Publications by authors named "Matthias von Herrath"

230 Publications

Current and future therapies for type 1 diabetes.

Authors:
Bernt Johan von Scholten Frederik F Kreiner Stephen C L Gough Matthias von Herrath

Diabetologia 2021 Feb 17. Epub 2021 Feb 17.

Global Chief Medical Office, Novo Nordisk A/S, Søborg, Denmark.

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February 2021

New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes.

Authors:
Christine Bender Sakthi Rajendran Matthias G von Herrath

Front Endocrinol (Lausanne) 2020 5;11:606434. Epub 2021 Jan 5.

Center for Autoimmunity and Inflammation, Type 1 Diabetes Center at La Jolla Institute for Immunology, La Jolla, CA, United States.

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January 2021

One in Ten CD8 Cells in the Pancreas of Living Individuals With Recent-Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI.

Authors:
Teresa Rodriguez-Calvo Lars Krogvold Natalie Amirian Knut Dahl-Jørgensen Matthias von Herrath

Diabetes 2021 Mar 7;70(3):752-758. Epub 2021 Jan 7.

La Jolla Institute for Immunology, La Jolla, CA.

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March 2021

The effect of Toll-like receptor stimulation on the motility of regulatory T cells.

Authors:
Grzegorz Chodaczek Philippe P Pagni Gustaf Christoffersson Sowbarnika S Ratliff Monika Toporkiewicz Agnieszka S Wegrzyn Matthias von Herrath

J Autoimmun 2021 Jan 12;116:102563. Epub 2020 Nov 12.

Type 1 Diabetes Center, La Jolla Institute for Immunology, La Jolla, CA, USA.

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January 2021

Corona Pandemic: Assisted Isolation and Care to Protect Vulnerable Populations May Allow Us to Shorten the Universal Lock-Down and Gradually Re-open Society.

Authors:
Johnny Ludvigsson Matthias G von Herrath Roberto Mallone Karsten Buschard Corrado Cilio Maria Craig Jorma Ilonen David Leslie Julie E M McGeoch Darius Schneider Jay S Skyler Malin Flodström Tullberg Didier Hober

Front Public Health 2020 30;8:562901. Epub 2020 Sep 30.

Université de Lille, CHU Lille, Laboratoire de Virologie-ULR3610, Lille, France.

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September 2020

The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes.

Authors:
Christine Bender Teresa Rodriguez-Calvo Natalie Amirian Ken T Coppieters Matthias G von Herrath

Sci Adv 2020 Oct 16;6(42). Epub 2020 Oct 16.

Center for Type 1 Diabetes Research, La Jolla Institute for Immunology, La Jolla, CA, USA.

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October 2020

Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice.

Authors:
Gustaf Christoffersson Sowbarnika S Ratliff Matthias G von Herrath

Sci Adv 2020 Aug 26;6(35). Epub 2020 Aug 26.

La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

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August 2020

Long-term viability through selective permeability.

Authors:
Ken Coppieters Louise Winkel Matthias von Herrath

Nat Biomed Eng 2020 08;4(8):763-764

Chief Medical Office, Novo Nordisk A/S, Søborg, Denmark.

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August 2020

The urgent need for integrated science to fight COVID-19 pandemic and beyond.

Authors:
Negar Moradian Hans D Ochs Constantine Sedikies Michael R Hamblin Carlos A Camargo J Alfredo Martinez Jacob D Biamonte Mohammad Abdollahi Pedro J Torres Juan J Nieto Shuji Ogino John F Seymour Ajith Abraham Valentina Cauda Sudhir Gupta Seeram Ramakrishna Frank W Sellke Armin Sorooshian A Wallace Hayes Maria Martinez-Urbistondo Manoj Gupta Leila Azadbakht Ahmad Esmaillzadeh Roya Kelishadi Alireza Esteghamati Zahra Emam-Djomeh Reza Majdzadeh Partha Palit Hamid Badali Idupulapati Rao Ali Akbar Saboury L Jagan Mohan Rao Hamid Ahmadieh Ali Montazeri Gian Paolo Fadini Daniel Pauly Sabu Thomas Ali A Moosavi-Movahed Asghar Aghamohammadi Mehrdad Behmanesh Vafa Rahimi-Movaghar Saeid Ghavami Roxana Mehran Lucina Q Uddin Matthias Von Herrath Bahram Mobasher Nima Rezaei

J Transl Med 2020 05 19;18(1):205. Epub 2020 May 19.

