Matthijs K C Hesselink

Matthijs K C Hesselink

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Publications by authors named "Matthijs K C Hesselink"

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Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox.

Mol Metab 2018 11 18;17:71-81. Epub 2018 Aug 18.

Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197504PMC
November 2018

Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 11 31;1863(11):1423-1432. Epub 2018 Aug 31.

Department of Nutrition and Movement Sciences, Maastricht University Medical Centre+, 6200 MD Maastricht, the Netherlands; NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.08.016DOI Listing
November 2018

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.

Proc Natl Acad Sci U S A 2018 07 9;115(30):7789-7794. Epub 2018 Jul 9.

Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1722295115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065021PMC
July 2018

Analysing a cycling grand tour: Can we monitor fatigue with intensity or load ratios?

J Sports Sci 2018 Jun 10;36(12):1385-1391. Epub 2017 Oct 10.

a Sport, Physical Activity and Health Research Centre, Newman University , Birmingham , United Kingdom.

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http://dx.doi.org/10.1080/02640414.2017.1388669DOI Listing
June 2018

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

J Physiol 2018 03 23;596(5):857-868. Epub 2017 Nov 23.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1113/JP275182
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http://dx.doi.org/10.1113/JP275182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830434PMC
March 2018

The effect of diet and exercise on lipid droplet dynamics in human muscle tissue.

J Exp Biol 2018 03 7;221(Pt Suppl 1). Epub 2018 Mar 7.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD Maastricht, The Netherlands

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http://dx.doi.org/10.1242/jeb.167015DOI Listing
March 2018

Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver.

Am J Physiol Endocrinol Metab 2018 02 7;314(2):E165-E173. Epub 2017 Nov 7.

NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center , Maastricht , The Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00266.2017DOI Listing
February 2018

Intramyocellular lipid droplets and insulin sensitivity, the human perspective.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Oct 22;1862(10 Pt B):1242-1249. Epub 2017 Jul 22.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.07.010DOI Listing
October 2017

Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes.

Clin Sci (Lond) 2017 Aug 7;131(15):1905-1917. Epub 2017 Jul 7.

NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands

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http://dx.doi.org/10.1042/CS20170261DOI Listing
August 2017

What are the benefits of being big?

J Physiol 2017 08 23;595(16):5409-5410. Epub 2017 Jul 23.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1113/JP274723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556144PMC
August 2017

Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes.

Diabetologia 2017 03 30;60(3):490-498. Epub 2016 Nov 30.

Department of Human Biology and Movement Science, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, PO Box 616, 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-016-4161-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518091PMC
March 2017

Mechanical Efficiency in Chronic Obstructive Pulmonary Disease.

J Cardiopulm Rehabil Prev 2017 Mar;37(2):146-153

Institute of Human Movement and Sports, Fontys University of Applied Sciences, Eindhoven, the Netherlands (Mr Gosens and Drs Oomen and Borghouts); Department of Human Movement Sciences, Maastricht University, Maastricht, the Netherlands (Mr Gosens and Dr Hesselink); Radboudumc, Department of Pulmonary Diseases, Nijmegen, the Netherlands (Dr van't Hul); and Revant, Rehabilitation Centre, Breda, the Netherlands (Dr van't Hul).

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http://dx.doi.org/10.1097/HCR.0000000000000241DOI Listing
March 2017

Longitudinal relaxation time editing for acetylcarnitine detection with H-MRS.

Magn Reson Med 2017 02 17;77(2):505-510. Epub 2016 Feb 17.

Department of Radiology, NUTRIM school for Nutrition and Translational Research in Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/mrm.26149DOI Listing
February 2017

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians.

Sci Rep 2017 02 14;7:42393. Epub 2017 Feb 14.

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/srep42393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307956PMC
February 2017

Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial.

Diabetes Care 2016 Dec 6;39(12):2211-2217. Epub 2016 Oct 6.

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands

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http://dx.doi.org/10.2337/dc16-0499DOI Listing
December 2016

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus.

Nat Rev Endocrinol 2016 11 22;12(11):633-645. Epub 2016 Jul 22.

Department of Human Biology and Human Movement Sciences, Maastricht University Medical Center, Universiteitsingel 50, 6229 ER, Maastricht, Netherlands.

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http://dx.doi.org/10.1038/nrendo.2016.104DOI Listing
November 2016

Effects of exercise training on intrahepatic lipid content in humans.

