Matti Jauhiainen

Matti Jauhiainen

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Matti Jauhiainen

Publications by authors named "Matti Jauhiainen"

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Disruption of Phospholipid Transfer Protein-Mediated High-Density Lipoprotein Maturation Reduces Scavenger Receptor BI Deficiency-Driven Atherosclerosis Susceptibility Despite Unexpected Metabolic Complications.

Arterioscler Thromb Vasc Biol 2020 Mar 16;40(3):611-623. Epub 2020 Jan 16.

From the Division of BioTherapeutics, Leiden Academic Centre for Drug Research, The Netherlands (M.H., R.J.v.d.S., R.B.H., B.L., Y.Z., T.J.C.v.B., M.v.E.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313862DOI Listing
March 2020

IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.

Arterioscler Thromb Vasc Biol 2020 Mar 30;40(3):597-610. Epub 2020 Jan 30.

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (X.Z., J.L., S.L., M.W., Q.H., Z.D., C.d.F., A.D., P.X.L., G.K.S., G.-P.S., J.G.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047522PMC
March 2020

ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Mar 6;1865(7):158679. Epub 2020 Mar 6.

Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Anatomy, University of Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2020.158679DOI Listing
March 2020

Fasting reveals largely intact systemic lipid mobilization mechanisms in respiratory chain complex III deficient mice.

Biochim Biophys Acta Mol Basis Dis 2020 Jan 29;1866(1):165573. Epub 2019 Oct 29.

Lund University, Department of Clinical Sciences, Lund, Pediatrics, Lund, Sweden; Folkhälsan Research Center, Helsinki, Finland; Children's Hospital, University of Helsinki, Helsinki. Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.165573DOI Listing
January 2020

Short-Term Cooling Increases Plasma ANGPTL3 and ANGPTL8 in Young Healthy Lean Men but Not in Middle-Aged Men with Overweight and Prediabetes.

J Clin Med 2019 Aug 14;8(8). Epub 2019 Aug 14.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.3390/jcm8081214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723119PMC
August 2019

Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells.

Cell Death Dis 2019 07 11;10(7):537. Epub 2019 Jul 11.

Medicum, Department of Biochemistry and Developmental Biology, Medical Faculty, University of Helsinki, POB 63, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41419-019-1758-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624261PMC
July 2019

Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice.

Biochim Biophys Acta Mol Basis Dis 2019 06 9;1865(6):1690-1700. Epub 2019 Apr 9.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.04.006DOI Listing
June 2019

Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice.

Endocrinology 2019 05;160(5):1119-1136

Genome-Scale Biology Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1210/en.2018-01088DOI Listing
May 2019

Metabolomic Signature of Angiopoietin-Like Protein 3 Deficiency in Fasting and Postprandial State.

Arterioscler Thromb Vasc Biol 2019 04;39(4):665-674

Department of Internal Medicine and Medical Specialties (I.M., A.D.C., L.D., M.A.), Sapienza University of Rome, Italy.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.312021
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http://dx.doi.org/10.1161/ATVBAHA.118.312021DOI Listing
April 2019

Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants.

Arterioscler Thromb Vasc Biol 2018 10;38(10):2327-2337

From the A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.T., T.V., S.K., K.H., H.N., H.L., M.U.K., S.Y.-H.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311549
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http://dx.doi.org/10.1161/ATVBAHA.118.311549DOI Listing
October 2018

New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk?

Atherosclerosis 2018 05 8;272:27-32. Epub 2018 Mar 8.

Minerva Foundation Institute for Medical Research, Biomedicum 2U, FI-00290 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.03.019DOI Listing
May 2018

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties.

Am J Pathol 2018 02 14;188(2):525-538. Epub 2017 Nov 14.

Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland; Helsinki University Lipidomics Unit, Department of Biosciences, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.09.019DOI Listing
February 2018

PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions.

Atherosclerosis 2018 02 12;269:159-165. Epub 2018 Jan 12.

Genentech, Development Sciences, 1 DNA Way MS 46-1A, South San Francisco, CA, 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183000
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.01.004DOI Listing
February 2018

ANGPTL3 serum concentration and rare genetic variants in Finnish population.

