Publications by authors named "Mattia Mori"

100Publications

Experimental and Computational Druggability Exploration of the 14-3-3ζ/SOS1pS PPI Interface.

J Chem Inf Model 2020 Nov 2. Epub 2020 Nov 2.

Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/acs.jcim.0c00722DOI Listing
November 2020

Inhibition of Melanoma Cell Migration and Invasion Targeting the Hypoxic Tumor Associated CAXII.

Cancers (Basel) 2020 Oct 17;12(10). Epub 2020 Oct 17.

Department of Medical Biotechnologies, Cellular and Molecular Physiology Unit, University of Siena, 53100 Siena, Italy.

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http://dx.doi.org/10.3390/cancers12103018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602957PMC
October 2020

What Makes Thienoguanosine an Outstanding Fluorescent DNA Probe?

J Am Chem Soc 2020 Oct 23;142(40):16999-17014. Epub 2020 Sep 23.

Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch, France.

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http://dx.doi.org/10.1021/jacs.0c06165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544670PMC
October 2020

-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors.

J Org Chem 2020 Aug 10;85(16):10891-10901. Epub 2020 Aug 10.

Department of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.1021/acs.joc.0c01459DOI Listing
August 2020

Potency and Selectivity Optimization of Tryptophanol-Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer.

ChemMedChem 2020 Jul 31. Epub 2020 Jul 31.

Department of Therapeutic and Pharmaceutical Chemistry, University of Lisbon, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.

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http://dx.doi.org/10.1002/cmdc.202000522DOI Listing
July 2020

A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia.

Bioorg Med Chem Lett 2020 Aug 12;30(16):127350. Epub 2020 Jun 12.

Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC 88040-900, Brazil; Universidade Federal do Piauí, CPCE, Bom Jesus, PI 64900-000, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2020.127350DOI Listing
August 2020

Natural Products as an Important Source in Drug Discovery.

Curr Pharm Des 2020 ;26(24):2805-2806

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.2174/138161282624200625104355DOI Listing
January 2020

A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds.

ACS Med Chem Lett 2020 May 27;11(5):698-705. Epub 2020 Jan 27.

Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 route du Rhin, 67401 Illkirch, France.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236033PMC
May 2020

In Memory of Maurizio Botta: His Vision of Medicinal Chemistry.

ACS Med Chem Lett 2020 May 14;11(5):611. Epub 2020 May 14.

Department of Biotechnology, Chemistry and Pharmacy, University of Siena.

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http://dx.doi.org/10.1021/acsmedchemlett.0c00210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236028PMC
May 2020

Dual SMO/BRAF Inhibition by Flavonolignans from .

Antioxidants (Basel) 2020 May 5;9(5). Epub 2020 May 5.

Department of QSAR and Molecular Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

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http://dx.doi.org/10.3390/antiox9050384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278695PMC
May 2020

A deadly spillover: SARS-CoV-2 outbreak.

Expert Opin Ther Pat 2020 Jul 29;30(7):481-485. Epub 2020 Apr 29.

Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche, Università Degli Studi Di Firenze , Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.1080/13543776.2020.1760838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196921PMC
July 2020

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction.

ACS Chem Biol 2020 04 20;15(4):1026-1035. Epub 2020 Mar 20.

Department of Biotechnology, Chemistry and Pharmacy-Department of Excellence 2018-2022, Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/acschembio.0c00039DOI Listing
April 2020

Hedgehog signaling pathway inhibitors: an updated patent review (2015-present).

Expert Opin Ther Pat 2020 Apr 19;30(4):235-250. Epub 2020 Feb 19.

Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1080/13543776.2020.1730327DOI Listing
April 2020

Discovery of small molecule inhibitors of Hsp90 chaperone.

J Enzyme Inhib Med Chem 2020 Dec;35(1):639-649

São Carlos Institute of Chemistry (IQSC), University of São Paulo (USP), São Carlos, Brazil.

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http://dx.doi.org/10.1080/14756366.2020.1726342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034072PMC
December 2020

Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro.

Antiviral Res 2020 03 10;175:104708. Epub 2020 Jan 10.

