Matthias von Herrath

Matthias von Herrath

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Matthias von Herrath

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CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor.

Authors:
Philippe P Pagni Anitra Wolf Mauro Lo Conte Ronald Yeh Guangsen Fu Fa Liu Matthias von Herrath Ken Coppieters

Diabetologia 2019 Sep 17;62(9):1727-1729. Epub 2019 May 17.

Novo Nordisk A/S Research Projects, Novo Nordisk Park, DK-2760, Måløv, Denmark.

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http://dx.doi.org/10.1007/s00125-019-4893-2DOI Listing
September 2019

Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study.

Authors:
Cate Speake Henry T Bahnson Johnna D Wesley Nikole Perdue David Friedrich Minh N Pham Erinn Lanxon-Cookson William W Kwok Birgit Sehested Hansen Matthias von Herrath Carla J Greenbaum

Front Immunol 2019 13;10:2023. Epub 2019 Sep 13.

Benaroya Research Institute at Virginia Mason, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.02023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753618PMC
September 2019

Distinct Housing Conditions Reveal a Major Impact of Adaptive Immunity on the Course of Obesity-Induced Type 2 Diabetes.

Authors:
Julia Sbierski-Kind Jonas Kath Sebastian Brachs Mathias Streitz Matthias G von Herrath Anja A Kühl Katharina Schmidt-Bleek Knut Mai Joachim Spranger Hans-Dieter Volk

Front Immunol 2018 28;9:1069. Epub 2018 May 28.

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.01069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985496PMC
July 2019

Regulatory Immune Mechanisms beyond Regulatory T Cells.

Authors:
Gustaf Christoffersson Matthias von Herrath

Trends Immunol 2019 Jun 14;40(6):482-491. Epub 2019 May 14.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Research Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2019.04.005DOI Listing
June 2019

Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes.

Authors:
Matthias von Herrath Philippe P Pagni Kevin Grove Gustaf Christoffersson Mads Tang-Christensen Allan Ertmann Karlsen Jacob Sten Petersen

Cell Metab 2019 Apr 14;29(4):795-802. Epub 2019 Mar 14.

Novo Nordisk A/S, Måløv, Denmark.

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http://dx.doi.org/10.1016/j.cmet.2019.02.004DOI Listing
April 2019

The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes.

Authors:
Ken Coppieters Matthias von Herrath

Front Med (Lausanne) 2018 9;5:283. Epub 2018 Oct 9.

Novo Nordisk (Denmark), Copenhagen, Denmark.

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https://www.frontiersin.org/article/10.3389/fmed.2018.00283/
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http://dx.doi.org/10.3389/fmed.2018.00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189286PMC
October 2018

Oral insulin does not alter gut microbiota composition of NOD mice.

Authors:
Pernille Kihl Lukasz Krych Karsten Buschard Johnna D Wesley Witold Kot Axel Kornerup Hansen Dennis S Nielsen Matthias G von Herrath

Diabetes Metab Res Rev 2018 09 1;34(6):e3010. Epub 2018 May 1.

Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1002/dmrr.3010DOI Listing
September 2018

Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.

Authors:
Florence Anquetil Giada Mondanelli Nathaly Gonzalez Teresa Rodriguez Calvo Jose Zapardiel Gonzalo Lars Krogvold Knut Dahl-Jørgensen Benoit Van den Eynde Ciriana Orabona Ursula Grohmann Matthias G von Herrath

Diabetes 2018 09 26;67(9):1858-1866. Epub 2018 Jun 26.

La Jolla Institute for Allergy and Immunology, La Jolla, CA

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http://dx.doi.org/10.2337/db17-1281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110313PMC
September 2018

OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration.

Authors:
Somayeh Sabouri Zbigniew Mikulski Matthias G von Herrath

Clin Immunol 2018 06 15;191:34-36. Epub 2018 Mar 15.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.03.006DOI Listing
June 2018

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Authors:
Marcela Brissova Rachana Haliyur Diane Saunders Shristi Shrestha Chunhua Dai David M Blodgett Rita Bottino Martha Campbell-Thompson Radhika Aramandla Gregory Poffenberger Jill Lindner Fong Cheng Pan Matthias G von Herrath Dale L Greiner Leonard D Shultz May Sanyoura Louis H Philipson Mark Atkinson David M Harlan Shawn E Levy Nripesh Prasad Roland Stein Alvin C Powers

Cell Rep 2018 03;22(10):2667-2676

Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368357PMC
March 2018

Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications.

Authors:
John Sidney Jose Luis Vela Dave Friedrich Ravi Kolla Matthias von Herrath Johnna D Wesley Alessandro Sette

BMC Immunol 2018 03 21;19(1):12. Epub 2018 Mar 21.

La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92130, USA.

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http://dx.doi.org/10.1186/s12865-018-0250-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863483PMC
March 2018

Suppression of diabetes by accumulation of non-islet-specific CD8 effector T cells in pancreatic islets.

