Matthias Sitzer

Matthias Sitzer

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Matthias Sitzer

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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Authors:
Nora Franceschini Claudia Giambartolomei Paul S de Vries Chris Finan Joshua C Bis Rachael P Huntley Ruth C Lovering Salman M Tajuddin Thomas W Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V Smith Edith Hofer Elisabeth M van Leeuwen Ilja M Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K Joshi Raymond Noordam Riccardo E Marioni Shih-Jen Hwang Solomon K Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B Zonderman Albert Hofman Alexander Teumer Amanda J Cox André G Uitterlinden Andrew Wong Andries J Smit Anne B Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W Penninx Carl D Langefeld Christina L Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H O'Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S Markus Ian J Deary J Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D Taylor Klodian Dhana Lambertus A L M Kiemeney Lars Lind Laura M Raffield Lenore J Launer Lesca M Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A Nalls Olle Melander Olli Raitakari Oscar H Franco Oscar L Rueda-Ochoa Panos Roussos Peter H Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W Morris Rona J Strawbridge S Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R Heckbert Susan Ring Tamara B Harris Terho Lehtimäki Tessel E Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba Abbas Dehghan Adrie Seldenrijk Alanna C Morrison Anders Hamsten Bruce M Psaty Cornelia M van Duijn Deborah A Lawlor Dennis O Mook-Kanamori Donald W Bowden Helena Schmidt James F Wilson James G Wilson Jerome I Rotter Joanna M Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K Evans Stéphanie Debette Steve E Humphries Uwe Völker Vilmundur Gudnason Aroon D Hingorani Johan L M Björkegren Juan P Casas Christopher J O'Donnell

Nat Commun 2018 12 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-07340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277418PMC
December 2018

Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.

September 2018

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.

PLoS One 2018 12;13(4):e0191172. Epub 2018 Apr 12.

Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191172PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896895PMC
July 2018

Common carotid intima-media thickness relates to cardiovascular events in adults aged <45 years.

Hypertension 2015 Apr 26;65(4):707-13. Epub 2015 Jan 26.

From the Department of Radiology (A.L.M.E.), Department of Cardiovascular Epidemiology, Julius Center for Health Sciences and Primary Care (K.A.G., D.E.G., S.A.E.P., M.L.B., H.M.d.R.), and Department of Experimental Cardiology (I.E.H., H.M.d.R.), University Medical Center, Utrecht, Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, London, United Kingdom (A.R.B.); Department of Clinical Sciences in Malmö, Lund University, Skåne University Hospital, Malmö, Sweden (G.E., B.H., M.R.); Department of Biostatistical Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, NC (G.W.E.); Division of Vascular Medicine, Department of General Internal Medicine, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands (J.d.G., S.H.); Department of Clinical Epidemiology, University of Malaya Medical Center, Kuala Lumpur, Malaysia (D.E.G.); Osaka Medical Center for Health Science and Promotion, Osaka, Japan (A.I., A.K.); Department of Neurology, Tokyo Women Medical University, Tokyo, Japan (K.K.); Division of Cardiology and Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (E.M.L.); Department of Neurology, University Hospital, Goethe-University, Frankfurt am Main, Germany (M.W.L., M.S.); Brain and Circulation Research Group, Department of Clinical Medicine, University of Tromsø, Tromsø, Norway (E.B.M.); Department of General Practice, EMGO Institute, VU Medical Center, Amsterdam, The Netherlands (G.N., J.M.D.); Stroke Center, Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan (S.O.); Department of Radiology, Tufts Medical Center, Boston, MA (D.H.O'L., J.F.P.); Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom (J.F.P., C.R.); Cardiology Division, De

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04658DOI Listing
April 2015

Prediction of asymptomatic carotid artery stenosis in the general population: identification of high-risk groups.

Stroke 2014 Aug 3;45(8):2366-71. Epub 2014 Jul 3.

