Matthias von Herrath

Matthias von Herrath

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Matthias von Herrath

Publications by authors named "Matthias von Herrath"

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CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor.

Diabetologia 2019 Sep 17;62(9):1727-1729. Epub 2019 May 17.

Novo Nordisk A/S Research Projects, Novo Nordisk Park, DK-2760, Måløv, Denmark.

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http://dx.doi.org/10.1007/s00125-019-4893-2DOI Listing
September 2019

Distinct Housing Conditions Reveal a Major Impact of Adaptive Immunity on the Course of Obesity-Induced Type 2 Diabetes.

Front Immunol 2018 28;9:1069. Epub 2018 May 28.

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.01069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985496PMC
July 2019

Regulatory Immune Mechanisms beyond Regulatory T Cells.

Trends Immunol 2019 Jun 14;40(6):482-491. Epub 2019 May 14.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Research Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2019.04.005DOI Listing
June 2019

Oral insulin does not alter gut microbiota composition of NOD mice.

Diabetes Metab Res Rev 2018 09 1;34(6):e3010. Epub 2018 May 1.

Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1002/dmrr.3010DOI Listing
September 2018

OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration.

Clin Immunol 2018 06 15;191:34-36. Epub 2018 Mar 15.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.03.006DOI Listing
June 2018

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Cell Rep 2018 03;22(10):2667-2676

Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368357PMC
March 2018

Suppression of diabetes by accumulation of non-islet-specific CD8 effector T cells in pancreatic islets.

Sci Immunol 2018 03;3(21)

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/sciimmunol.aam6533DOI Listing
March 2018

The shifting paradigm of a "cure" for type 1 diabetes: is technology replacing immune-based therapies?

Acta Diabetol 2018 Feb 29;55(2):117-120. Epub 2017 Nov 29.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/s00592-017-1069-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816711PMC
February 2018

Antigen-Specific Peptide Immunotherapy for Type 1 Diabetes: Proof of Safety, Hope for Efficacy.

Cell Metab 2017 Oct;26(4):595-597

Type 1 Diabetes Research Center, Novo Nordisk, Seattle, WA, USA; Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92014, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.09.016DOI Listing
October 2017

β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?

Nat Rev Endocrinol 2017 09 7;13(9). Epub 2017 Jul 7.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA; and at the Novo Nordisk Diabetes Research &Development Center, 530 Fairview Ave N # 5000, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1038/nrendo.2017.83DOI Listing
September 2017

Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice.

Diabetologia 2017 08 28;60(8):1475-1482. Epub 2017 Apr 28.

Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID) and Clinical Genomics Program, NIAID, National Institutes of Health, Building 10, Room 11D14, 10 Center Drive, Bethesda, MD, 20814, USA.

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http://link.springer.com/10.1007/s00125-017-4276-5
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http://dx.doi.org/10.1007/s00125-017-4276-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661969PMC
August 2017

Alpha cells, the main source of IL-1β in human pancreas.

J Autoimmun 2017 Jul 18;81:68-73. Epub 2017 Mar 18.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, Washington, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411163026
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http://dx.doi.org/10.1016/j.jaut.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507672PMC
July 2017

Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes.

Diabetes Obes Metab 2017 05 10;19(5):705-712. Epub 2017 Mar 10.

Metabolic Disease Research, Global Research, Novo Nordisk A/S, Måløv, Denmark.

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http://dx.doi.org/10.1111/dom.12879DOI Listing
May 2017

Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process?

Cell Metab 2017 02 10;25(2):233-241. Epub 2016 Nov 10.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92014, USA; Novo Nordisk Diabetes Research and Development Center, Seattle, WA 98191, USA. Electronic address:

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(16)30540-
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http://dx.doi.org/10.1016/j.cmet.2016.10.009DOI Listing
February 2017

Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes.

Cell Transplant 2016 21;25(3):609-14. Epub 2015 Aug 21.

Type 1 Diabetes Center at the La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.

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http://dx.doi.org/10.3727/096368915X688939DOI Listing
December 2016

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.

Diabetologia 2016 11 9;59(11):2448-2458. Epub 2016 Aug 9.

Islet Biology Exeter (IBEx), Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building (Level 4), Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00125-016-4067-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042874PMC
November 2016

CD40L expression by CD4 but not CD8 T cells regulates antiviral immune responses in acute LCMV infection in mice.

