March 2004

Molecular modelling of CYP2B6 based on homology with the CYP2C5 crystal structure: analysis of enzyme-substrate interactions.

Drug Metabol Drug Interact 2002 ;19(2):115-35

School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, UK.

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http://dx.doi.org/10.1515/dmdi.2002.19.2.115DOI Listing
June 2003

Structure-activity relationship for human cytochrome P450 substrates and inhibitors.

Drug Metab Rev 2002 Feb-May;34(1-2):69-82

School of Biomedical and Life Sciences, University of Surrey, Guildford, UK.

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http://www.tandfonline.com/doi/full/10.1081/DMR-120001391
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http://dx.doi.org/10.1081/dmr-120001391DOI Listing
October 2002

Substrate SARs in human P450s.

Drug Discov Today 2002 Sep;7(17):918-25

School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, UK GU2 7XH.

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http://dx.doi.org/10.1016/s1359-6446(02)02412-1DOI Listing
September 2002

The importance of predictive ADME simulation.

Drug Discov Today 2002 Jul;7(14):755-6

Metabolism and Extrapolation Technologies, GlaxoSmithKline R&D, Park Road, Ware, Herts, UK SG12 0DP.

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http://dx.doi.org/10.1016/s1359-6446(02)02357-7DOI Listing
July 2002