Diabetologia 2016 10 8;59(10):2068-79. Epub 2016 Jul 8.

NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center +, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-016-4037-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016557PMC
October 2016

Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes.

Sci Rep 2016 10 19;6:35047. Epub 2016 Oct 19.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/srep35047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069469PMC
October 2016

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.

Mol Metab 2016 Aug 1;5(8):635-645. Epub 2016 Jul 1.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021670PMC
August 2016

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans.

Diabetologia 2016 May 10;59(5):1040-8. Epub 2016 Feb 10.

Department of Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD, Maastricht, the Netherlands.

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http://link.springer.com/10.1007/s00125-016-3865-z
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http://dx.doi.org/10.1007/s00125-016-3865-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826431PMC
May 2016

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity.

Diabetologia 2016 May 17;59(5):1030-9. Epub 2016 Feb 17.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P. O. Box 616, 6200MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-016-3885-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826430PMC
May 2016

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats.

Sci Rep 2016 Mar 14;6:22854. Epub 2016 Mar 14.

Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/srep22854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789602PMC
March 2016

Microscopy tools for the investigation of intracellular lipid storage and dynamics.

Mol Metab 2016 Mar 31;5(3):153-163. Epub 2015 Dec 31.

Department of Human Movement Sciences and Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2015.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770264PMC
March 2016

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.

Nat Med 2015 Aug 6;21(8):863-5. Epub 2015 Jul 6.

Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1038/nm.3891DOI Listing
August 2015

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.

Diabetes 2015 Apr 28;64(4):1193-201. Epub 2014 Oct 28.

Department of Human Biology, Maastricht University Medical Center, Maastricht, the Netherlands School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands

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http://dx.doi.org/10.2337/db14-0667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375076PMC
April 2015

Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging.

Integr Biol (Camb) 2015 Apr;7(4):467-76

Department of Molecular Spectroscopy, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.

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http://dx.doi.org/10.1039/c4ib00271gDOI Listing
April 2015

Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein.

Am J Clin Nutr 2015 Jan 5;101(1):65-71. Epub 2014 Nov 5.

From the Departments of Radiology (LL, CIN, JEW, and VBS-H), Human Biology (LL, PS, and VBS-H), and Human Movement Sciences (CIN and MKCH), NUTRIM, Maastricht University Medical Center, Maastricht, The Netherlands, and Top Institute Food and Nutrition (LL, CIN, PS, and VBS-H), Wageningen, The Netherlands.

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https://academic.oup.com/ajcn/article/101/1/65/4564329
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http://dx.doi.org/10.3945/ajcn.114.094730DOI Listing
January 2015

Reduced incorporation of fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes.

Diabetes 2014 May 31;63(5):1583-1593. Epub 2014 Jan 31.

Department of Human Biology, NUTRIM-School for Nutrition, Toxicology and Metabolism, Departments of Human Biology, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db13
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http://dx.doi.org/10.2337/db13-1123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023412PMC
May 2014

Chemical imaging of lipid droplets in muscle tissues using hyperspectral coherent Raman microscopy.

Histochem Cell Biol 2014 Mar 2;141(3):263-73. Epub 2013 Nov 2.

Molecular Spectroscopy Department, Max Plank Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.

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http://dx.doi.org/10.1007/s00418-013-1161-2DOI Listing
March 2014

Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?

Ann N Y Acad Sci 2013 Jul;1290:83-9

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1111/nyas.12185DOI Listing
July 2013

Blocking the entrance to open the gate.

Diabetes 2013 Mar;62(3):703-5

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.2337/db12-1663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581194PMC
March 2013

Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels.

Diabetes 2012 Nov 17;61(11):2679-90. Epub 2012 Jul 17.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.2337/db11-1402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478528PMC
November 2012

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Diabetes 2012 Oct 10;61(10):2472-8. Epub 2012 Jul 10.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.2337/db11-1832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447923PMC
October 2012

Physical activity energy expenditure in Dutch adolescents: contribution of active transport to school, physical education, and leisure time activities.

J Sch Health 2012 May;82(5):225-32

Physical Activity and Health Research Group, Fontys University of Applied Sciences, Tilburg, the Netherlands.

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http://dx.doi.org/10.1111/j.1746-1561.2012.00691.xDOI Listing
May 2012

Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1α overexpressing mice.