Scand J Clin Lab Invest 2017 Dec 3;77(8):601-609. Epub 2017 Oct 3.

a Genomics and Biomarkers Unit , National Institute for Health and Welfare , Helsinki , Finland.

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https://www.tandfonline.com/doi/full/10.1080/00365513.2017.1
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http://dx.doi.org/10.1080/00365513.2017.1379608DOI Listing
December 2017

Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [F]FDG uptake in LdlrApob mice.

Atherosclerosis 2017 08 11;263:369-376. Epub 2017 Apr 11.

Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, FI-20520 Turku, Finland; Heart Center, Turku University Hospital, Hämeentie 11, FI-20520 Turku, Finland; Clinical Medicine, Turku University Hospital, Hämeentie 11, FI-20520 Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.004DOI Listing
August 2017

LXR-dependent regulation of macrophage-specific reverse cholesterol transport is impaired in a model of genetic diabesity.

Transl Res 2017 08 18;186:19-35.e5. Epub 2017 May 18.

Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau - Institut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain; Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2017.05.004DOI Listing
August 2017

Haptoglobin Hp2 Variant Promotes Premature Cardiovascular Death in Stroke Survivors.

Stroke 2017 06 9;48(6):1463-1469. Epub 2017 May 9.

From the Clinical Neurosciences, Neurology (I.P., S.M., T.P., M.K., P.L., T.E.) and Research Programs Unit, Molecular Neurology, Biomedicum Helsinki (I.P., J.S., P.L.), University of Helsinki, Finland; Department of Neurology, Helsinki University Hospital, Finland (I.P., S.M., T.P., M.K., P.L., T.E.); National Institute for Health and Welfare, Helsinki, Finland (A.J., M.J.); Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland (M.J.); School of Medicine, University of Tampere, Finland (N.O., P.J.K.); and FimLab Laboratories Ltd (N.O., P.J.K.) and Division of Vascular Surgery, Department of Surgery (N.O.), Tampere University Hospital, Finland.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.116.015683
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http://dx.doi.org/10.1161/STROKEAHA.116.015683DOI Listing
June 2017

Thermodynamic and kinetic approaches for evaluation of monoclonal antibody - Lipoprotein interactions.

Anal Biochem 2017 Feb 27;518:25-34. Epub 2016 Oct 27.

Laboratory of Analytical Chemistry, Department of Chemistry, P.O. Box 55, FI-00014, University of Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.10.024DOI Listing
February 2017

Tailor-made approach for selective isolation and elution of low-density lipoproteins by immunoaffinity sorbent on silica.

Anal Biochem 2016 12 10;514:12-23. Epub 2016 Sep 10.

Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, PO. Box 55, FI-00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.09.005DOI Listing
December 2016

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.

Atherosclerosis 2016 06 11;249:140-7. Epub 2016 Apr 11.

Department of Anatomy, Faculty of Medicine, University of Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.04.005DOI Listing
June 2016

The role of ANGPTL3 in controlling lipoprotein metabolism.

Endocrine 2016 May 11;52(2):187-93. Epub 2016 Jan 11.

National Institute for Health and Welfare. Genomics and Biomarkers Unit, Biomedicum, Haartmaninkatu 8, 00250, Helsinki, Finland.

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http://dx.doi.org/10.1007/s12020-015-0838-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824806PMC
May 2016

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism.

Biol Open 2016 May 15;5(5):584-95. Epub 2016 May 15.

Folkhälsan Institute of Genetics, FI-00290 Helsinki, Finland Research Programs Unit, Molecular Neurology, University of Helsinki, FI-00290 Helsinki, Finland Neuroscience Center, University of Helsinki, FI-00790 Helsinki, Finland

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http://dx.doi.org/10.1242/bio.016246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874348PMC
May 2016

Identification and analysis of anti-HDL scFv-antibodies obtained from phage display based synthetic antibody library.

Clin Biochem 2016 Apr 2;49(6):472-479. Epub 2015 Dec 2.

Department of Biochemistry, Division of Biotechnology, University of Turku, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2015.11.020DOI Listing
April 2016

Steroid sulfatase activity in subcutaneous and visceral adipose tissue: a comparison between pre- and postmenopausal women.

Eur J Endocrinol 2016 Feb 9;174(2):167-75. Epub 2015 Nov 9.

