Matthias Staufenbiel

Matthias Staufenbiel

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Matthias Staufenbiel

Matthias Staufenbiel

Publications by authors named "Matthias Staufenbiel"

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Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.

Bioorg Med Chem Lett 2018 07 3;28(12):2195-2200. Epub 2018 May 3.

Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183039
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http://dx.doi.org/10.1016/j.bmcl.2018.05.003DOI Listing
July 2018

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.

EMBO Rep 2017 09 12;18(9):1536-1544. Epub 2017 Jul 12.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

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http://dx.doi.org/10.15252/embr.201744067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579388PMC
September 2017

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition.

Alzheimers Dement 2017 Jun 14;13(6):701-709. Epub 2016 Oct 14.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.09.005DOI Listing
June 2017

Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties.

Curr Alzheimer Res 2015 ;12(9):886-91

Institute of Pathology, University Hospital Basel, Basel, Switzerland.

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August 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Neuron 2016 07 9;91(1):56-66. Epub 2016 Jun 9.

German Center for Neurodegenerative Diseases (DZNE), Tuebingen, D-72076 Tuebingen, Germany; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D-72076 Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.05.018DOI Listing
July 2016

Highly potent intracellular membrane-associated Aβ seeds.

Sci Rep 2016 06 17;6:28125. Epub 2016 Jun 17.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1038/srep28125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911570PMC
June 2016

Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model.

J Neurosci 2016 05;36(18):5084-93

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen D-72076, Germany, DZNE, German Center for Neurodegenerative Diseases, Tübingen D-72076, Germany,

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http://dx.doi.org/10.1523/JNEUROSCI.0258-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601857PMC
May 2016

Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.

Neurobiol Learn Mem 2016 Apr 28;130:34-43. Epub 2016 Jan 28.

Clem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), University of Queensland, St Lucia Campus, Brisbane, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nlm.2016.01.007DOI Listing
April 2016

Statin Therapy and the Development of Cerebral Amyloid Angiopathy--A Rodent in Vivo Approach.

Int J Mol Sci 2016 Jan 19;17(1). Epub 2016 Jan 19.

Department of Neurology, Universitätsmedizin Mannheim, Heidelberg University, 68167 Mannheim, Germany.

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http://dx.doi.org/10.3390/ijms17010126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730367PMC
January 2016

Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration.

Neuropathol Appl Neurobiol 2015 Dec 30;41(7):906-25. Epub 2015 May 30.

Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1111/nan.12233DOI Listing
December 2015

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models.

Nat Neurosci 2015 Dec 9;18(12):1725-7. Epub 2015 Nov 9.

Institute of Neuroscience, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1038/nn.4163DOI Listing
December 2015

Persistence of Aβ seeds in APP null mouse brain.

Nat Neurosci 2015 Nov 9;18(11):1559-61. Epub 2015 Sep 9.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1038/nn.4117DOI Listing
November 2015

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.

Neurobiol Aging 2015 Jul 25;36(7):2241-2247. Epub 2015 Mar 25.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457564PMC
July 2015

Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models.

EMBO Mol Med 2015 Jul;7(7):895-903

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research University of Tübingen, Tübingen, Germany DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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http://dx.doi.org/10.15252/emmm.201505026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520655PMC
July 2015

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice.

Acta Neuropathol Commun 2015 Jul 4;3:41. Epub 2015 Jul 4.

Institute of Pathology - Laboratory of Neuropathology, Center of Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, D-89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s40478-015-0217-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491274PMC
July 2015

Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice.

Hum Mol Genet 2014 Dec 15;23(24):6512-27. Epub 2014 Jul 15.

Center for Advanced Therapeutic Strategies for Brain Disorders and, Department of Neurology, University of Florida College of Medicine, Gainesville FL32610, USA

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http://dx.doi.org/10.1093/hmg/ddu370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296204PMC
December 2014

Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.

Hum Mol Genet 2014 Sep 13;23(18):4906-18. Epub 2014 May 13.

Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA, Department of Physiology, Medical College of Qingdao University, Qingdao, China, Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA

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http://hmg.oxfordjournals.org/content/early/2014/05/13/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu206
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http://dx.doi.org/10.1093/hmg/ddu206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148612PMC
September 2014

Thrombolysis in experimental cerebral amyloid angiopathy and the risk of secondary intracerebral hemorrhage.

Stroke 2014 Aug 8;45(8):2411-6. Epub 2014 Jul 8.

From the Department of Neurology, Universitätsmedizin Mannheim (B.R., S.G., E.C., S.M., A.E., M.G.H., M.F.) and Computer Assisted Clinical Medicine, Medical Faculty Mannheim (P.H., L.R.S.), University of Heidelberg, Mannheim, Germany; and Nervous System Department, Novartis Institutes for Biomedical Research, Basel, Switzerland (M.S.).