From the Julius Center for Health Sciences and Primary Care (M.d.W., J.P.G., M.L.B.) and Department of Vascular Surgery (G.J.d.B.), University Medical Center Utrecht, Utrecht, The Netherlands; Department of Clinical Sciences, Cardiovascular Epidemiology (B.H.) and Department of Clinical Sciences, Social Epidemiology (M.R.), Lund University, Malmö University Hospital, Malmö, Sweden; Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (M.W.L., M.S.); Department of Clinical Medicine, University of Tromsø, Tromsø, Norway (E.B.M.); Tufts University School of Medicine, Boston, MA (D.H.O'L.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands (E.B.).

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.114.005145
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http://dx.doi.org/10.1161/STROKEAHA.114.005145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763934PMC
August 2014

Clinical usefulness of carotid ultrasound to improve stroke risk assessment: ten-year results from the Carotid Atherosclerosis Progression Study (CAPS).

Eur J Prev Cardiol 2013 Oct 22;20(5):837-43. Epub 2012 May 22.

Department of Neurology, Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1177/2047487312449589DOI Listing
October 2013

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.

Nat Genet 2011 Sep 11;43(10):940-7. Epub 2011 Sep 11.

Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/ng.920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257519PMC
September 2011

Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness.

Stroke 2011 Jun 7;42(6):1510-4. Epub 2011 Apr 7.

Stroke and Dementia Research Centre, Clinical Sciences, St George's University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.110.602375
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http://dx.doi.org/10.1161/STROKEAHA.110.602375DOI Listing
June 2011

Pituitary function and IGF-I levels following ischemic stroke.

Cerebrovasc Dis 2011 4;31(2):163-9. Epub 2010 Dec 4.

Department of Internal Medicine 1, Division of Endocrinology, Diabetes and Metabolism, Stroke Unit, J.W. Goethe University, Frankfurt/M., Germany.

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http://dx.doi.org/10.1159/000321738DOI Listing
April 2011

Predictors of acute poststroke seizures.

Cerebrovasc Dis 2010 14;30(6):584-9. Epub 2010 Oct 14.

Asklepios Neurological Hospital Falkenstein, Königstein/Taunus, Germany.

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http://dx.doi.org/10.1159/000319777DOI Listing
March 2011

Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson's disease.

J Neurol Neurosurg Psychiatry 2010 Oct 11;81(10):1087-92. Epub 2010 Jun 11.

Department of Neurology, University Hospital, Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1136/jnnp.2009.196352DOI Listing
October 2010

Is carotid intima media thickness useful for individual prediction of cardiovascular risk? Ten-year results from the Carotid Atherosclerosis Progression Study (CAPS).

Eur Heart J 2010 Aug 8;31(16):2041-8. Epub 2010 Jun 8.

Department of Neurology, Johann Wolfgang Goethe-University, Schleusenweg 2-16, Frankfurt am Main D-60528, Germany.

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehq189DOI Listing
August 2010

Characterisation of the diagnostic window of serum glial fibrillary acidic protein for the differentiation of intracerebral haemorrhage and ischaemic stroke.

Cerebrovasc Dis 2009 15;27(1):37-41. Epub 2008 Nov 15.

Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1159/000172632DOI Listing
April 2009

Abrupt shift of the pattern of diurnal variation in stroke onset with daylight saving time transitions.

Circulation 2008 Jul 23;118(3):284-90. Epub 2008 Jun 23.

Department of Neurology, Goethe University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.7
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http://dx.doi.org/10.1161/CIRCULATIONAHA.108.771246DOI Listing
July 2008

The interdisciplinary treatment of unruptured intracranial aneurysms.

Dtsch Arztebl Int 2008 Jun 20;105(25):449-56. Epub 2008 Jun 20.

Klinik für Neurochirurgie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Schleusenweg 2-16, Frankfurt/Main, Germany.

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http://dx.doi.org/10.3238/arztebl.2008.0449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696898PMC
June 2008

The projected burden of stroke in the German federal state of Hesse up to the year 2050.

Dtsch Arztebl Int 2008 Jun 27;105(26):467-73. Epub 2008 Jun 27.

Klinikum der Johann-Wolfgang-Goethe-Universität, Schleusenweg 2-16, Frankfurt am Main, Germany.