Folkhälsan Research CenterBiomedicum Helsinki, 00290 Helsinki, FinlandUniversity of Helsinki and Helsinki University Central HospitalHeart and Lung Center, Helsinki, FinlandUniversity of Helsinki and Helsinki University Central HospitalObstetrics and Gynecology, Helsinki, FinlandHelsinki University Central HospitalHUSLAB, Helsinki, FinlandNational Institute for Health and WelfareGenomics and Biomarkers Unit, Helsinki, Finland Folkhälsan Research CenterBiomedicum Helsinki, 00290 Helsinki, FinlandUniversity of Helsinki and Helsinki University Central HospitalHeart and Lung Center, Helsinki, FinlandUniversity of Helsinki and Helsinki University Central HospitalObstetrics and Gynecology, Helsinki, FinlandHelsinki University Central HospitalHUSLAB, Helsinki, FinlandNational Institute for Health and WelfareGenomics and Biomarkers Unit, Helsinki, Finland.

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http://www.eje-online.org/content/early/2015/11/09/EJE-15-08
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http://www.eje-online.org/content/174/2/167.full.pdf
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http://www.eje-online.org/lookup/doi/10.1530/EJE-15-0831
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http://dx.doi.org/10.1530/EJE-15-0831DOI Listing
February 2016

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.

Arterioscler Thromb Vasc Biol 2016 Feb 17;36(2):274-84. Epub 2015 Dec 17.

From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (M.N., A.M.F.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725095PMC
February 2016

Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth.

J Neurochem 2016 Jan 19;136(2):306-15. Epub 2015 Nov 19.

Department of Biochemistry and Developmental Biology, Medical Faculty, Medicum, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/jnc.13397DOI Listing
January 2016

Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.

J Biol Chem 2015 Nov 14;290(48):28977-87. Epub 2015 Oct 14.

From the Department of Bacteriology and Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1074/jbc.M115.669226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661410PMC
November 2015

Coronary heart disease prediction: Apolipoprotein B shows its might again--but still in vain?

Eur J Prev Cardiol 2015 Oct 14;22(10):1317-20. Epub 2015 Apr 14.

National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki 1, Helsinki, Finland.

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http://dx.doi.org/10.1177/2047487315580892DOI Listing
October 2015

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.

J Clin Endocrinol Metab 2015 Oct 23;100(10):E1299-307. Epub 2015 Jul 23.

Minerva Foundation Institute for Medical Research (P.A.N.H., J.S., S.S., R.M., J.P., V.M.O., H.J.-J.), FI-00290 Helsinki, Finland; Public Health Genomics Unit (J.S., J.M., C.E., M.J.), National Institute for Health and Welfare, Helsinki, FI-00290 Helsinki, Finland; Department of Medicine (S.S.), FI-00014 University of Helsinki, Helsinki, Finland; Department of Internal Medicine (F.Q.), University of Texas Southwestern Medical Center, Dallas, Texas 75390; Haartman Institute (A.P., O.R.), FI-00014 University of Helsinki, FI-00029 Helsinki, Finland; Department of Surgery (M.L.), Helsinki University Central Hospital, University of Helsinki, FI-00029 Helsinki, Finland; Department of Biochemistry and Cancer Biology and Center for Diabetes and Endocrine Research (C.M.S.), University of Toledo College of Medicine, Toledo, Ohio 43614; Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine (P.F.-P., M.W.), University of Ulm, D-89075 Ulm Germany.

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http://dx.doi.org/10.1210/jc.2015-1254DOI Listing
October 2015

Influence of Isoforms and Carboxyl-Terminal Truncations on the Capacity of Apolipoprotein E To Associate with and Activate Phospholipid Transfer Protein.

Biochemistry 2015 Sep 17;54(38):5856-66. Epub 2015 Sep 17.

Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos" , Agia Paraskevi 15310, Athens, Greece.

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http://dx.doi.org/10.1021/acs.biochem.5b00681DOI Listing
September 2015

Partial filling affinity capillary electrophoresis including adsorption energy distribution calculations--towards reliable and feasible biomolecular interaction studies.

Analyst 2015 May 9;140(9):3175-82. Epub 2015 Mar 9.