Authors:
Gustaf Christoffersson Grzegorz Chodaczek Sowbarnika S Ratliff Ken Coppieters Matthias G von Herrath

Sci Immunol 2018 03;3(21)

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/sciimmunol.aam6533DOI Listing
March 2018

The shifting paradigm of a "cure" for type 1 diabetes: is technology replacing immune-based therapies?

Authors:
Jeremy Pettus Matthias Von Herrath

Acta Diabetol 2018 Feb 29;55(2):117-120. Epub 2017 Nov 29.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/s00592-017-1069-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816711PMC
February 2018

Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes.

Authors:
Anna K Rydén Nikole R Perdue Philippe P Pagni Claire B Gibson Sowbarnika S Ratliff Rikke K Kirk Travis J Friesen Claus Haase Ken Coppieters Matthias G von Herrath Tamar E Boursalian

J Autoimmun 2017 Nov 12;84:65-74. Epub 2017 Jul 12.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.07.006DOI Listing
November 2017

Antigen-Specific Peptide Immunotherapy for Type 1 Diabetes: Proof of Safety, Hope for Efficacy.

Authors:
Ken Coppieters Matthias von Herrath

Cell Metab 2017 Oct;26(4):595-597

Type 1 Diabetes Research Center, Novo Nordisk, Seattle, WA, USA; Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92014, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.09.016DOI Listing
October 2017

β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?

Authors:
Teresa Rodriguez-Calvo Mark Atkinson Matthias von Herrath

Nat Rev Endocrinol 2017 09 7;13(9). Epub 2017 Jul 7.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA; and at the Novo Nordisk Diabetes Research &Development Center, 530 Fairview Ave N # 5000, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1038/nrendo.2017.83DOI Listing
September 2017

Response to Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334-1345.

Authors:
Teresa Rodriguez-Calvo Mark Atkinson Matthias G von Herrath

Diabetes 2017 09;66(9):e10-e11

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA

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http://dx.doi.org/10.2337/dbi17-0029DOI Listing
September 2017

Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice.

Authors:
Juha Grönholm Philippe P Pagni Minh N Pham Claire B Gibson Paul F Macomber José Luis Vela Matthias von Herrath Michael J Lenardo

Diabetologia 2017 08 28;60(8):1475-1482. Epub 2017 Apr 28.

Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID) and Clinical Genomics Program, NIAID, National Institutes of Health, Building 10, Room 11D14, 10 Center Drive, Bethesda, MD, 20814, USA.

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http://link.springer.com/10.1007/s00125-017-4276-5
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http://dx.doi.org/10.1007/s00125-017-4276-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661969PMC
August 2017

Alpha cells, the main source of IL-1β in human pancreas.

Authors:
Florence Anquetil Somayeh Sabouri Charles Thivolet Teresa Rodriguez-Calvo Jose Zapardiel-Gonzalo Natalie Amirian Darius Schneider Ericka Castillo Yasaman Lajevardi Matthias G von Herrath

J Autoimmun 2017 Jul 18;81:68-73. Epub 2017 Mar 18.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, Washington, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411163026
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http://dx.doi.org/10.1016/j.jaut.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507672PMC
July 2017

Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes.

Authors:
Rikke K Kirk Charles Pyke Matthias G von Herrath Jane P Hasselby Lars Pedersen Pia G Mortensen Lotte B Knudsen Ken Coppieters

Diabetes Obes Metab 2017 05 10;19(5):705-712. Epub 2017 Mar 10.

Metabolic Disease Research, Global Research, Novo Nordisk A/S, Måløv, Denmark.

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http://dx.doi.org/10.1111/dom.12879DOI Listing
May 2017

Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset.

Authors:
Teresa Rodriguez-Calvo Jose Zapardiel-Gonzalo Natalie Amirian Ericka Castillo Yasaman Lajevardi Lars Krogvold Knut Dahl-Jørgensen Matthias G von Herrath

Diabetes 2017 05 30;66(5):1334-1345. Epub 2017 Jan 30.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db16
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http://dx.doi.org/10.2337/db16-1343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399615PMC
May 2017

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Authors:
Martha L Campbell-Thompson Mark A Atkinson Alexandra E Butler Ben N Giepmans Matthias G von Herrath Heikki Hyöty Thomas W Kay Noel G Morgan Alvin C Powers Alberto Pugliese Sarah J Richardson Peter A In't Veld

Diabetologia 2017 04 9;60(4):753-755. Epub 2017 Jan 9.

Department of Pathology, Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.

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http://link.springer.com/10.1007/s00125-016-4195-x
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http://dx.doi.org/10.1007/s00125-016-4195-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415083PMC
April 2017

Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process?

Authors:
Hubert Kolb Matthias von Herrath

Cell Metab 2017 02 10;25(2):233-241. Epub 2016 Nov 10.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92014, USA; Novo Nordisk Diabetes Research and Development Center, Seattle, WA 98191, USA. Electronic address:

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(16)30540-
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http://dx.doi.org/10.1016/j.cmet.2016.10.009DOI Listing
February 2017

Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes.