Eur J Immunol 2016 11 20;46(11):2566-2573. Epub 2016 Sep 20.

Regenerative Immunology and Aging, Berlin-Brandenburger Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201646420DOI Listing
November 2016

The viral paradigm in type 1 diabetes: Who are the main suspects?

Autoimmun Rev 2016 Oct 1;15(10):964-9. Epub 2016 Aug 1.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2016.07.019DOI Listing
October 2016

A Deeper Look into Type 1 Diabetes - Imaging Immune Responses during Onset of Disease.

Front Immunol 2016 15;7:313. Epub 2016 Aug 15.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Diabetes Research and Development Center, Seattle, WA, USA.

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http://dx.doi.org/10.3389/fimmu.2016.00313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983548PMC
August 2016

Non-antigenic and antigenic interventions in type 1 diabetes.

Hum Vaccin Immunother 2014 28;10(4):838-46. Epub 2013 Oct 28.

Type 1 Diabetes R&D Center; Novo Nordisk Inc.; Seattle, WA USA; Pacific Northwest Diabetes Research Institute; Seattle, WA USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896560PMC
http://dx.doi.org/10.4161/hv.26890DOI Listing
April 2016

Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse.

Clin Immunol 2016 Mar 25;164:28-33. Epub 2016 Jan 25.

Type 1 Diabetes R&D Center, Novo Nordisk Research Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.01.013DOI Listing
March 2016

Recent advances in understanding Type 1 Diabetes.

F1000Res 2016 27;5. Epub 2016 Jan 27.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, 92037, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, Washington, 98109, USA.

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http://dx.doi.org/10.12688/f1000research.7356.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755393PMC
February 2016

BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells.

PLoS One 2014 13;9(11):e112242. Epub 2014 Nov 13.

Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA; Type 1 Diabetes R&D center, Novo Nordisk Inc., Seattle, Washington, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112242PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231041PMC
January 2016

Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes.

Front Immunol 2015 11;6:651. Epub 2016 Jan 11.

Novo Nordisk Research Center , Seattle, WA , USA.

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http://dx.doi.org/10.3389/fimmu.2015.00651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707297PMC
January 2016

Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success.

Clin Immunol 2015 Nov 27;161(1):37-43. Epub 2015 Jun 27.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.05.021DOI Listing
November 2015

New horizons in biomarker research.

Clin Immunol 2015 Nov 15;161(1). Epub 2015 Sep 15.

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http://dx.doi.org/10.1016/j.clim.2015.09.005DOI Listing
November 2015

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase.

J Histochem Cytochem 2015 08;63(8):626-36

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California (TRC, JSS, NA, JZG, FA, SS, MGVH)

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http://dx.doi.org/10.1369/0022155415576543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530397PMC
August 2015

The Hsp60 peptide p277 enhances anti-CD3 mediated diabetes remission in non-obese diabetic mice.

J Autoimmun 2015 May 13;59:61-6. Epub 2015 Mar 13.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Type 1 Diabetes R&D Center, Novo Nordisk, Inc., Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.02.003DOI Listing
May 2015

Enterovirus infection and type 1 diabetes: closing in on a link?

Diabetes 2015 May;64(5):1503-5

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA Novo Nordisk Diabetes Research and Development Center, Seattle, WA

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-1931DOI Listing
May 2015

Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine.

Rev Med Virol 2015 Jan 27;25(1):19-32. Epub 2014 Nov 27.

Department of Medical Microbiology and Immunology, School of Medicine, Creighton University, Omaha, NE, USA.

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http://dx.doi.org/10.1002/rmv.1815DOI Listing
January 2015

Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes.

Diabetes 2014 Nov 19;63(11):3880-90. Epub 2014 Jun 19.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA Novo Nordisk Diabetes Research & Development Center, Seattle, WA

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http://dx.doi.org/10.2337/db14-0549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207385PMC
November 2014

Higher proinflammatory cytokine production and spontaneous activation in some type 1 and type 2 diabetic subjects.

Clin Immunol 2014 Nov 27;155(1):27-9. Epub 2014 Aug 27.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Diabetes Research and Development Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2014.08.007DOI Listing
November 2014

The type 1 diabetes signature: hardwired to trigger inflammation?