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http://dx.doi.org/10.1161/STROKEAHA.113.004483DOI Listing
August 2014

Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

J Neurosci 2014 Jul;34(31):10264-73

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany, German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany, and

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http://dx.doi.org/10.1523/JNEUROSCI.1608-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608275PMC
July 2014

Amyloid precursor protein mutation disrupts reproductive experience-enhanced normal cognitive development in a mouse model of Alzheimer's disease.

Mol Neurobiol 2014 Feb 14;49(1):103-12. Epub 2013 Jul 14.

Center for Hormone Advanced Science and Education, Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA.

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http://dx.doi.org/10.1007/s12035-013-8503-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891906PMC
February 2014

Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.

J Neurosci 2013 Dec;33(49):19284-94

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany, Graduate School for Cellular and Molecular Neuroscience, University of Tübingen, D-72076 Tübingen, Germany, German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany, and Animal Health and Veterinary Laboratories Agency, Lasswade Laboratory, Penicuik EH26 0PZ, Midlothian, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.2542-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618790PMC
December 2013

Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.

Sci Transl Med 2013 Jul;5(194):194re2

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1126/scitranslmed.3006446DOI Listing
July 2013

Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice.

Mol Neurobiol 2013 Jun 20;47(3):857-67. Epub 2012 Nov 20.

Center for Hormone Advanced Science and Education, Roskamp Institute, 2040 Whitfield Ave., Sarasota, FL 34243, USA.

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http://dx.doi.org/10.1007/s12035-012-8377-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586290PMC
June 2013

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Eur J Neurosci 2013 Jun;37(12):1962-9

Department of Psychiatry, Townsend Family Laboratories, Brain Research Center, Graduate Program in Neuroscience, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1111/ejn.12235DOI Listing
June 2013

Role of hippocalcin in mediating Aβ toxicity.

Biochim Biophys Acta 2012 Aug 20;1822(8):1247-57. Epub 2012 Apr 20.

Alzheimer's & Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1016/j.bbadis.2012.04.007DOI Listing
August 2012

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.

Proc Natl Acad Sci U S A 2012 May 16;109(22):8740-5. Epub 2012 May 16.

Institut für Neurowissenschaften, Technische Universität München, 80802 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.1206171109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365221PMC
May 2012

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease.

Nat Commun 2012 Apr 10;3:774. Epub 2012 Apr 10.

Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstr. 29, 80802 Munich, Germany.

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http://dx.doi.org/10.1038/ncomms1783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337977PMC
April 2012

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.

FASEB J 2012 Mar 15;26(3):1204-17. Epub 2011 Dec 15.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1096/fj.11-187740DOI Listing
March 2012

The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.

J Neurochem 2011 Oct 1;119(1):231-9. Epub 2011 Sep 1.

Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland.

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http://doi.wiley.com/10.1111/j.1471-4159.2011.07412.x
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http://dx.doi.org/10.1111/j.1471-4159.2011.07412.xDOI Listing
October 2011

Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition.

J Neurosci 2011 Oct;31(41):14488-95

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.3088-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229270PMC
October 2011

Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.

J Biol Chem 2011 Sep 27;286(39):33747-58. Epub 2011 Jul 27.

Department of Psychiatry and Psychotherapy, LVR-Klinikum, Essen, University of Duisburg-Essen, D-45147 Essen, Germany.

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http://dx.doi.org/10.1074/jbc.M111.246561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190810PMC
September 2011

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

Science 2010 Nov 21;330(6006):980-2. Epub 2010 Oct 21.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1194516
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http://dx.doi.org/10.1126/science.1194516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233904PMC
November 2010

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

Cell 2010 Aug 22;142(3):387-97. Epub 2010 Jul 22.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney NSW 2050, Australia.

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http://dx.doi.org/10.1016/j.cell.2010.06.036DOI Listing
August 2010

Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta.

PLoS One 2010 Jun 11;5(6):e11070. Epub 2010 Jun 11.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884018PMC
June 2010

Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances.

Neurobiol Aging 2009 Dec 21;30(12):1936-48. Epub 2008 Mar 21.

Department of Neuropathology, University of Bonn, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.017DOI Listing
December 2009

Expression of complement system components during aging and amyloid deposition in APP transgenic mice.

J Neuroinflammation 2009 Nov 17;6:35. Epub 2009 Nov 17.

Novartis Institutes for BioMedical Research, Forum1, Novartis Campus, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1186/1742-2094-6-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784442PMC
November 2009

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease.

Hippocampus 2009 Oct;19(10):1008-18

Genomics of Regeneration in CNS, Center for Regenerative Therapies Dresden (CRTD), Dresden, Germany.

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http://dx.doi.org/10.1002/hipo.20560DOI Listing
October 2009

Age-dependent changes in noradrenergic locus coeruleus system in wild-type and APP23 transgenic mice.

Neurosci Lett 2009 Sep 23;463(1):93-7. Epub 2009 Jul 23.

Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, and Department of Psychiatry and Behavioral Science, University of Washington, Seattle 98195, USA.

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http://dx.doi.org/10.1016/j.neulet.2009.07.055DOI Listing
September 2009

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice.

Neurobiol Aging 2009 Aug 20;30(8):1227-37. Epub 2008 Feb 20.

Zentrum für Neuropathologie und Prionforschung, Ludwig-Maximilians Universität, München, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.10.016DOI Listing
August 2009

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.

Proc Natl Acad Sci U S A 2009 Aug 21;106(31):12926-31. Epub 2009 Jul 21.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1073/pnas.0903200106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722323PMC
August 2009

Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification.

Int J Alzheimers Dis 2009 Jul 14;2009. Epub 2009 Jul 14.

School of Health Sciences, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8514, Japan.

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http://dx.doi.org/10.4061/2009/689285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925098PMC
July 2009

Independent effects of intra- and extracellular Abeta on learning-related gene expression.

Am J Pathol 2009 Jul;175(1):271-82

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Germany.

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http://dx.doi.org/10.2353/ajpath.2009.090044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708813PMC
July 2009

Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

Biol Pharm Bull 2009 Jul;32(7):1307-9

Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University.

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http://dx.doi.org/10.1248/bpb.32.1307DOI Listing
July 2009

Memory deficits in APP23/Abca1+/- mice correlate with the level of Aβ oligomers.

ASN Neuro 2009 Apr 30;1(2). Epub 2009 Apr 30.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1042/AN20090015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695585PMC
April 2009

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.

Bioorg Med Chem Lett 2009 Mar 22;19(5):1366-70. Epub 2009 Jan 22.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, PO Box, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2009.01.055DOI Listing
March 2009

E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition.

Am J Pathol 2009 Mar 13;174(3):722-6. Epub 2009 Feb 13.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Strasse 27, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.2353/ajpath.2009.080790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665734PMC
March 2009

Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.

Brain Res 2008 Dec 18;1243:124-33. Epub 2008 Sep 18.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.brainres.2008.09.024DOI Listing
December 2008

Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.

J Exp Med 2008 Nov 27;205(12):2781-9. Epub 2008 Oct 27.

Department of Psychiatry, Townsend Family Laboratories, Brain Research Center, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1084/jem.20081588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585842PMC
November 2008

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

Science 2008 Sep;321(5896):1686-9

Institut für Neurowissenschaften, Technische Universität München (TUM), 80802 München, Germany.

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http://dx.doi.org/10.1126/science.1162844DOI Listing
September 2008

Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory.

Behav Brain Res 2008 Jun 16;190(1):147-51. Epub 2008 Feb 16.

Laboratory of Neurochemistry & Behaviour, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, Wilrijk, Belgium.

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http://dx.doi.org/10.1016/j.bbr.2008.02.014DOI Listing
June 2008

Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis.

Am J Pathol 2008 Jun 8;172(6):1520-8. Epub 2008 May 8.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.2353/ajpath.2008.060520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408413PMC
June 2008

Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model.

Behav Neurosci 2008 Jun;122(3):491-7

Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium.

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http://dx.doi.org/10.1037/0735-7044.122.3.491DOI Listing
June 2008

Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease.

Proc Natl Acad Sci U S A 2008 Mar 27;105(9):3587-92. Epub 2008 Feb 27.

Department of Zoology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1073/pnas.0709788105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265182PMC
March 2008

Proteomic 2-D DIGE profiling of APP23 transgenic mice brain from pre-plaque and plaque phenotypes.

J Alzheimers Dis 2008 Feb;13(1):17-30

BioMarker Development, Novartis, Klybeckstrasse, Basel, Switzerland.

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February 2008

Cystatin C modulates cerebral beta-amyloidosis.

Nat Genet 2007 Dec 18;39(12):1437-9. Epub 2007 Nov 18.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Strasse 27, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1038/ng.2007.23DOI Listing
December 2007

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.

Am J Pathol 2007 Dec 30;171(6):2012-20. Epub 2007 Nov 30.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Str.27, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.2353/ajpath.2007.070403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111123PMC
December 2007

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.

Neurodegener Dis 2007 ;4(2-3):127-35

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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https://www.karger.com/Article/FullText/101837
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http://dx.doi.org/10.1159/000101837DOI Listing
October 2007

Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment.

Mol Neurodegener 2007 Oct 22;2:20. Epub 2007 Oct 22.

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1186/1750-1326-2-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214725PMC
October 2007

Mood and male sexual behaviour in the APP23 model of Alzheimer's disease.

Behav Brain Res 2007 Jun 12;180(2):146-51. Epub 2007 Mar 12.

Laboratory of Neurochemistry & Behaviour, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium.

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http://dx.doi.org/10.1016/j.bbr.2007.03.002DOI Listing
June 2007