Authors:
Tobias Boettler Darius Schneider Yang Cheng Kuniko Kadoya Eugene P Brandon Laura Martinson Matthias von Herrath

Cell Transplant 2016 21;25(3):609-14. Epub 2015 Aug 21.

Type 1 Diabetes Center at the La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.

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http://dx.doi.org/10.3727/096368915X688939DOI Listing
December 2016

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.

Authors:
Sarah J Richardson Teresa Rodriguez-Calvo Ivan C Gerling Clayton E Mathews John S Kaddis Mark A Russell Marie Zeissler Pia Leete Lars Krogvold Knut Dahl-Jørgensen Matthias von Herrath Alberto Pugliese Mark A Atkinson Noel G Morgan

Diabetologia 2016 11 9;59(11):2448-2458. Epub 2016 Aug 9.

Islet Biology Exeter (IBEx), Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building (Level 4), Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00125-016-4067-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042874PMC
November 2016

CD40L expression by CD4 but not CD8 T cells regulates antiviral immune responses in acute LCMV infection in mice.

Authors:
Sibel Durlanik Lucie Loyal Regina Stark Özen Sercan Alp Anett Hartung Andreas Radbruch Matthias von Herrath Nadine Matzmohr Marco Frentsch Andreas Thiel

Eur J Immunol 2016 11 20;46(11):2566-2573. Epub 2016 Sep 20.

Regenerative Immunology and Aging, Berlin-Brandenburger Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201646420DOI Listing
November 2016

The viral paradigm in type 1 diabetes: Who are the main suspects?

Authors:
Teresa Rodriguez-Calvo Somayeh Sabouri Florence Anquetil Matthias G von Herrath

Autoimmun Rev 2016 Oct 1;15(10):964-9. Epub 2016 Aug 1.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2016.07.019DOI Listing
October 2016

A Deeper Look into Type 1 Diabetes - Imaging Immune Responses during Onset of Disease.

Authors:
Gustaf Christoffersson Matthias G von Herrath

Front Immunol 2016 15;7:313. Epub 2016 Aug 15.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Diabetes Research and Development Center, Seattle, WA, USA.

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http://dx.doi.org/10.3389/fimmu.2016.00313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983548PMC
August 2016

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.

Authors:
Ronald G Gill Philippe P Pagni Tinalyn Kupfer Clive H Wasserfall Songyan Deng Amanda Posgai Yulia Manenkova Amira Bel Hani Laura Straub Philip Bernstein Mark A Atkinson Kevan C Herold Matthias von Herrath Teodora Staeva Mario R Ehlers Gerald T Nepom

Diabetes 2016 05 30;65(5):1310-6. Epub 2015 Dec 30.

Benaroya Research Institute, Seattle, WA.

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http://dx.doi.org/10.2337/db15-0492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860426PMC
May 2016

Non-antigenic and antigenic interventions in type 1 diabetes.

Authors:
Anna K E Rydén Johnna D Wesley Ken T Coppieters Matthias G Von Herrath

Hum Vaccin Immunother 2014 28;10(4):838-46. Epub 2013 Oct 28.

Type 1 Diabetes R&D Center; Novo Nordisk Inc.; Seattle, WA USA; Pacific Northwest Diabetes Research Institute; Seattle, WA USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896560PMC
http://dx.doi.org/10.4161/hv.26890DOI Listing
April 2016

Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells.

Authors:
Carmen Baca Jones Christophe Filippi Sowbarnika Sachithanantham Teresa Rodriguez-Calvo Katrin Ehrhardt Matthias von Herrath

PLoS One 2014 10;9(3):e90855. Epub 2014 Mar 10.

Type 1 Diabetes Center, Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090855PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948950PMC
March 2016

Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse.

Authors:
Minh N Pham Claire Gibson Anna K E Rydén Nikole Perdue Tamar E Boursalian Philippe P Pagni Ken Coppieters Christian Skonberg Trine Porsgaard Matthias von Herrath Jose Luis Vela

Clin Immunol 2016 Mar 25;164:28-33. Epub 2016 Jan 25.

Type 1 Diabetes R&D Center, Novo Nordisk Research Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.01.013DOI Listing
March 2016

Recent advances in understanding Type 1 Diabetes.

Authors:
Gustaf Christoffersson Teresa Rodriguez-Calvo Matthias von Herrath

F1000Res 2016 27;5. Epub 2016 Jan 27.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, 92037, USA; Novo Nordisk Diabetes Research & Development Center, Seattle, Washington, 98109, USA.

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http://dx.doi.org/10.12688/f1000research.7356.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755393PMC
February 2016

BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells.

Authors:
Ghanashyam Sarikonda Georgia Fousteri Sowbarnika Sachithanantham Jacqueline F Miller Amy Dave Therese Juntti Ken T Coppieters Matthias von Herrath

PLoS One 2014 13;9(11):e112242. Epub 2014 Nov 13.

Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA; Type 1 Diabetes R&D center, Novo Nordisk Inc., Seattle, Washington, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112242PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231041PMC
January 2016

Erratum. Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes. Diabetes 2014;63:3880-3890.

Authors:
Teresa Rodriguez-Calvo Olov Ekwall Natalie Amirian Jose Zapardiel-Gonzalo Matthias G von Herrath

Diabetes 2016 Jan;65(1):303

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http://dx.doi.org/10.2337/db16-er01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877679PMC
January 2016

Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes.

Authors:
Minh N Pham Matthias G von Herrath Jose Luis Vela

Front Immunol 2015 11;6:651. Epub 2016 Jan 11.

Novo Nordisk Research Center , Seattle, WA , USA.

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http://dx.doi.org/10.3389/fimmu.2015.00651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707297PMC
January 2016

Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success.

Authors:
Niels V Rekers Matthias G von Herrath Johnna D Wesley

Clin Immunol 2015 Nov 27;161(1):37-43. Epub 2015 Jun 27.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.05.021DOI Listing
November 2015

New horizons in biomarker research.

Authors:
Matthias Von Herrath Wael N Jarjour

Clin Immunol 2015 Nov 15;161(1). Epub 2015 Sep 15.

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http://dx.doi.org/10.1016/j.clim.2015.09.005DOI Listing
November 2015

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase.

Authors:
Teresa Rodriguez-Calvo Jessica S Suwandi Natalie Amirian Jose Zapardiel-Gonzalo Florence Anquetil Somayeh Sabouri Matthias G von Herrath

J Histochem Cytochem 2015 08;63(8):626-36

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California (TRC, JSS, NA, JZG, FA, SS, MGVH)

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http://dx.doi.org/10.1369/0022155415576543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530397PMC
August 2015

Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease.

Authors:
Mark A Atkinson Matthias von Herrath Alvin C Powers Michael Clare-Salzler

Diabetes Care 2015 Jun;38(6):979-88

Department of Pathology, University of Florida, Gainesville, FL.

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http://dx.doi.org/10.2337/dc15-0144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439528PMC
June 2015

The Hsp60 peptide p277 enhances anti-CD3 mediated diabetes remission in non-obese diabetic mice.

Authors:
Ghanashyam Sarikonda Sowbarnika Sachithanantham Jacqueline F Miller Philippe P Pagni Ken T Coppieters Matthias von Herrath

J Autoimmun 2015 May 13;59:61-6. Epub 2015 Mar 13.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Type 1 Diabetes R&D Center, Novo Nordisk, Inc., Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.02.003DOI Listing
May 2015

Enterovirus infection and type 1 diabetes: closing in on a link?

Authors:
Teresa Rodriguez-Calvo Matthias G von Herrath

Diabetes 2015 May;64(5):1503-5

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA Novo Nordisk Diabetes Research and Development Center, Seattle, WA

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-1931DOI Listing
May 2015

Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during type 1 diabetes.

Authors:
Linda Yip Rebecca Fuhlbrigge Cariel Taylor Remi J Creusot Teppei Nishikawa-Matsumura Chan C Whiting Jill M Schartner Rahima Akter Matthias von Herrath C Garrison Fathman

Diabetes 2015 Feb 3;64(2):604-17. Epub 2014 Sep 3.

Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA.

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http://dx.doi.org/10.2337/db14-0803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303971PMC
February 2015

Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine.

Authors:
Kristen M Drescher Matthias von Herrath Steven Tracy

Rev Med Virol 2015 Jan 27;25(1):19-32. Epub 2014 Nov 27.

Department of Medical Microbiology and Immunology, School of Medicine, Creighton University, Omaha, NE, USA.

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http://dx.doi.org/10.1002/rmv.1815DOI Listing
January 2015

Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes.

Authors:
Tom L Van Belle Philippe P Pagni Jeanette Liao Sowbarnika Sachithanantham Amy Dave Amira Bel Hani Yulia Manenkova Natalie Amirian Cheng Yang Bret Morin Haiqing Zhang Iain L Campbell Matthias G von Herrath

J Autoimmun 2014 Dec 26;55:24-32. Epub 2014 Feb 26.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2014.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143487PMC
December 2014

Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes.

Authors:
Teresa Rodriguez-Calvo Olov Ekwall Natalie Amirian Jose Zapardiel-Gonzalo Matthias G von Herrath

Diabetes 2014 Nov 19;63(11):3880-90. Epub 2014 Jun 19.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA Novo Nordisk Diabetes Research & Development Center, Seattle, WA

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http://dx.doi.org/10.2337/db14-0549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207385PMC
November 2014

Higher proinflammatory cytokine production and spontaneous activation in some type 1 and type 2 diabetic subjects.

Authors:
Ghanashyam Sarikonda Sowbarnika Sachithanantham Jeremy Pettus Teresa Rodriguez-Calvo Sonal Phatak Steve Edelman Matthias von Herrath

Clin Immunol 2014 Nov 27;155(1):27-9. Epub 2014 Aug 27.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Diabetes Research and Development Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2014.08.007DOI Listing
November 2014

The type 1 diabetes signature: hardwired to trigger inflammation?