J Cell Physiol 2012 Mar;227(3):1026-33

NUTRIM-School for Nutrition, Toxicology and Metabolism, Department of Human Biology, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/jcp.22812DOI Listing
March 2012

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria.

Histochem Cell Biol 2012 Feb 30;137(2):205-16. Epub 2011 Nov 30.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s00418-011-0888-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262136PMC
February 2012

Long- and medium-chain fatty acids induce insulin resistance to a similar extent in humans despite marked differences in muscle fat accumulation.

J Clin Endocrinol Metab 2012 Jan 26;97(1):208-16. Epub 2011 Oct 26.

NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Human Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2011-1884DOI Listing
January 2012

Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity.

Prog Lipid Res 2012 Jan 19;51(1):36-49. Epub 2011 Nov 19.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, 6200MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.plipres.2011.11.003DOI Listing
January 2012

Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure.

FEBS Lett 2011 Dec 21;585(24):4010-7. Epub 2011 Nov 21.

Departments of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2011.11.012DOI Listing
December 2011

Diet or diet plus physical activity in patients with early type 2 diabetes.

Lancet 2011 Dec;378(9809):2066-7; author reply 2067-8

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http://dx.doi.org/10.1016/S0140-6736(11)61892-8DOI Listing
December 2011

Lipids in metabolic health and disease.

Prostaglandins Leukot Essent Fatty Acids 2011 Nov 2;85(5):195. Epub 2011 May 2.

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http://dx.doi.org/10.1016/j.plefa.2011.04.006DOI Listing
November 2011

Stimulation of human whole-body energy expenditure by salsalate is fueled by higher lipid oxidation under fasting conditions and by higher oxidative glucose disposal under insulin-stimulated conditions.

J Clin Endocrinol Metab 2011 May 2;96(5):1415-23. Epub 2011 Feb 2.

NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Human Movement Sciences, Maastricht University Medical Centre, NL6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2010-1816DOI Listing
May 2011

Skeletal muscle lipase content and activity in obesity and type 2 diabetes.

J Clin Endocrinol Metab 2010 Dec 15;95(12):5449-53. Epub 2010 Sep 15.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2010-0776DOI Listing
December 2010

Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance.

Diabetes 2010 Sep 23;59(9):2117-25. Epub 2010 Jun 23.

Department of Human Biology, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands.

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http://dx.doi.org/10.2337/db10-0519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927932PMC
September 2010

Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.

Obesity (Silver Spring) 2010 Jun 29;18(6):1100-7. Epub 2009 Oct 29.

NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1038/oby.2009.372
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http://dx.doi.org/10.1038/oby.2009.372DOI Listing
June 2010

The ceramide transporter and the Goodpasture antigen binding protein: one protein--one function?

J Neurochem 2010 Jun 17;113(6):1369-86. Epub 2010 Mar 17.

Department of Neuroscience, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06673.xDOI Listing
June 2010

Hyperglycemic diet and training alter insulin sensitivity, intramyocellular lipid content but not UCP3 protein expression in rat skeletal muscles.

Int J Mol Med 2010 Jun;25(6):905-13

Department of Biomedical Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, Research Centre for Exercise and Health, K.U. Leuven, B-3001 Leuven, Belgium.

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http://dx.doi.org/10.3892/ijmm_00000421DOI Listing
June 2010

The use of statins potentiates the insulin-sensitizing effect of exercise training in obese males with and without Type 2 diabetes.

Clin Sci (Lond) 2010 Jun 25;119(7):293-301. Epub 2010 Jun 25.

Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1042/CS20100153DOI Listing
June 2010

Improved ejection fraction after exercise training in obesity is accompanied by reduced cardiac lipid content.

J Clin Endocrinol Metab 2010 Apr 19;95(4):1932-8. Epub 2010 Feb 19.

Department of Radiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2009-2076DOI Listing
April 2010

Mitochondrial dysfunction and lipotoxicity.

Biochim Biophys Acta 2010 Mar 24;1801(3):266-71. Epub 2009 Sep 24.

Maastricht University Medical Centre (MUMC), Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Human Biology, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S138819810900224
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http://dx.doi.org/10.1016/j.bbalip.2009.09.011DOI Listing
March 2010

Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.

J Clin Endocrinol Metab 2009 Oct 14;94(10):4077-85. Epub 2009 Jul 14.

NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Human Movement Sciences, Maastricht University Medical Center+, NL-6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2009-0352DOI Listing
October 2009

Modulation of myocellular fat stores: lipid droplet dynamics in health and disease.