Department of Medical Biotechnologies, University of Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2020.104708DOI Listing
March 2020

In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design.

J Chem Inf Model 2019 12 5;59(12):4961-4967. Epub 2019 Dec 5.

Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022 , University of Siena , via Aldo Moro 2 , 53100 Siena , Italy.

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http://dx.doi.org/10.1021/acs.jcim.9b01043DOI Listing
December 2019

Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of -Induced Infections.

Toxins (Basel) 2019 09 1;11(9). Epub 2019 Sep 1.

Department of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy.

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http://dx.doi.org/10.3390/toxins11090511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783983PMC
September 2019

A Molecular Tool Targeting the Base-Flipping Activity of Human UHRF1.

Chemistry 2019 Oct 13;25(58):13363-13375. Epub 2019 Sep 13.

Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1002/chem.201902605DOI Listing
October 2019

Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1.

Bioorg Med Chem 2019 07 15;27(13):2883-2892. Epub 2019 May 15.

University of Maryland, Baltimore County, Department of Chemistry and Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556414PMC
July 2019

Excited-State Dynamics of Thienoguanosine, an Isomorphic Highly Fluorescent Analogue of Guanosine.

Chemistry 2019 05 7;25(30):7375-7386. Epub 2019 May 7.

Consiglio Nazionale delle Ricerche, Istituto Biostrutture e Bioimmagini, Via Mezzocannone 16, 80134, Napoli, Italy.

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http://dx.doi.org/10.1002/chem.201900677DOI Listing
May 2019

Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02.

J Enzyme Inhib Med Chem 2019 Dec;34(1):657-664

a Department of Biotechnology, Chemistry and Pharmacy , Università degli Studi di Siena , Siena , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1
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http://dx.doi.org/10.1080/14756366.2019.1574779DOI Listing
December 2019

Natural Products Inspired Modulators of Cancer Stem Cells-specific Signaling Pathways Notch and Hedgehog.

Curr Pharm Des 2018 ;24(36):4251-4269

Department of Biotechnology, Chemistry and Pharmacy, "Department of Excellence 2018-2022", University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.2174/1381612825666190111124822DOI Listing
October 2019

Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors.

Bioorg Med Chem 2018 11 27;26(21):5742-5750. Epub 2018 Oct 27.

Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, CEBIME-UFSC, Universidade Federal de Santa Catarina, Campus Trindade, 88040-900 Florianópolis, SC, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183129
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http://dx.doi.org/10.1016/j.bmc.2018.10.030DOI Listing
November 2018

Current trends in Hedgehog signaling pathway inhibition by small molecules.

Bioorg Med Chem Lett 2018 10 27;28(19):3131-3140. Epub 2018 Aug 27.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2018.08.033DOI Listing
October 2018

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold.

Eur J Med Chem 2018 Aug 9;156:554-562. Epub 2018 Jul 9.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.07.017DOI Listing
August 2018

Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

Bioorg Med Chem Lett 2018 02 31;28(4):637-641. Epub 2018 Jan 31.

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53019 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg., Suite 333, 1900 N 12th Street, Philadelphia, PA 19122, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183004
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http://dx.doi.org/10.1016/j.bmcl.2018.01.031DOI Listing
February 2018

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein.

Eur J Med Chem 2018 Feb 24;145:154-164. Epub 2017 Dec 24.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via A. Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2017.12.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092364PMC
February 2018

Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.

Eur J Med Chem 2018 Jan 7;144:277-288. Epub 2017 Dec 7.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Roma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.11.087DOI Listing
January 2018

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.

Molecules 2017 Dec 22;23(1). Epub 2017 Dec 22.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via Aldo Moro 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.3390/molecules23010017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943959PMC
December 2017

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation.

Circ Res 2018 01 20;122(1):31-46. Epub 2017 Nov 20.