Authors:
Ken T Coppieters Matthias G von Herrath

Diabetes 2014 Nov;63(11):3581-3

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, CA

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http://dx.doi.org/10.2337/db14-0824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860372PMC
November 2014

Potential viral pathogenic mechanism in human type 1 diabetes.

Authors:
Darius A Schneider Matthias G von Herrath

Diabetologia 2014 Oct 30;57(10):2009-18. Epub 2014 Jul 30.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s00125-014-3340-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153966PMC
October 2014

Temporal intra-individual variation of immunological biomarkers in type 1 diabetes patients: implications for future use in cross-sectional assessment.

Authors:
Ghanashyam Sarikonda Jeremy Pettus Sowbarnika Sachithanantham Sonal Phatak Jacqueline F Miller Lakshmi Ganesan Ji Chae Ronna Mallios Steve Edelman Bjoern Peters Matthias von Herrath

PLoS One 2013 4;8(11):e79383. Epub 2013 Nov 4.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079383PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817042PMC
August 2014

Regulatory T cells control diabetes without compromising acute anti-viral defense.

Authors:
Carmen Baca Jones Philippe P Pagni Georgia Fousteri Sowbarnika Sachithanantham Amy Dave Teresa Rodriguez-Calvo Jacqueline Miller Matthias von Herrath

Clin Immunol 2014 Aug 22;153(2):298-307. Epub 2014 May 22.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.clim.2014.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889438PMC
August 2014

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.

Authors:
Tina Fløyel Caroline Brorsson Lotte B Nielsen Michela Miani Claus Heiner Bang-Berthelsen Martin Friedrichsen Anne Julie Overgaard Lukas A Berchtold Anna Wiberg Pernille Poulsen Lars Hansen Silke Rosinger Bernhard O Boehm Ramesh Ram Quang Nguyen Munish Mehta Grant Morahan Patrick Concannon Regine Bergholdt Jens H Nielsen Thomas Reinheckel Matthias von Herrath Allan Vaag Decio Laks Eizirik Henrik B Mortensen Joachim Størling Flemming Pociot

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10305-10. Epub 2014 Jun 30.

Department of Pediatrics, Herlev University Hospital, 2730 Herlev, Denmark;Glostrup Research Institute, Glostrup University Hospital, 2600 Glostrup, Denmark,Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; and

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http://dx.doi.org/10.1073/pnas.1402571111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104872PMC
July 2014

Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model.

Authors:
Philippe P Pagni Damien Bresson Teresa Rodriguez-Calvo Amira Bel Hani Yulia Manenkova Natalie Amirian Alecia Blaszczak Sina Faton Sowbarnika Sachithanantham Matthias G von Herrath

Diabetes 2014 Jun 11;63(6):2015-25. Epub 2014 Feb 11.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db13-12
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http://dx.doi.org/10.2337/db13-1257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030110PMC
June 2014

Metabolic syndrome - Removing roadblocks to therapy: Antigenic immunotherapies.

Authors:
Ken T Coppieters Matthias G von Herrath

Mol Metab 2014 Jun 21;3(3):275-83. Epub 2014 Jan 21.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA ; Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.molmet.2013.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986497PMC
June 2014

CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes.

Authors:
Ghanashyam Sarikonda Jeremy Pettus Sonal Phatak Sowbarnika Sachithanantham Jacqueline F Miller Johnna D Wesley Eithon Cadag Ji Chae Lakshmi Ganesan Ronna Mallios Steve Edelman Bjoern Peters Matthias von Herrath

J Autoimmun 2014 May 30;50:77-82. Epub 2013 Dec 30.

La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Novo Nordisk Type 1 Diabetes R & D Center, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2013.12.003DOI Listing
May 2014

Clinical potential of antigen-specific therapies in type 1 diabetes.

Authors:
Ken T Coppieters Birgit Sehested Hansen Matthias G von Herrath

Rev Diabet Stud 2012 28;9(4):328-37. Epub 2012 Dec 28.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1900/RDS.2012.9.328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740700PMC
January 2014

Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice.

Authors:
Ghanashyam Sarikonda Sowbarnika Sachithanantham Yulia Manenkova Tinalyn Kupfer Amanda Posgai Clive Wasserfall Philip Bernstein Laura Straub Philippe P Pagni Darius Schneider Teresa Rodriguez Calvo Marilyne Coulombe Kevan Herold Ronald G Gill Mark Atkinson Gerald Nepom Mario Ehlers Teodora Staeva Hideki Garren Lawrence Steinman Andrew C Chan Matthias von Herrath

PLoS One 2013 6;8(2):e54712. Epub 2013 Feb 6.

La Jolla Institute for Allergy and Immunology, Diabetes Center, La Jolla, CA, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054712PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566105PMC
December 2013

Trials in type 1 diabetes: Antigen-specific therapies.