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https://www.aerzteblatt.de/10.3238/arztebl.2008.0467
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http://dx.doi.org/10.3238/arztebl.2008.0467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696913PMC
June 2008

Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness.

Stroke 2007 Nov 27;38(11):2895-9. Epub 2007 Sep 27.

Centre for Clinical Neuroscience, St. George's University of London, Cranmer Terrace, Tooting, London, UK.

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http://stroke.ahajournals.org/content/38/11/2895.full.pdf
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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.107.
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http://dx.doi.org/10.1161/STROKEAHA.107.491696DOI Listing
November 2007

Influence of temporal insonation window quality on the assessment of cerebral autoregulation with transcranial Doppler sonography.

Ultrasound Med Biol 2007 Oct 4;33(10):1540-5. Epub 2007 Jun 4.

Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2007.04.010DOI Listing
October 2007

High-sensitivity C-reactive protein is not associated with carotid intima-media progression: the carotid atherosclerosis progression study.

Stroke 2007 Jun 19;38(6):1774-9. Epub 2007 Apr 19.

Department of Neurology, J.W. Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1161/STROKEAHA.106.476135DOI Listing
June 2007

Atherosclerotic carotid stenosis and occlusion.

Authors:
Matthias Sitzer

Front Neurol Neurosci 2006 ;21:36-56

Department of Neurology, Centre for Neurology and Neurosurgery, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1159/000092383DOI Listing
May 2007

Toll receptor polymorphisms and carotid artery intima-media thickness.

Stroke 2007 Apr 1;38(4):1179-84. Epub 2007 Mar 1.

Centre for Clinical Neuroscience, St. George's University of London, London, UK.

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https://www.ahajournals.org/doi/10.1161/01.STR.0000260184.85
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http://dx.doi.org/10.1161/01.STR.0000260184.85257.2bDOI Listing
April 2007

Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis.

Circulation 2007 Jan 22;115(4):459-67. Epub 2007 Jan 22.

Johann Wolfgang Goethe-University, Department for Neurology, Schleusenweg 2-16, D-60528 Frankfurt/Main, Germany.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.6
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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.628875DOI Listing
January 2007

Pretreatment with antiplatelet agents is not independently associated with unfavorable outcome in intracerebral hemorrhage.

Stroke 2006 Aug 29;37(8):2165-7. Epub 2006 Jun 29.

Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1161/01.STR.0000231842.32153.74DOI Listing
August 2006

Difference in recognition of right and left hemispheric stroke.

Lancet 2005 Jul 30-Aug 5;366(9483):392-3

Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S014067360567024
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http://dx.doi.org/10.1016/S0140-6736(05)67024-9DOI Listing
October 2005

Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: relevance of interactions between thrombotic material and thrombolytic agent.

Vascul Pharmacol 2005 Oct 26;43(4):254-9. Epub 2005 Sep 26.

Department of Neurology, University Hospital, JW Goethe University Frankfurt, Schleusenweg 2-16, ZNN, 60528 Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.vph.2005.07.008DOI Listing
October 2005

Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction.

Arch Neurol 2005 Jul;62(7):1130-4

Department of Neurology, Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1001/archneur.62.7.1130DOI Listing
July 2005

Inflammatory gene load is associated with enhanced inflammation and early carotid atherosclerosis in smokers.

Stroke 2004 Nov 7;35(11):2438-43. Epub 2004 Oct 7.

Department of Clinical Neurosciences, St. George's Hospital Medical School, Cranmer Terrace, London SW170RE.

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http://dx.doi.org/10.1161/01.STR.0000144681.46696.b3DOI Listing
November 2004

Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study.

Stroke 2004 Sep 8;35(9):2150-4. Epub 2004 Jul 8.

Department of Clinical Neurosciences, St. George's Hospital Medical School, Cranmer Terrace, Tooting, London, United Kingdom.

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http://dx.doi.org/10.1161/01.STR.0000136720.21095.f3DOI Listing
September 2004

Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion.

Stroke 2004 Sep 5;35(9):2160-4. Epub 2004 Aug 5.