Laboratory of Analytical Chemistry, Department of Chemistry, P.O. Box 55, FIN-00014 University of Helsinki, Finland.

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http://xlink.rsc.org/?DOI=C5AN00210A
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http://dx.doi.org/10.1039/c5an00210aDOI Listing
May 2015

HDL biogenesis, remodeling, and catabolism.

Handb Exp Pharmacol 2015 ;224:53-111

Molecular Genetics, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, 02118, USA,

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http://dx.doi.org/10.1007/978-3-319-09665-0_2DOI Listing
April 2015

Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux capacity.

FASEB J 2015 Apr 30;29(4):1435-45. Epub 2014 Dec 30.

*Institute of Dentistry, University of Helsinki, Helsinki, Finland; Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland; Department of Diagnostics and Oral Medicine, Institute of Dentistry, and Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland; National Institute for Health and Welfare, Public Health Genomics Unit, Biomedicum, Helsinki, Finland; Meilahti Clinical Proteomics Core Unit, Department of Biochemistry and Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Finland; and Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1096/fj.14-262956DOI Listing
April 2015

PPAR-β/δ activation promotes phospholipid transfer protein expression.

Biochem Pharmacol 2015 Mar 7;94(2):101-8. Epub 2015 Feb 7.

Institut d'Investigacions Biomèdiques (IIB) Sant Pau, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain; Departament de Bioquímica i Biología Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.01.016DOI Listing
March 2015

Atomistic MD simulation reveals the mechanism by which CETP penetrates into HDL enabling lipid transfer from HDL to CETP.

J Lipid Res 2015 Jan 25;56(1):98-108. Epub 2014 Nov 25.

Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M054288
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http://dx.doi.org/10.1194/jlr.M054288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274075PMC
January 2015

[Apolipoprotein A-I and B in laboratory diagnostics of dyslipidemia--what benefits do we gain compared with cholesterol measurements?].

Duodecim 2014 ;130(22-23):2331-7

THL, Kansantautien ehkäisyn osato, tautiriskiyksikkö.

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January 2015

Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet).

PLoS One 2014 28;9(2):e90352. Epub 2014 Feb 28.

Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland ; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090352PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938672PMC
October 2014

Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability.

Circ Cardiovasc Genet 2014 Oct 13;7(5):588-98. Epub 2014 Aug 13.

From the Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland (J.S., P.I., K.N., P.M.I., P.J.L.); HUSLAB, Division of Pathology (M.I.M.), Division of Cardiology, Department of Medicine (J.S., M.S.N.), Department of Neurology (P.I., K.N., M.K., P.J.L.), Helsinki University Central Hospital, Helsinki, Finland; Department of Pathology (M.I.M.), Transplantation Laboratory (M.-L.L.), Haartman Institute, Helsinki University, Helsinki, Finland; Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland (M.P., J.K.); Department of Clinical Neurosciences, University of Helsinki, Helsinki, Finland (P.J.L.); Finnish Red Cross Blood Service, Helsinki, Finland (J.T.); Wihuri Research Institute, Helsinki, Finland (E.L.-S., P.T.K.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.J., M.P., A.S.H., V.S., J.K., M.J.); and The Estonian Genome Center, University of Tartu, Tartu, Estonia (M.P.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000499DOI Listing
October 2014

A metabolic view on menopause and ageing.

Nat Commun 2014 Aug 21;5:4708. Epub 2014 Aug 21.

1] Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Biomedicum 1, Haartmaninkatu 8, Helsinki 00290, Finland [2] Institute for Molecular Medicine (FIMM), University of Helsinki, Biomedicum 2, Tukholmankatu 8, Helsinki 00290, Finland [3] Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.

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http://dx.doi.org/10.1038/ncomms5708DOI Listing
August 2014

The orientation and dynamics of estradiol and estradiol oleate in lipid membranes and HDL disc models.

Biophys J 2014 Jul;107(1):114-25

Institute of Medical Physics and Biophysics, University of Leipzig, Leipzig, Germany; Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.04.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119277PMC
July 2014

Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals.

Nutr Metab (Lond) 2014 13;11:28. Epub 2014 Jun 13.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum, Helsinki, Finland ; Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland ; Diabetes & Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1743-7075-11-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067102PMC
June 2014

Lipid-modifying enzymes in human tear fluid and corneal epithelial stress response.