Authors:
Ken T Coppieters Leonard C Harrison Matthias G von Herrath

Clin Immunol 2013 Dec 15;149(3):345-55. Epub 2013 Feb 15.

Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.clim.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777514PMC
December 2013

Keeping the patient perspective: Where are we in the world of type 1 diabetes?

Authors:
Jeremy Pettus Matthias von Herrath

Clin Immunol 2013 Dec 9;149(3):265-7. Epub 2013 Aug 9.

University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.clim.2013.08.003DOI Listing
December 2013

Combination therapy with anti-CD6 and oral insulin immunization reverses recent onset diabetes in non obese diabetic mice but fails to induce lasting tolerance.

Authors:
Darius A Schneider Ghanashyam Sarikonda Enrique Montero Matthias G von Herrath

Clin Immunol 2013 Dec 15;149(3):440-1. Epub 2013 Aug 15.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.clim.2013.08.004DOI Listing
December 2013

Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.

Authors:
Tobias Boettler Youn Soo Choi Shahram Salek-Ardakani Yang Cheng Friedrich Moeckel Michael Croft Shane Crotty Matthias von Herrath

J Immunol 2013 Nov 7;191(10):5026-35. Epub 2013 Oct 7.

Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037;

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http://dx.doi.org/10.4049/jimmunol.1300013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915873PMC
November 2013

The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes.

Authors:
Tobias Boettler Philippe P Pagni Rachel Jaffe Yang Cheng Peter Zerhouni Matthias von Herrath

J Autoimmun 2013 Aug 13;44:40-8. Epub 2013 Jun 13.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2013.05.002DOI Listing
August 2013

Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice.

Authors:
Selina Christen Ken Coppieters Kerstin Rose Martin Holdener Monika Bayer Josef M Pfeilschifter Edith Hintermann Matthias G von Herrath Michel Aurrand-Lions Beat A Imhof Urs Christen

PLoS One 2013 25;8(1):e54675. Epub 2013 Jan 25.

Pharmazentrum Frankfurt/ZAFES, Goethe University Hospital, Frankfurt am Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054675PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556033PMC
July 2013

Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model.

Authors:
Ken T Coppieters Natalie Amirian Philippe P Pagni Carmen Baca Jones Anna Wiberg Stanley Lasch Edith Hintermann Urs Christen Matthias G von Herrath

Diabetes 2013 Jul 22;62(7):2492-9. Epub 2013 Feb 22.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

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http://dx.doi.org/10.2337/db12-1370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712024PMC
July 2013

The microbiology of human hygiene and its impact on type 1 diabetes.

Authors:
Nora M Chapman Ken Coppieters Matthias von Herrath Steven Tracy

Islets 2012 Jul-Aug;4(4):253-61. Epub 2012 Jul 1.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.4161/isl.21570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496651PMC
June 2013

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.

Authors:
Bart O Roep Nanette Solvason Peter A Gottlieb Joana R F Abreu Leonard C Harrison George S Eisenbarth Liping Yu Michael Leviten William A Hagopian John B Buse Matthias von Herrath Joanne Quan Robert S King William H Robinson Paul J Utz Hideki Garren Lawrence Steinman

Sci Transl Med 2013 Jun;5(191):191ra82

Bayhill Therapeutics, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516024PMC
June 2013

Antibody cross-reactivity and the viral aetiology of type 1 diabetes.

Authors:
Ken T Coppieters Matthias von Herrath

J Pathol 2013 May 12;230(1):1-3. Epub 2013 Mar 12.

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http://dx.doi.org/10.1002/path.4174DOI Listing
May 2013

Viruses and Type 1 diabetes: a dynamic labile equilibrium.

Authors:
Darius A Schneider Matthias G von Herrath

Diabetes Manag (Lond) 2013 May;3(3):217-223

Center for Type 1 Diabetes Research, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.2217/dmt.13.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949992PMC
May 2013

NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes.

Authors:
Tom L Van Belle Ellie Ling Claus Haase Damien Bresson Birgitte Ursø Matthias G von Herrath

J Autoimmun 2013 Feb 1;40:66-73. Epub 2012 Sep 1.

Type 1 Diabetes Center of San Diego, La Jolla Institute for Allergy and Immunology, La Jolla, 9420 Athena Circle, San Diego, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2012.08.001DOI Listing
February 2013

Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB).

Authors:
Kerrie Vaughan Bjoern Peters Roberto Mallone Matthias von Herrath Bart O Roep Alessandro Sette

Immunome Res 2013 ;9(1)

Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA.

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https://www.omicsonline.com/open-access/navigating-diabetesr
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http://dx.doi.org/10.4172/1745-7580.1000063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134942PMC
January 2013

Viral infections and molecular mimicry in type 1 diabetes.

Authors:
Ken T Coppieters Anna Wiberg Matthias G von Herrath

APMIS 2012 Dec 11;120(12):941-9. Epub 2012 Oct 11.

Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1111/apm.12011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774991PMC
December 2012

OX40 facilitates control of a persistent virus infection.