Diabetes 2014 Nov;63(11):3581-3

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, CA

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http://dx.doi.org/10.2337/db14-0824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860372PMC
November 2014

Potential viral pathogenic mechanism in human type 1 diabetes.

Diabetologia 2014 Oct 30;57(10):2009-18. Epub 2014 Jul 30.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s00125-014-3340-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153966PMC
October 2014

Regulatory T cells control diabetes without compromising acute anti-viral defense.

Clin Immunol 2014 Aug 22;153(2):298-307. Epub 2014 May 22.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.clim.2014.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889438PMC
August 2014

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10305-10. Epub 2014 Jun 30.

Department of Pediatrics, Herlev University Hospital, 2730 Herlev, Denmark;Glostrup Research Institute, Glostrup University Hospital, 2600 Glostrup, Denmark,Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; and

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http://dx.doi.org/10.1073/pnas.1402571111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104872PMC
July 2014

Metabolic syndrome - Removing roadblocks to therapy: Antigenic immunotherapies.

Mol Metab 2014 Jun 21;3(3):275-83. Epub 2014 Jan 21.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA ; Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.molmet.2013.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986497PMC
June 2014

CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes.

J Autoimmun 2014 May 30;50:77-82. Epub 2013 Dec 30.

La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Type 1 Diabetes R & D Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2013.12.003DOI Listing
May 2014

Clinical potential of antigen-specific therapies in type 1 diabetes.

Rev Diabet Stud 2012 28;9(4):328-37. Epub 2012 Dec 28.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1900/RDS.2012.9.328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740700PMC
January 2014

Trials in type 1 diabetes: Antigen-specific therapies.

Clin Immunol 2013 Dec 15;149(3):345-55. Epub 2013 Feb 15.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.clim.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777514PMC
December 2013

Keeping the patient perspective: Where are we in the world of type 1 diabetes?

Clin Immunol 2013 Dec 9;149(3):265-7. Epub 2013 Aug 9.

University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.clim.2013.08.003DOI Listing
December 2013

Combination therapy with anti-CD6 and oral insulin immunization reverses recent onset diabetes in non obese diabetic mice but fails to induce lasting tolerance.

Clin Immunol 2013 Dec 15;149(3):440-1. Epub 2013 Aug 15.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.clim.2013.08.004DOI Listing
December 2013

The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes.

J Autoimmun 2013 Aug 13;44:40-8. Epub 2013 Jun 13.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2013.05.002DOI Listing
August 2013

The microbiology of human hygiene and its impact on type 1 diabetes.

Islets 2012 Jul-Aug;4(4):253-61. Epub 2012 Jul 1.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.4161/isl.21570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496651PMC
June 2013

Antibody cross-reactivity and the viral aetiology of type 1 diabetes.

J Pathol 2013 May 12;230(1):1-3. Epub 2013 Mar 12.

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http://dx.doi.org/10.1002/path.4174DOI Listing
May 2013

Viruses and Type 1 diabetes: a dynamic labile equilibrium.

Diabetes Manag (Lond) 2013 May;3(3):217-223

Center for Type 1 Diabetes Research, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.2217/dmt.13.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949992PMC
May 2013

NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes.

J Autoimmun 2013 Feb 1;40:66-73. Epub 2012 Sep 1.

Type 1 Diabetes Center of San Diego, La Jolla Institute for Allergy and Immunology, La Jolla, 9420 Athena Circle, San Diego, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2012.08.001DOI Listing
February 2013

Viral infections and molecular mimicry in type 1 diabetes.

APMIS 2012 Dec 11;120(12):941-9. Epub 2012 Oct 11.

Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1111/apm.12011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774991PMC
December 2012

OX40 facilitates control of a persistent virus infection.

PLoS Pathog 2012 Sep 6;8(9):e1002913. Epub 2012 Sep 6.

Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435255PMC
September 2012

Infection as a cause of type 1 diabetes?

Curr Opin Rheumatol 2012 Jul;24(4):417-23

Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1097/BOR.0b013e3283533719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828240PMC
July 2012

IL-7 receptor α blockade, an off-switch for autoreactive T cells.

Proc Natl Acad Sci U S A 2012 Jul 23;109(31):12270-1. Epub 2012 Jul 23.

Department of Internal Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1073/pnas.1209749109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412005PMC
July 2012

Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets.