Invest Ophthalmol Vis Sci 2014 Jan 2;55(1):16-24. Epub 2014 Jan 2.

Helsinki Eye Lab, Department of Ophthalmology, University of Helsinki, Helsinki, Finland.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.13-12577DOI Listing
January 2014

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects.

Cardiovasc Diabetol 2013 Nov 22;12:173. Epub 2013 Nov 22.

Lipids Laboratory (LIM-10), Endocrinology and Metabolism Division of Hospital das Clinicas, Faculty of Medical Sciences, University of Sao Paulo, Av, Dr, Arnaldo, 455 - room 3305, Sao Paulo CEP 01246-00, Brazil.

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http://www.cardiab.com/content/pdf/1475-2840-12-173.pdf
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http://www.cardiab.com/content/12/1/173
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http://dx.doi.org/10.1186/1475-2840-12-173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222276PMC
November 2013

Methionine-induced hyperhomocysteinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo macrophage-specific reverse cholesterol transport.

Mol Nutr Food Res 2013 Oct 10;57(10):1814-24. Epub 2013 Jun 10.

Institut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Spain.

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http://dx.doi.org/10.1002/mnfr.201300133DOI Listing
October 2013

Ceramides in the pathophysiology of the anterior segment of the eye.

Curr Eye Res 2013 Oct 25;38(10):1006-16. Epub 2013 Jul 25.

Department of Ophthalmology, University of Helsinki, Helsinki Eye Lab, Helsinki, Finland.

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http://dx.doi.org/10.3109/02713683.2013.810273DOI Listing
October 2013

Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events.

Atherosclerosis 2013 Oct 25;230(2):228-34. Epub 2013 Jul 25.

Department of Neurology, Helsinki University Central Hospital, Finland; Research Programs Unit, Molecular Neurology, Biomedicum-Helsinki and Department of Clinical Neurosciences, University of Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.07.008DOI Listing
October 2013

The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models.

Cardiovasc Res 2013 Sep 10;99(4):716-23. Epub 2013 Jun 10.

Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

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http://cardiovascres.oxfordjournals.org/content/cardiovascre
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http://cardiovascres.oxfordjournals.org/cgi/doi/10.1093/cvr/
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http://dx.doi.org/10.1093/cvr/cvt148DOI Listing
September 2013

Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension: a preliminary study.

Hypertens Pregnancy 2013 Aug;32(3):203-13

Department of Obstetrics and Gynecology, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.

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http://dx.doi.org/10.3109/10641955.2013.784783DOI Listing
August 2013

Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function.

Metabolism 2013 May 4;62(5):661-8. Epub 2012 Dec 4.

Institute of Dentistry, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.metabol.2012.09.015DOI Listing
May 2013

The absence of macrophage Nrf2 promotes early atherogenesis.

Cardiovasc Res 2013 Apr 22;98(1):107-15. Epub 2013 Jan 22.

Department of Biotechnology and Molecular Medicine, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, Kuopio FIN-70211, Finland.

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http://dx.doi.org/10.1093/cvr/cvt008DOI Listing
April 2013

The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport.

Eur J Clin Invest 2013 Apr 9;43(4):317-23. Epub 2013 Feb 9.

Turku PET Centre, Turku University Central Hospital, Turku, Finland.

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http://dx.doi.org/10.1111/eci.12044DOI Listing
April 2013

Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice.

Dis Model Mech 2013 Mar 12;6(2):342-57. Epub 2012 Oct 12.

National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland.

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http://dx.doi.org/10.1242/dmm.010140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597017PMC
March 2013

What have we learnt about high-density lipoprotein cholesterol measurements during 32 years? Experiences in Finland 1980-2012.

Clin Chim Acta 2013 Jan 18;415:118-23. Epub 2012 Oct 18.

Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.cca.2012.10.027DOI Listing
January 2013

Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2.

J Lipid Res 2012 Nov 15;53(11):2286-95. Epub 2012 Aug 15.

Helsinki Eye Lab, Department of Ophthalmology, Haartmaninkatu 4 C, University of Helsinki, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1194/jlr.M026732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465998PMC
November 2012