Authors:
Tobias Boettler Friedrich Moeckel Yang Cheng Maximilian Heeg Shahram Salek-Ardakani Shane Crotty Michael Croft Matthias G von Herrath

PLoS Pathog 2012 Sep 6;8(9):e1002913. Epub 2012 Sep 6.

Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435255PMC
September 2012

Infection as a cause of type 1 diabetes?

Authors:
Urs Christen Christine Bender Matthias G von Herrath

Curr Opin Rheumatol 2012 Jul;24(4):417-23

Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1097/BOR.0b013e3283533719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828240PMC
July 2012

IL-7 receptor α blockade, an off-switch for autoreactive T cells.

Authors:
Tobias Boettler Matthias von Herrath

Proc Natl Acad Sci U S A 2012 Jul 23;109(31):12270-1. Epub 2012 Jul 23.

Department of Internal Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1073/pnas.1209749109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412005PMC
July 2012

Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3.

Authors:
Alusha A Mamchak Yulia Manenkova Wilhem Leconet Yanan Zheng Jason R Chan Cynthia L Stokes Lisl K M Shoda Matthias von Herrath Damien Bresson

Diabetes 2012 Jun 23;61(6):1490-9. Epub 2012 Feb 23.

Entelos Inc, Foster City, California, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db11-13
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http://dx.doi.org/10.2337/db11-1304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357270PMC
June 2012

Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets.

Authors:
Tom L Van Belle Stefan Nierkens Ramon Arens Matthias G von Herrath

Immunity 2012 Jun 10;36(6):1060-72. Epub 2012 May 10.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810457PMC
June 2012

TGF-β blockade does not improve control of an established persistent viral infection.

Authors:
Tobias Boettler Yang Cheng Katrin Ehrhardt Matthias von Herrath

Viral Immunol 2012 Jun 23;25(3):232-8. Epub 2012 May 23.

La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

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http://dx.doi.org/10.1089/vim.2011.0079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366339PMC
June 2012

Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.

Authors:
Georgia Fousteri Jean Jasinski Amy Dave Maki Nakayama Philippe Pagni Florence Lambolez Therese Juntti Ghanashyam Sarikonda Yang Cheng Michael Croft Hilde Cheroutre George Eisenbarth Matthias von Herrath

Diabetes 2012 May 8;61(5):1169-79. Epub 2012 Mar 8.

Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

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http://dx.doi.org/10.2337/db11-0671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331775PMC
May 2012

Combination therapy with InsB9-23 peptide immunization and CTLA4-IgG does not reverse diabetes in NOD mice.

Authors:
Darius A Schneider Ghanashyam Sarikonda Matthias G von Herrath

Clin Immunol 2012 Mar 23;142(3):402-3. Epub 2011 Dec 23.

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https://linkinghub.elsevier.com/retrieve/pii/S15216616110034
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http://dx.doi.org/10.1016/j.clim.2011.12.005DOI Listing
March 2012

Can an immune-regulatory vaccine prevent HIV infection?

Authors:
Tobias Boettler Edecio Cunha-Neto Jorge Kalil Matthias von Herrath

Expert Rev Anti Infect Ther 2012 Mar;10(3):299-305

Division of Developmental Immunology at the La Jolla Institute for Allergy & Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://www.tandfonline.com/doi/full/10.1586/eri.11.178
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http://dx.doi.org/10.1586/eri.11.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318911PMC
March 2012

Motifs for a deadly encounter.

Authors:
Ken T Coppieters Matthias G von Herrath

Nat Immunol 2012 Feb 16;13(3):205-6. Epub 2012 Feb 16.

Unit for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1038/ni.2226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679406PMC
February 2012

Intravital imaging of CTLs killing islet cells in diabetic mice.

Authors:
Ken Coppieters Natalie Amirian Matthias von Herrath

J Clin Invest 2012 Jan 1;122(1):119-31. Epub 2011 Dec 1.

Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

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http://dx.doi.org/10.1172/JCI59285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248300PMC
January 2012

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

Authors:
Ken T Coppieters Francesco Dotta Natalie Amirian Peter D Campbell Thomas W H Kay Mark A Atkinson Bart O Roep Matthias G von Herrath

J Exp Med 2012 Jan 2;209(1):51-60. Epub 2012 Jan 2.

Type 1 Diabetes Center, the La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20111187
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http://dx.doi.org/10.1084/jem.20111187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260877PMC
January 2012

Unraveling the autoimmune translational research process layer by layer.

Authors:
Richard S Blumberg Bonnie Dittel David Hafler Matthias von Herrath Frank O Nestle

Nat Med 2012 Jan 6;18(1):35-41. Epub 2012 Jan 6.

Division of Gastroenterology and Hepatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.2632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592149PMC
January 2012

Virus infections in type 1 diabetes.

Authors:
Ken T Coppieters Tobias Boettler Matthias von Herrath

Cold Spring Harb Perspect Med 2012 Jan;2(1):a007682

Center for Type 1 Diabetes Research, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/cshperspect.a007682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253029PMC
January 2012

Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment.