Immunity 2012 Jun 10;36(6):1060-72. Epub 2012 May 10.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810457PMC
June 2012

TGF-β blockade does not improve control of an established persistent viral infection.

Viral Immunol 2012 Jun 23;25(3):232-8. Epub 2012 May 23.

La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

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http://dx.doi.org/10.1089/vim.2011.0079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366339PMC
June 2012

Can an immune-regulatory vaccine prevent HIV infection?

Expert Rev Anti Infect Ther 2012 Mar;10(3):299-305

Division of Developmental Immunology at the La Jolla Institute for Allergy & Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://www.liai.org/files/Von_Herrath_-_Immune_Regulatory_20
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http://www.tandfonline.com/doi/full/10.1586/eri.11.178
Publisher Site
http://dx.doi.org/10.1586/eri.11.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318911PMC
March 2012

Motifs for a deadly encounter.

Nat Immunol 2012 Feb 16;13(3):205-6. Epub 2012 Feb 16.

Unit for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1038/ni.2226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679406PMC
February 2012

Intravital imaging of CTLs killing islet cells in diabetic mice.

J Clin Invest 2012 Jan 1;122(1):119-31. Epub 2011 Dec 1.

Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

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http://dx.doi.org/10.1172/JCI59285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248300PMC
January 2012

Unraveling the autoimmune translational research process layer by layer.

Nat Med 2012 Jan 6;18(1):35-41. Epub 2012 Jan 6.

Division of Gastroenterology and Hepatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.2632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592149PMC
January 2012

Virus infections in type 1 diabetes.

Cold Spring Harb Perspect Med 2012 Jan;2(1):a007682

Center for Type 1 Diabetes Research, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/cshperspect.a007682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253029PMC
January 2012

Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment.

J Autoimmun 2011 Dec 6;37(4):342-51. Epub 2011 Nov 6.

Diabetes Center, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2011.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811160PMC
December 2011

Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals.

Diabetes Metab Res Rev 2011 Nov;27(8):746-54

Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/dmrr.1246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706467PMC
November 2011

Viruses and cytotoxic T lymphocytes in type 1 diabetes.

Clin Rev Allergy Immunol 2011 Oct;41(2):169-78

Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, CA, 92037, USA.

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http://dx.doi.org/10.1007/s12016-010-8220-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676523PMC
October 2011

Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.

J Immunol 2011 Sep 10;187(6):2915-22. Epub 2011 Aug 10.

Diabetes Center of San Diego, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.1000180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169711PMC
September 2011

2011 Update: antigen-specific therapy in type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2011 Aug;18(4):235-40

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1097/MED.0b013e32834803aeDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016762PMC
August 2011

Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

Cell Mol Immunol 2011 May 24;8(3):193-8. Epub 2011 Jan 24.

Pharmazentrum Frankfurt/ZAFES, Klinikum der Goethe Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/cmi.2010.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012874PMC
May 2011

Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis.

J Autoimmun 2011 May 17;36(3-4):210-20. Epub 2011 Feb 17.

Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2011.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079777PMC
May 2011

TLR2 signaling improves immunoregulation to prevent type 1 diabetes.

Eur J Immunol 2011 May;41(5):1399-409

La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/eji.200939841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100206PMC
May 2011

Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.

J Immunol 2011 Sep 10;187(6):2915-22. Epub 2011 Aug 10.

Diabetes Center of San Diego, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.1000180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169711PMC
September 2011

Humanizing animal models: a key to autoimmune diabetes treatment.

Sci Transl Med 2011 Feb;3(68):68ps4

Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scitranslmed.3002102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137650PMC
February 2011

Beta cells under attack: toward a better understanding of type 1 diabetes immunopathology.

Semin Immunopathol 2011 Jan 18;33(1):1-7. Epub 2010 Dec 18.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s00281-010-0236-6DOI Listing
January 2011

Type 1 diabetes: etiology, immunology, and therapeutic strategies.

Physiol Rev 2011 Jan;91(1):79-118

Center for Type 1 Diabetes Research, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1152/physrev.00003.2010DOI Listing
January 2011

A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy.

PLoS One 2010 Dec 23;5(12):e15732. Epub 2010 Dec 23.

Type 1 Diabetes Center at the La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015732PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009738PMC
December 2010