Universal Scientific Education and Research Network (USERN), , .

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May 2020

IL-4R is expressed on alpha and beta cells of human pancreata.

Authors:
Sakthi Rajendran Madeleine Graef Tiffany Chu Matthias von Herrath

Clin Immunol 2020 05 26;214:108394. Epub 2020 Mar 26.

La Jolla Institute for Immunology, La Jolla, CA, United States of America. Electronic address:

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May 2020

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.

Authors:
Melanie R Shapiro Clive H Wasserfall Sean M McGrail Amanda L Posgai Rhonda Bacher Andrew Muir Michael J Haller Desmond A Schatz Johnna D Wesley Matthias von Herrath William A Hagopian Cate Speake Mark A Atkinson Todd M Brusko

Diabetes 2020 03 11;69(3):413-423. Epub 2019 Dec 11.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL

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March 2020

Human herpesvirus-6 is present at higher levels in the pancreatic tissues of donors with type 1 diabetes.

Authors:
Somayeh Sabouri Mehdi A Benkahla William B Kiosses Teresa Rodriguez-Calvo Jose Zapardiel-Gonzalo Ericka Castillo Matthias G von Herrath

J Autoimmun 2020 02 6;107:102378. Epub 2019 Dec 6.

Type 1 Diabetes Center, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA. Electronic address:

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February 2020

IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes.

Authors:
Sakthi Rajendran Florence Anquetil Estefania Quesada-Masachs Madeleine Graef Nathaly Gonzalez Sara McArdle Tiffany Chu Lars Krogvold Knut Dahl-Jørgensen Matthias von Herrath

Clin Immunol 2020 02 3;211:108320. Epub 2019 Dec 3.

La Jolla Institute for Immunology, La Jolla, CA, United States of America. Electronic address:

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February 2020

Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study.

Authors:
Cate Speake Henry T Bahnson Johnna D Wesley Nikole Perdue David Friedrich Minh N Pham Erinn Lanxon-Cookson William W Kwok Birgit Sehested Hansen Matthias von Herrath Carla J Greenbaum

Front Immunol 2019 13;10:2023. Epub 2019 Sep 13.

Benaroya Research Institute at Virginia Mason, Seattle, WA, United States.

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October 2020

CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor.

Authors:
Philippe P Pagni Anitra Wolf Mauro Lo Conte Ronald Yeh Guangsen Fu Fa Liu Matthias von Herrath Ken Coppieters

Diabetologia 2019 09 17;62(9):1727-1729. Epub 2019 May 17.

Novo Nordisk A/S Research Projects, Novo Nordisk Park, DK-2760, Måløv, Denmark.

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September 2019

Regulatory Immune Mechanisms beyond Regulatory T Cells.

Authors:
Gustaf Christoffersson Matthias von Herrath

Trends Immunol 2019 06 14;40(6):482-491. Epub 2019 May 14.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Research Center, Seattle, WA, USA. Electronic address:

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June 2019

Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes.

Authors:
Matthias von Herrath Philippe P Pagni Kevin Grove Gustaf Christoffersson Mads Tang-Christensen Allan Ertmann Karlsen Jacob Sten Petersen

Cell Metab 2019 04 14;29(4):795-802. Epub 2019 Mar 14.

Novo Nordisk A/S, Måløv, Denmark.

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April 2019

The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes.

Authors:
Ken Coppieters Matthias von Herrath

Front Med (Lausanne) 2018 9;5:283. Epub 2018 Oct 9.

Novo Nordisk (Denmark), Copenhagen, Denmark.

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October 2018

Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.

Authors:
Florence Anquetil Giada Mondanelli Nathaly Gonzalez Teresa Rodriguez Calvo Jose Zapardiel Gonzalo Lars Krogvold Knut Dahl-Jørgensen Benoit Van den Eynde Ciriana Orabona Ursula Grohmann Matthias G von Herrath

Diabetes 2018 09 26;67(9):1858-1866. Epub 2018 Jun 26.