Am J Physiol Regul Integr Comp Physiol 2009 Oct 19;297(4):R913-24. Epub 2009 Aug 19.

Departments of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1152/ajpregu.91053.2008DOI Listing
October 2009

Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss.

Metabolism 2009 Aug 18;58(8):1145-52. Epub 2009 Jun 18.

Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.metabol.2009.03.014DOI Listing
August 2009

The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice.

FEBS Lett 2008 Dec 27;582(30):4147-52. Epub 2008 Nov 27.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2008.11.016DOI Listing
December 2008

Habitual physical activity in daily life correlates positively with markers for mitochondrial capacity.

J Appl Physiol (1985) 2008 Aug 29;105(2):561-8. Epub 2008 May 29.

Department of Human Biology, Maastrict University, Maastricht, The Netherlands.

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http://www.physiology.org/doi/10.1152/japplphysiol.00091.200
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http://dx.doi.org/10.1152/japplphysiol.00091.2008DOI Listing
August 2008

The insulin-sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function.

J Clin Endocrinol Metab 2008 Jul 6;93(7):2917-21. Epub 2008 May 6.

Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2008-0267DOI Listing
July 2008

Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding.

FEBS Lett 2008 Feb 28;582(4):510-6. Epub 2008 Jan 28.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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February 2008

Eat the meat or feed the meat: protein turnover in remodeling muscle.

Curr Opin Clin Nutr Metab Care 2006 Nov;9(6):672-6

Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Movement Sciences, Maastricht University, 6200 MD Maastricht, the Netherlands.

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November 2006

UCP3 in muscle wasting, a role in modulating lipotoxicity?

FEBS Lett 2006 Oct 5;580(22):5172-6. Epub 2006 Sep 5.

Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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October 2006

Involvement of UCP3 in mild uncoupling and lipotoxicity.

Exp Gerontol 2006 Jul 27;41(7):658-62. Epub 2006 Mar 27.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands.

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July 2006

Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease.

Am J Physiol Endocrinol Metab 2006 May 13;290(5):E976-81. Epub 2005 Dec 13.

Dept. of Respiratory Medicine, Maastricht Univ., Nutrition and Toxicology Research Institute Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00336.2005DOI Listing
May 2006

Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment.

J Clin Endocrinol Metab 2006 Apr 29;91(4):1520-5. Epub 2005 Dec 29.

Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, P.O. Box 616, NL-6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2005-1572DOI Listing
April 2006

Intramyocellular lipid content in human skeletal muscle.

Obesity (Silver Spring) 2006 Mar;14(3):357-67

Department of Radiology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.

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http://doi.wiley.com/10.1038/oby.2006.47
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March 2006

The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice.

FEBS Lett 2006 Feb 26;580(5):1371-5. Epub 2006 Jan 26.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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February 2006

Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism?

Prog Lipid Res 2006 Jan 9;45(1):17-41. Epub 2005 Dec 9.

Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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January 2006

Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes.

Am J Physiol Endocrinol Metab 2005 Dec 19;289(6):E1023-9. Epub 2005 Jul 19.

Dept. of Human Physiology, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.

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December 2005

Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise.

FASEB J 2005 Jun 6;19(8):986-8. Epub 2005 Apr 6.

Clinique Romande de Réadaptation SUVA Care, Sion, Switzerland.

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June 2005

Uncoupling proteins in the failing human heart: friend or foe?

Lancet 2005 Jan 29-Feb 4;365(9457):385-6

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February 2005

A modified PAS stain combined with immunofluorescence for quantitative analyses of glycogen in muscle sections.

Histochem Cell Biol 2004 Aug 3;122(2):161-9. Epub 2004 Aug 3.

Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://link.springer.com/10.1007/s00418-004-0690-0
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August 2004

Intramyocellular lipids and insulin sensitivity: does size really matter?

Obes Res 2004 May;12(5):741-2

Departments of Movement Sciences, Maastricht University, Nutrition and Toxiology Research Institute Maastricht, The Netherlands.

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May 2004

Physical activity and health, novel concepts and new targets: report from the 12th Conference of the International Research Group on the Biochemistry of Exercise.

Proc Nutr Soc 2004 May;63(2):189-97

Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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May 2004

The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?

Proc Nutr Soc 2004 May;63(2):287-92

Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Departments of Human Biology and Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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May 2004