Department of Neurology, Johann Wolfgang Goethe-University Frankfurt am Main, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1161/01.STR.0000138730.03264.acDOI Listing
September 2004

Functional impairment, disability, and quality of life outcome after decompressive hemicraniectomy in malignant middle cerebral artery infarction.

J Neurosurg 2004 Aug;101(2):248-54

Department of Neurology and Neurosurgery, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.3171/jns.2004.101.2.0248DOI Listing
August 2004

Practical limitations of acute stroke MRI due to patient-related problems.

Neurology 2004 May;62(10):1848-9

Department of Neurology, J.W. Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1212/01.wnl.0000125320.53244.faDOI Listing
May 2004

Recurrent symptomatic high-grade intracranial stenoses: safety and efficacy of undersized stents--initial experience.

Radiology 2004 Apr;231(1):45-9

Institute of Neuroradiology and Department of Neurology, Johann Wolfgang Goethe-University Frankfurt, Schleusenweg 2-16, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1148/radiol.2311030183DOI Listing
April 2004

"Economy class" stroke syndrome.

Neurology 2004 Mar;62(6):1026

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http://dx.doi.org/10.1212/wnl.62.6.1026DOI Listing
March 2004

Symptomatic carotid artery stenosis: heterogeneity of destabilizing mechanisms?

Stroke 2003 Jun 15;34(6):e41; author reply e41. Epub 2003 May 15.

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http://dx.doi.org/10.1161/01.STR.0000074927.11687.91DOI Listing
June 2003

Internal carotid artery angle of origin: a novel risk factor for early carotid atherosclerosis.

Stroke 2003 Apr 13;34(4):950-5. Epub 2003 Mar 13.

Department of Neurology, J.W. Goethe University Frankfurt am Main, Schleusenweg 2-16, 60528 Frankfurt/Main, Germany.

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http://dx.doi.org/10.1161/01.STR.0000060895.38298.C4DOI Listing
April 2003

Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: the Carotid Atherosclerosis Progression Study (CAPS).

Stroke 2003 Mar 30;34(3):600-4. Epub 2003 Jan 30.

Department of Clinical Neurosciences, St George's Hospital Medical School, Cranmer Terr, Tooting, London SW17 0RE, UK.

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http://dx.doi.org/10.1161/01.STR.0000055941.61801.5ADOI Listing
March 2003

Early carotid atherosclerosis and family history of vascular disease: specific effects on arterial sites have implications for genetic studies.

Arterioscler Thromb Vasc Biol 2003 Feb;23(2):302-6

Department of Clinical Neurosciences, St Georges Hospital Medical School, London, UK.

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February 2003

Economy class stroke syndrome.

Neurology 2002 Sep;59(6):962-3; author reply 963

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http://dx.doi.org/10.1212/wnl.59.6.962-bDOI Listing
September 2002

C-reactive protein and carotid intimal medial thickness in a community population.

J Cardiovasc Risk 2002 Apr;9(2):97-103

Department of Neurology, J.W. Goethe-University Frankfurt am Main, Germany, St George's Hospital Medical School, London, UK.

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April 2002

Magnetic resonance imaging in basilar artery occlusion.

Arch Neurol 2002 Mar;59(3):398-402

Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1001/archneur.59.3.398DOI Listing
March 2002

Helicobacter pylori infection, the cytotoxin gene A strain, and carotid artery intima-media thickness.

J Cardiovasc Risk 2002 Feb;9(1):1-6

Department of Clinical Neuroscience, St. George's Hospital Medical School, London, UK.

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February 2002

Recanalization results after carotid stent placement.

AJNR Am J Neuroradiol 2002 Jan;23(1):113-20

Institute of Neuroradiology, Johann Wolfgang Goethe-University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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http://www.ajnr.org/content/23/1/113.full.pdf
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January 2002

Microembolism in Carotid Artery Disease.

Echocardiography 1996 Sep;13(5):529-536

Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, P.O. Box 101007, D-40001 Düsseldorf, Germany.

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September 1996