Matthias Schlesner

Matthias Schlesner

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Matthias Schlesner

Matthias Schlesner

Publications by authors named "Matthias Schlesner"

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Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation.

Acta Crystallogr F Struct Biol Commun 2019 Sep 30;75(Pt 9):576-585. Epub 2019 Aug 30.

Department of Membrane Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1107/S2053230X19010896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718144PMC
September 2019

Distributed Ledger Technology in genomics: a call for Europe.

Eur J Hum Genet 2019 Sep 16. Epub 2019 Sep 16.

Department of Economics and Management, Karlsruhe Institute of Technology, Kaiserstr. 89, 76133, Karlsruhe, Germany.

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http://dx.doi.org/10.1038/s41431-019-0512-4DOI Listing
September 2019

A report of whole-genome sequencing in neurologic Wilson's disease.

Neurol India 2017 May-Jun;65(3):629-631

Synaptic Signaling and Neurodegeneration, German Cancer Research Center, Heidelberg; Synaptic Signaling and Neurodegeneration, German Center for Neurodegenerative Diseases, Bonn; Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.4103/neuroindia.NI_1274_16DOI Listing
July 2019

Evaluation of Whole Genome Sequencing Data.

Methods Mol Biol 2019 ;1956:321-336

Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-9151-8_15DOI Listing
July 2019

Evolutionary Trajectories of IDH Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis.

Cancer Cell 2019 Apr 21;35(4):692-704.e12. Epub 2019 Mar 21.

Division of Molecular Genetics, German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193010
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http://dx.doi.org/10.1016/j.ccell.2019.02.007DOI Listing
April 2019

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 12;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.10.016DOI Listing
December 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Nat Methods 2018 04 30;15(4):239-240. Epub 2018 Mar 30.

Center for Genome Engineering, Institute for Basic Science, Seoul, South Korea.

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http://dx.doi.org/10.1038/nmeth.4554DOI Listing
April 2018

EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations.

BMC Genomics 2018 Apr 4;19(1):234. Epub 2018 Apr 4.

Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12864-018-4625-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885322PMC
April 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas.

Am J Surg Pathol 2017 Feb;41(2):195-203

*Institute of Pathology ¶Department of Paediatrics, University Hospital, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen †Division of Theoretical Bioinformatics (B080) #Division Molecular Genome Analysis **Genomics & Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg §Institute of Pathology, St. Vincent's Hospital, Karlsruhe ∥Institute of Pathology, Klinikum Augsburg, Augsburg ‡‡Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany ‡Department of Pathology, Faculty of Medicine in Plzen and Charles University Hospital, Biomedical Center ††Department of Pathology, Faculty of Medicine, Charles University, Plzen, Czech Republic.

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http://dx.doi.org/10.1097/PAS.0000000000000752DOI Listing
February 2017

Complex heatmaps reveal patterns and correlations in multidimensional genomic data.

Bioinformatics 2016 09 20;32(18):2847-9. Epub 2016 May 20.

Division of Theoretical Bioinformatics.

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http://dx.doi.org/10.1093/bioinformatics/btw313DOI Listing
September 2016

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

HilbertCurve: an R/Bioconductor package for high-resolution visualization of genomic data.

Bioinformatics 2016 08 24;32(15):2372-4. Epub 2016 Mar 24.

Division of Theoretical Bioinformatics.

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http://dx.doi.org/10.1093/bioinformatics/btw161DOI Listing
August 2016

Pedigree based DNA sequencing pipeline for germline genomes of cancer families.

Hered Cancer Clin Pract 2016 9;14:16. Epub 2016 Aug 9.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), D69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13053-016-0058-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977614PMC
August 2016

Identification of immunotherapeutic targets by genomic profiling of rectal NET metastases.

Oncoimmunology 2016 22;5(11):e1213931. Epub 2016 Jul 22.

Clinical Cooperation Unit "Applied Tumor Immunity", National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases (NCT) and University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1080/2162402X.2016.1213931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139646PMC
July 2016

Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma.

Haematologica 2016 06 18;101(6):e259-61. Epub 2016 Mar 18.

Institute of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein Campus Kiel, Christian-Albrechts University Kiel, Germany

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http://dx.doi.org/10.3324/haematol.2015.138701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013970PMC
June 2016

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Blood 2016 06 5;127(22):2732-41. Epub 2016 Apr 5.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany; and Center of Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-11-684183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891954PMC
June 2016

gtrellis: an R/Bioconductor package for making genome-level Trellis graphics.

BMC Bioinformatics 2016 Apr 18;17:169. Epub 2016 Apr 18.

Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12859-016-1051-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835841PMC
April 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

Nat Commun 2015 Dec 9;6:10001. Epub 2015 Dec 9.

CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1038/ncomms10001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682041PMC
December 2015

Hypermutation takes the driver's seat.

Genome Med 2015 28;7(1):31. Epub 2015 Mar 28.

Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, 69120 Germany ; Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, 69120 Germany ; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, 69120 Germany.

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http://dx.doi.org/10.1186/s13073-015-0159-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376156PMC
March 2015

Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions.

Nucleic Acids Res 2015 Jan 11;43(2):e10. Epub 2014 Nov 11.

Cell Networks, University of Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany Bioquant, University of Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany

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http://dx.doi.org/10.1093/nar/gku1094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333368PMC
January 2015

circlize Implements and enhances circular visualization in R.

Bioinformatics 2014 Oct 14;30(19):2811-2. Epub 2014 Jun 14.

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg Center for Personalized Oncology (DKFZ-HIPO) and Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant Center, Heidelberg University, 69120 Heidelberg, Germany Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg Center for Personalized Oncology (DKFZ-HIPO) and Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant Center, Heidelberg University, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btu393DOI Listing
October 2014

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:1982973/compon
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http://www.nature.com/doifinder/10.1038/ng.2682
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http://dx.doi.org/10.1038/ng.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951336PMC
August 2013

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

The protein interaction network of a taxis signal transduction system in a halophilic archaeon.

BMC Microbiol 2012 Nov 21;12:272. Epub 2012 Nov 21.

Department of Membrane Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1186/1471-2180-12-272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579733PMC
November 2012

Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma.

Br J Haematol 2012 Jun 3;157(6):702-8. Epub 2012 Apr 3.

Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School, Essen, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2012.09113.xDOI Listing
June 2012

Identification of Archaea-specific chemotaxis proteins which interact with the flagellar apparatus.

BMC Microbiol 2009 Mar 16;9:56. Epub 2009 Mar 16.

Department of Membrane Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1186/1471-2180-9-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666748PMC
March 2009

What do we learn from high-throughput protein interaction data?

Expert Rev Proteomics 2004 Jun;1(1):111-21

Institut fur Genetik, Forschungszentrum Karlsruhe, Box 3640, D-76021 Karlsruhe, Germany.

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http://dx.doi.org/10.1586/14789450.1.1.111DOI Listing
June 2004