From the Goethe University, Frankfurt am Main, Germany (F. Spallotta, C.C., S.A., S.Z., D.S., F. Schnütgen, H.v.M., A.F., I.F., A.M.Z., C.G.); University of Turin, Torino, Italy (D.G., M. Cocco, R.M., A.D.S., M.A., M. Collino, M. Bertinaria); Istituto Italiano di Tecnologia CLNS@Sapienza Rome, Italy (M.M.); Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (C.K., S.G., T.B.); Università Cattolica del Sacro Cuore, Rome, Italy (S.N.); Karolinska Institutet, Huddinge, Sweden (V.A.); University of Mainz, Germany (A.K., A.B.-F.); NXT-Dx, Ghent, Belgium (M. Braspenning); Ghent University, Belgium (W.v.C.); Baker IDI Heart and Diabetes Institute, Melbourne VIC, Australia (M.J.D.B., R.H.R.); IRCCS Policlinico San Donato, Milan, Italy (G.Z., F.M.); National Research Council, Rome, Italy (A.F., C.C.); and Sapienza University, Rome, Italy (B.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311300DOI Listing
January 2018

Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids.

Int J Mol Sci 2017 Nov 20;18(11). Epub 2017 Nov 20.

Deaprtment of Biochemical Sciences "A.Rossi Fanelli", Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.3390/ijms18112464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713430PMC
November 2017

Natural modulators of nonalcoholic fatty liver disease: Mode of action analysis and in silico ADME-Tox prediction.

Toxicol Appl Pharmacol 2017 12 5;337:45-66. Epub 2017 Nov 5.

Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 105, 1113 Sofia, Bulgaria. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2017.10.013DOI Listing
December 2017

Differentially activated Src kinase in chemo-naïve human primary osteosarcoma cells and effects of a Src kinase inhibitor.

Biofactors 2017 Nov 8;43(6):801-811. Epub 2017 Aug 8.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via A. Moro 2, Siena, 53100, Italy.

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http://dx.doi.org/10.1002/biof.1382DOI Listing
November 2017

Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.

Molecules 2017 Jun 24;22(7). Epub 2017 Jun 24.

NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.3390/molecules22071049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151984PMC
June 2017

High-Affinity "Click" RGD Peptidomimetics as Radiolabeled Probes for Imaging α β Integrin.

ChemMedChem 2017 07 3;12(14):1142-1151. Epub 2017 Jul 3.

Institute of Medical Sciences and Kosterlitz Centre for Therapeutics, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201700328DOI Listing
July 2017

Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update.

Curr Med Chem 2018 ;25(1):5-21

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, Siena. Italy.

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http://dx.doi.org/10.2174/0929867324666170426095015DOI Listing
February 2018

Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway.

J Med Chem 2017 02 10;60(4):1469-1477. Epub 2017 Feb 10.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia , Viale Regina Elena 291, 00161 Rome, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01135DOI Listing
February 2017

The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro.

Chem Biol Interact 2016 Dec 5;260:248-255. Epub 2016 Oct 5.

Uludag University, Faculty of Medicine, Department of Medical Biochemistry, Bursa, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.10.001DOI Listing
December 2016

Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations.

Org Biomol Chem 2016 Sep 17;14(35):8322-30. Epub 2016 Aug 17.

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1039/c6ob01477aDOI Listing
September 2016

Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels.

Angew Chem Int Ed Engl 2016 07 8;55(28):7974-7978. Epub 2016 Jun 8.

Laboratoire de Biophotonique et Pharmacologie Faculté de Pharmacie, UMR 7213 CNRS, Université de Strasbourg 74 route du Rhin, 67401 Illkirch (France).

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http://dx.doi.org/10.1002/anie.201601688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978544PMC
July 2016

Discovery of in vitro antitubercular agents through in silico ligand-based approaches.

Eur J Med Chem 2016 Oct 20;121:169-180. Epub 2016 May 20.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53019 Siena, Italy; Sbarro Institute for Cancer Research & Molecular Medicine, Center for Biotechnology, College of Science & Technology, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, PA 19122, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.05.032DOI Listing
October 2016

Challenging Organic Syntheses and Pharmacological Applications of Natural Products and their Derivatives - Part II.

Curr Pharm Des 2016 ;22(12):1559-60

Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.

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http://dx.doi.org/10.2174/138161282212160329130153DOI Listing
December 2016

Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5.

