Matthieu Schapira

Matthieu Schapira

UNVERIFIED PROFILE

Are you Matthieu Schapira?   Register this Author

Register author
Matthieu Schapira

Matthieu Schapira

Publications by authors named "Matthieu Schapira"

Are you Matthieu Schapira?   Register this Author

95Publications

2430Reads

8Profile Views

Targeted protein degradation: expanding the toolbox.

Nat Rev Drug Discov 2019 Dec 30;18(12):949-963. Epub 2019 Oct 30.

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41573-019-0047-yDOI Listing
December 2019

Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.

J Med Chem 2019 Nov 12;62(22):10144-10155. Epub 2019 Nov 12.

Structural Genomics Consortium, University of Toronto, MaRS Centre , South Tower, 101 College St., Suite 700 , Toronto , Ontario M5G 1L7 , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.9b00988DOI Listing
November 2019

Targeting non-bromodomain chromatin readers.

Nat Struct Mol Biol 2019 Oct 3;26(10):863-869. Epub 2019 Oct 3.

Structural Genomics Consortium, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41594-019-0290-2DOI Listing
October 2019

Identification and characterization of the first fragment hits for SETDB1 Tudor domain.

Bioorg Med Chem 2019 Sep 12;27(17):3866-3878. Epub 2019 Jul 12.

Structural Genomics Consortium, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2019.07.020DOI Listing
September 2019

UbiHub: a data hub for the explorers of ubiquitination pathways.

Bioinformatics 2019 Aug;35(16):2882-2884

Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/bty1067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691330PMC
August 2019

Open laboratory notebooks: good for science, good for society, good for scientists.

F1000Res 2019 22;8:87. Epub 2019 Jan 22.

Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.17710.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694453PMC
January 2019

Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.

J Med Chem 2018 05 9;61(10):4517-4527. Epub 2018 May 9.

Structural Genomics Consortium , University of Toronto , MaRS South Tower, Suite 700, 101 College Street , Toronto , Ontario M5G 1L7 , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.8b00258DOI Listing
May 2018

Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.

J Med Chem 2017 11 27;60(21):9090-9096. Epub 2017 Oct 27.

Structural Genomics Consortium, University of Toronto , MaRS South Tower, Suite 700, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.7b00933DOI Listing
November 2017

WD40 repeat domain proteins: a novel target class?

Nat Rev Drug Discov 2017 Nov 13;16(11):773-786. Epub 2017 Oct 13.

Structural Genomics Consortium, University of Toronto, Toronto, 101 College St, MaRS South Tower, Suite 700, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nrd.2017.179
Publisher Site
http://dx.doi.org/10.1038/nrd.2017.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975957PMC
November 2017

Disease Association and Druggability of WD40 Repeat Proteins.

J Proteome Res 2017 10 28;16(10):3766-3773. Epub 2017 Sep 28.

Structural Genomics Consortium, University of Toronto , Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.7b00451DOI Listing
October 2017

A systematic analysis of atomic protein-ligand interactions in the PDB.

Medchemcomm 2017 Oct 26;8(10):1970-1981. Epub 2017 Sep 26.

Structural Genomics Consortium , University of Toronto , Toronto , ON M5G 1L7 , Canada . Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7md00381aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708362PMC
October 2017

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.

Cell Rep 2016 12;17(10):2724-2737

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177622PMC
December 2016

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.

Bioorg Med Chem Lett 2016 09 21;26(18):4518-4522. Epub 2016 Jul 21.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2016.07.041DOI Listing
September 2016

Chemical Inhibition of Protein Methyltransferases.

Cell Chem Biol 2016 Sep 25;23(9):1067-1076. Epub 2016 Aug 25.

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2016.07.014DOI Listing
September 2016

Methyltransferase inhibitors for modulation of the epigenome and beyond.

Curr Opin Chem Biol 2016 08 16;33:81-7. Epub 2016 Jun 16.

Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, 101 College St., Toronto, ON M5G 1L7, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpa.2016.05.030DOI Listing
August 2016

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.

J Biol Chem 2016 Jun 29;291(26):13509-19. Epub 2016 Apr 29.

From the Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, the Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.721472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919437PMC
June 2016

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates.

J Proteome Res 2016 06 10;15(6):2052-9. Epub 2016 May 10.

Structural Genomics Consortium, University of Toronto , 101 College Street, MaRS Centre, South Tower, Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.6b00220DOI Listing
June 2016

Structural Chemistry of Human RNA Methyltransferases.

ACS Chem Biol 2016 Mar 13;11(3):575-82. Epub 2015 Nov 13.

Structural Genomics Consortium, University of Toronto , Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00781DOI Listing
March 2016

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

ACS Chem Biol 2016 Mar 8;11(3):772-781. Epub 2015 Dec 8.

Departments of Structural and Chemical Biology, Oncological Sciences, and Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798913PMC
March 2016

Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.

J Biol Chem 2015 Oct 28;290(41):24902-13. Epub 2015 Aug 28.

From the Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7 and the Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8 Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.680389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598999PMC
October 2015

STRUCTURAL BIOLOGY. Chromatin complex, crystal clear.

Science 2015 Oct;350(6258):278-9

Structural Genomics Consortium and Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aad5203DOI Listing
October 2015

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2.

Biochim Biophys Acta 2015 Sep 19;1850(9):1842-8. Epub 2015 May 19.

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagen.2015.05.013DOI Listing
September 2015

Probing the epigenome.

Nat Chem Biol 2015 Aug;11(8):542-5

1] Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada. [2] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1871DOI Listing
August 2015

Structural diversity of the epigenetics pocketome.

Proteins 2015 Jul 29;83(7):1316-26. Epub 2015 May 29.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.24830DOI Listing
July 2015

Discovery of a Dual PRMT5-PRMT7 Inhibitor.

ACS Med Chem Lett 2015 Apr 2;6(4):408-12. Epub 2015 Mar 2.

Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada ; The Department of Pharmacology and Toxicology, University of Toronto , Toronto, ON M5S 1A8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ml500467hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394339PMC
April 2015

A global assessment of cancer genomic alterations in epigenetic mechanisms.

Epigenetics Chromatin 2014 4;7(1):29. Epub 2014 Dec 4.

Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, 101 College Street, Toronto, M5G 1L7 ON Canada ; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8 ON Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-8935-7-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258301PMC
December 2014

Structural biology and chemistry of protein arginine methyltransferases.

Medchemcomm 2014 Dec 12;5(12):1779-1788. Epub 2014 Sep 12.

Structural Genomics Consortium , University of Toronto , Toronto , ON M5G 1L7 , Canada . Email: ; Tel: +1-416-978-3092.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c4md00269eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655611PMC
December 2014

Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.

PLoS One 2013 19;8(12):e83737. Epub 2013 Dec 19.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada ; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083737PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868588PMC
October 2014

A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro.

J Biomol Screen 2014 Jul 4;19(6):928-35. Epub 2014 Mar 4.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1087057114525854DOI Listing
July 2014

ChromoHub V2: cancer genomics.

Bioinformatics 2014 Feb 6;30(4):590-2. Epub 2013 Dec 6.

Structural Genomics Consortium, and Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btt710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928521PMC
February 2014

Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.

Proteins 2013 Aug 2;81(8):1466-72. Epub 2013 Jul 2.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.24290DOI Listing
August 2013

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Bioorg Med Chem 2013 Apr 30;21(7):1787-1794. Epub 2013 Jan 30.

Structural Genomics Consortium, University of Toronto; 101 College Street, MaRS Centre, South tower, Toronto, Ontario, M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2013.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780262PMC
April 2013

Strategy to target the substrate binding site of SET domain protein methyltransferases.