La Jolla Institute for Allergy and Immunology, La Jolla, CA

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September 2018

Distinct Housing Conditions Reveal a Major Impact of Adaptive Immunity on the Course of Obesity-Induced Type 2 Diabetes.

Authors:
Julia Sbierski-Kind Jonas Kath Sebastian Brachs Mathias Streitz Matthias G von Herrath Anja A Kühl Katharina Schmidt-Bleek Knut Mai Joachim Spranger Hans-Dieter Volk

Front Immunol 2018 28;9:1069. Epub 2018 May 28.

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

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July 2019

Oral insulin does not alter gut microbiota composition of NOD mice.

Authors:
Pernille Kihl Lukasz Krych Karsten Buschard Johnna D Wesley Witold Kot Axel Kornerup Hansen Dennis S Nielsen Matthias G von Herrath

Diabetes Metab Res Rev 2018 09 1;34(6):e3010. Epub 2018 May 1.

Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.

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September 2018

Suppression of diabetes by accumulation of non-islet-specific CD8 effector T cells in pancreatic islets.

Authors:
Gustaf Christoffersson Grzegorz Chodaczek Sowbarnika S Ratliff Ken Coppieters Matthias G von Herrath

Sci Immunol 2018 03;3(21)

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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March 2018

Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications.

Authors:
John Sidney Jose Luis Vela Dave Friedrich Ravi Kolla Matthias von Herrath Johnna D Wesley Alessandro Sette

BMC Immunol 2018 03 21;19(1):12. Epub 2018 Mar 21.

La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92130, USA.

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March 2018

OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration.

Authors:
Somayeh Sabouri Zbigniew Mikulski Matthias G von Herrath

Clin Immunol 2018 06 15;191:34-36. Epub 2018 Mar 15.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, Washington, USA. Electronic address:

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June 2018

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Authors:
Marcela Brissova Rachana Haliyur Diane Saunders Shristi Shrestha Chunhua Dai David M Blodgett Rita Bottino Martha Campbell-Thompson Radhika Aramandla Gregory Poffenberger Jill Lindner Fong Cheng Pan Matthias G von Herrath Dale L Greiner Leonard D Shultz May Sanyoura Louis H Philipson Mark Atkinson David M Harlan Shawn E Levy Nripesh Prasad Roland Stein Alvin C Powers

Cell Rep 2018 03;22(10):2667-2676

Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. Electronic address:

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March 2018

The shifting paradigm of a "cure" for type 1 diabetes: is technology replacing immune-based therapies?

Authors:
Jeremy Pettus Matthias Von Herrath

Acta Diabetol 2018 Feb 29;55(2):117-120. Epub 2017 Nov 29.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.

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February 2018

Antigen-Specific Peptide Immunotherapy for Type 1 Diabetes: Proof of Safety, Hope for Efficacy.

Authors:
Ken Coppieters Matthias von Herrath

Cell Metab 2017 Oct;26(4):595-597

Type 1 Diabetes Research Center, Novo Nordisk, Seattle, WA, USA; Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92014, USA. Electronic address:

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October 2017

Response to Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334-1345.

Authors:
Teresa Rodriguez-Calvo Mark Atkinson Matthias G von Herrath

Diabetes 2017 09;66(9):e10-e11

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA

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September 2017

Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes.

Authors:
Anna K Rydén Nikole R Perdue Philippe P Pagni Claire B Gibson Sowbarnika S Ratliff Rikke K Kirk Travis J Friesen Claus Haase Ken Coppieters Matthias G von Herrath Tamar E Boursalian

J Autoimmun 2017 Nov 12;84:65-74. Epub 2017 Jul 12.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA. Electronic address:

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November 2017

β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?

Authors:
Teresa Rodriguez-Calvo Mark Atkinson Matthias von Herrath

Nat Rev Endocrinol 2017 09 7;13(9). Epub 2017 Jul 7.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA; and at the Novo Nordisk Diabetes Research &Development Center, 530 Fairview Ave N # 5000, Seattle, Washington 98109, USA.

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September 2017