Authors:
Damien Bresson Georgia Fousteri Yulia Manenkova Michael Croft Matthias von Herrath

J Autoimmun 2011 Dec 6;37(4):342-51. Epub 2011 Nov 6.

Diabetes Center, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2011.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811160PMC
December 2011

Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals.

Authors:
Ken T Coppieters Anna Wiberg Natalie Amirian Thomas W Kay Matthias G von Herrath

Diabetes Metab Res Rev 2011 Nov;27(8):746-54

Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/dmrr.1246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706467PMC
November 2011

Viruses and cytotoxic T lymphocytes in type 1 diabetes.

Authors:
Ken T Coppieters Matthias G von Herrath

Clin Rev Allergy Immunol 2011 Oct;41(2):169-78

Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, CA, 92037, USA.

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http://dx.doi.org/10.1007/s12016-010-8220-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676523PMC
October 2011

Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.

Authors:
Tom L Van Belle Enric Esplugues Jeanette Liao Therese Juntti Richard A Flavell Matthias G von Herrath

J Immunol 2011 Sep 10;187(6):2915-22. Epub 2011 Aug 10.

Diabetes Center of San Diego, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.1000180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169711PMC
September 2011

2011 Update: antigen-specific therapy in type 1 diabetes.

Authors:
Aaron W Michels Matthias von Herrath

Curr Opin Endocrinol Diabetes Obes 2011 Aug;18(4):235-40

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1097/MED.0b013e32834803aeDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016762PMC
August 2011

Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

Authors:
Urs Christen Matthias G von Herrath

Cell Mol Immunol 2011 May 24;8(3):193-8. Epub 2011 Jan 24.

Pharmazentrum Frankfurt/ZAFES, Klinikum der Goethe Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/cmi.2010.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012874PMC
May 2011

Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis.

Authors:
Georgia Fousteri Amy Dave Bret Morin Shaida Omid Michael Croft Matthias G von Herrath

J Autoimmun 2011 May 17;36(3-4):210-20. Epub 2011 Feb 17.

Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2011.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079777PMC
May 2011

TLR2 signaling improves immunoregulation to prevent type 1 diabetes.

Authors:
Christophe M Filippi Katrin Ehrhardt Elizabeth A Estes Par Larsson Janine E Oldham Matthias G von Herrath

Eur J Immunol 2011 May;41(5):1399-409

La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/eji.200939841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100206PMC
May 2011

Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.

Authors:
Tom L Van Belle Enric Esplugues Jeanette Liao Therese Juntti Richard A Flavell Matthias G von Herrath

J Immunol 2011 Sep 10;187(6):2915-22. Epub 2011 Aug 10.

Diabetes Center of San Diego, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.1000180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169711PMC
September 2011

Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay.

Authors:
Julien Diana Vedran Brezar Lucie Beaudoin Marc Dalod Andrew Mellor Anna Tafuri Matthias von Herrath Christian Boitard Roberto Mallone Agnès Lehuen

J Exp Med 2011 Apr 28;208(4):729-45. Epub 2011 Mar 28.

Institut National de la Santé et de la Recherche Médicale Unité 986, Hôpital Cochin/St Vincent de Paul, 75674 Paris, Cedex 14, France.

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http://jem.rupress.org/content/208/4/729.full.pdf
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http://dx.doi.org/10.1084/jem.20101692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135349PMC
April 2011

Humanizing animal models: a key to autoimmune diabetes treatment.

Authors:
Damien Bresson Matthias von Herrath

Sci Transl Med 2011 Feb;3(68):68ps4

Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scitranslmed.3002102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137650PMC
February 2011

Beta cells under attack: toward a better understanding of type 1 diabetes immunopathology.

Authors:
Ken T Coppieters Bart O Roep Matthias G von Herrath

Semin Immunopathol 2011 Jan 18;33(1):1-7. Epub 2010 Dec 18.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s00281-010-0236-6DOI Listing
January 2011

Type 1 diabetes: etiology, immunology, and therapeutic strategies.

Authors:
Tom L van Belle Ken T Coppieters Matthias G von Herrath

Physiol Rev 2011 Jan;91(1):79-118

Center for Type 1 Diabetes Research, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1152/physrev.00003.2010DOI Listing
January 2011

Increased memory conversion of naïve CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure.

Authors:
Georgia Fousteri Amy Dave Amy Juedes Therese Juntti Bret Morin Lisa Togher Donna L Farber Matthias von Herrath

PLoS One 2011 Jan 6;6(1):e14502. Epub 2011 Jan 6.

Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014502PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017078PMC
January 2011

A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy.

Authors:
Ken Coppieters Marianne M Martinic William B Kiosses Natalie Amirian Matthias von Herrath

PLoS One 2010 Dec 23;5(12):e15732. Epub 2010 Dec 23.

Type 1 Diabetes Center at the La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015732PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009738PMC
December 2010