J Chem Inf Model 2013 Mar 1;53(3):681-91. Epub 2013 Mar 1.

Structural Genomics Consortium, University of Toronto , MaRS Centre, South Tower, seventh floor, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci300596xDOI Listing
March 2013

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.

J Med Chem 2013 Mar 27;56(5):2110-24. Epub 2013 Feb 27.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm3018332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319713PMC
March 2013

ChromoHub: a data hub for navigators of chromatin-mediated signalling.

Bioinformatics 2012 Aug 19;28(16):2205-6. Epub 2012 Jun 19.

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/bts340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413389PMC
August 2012

Epigenetic protein families: a new frontier for drug discovery.

Nat Rev Drug Discov 2012 Apr 13;11(5):384-400. Epub 2012 Apr 13.

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd3674DOI Listing
April 2012

Structural biology of human metal-dependent histone deacetylases.

Handb Exp Pharmacol 2011 ;206:225-40

Structural Genomics Consortium and Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-642-21631-2_10DOI Listing
November 2011

Structural Chemistry of Human SET Domain Protein Methyltransferases.

Curr Chem Genomics 2011 22;5(Suppl 1):85-94. Epub 2011 Aug 22.

Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://benthamopen.com/ABSTRACT/CCGTM-5-85
Publisher Site
http://dx.doi.org/10.2174/1875397301005010085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178901PMC
November 2011

Normalizing molecular docking rankings using virtually generated decoys.

J Chem Inf Model 2011 Aug 13;51(8):1817-30. Epub 2011 Jul 13.

Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci200175hDOI Listing
August 2011

Newly discovered and characterized antivirulence compounds inhibit bacterial mono-ADP-ribosyltransferase toxins.

Antimicrob Agents Chemother 2011 Mar 6;55(3):983-91. Epub 2010 Dec 6.

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01164-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067067PMC
March 2011

Structural chemistry of the histone methyltransferases cofactor binding site.

J Chem Inf Model 2011 Mar 3;51(3):612-23. Epub 2011 Mar 3.

Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci100479zDOI Listing
March 2011

Recognition and specificity determinants of the human cbx chromodomains.

J Biol Chem 2011 Jan 3;286(1):521-9. Epub 2010 Nov 3.

Ontario Cancer Institute, Campbell Family Cancer Research Institute and Department of Medical Biophysics, University of Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.191411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013012PMC
January 2011

Structural genomics of histone tail recognition.

Bioinformatics 2010 Oct 24;26(20):2629-30. Epub 2010 Aug 24.

Structural Genomics Consortium, University of Oxford, Headington, Oxford OX37DQ, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/bioinformatics/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btq491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951094PMC
October 2010

Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity.

PLoS One 2010 Apr 1;5(4):e9934. Epub 2010 Apr 1.

Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009934PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848575PMC
April 2010

Finding Inspiration in the Protein Data Bank to Chemically Antagonize Readers of the Histone Code.

Mol Inform 2010 Apr 9;29(4):322-31. Epub 2010 Apr 9.

Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, 7thfloor, 101 College Street, Toronto, Ontario, Canada, M5G 1L7 fax: 416-946-0880.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/minf.201000018DOI Listing
April 2010

Pharmacophore screening of the protein data bank for specific binding site chemistry.

J Chem Inf Model 2010 Mar;50(3):358-67

Structural Genomics Consortium, University of Toronto, MaRS Centre, 101 College Street, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci900427bDOI Listing
March 2010

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.

Biochem J 2009 Oct 23;424(1):15-26. Epub 2009 Oct 23.

Structural Genomics Consortium, University of Toronto, 101 College Street, Room 839, MaRS Centre, South Tower, Toronto, ON, Canada M5G 1L7.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20090723DOI Listing
October 2009

Evaluation of virtual screening as a tool for chemical genetic applications.