J Enzyme Inhib Med Chem 2016 Dec 30;31(6):1632-7. Epub 2016 Mar 30.

a Istituto Pasteur Fondazione Cenci Bolognetti, Department of Biology and Biotechnology, Sapienza University of Rome , Rome , Italy .

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http://dx.doi.org/10.3109/14756366.2016.1160901DOI Listing
December 2016

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions.

Bioorg Med Chem Lett 2016 Feb 21;26(3):894-898. Epub 2015 Dec 21.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli studi di Siena, via A. Moro snc, Via Aldo Moro 2, 53100 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, PA 19122, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.12.066DOI Listing
February 2016

One Hundred Faces of Cyclopamine.

Curr Pharm Des 2016 ;22(12):1658-81

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Roma, Italy.

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http://dx.doi.org/10.2174/1381612822666160112130157DOI Listing
December 2016

Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs.

Curr Pharm Des 2016 ;22(12):1561-9

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, viale Regina Elena 291, 00161 Roma, Italy.

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http://dx.doi.org/10.2174/1381612822666160112130539DOI Listing
December 2016

Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine.

Chirality 2016 Mar 5;28(3):169-80. Epub 2016 Jan 5.

Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1002/chir.22566DOI Listing
March 2016

Exploring Oxidovanadium(IV) Complexes as YopH Inhibitors: Mechanism of Action and Modeling Studies.

ACS Med Chem Lett 2015 Oct 31;6(10):1035-40. Epub 2015 Aug 31.

Centro de Biologia Molecular Estrutural-CEBIME, Universidade Federal de Santa Catarina , Campus Trindade, 88040-900 Florianópolis, Santa Catarina, Brasil.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641580PMC
October 2015

Editorial: Challenging Organic Syntheses and Pharmacological Applications of Natural Products and their Derivatives.

Curr Pharm Des 2015 ;21(38):5451-2

Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.

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http://dx.doi.org/10.2174/138161282138151112192352DOI Listing
September 2016

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions.

J Chem Inf Model 2015 Dec 19;55(12):2611-22. Epub 2015 Nov 19.

Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità , Viale Regina Elena 299, 00161 Roma, Italy.

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http://dx.doi.org/10.1021/acs.jcim.5b00452DOI Listing
December 2015

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

ACS Chem Biol 2015 Sep 1;10(9):1964-9. Epub 2015 Jul 1.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena , via Aldo Moro 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1021/acschembio.5b00337DOI Listing
September 2015

Targeting GLI factors to inhibit the Hedgehog pathway.

Trends Pharmacol Sci 2015 Aug 10;36(8):547-58. Epub 2015 Jun 10.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy; Department of Molecular Medicine, "La Sapienza" University, 00161 Rome, Italy; Pasteur Institute/Cenci Bolognetti Foundation, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.05.006DOI Listing
August 2015

Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib.

Chempluschem 2015 Jun 27;80(6):938-943. Epub 2015 Feb 27.

Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano (Italy), Fax: (+39) 02-50314078.

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http://dx.doi.org/10.1002/cplu.201402435DOI Listing
June 2015

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1.

Curr Top Microbiol Immunol 2015 ;389:53-92

Dipartimento di Biotecnologie Chimica e Farmacia, Università degli Studi di Siena, via A. Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1007/82_2015_433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122173PMC
July 2015

Synergistic effects of trace amounts of water in the enantiodiscrimination processes by lipodex E: a spectroscopic and computational investigation.

Chirality 2015 Feb 20;27(2):95-103. Epub 2014 Oct 20.

Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1002/chir.22394DOI Listing
February 2015

Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold.

ACS Med Chem Lett 2013 Jun 14;4(6):565-9. Epub 2013 May 14.

ICCOM-CNR , Dipartimento di Chimica "U. Schiff", via della Lastruccia 13, I-50019 Sesto Fiorentino, Italy.

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http://dx.doi.org/10.1021/ml300446aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027459PMC
June 2013

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.

Bioorg Med Chem Lett 2014 Jun 13;24(11):2508-11. Epub 2014 Apr 13.

Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg., Suite 333, 1900 N 12th Street, Philadelphia, PA 19122, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.04.004DOI Listing
June 2014

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

ChemMedChem 2014 May 8;9(5):973-83. Epub 2014 Apr 8.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena (Italy); Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Roma (Italy).

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http://dx.doi.org/10.1002/cmdc.201400044DOI Listing
May 2014

Small molecules modulation of 14-3-3 protein-protein interactions.

Drug Discov Today Technol 2013 Dec;10(4):e541-7

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http://dx.doi.org/10.1016/j.ddtec.2012.10.001DOI Listing
December 2013

Structure prediction and validation of the ERK8 kinase domain.

PLoS One 2013 11;8(1):e52011. Epub 2013 Jan 11.

Istituto Toscano Tumori-Core Research Laboratory, Signal Transduction Unit, AOU Senese, Siena, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052011PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543423PMC
July 2013

Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.

J Chem Theory Comput 2013 Jan 16;9(1):698-706. Epub 2012 Nov 16.

Dipartimento Farmaco-Chimico Tecnologico, Facoltà di Farmacia, Università degli Studi di Siena , I-53100 Siena, Italy.

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http://dx.doi.org/10.1021/ct3006612DOI Listing
January 2013

Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein.

Virus Res 2012 Nov 24;169(2):377-87. Epub 2012 May 24.

Università di Roma La Sapienza, Dipartimento di Chimica e Tecnologie del Farmaco, piazzale A. Moro 5, I-00185 Roma, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S016817021200182
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http://dx.doi.org/10.1016/j.virusres.2012.05.011DOI Listing
November 2012

A highly soluble matrix metalloproteinase-9 inhibitor for potential treatment of dry eye syndrome.

Basic Clin Pharmacol Toxicol 2012 Nov 18;111(5):289-95. Epub 2012 May 18.

ProtEra Srl, Scientific Campus of the University of Florence, Florence, Italy.

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http://dx.doi.org/10.1111/j.1742-7843.2012.00896.xDOI Listing
November 2012

Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case.

Bioorg Med Chem Lett 2011 Nov 10;21(22):6867-71. Epub 2011 Sep 10.

Dipartimento Farmaco Chimico Tecnologico, University of Siena,Via Alcide de Gasperi 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2011.09.011DOI Listing
November 2011

Targeting protein-protein and protein-nucleic acid interactions for anti-HIV therapy.

Curr Pharm Des 2011 Nov;17(33):3713-28

Faculty of Pharmacy, Università degli Studi di Siena, Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.2174/138161211798220972DOI Listing
November 2011

Predicting the binding mode of known NCp7 inhibitors to facilitate the design of novel modulators.

J Chem Inf Model 2011 Feb 20;51(2):446-54. Epub 2010 Dec 20.

Dipartimento Farmaco Chimico Tecnologico, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1021/ci100393mDOI Listing
February 2011

2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

Eur J Med Chem 2010 Dec 8;45(12):5958-64. Epub 2010 Oct 8.

Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2010.09.062DOI Listing
December 2010

Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses.

Chem Biol 2010 Mar;17(3):243-53

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain.

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http://dx.doi.org/10.1016/j.chembiol.2010.02.006DOI Listing
March 2010

Molecular dynamics and DFT study on HIV-1 nucleocapsid protein-7 in complex with viral genome.

J Chem Inf Model 2010 Apr;50(4):638-50

Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1021/ci100070mDOI Listing
April 2010

Theoretical study on binding of S100B protein.

J Mol Model 2007 Nov 23;13(11):1123-31. Epub 2007 Aug 23.

Protera S. r. l., Viale delle Idee, 22, 50019, Sesto Fiorentino, Fi, Italy.

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http://dx.doi.org/10.1007/s00894-007-0231-6DOI Listing
November 2007

Fragment docking to S100 proteins reveals a wide diversity of weak interaction sites.

ChemMedChem 2007 Nov;2(11):1648-54

ProtEra S.r.l. University Scientific Campus viale delle Idee, 22, 50019 Sesto Fiorentino FI, Italy.

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http://dx.doi.org/10.1002/cmdc.200700096DOI Listing
November 2007