J Chem Inf Model 2009 Sep;49(9):2082-91

Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, seventh floor, 101 College Street, Toronto, Ontario, Canada M5G 1L7.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci900219uDOI Listing
September 2009

Substrate recognition and hydrolysis by a fungal xyloglucan-specific family 12 hydrolase.

Carbohydr Res 2009 Jul 22;344(10):1175-9. Epub 2009 Apr 22.

Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montreal, Quebec, Canada H4B 1R6.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carres.2009.04.020DOI Listing
July 2009

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii.

EMBO J 2009 Apr 5;28(7):969-79. Epub 2009 Feb 5.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emboj.2009.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670854PMC
April 2009

Structural genomics and drug discovery: all in the family.

Curr Opin Chem Biol 2008 Feb 7;12(1):32-9. Epub 2008 Mar 7.

Structural Genomics Consortium, Karolinska Institutet, MBB/SGC, 171 77 Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpa.2008.01.045DOI Listing
February 2008

A comparative analysis of perturbations caused by a gene knock-out, a dominant negative allele, and a set of peptide aptamers.

Mol Cell Proteomics 2007 Dec 4;6(12):2110-21. Epub 2007 Sep 4.

Differentiation and Cell Cycle Group, Laboratoire de Biologie Moléculaire de la Cellule, UMR 5239 CNRS/ENS Lyon, Université Lyon 1, Ecole Normale Supérieure de Lyon, IFR 128 BioSciences Lyon-Gerland, 46 allée d'Italie, 69364 Lyon cedex 07, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M700105-MCP200DOI Listing
December 2007

Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors.

Mol Endocrinol 2007 Nov 31;21(11):2672-86. Epub 2007 Jul 31.

Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2007-0080DOI Listing
November 2007

Identification of 12Cysbeta on tubulin as the binding site of tubulyzine.

Bioorg Med Chem 2006 Feb 2;14(4):1169-75. Epub 2005 Nov 2.

National Institute of Diabetes, Digestive, Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2005.09.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1408322PMC
February 2006

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine.

BMC Struct Biol 2002 18;2. Epub 2002 Jan 18.

Molsoft LLC, 3366 North Torrey Pines Court, Suite 300, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC65631PMC
http://dx.doi.org/10.1186/1472-6807-2-1DOI Listing
December 2003

Structural basis of urothelial permeability barrier function as revealed by Cryo-EM studies of the 16 nm uroplakin particle.

J Cell Sci 2003 Oct;116(Pt 20):4087-94

Structural Biology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article

Download full-text PDF

Source
http://jcs.biologists.org/cgi/doi/10.1242/jcs.00811
Publisher Site
http://dx.doi.org/10.1242/jcs.00811DOI Listing
October 2003

Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling.

J Biol Chem 2003 Sep 30;278(38):36547-55. Epub 2003 Jun 30.

Departments of Microbiology, Urology, and Structural Biology, Skirball Institute of Biomolecular Medicine.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M305960200DOI Listing
September 2003

Nuclear hormone receptor targeted virtual screening.

J Med Chem 2003 Jul;46(14):3045-59

Molsoft LLC, 3366 North Torrey Pines Court, Suite 300, La Jolla, California 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm0300173DOI Listing
July 2003

Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking.

Proc Natl Acad Sci U S A 2003 Jun 30;100(12):7354-9. Epub 2003 May 30.

Molsoft LLC, 3366 North Torrey Pines Court, Suite 300, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1131854100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165879PMC
June 2003

Two distinct regions on the surface of an RNA-binding domain are crucial for RNase E function.

Mol Microbiol 2002 Nov;46(4):959-69

Skirball Institute of Biomolecural Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2958.2002.03231.xDOI Listing
November 2002

Pharmacogenomics opportunities in nuclear receptor targeted cancer therapy.

Curr Cancer Drug Targets 2002 Sep;2(3):243-56

Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1568009023333845DOI Listing
September 2002