Matthias Rottmann

Matthias Rottmann

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Matthias Rottmann

Matthias Rottmann

Publications by authors named "Matthias Rottmann"

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46Publications

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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.

Eur J Med Chem 2018 Feb 31;146:651-667. Epub 2018 Jan 31.

Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.01.062DOI Listing
February 2018

Heterochromatin protein 1 secures survival and transmission of malaria parasites.

Cell Host Microbe 2014 Aug;16(2):165-176

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4051, Switzerland; University of Basel, Petersplatz 1, Basel 4003, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.07.004DOI Listing
August 2014

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.

Angew Chem Int Ed Engl 2014 Jul 4;53(27):7079-84. Epub 2014 Jun 4.

Departement Chemie und Angewandte Biowissenschaften, ETH Zürich, Vladimir-Prelog-Weg 3-4, 8093 Zürich (Switzerland).

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http://dx.doi.org/10.1002/anie.201311162DOI Listing
July 2014

Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium.

J Control Release 2014 Mar 7;177:84-95. Epub 2014 Jan 7.

Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 10-12, ES-08028 Barcelona, Spain; Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Rosselló 149-153, ES-08036 Barcelona, Spain; Biomolecular Interactions Team, Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Martí i Franquès 1, ES-08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2013.12.032DOI Listing
March 2014

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD.

Angew Chem Int Ed Engl 2014 Feb 20;53(8):2235-9. Epub 2014 Jan 20.

Center for Integrated Protein Science Munich, Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching (Germany).

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http://doi.wiley.com/10.1002/anie.201309557
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http://dx.doi.org/10.1002/anie.201309557DOI Listing
February 2014

Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.

J Biol Chem 2013 Sep 2;288(38):27002-18. Epub 2013 Aug 2.

From the Department of Microbiology and Molecular Medicine, University Medical Center (CMU), University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland.

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http://dx.doi.org/10.1074/jbc.M113.460709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779702PMC
September 2013

Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.

PLoS Negl Trop Dis 2012 25;6(10):e1805. Epub 2012 Oct 25.

BASF SE, Global Research Herbicides, Ludwigshafen, Germany.

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https://dx.plos.org/10.1371/journal.pntd.0001805
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http://dx.doi.org/10.1371/journal.pntd.0001805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493374PMC
March 2013

Antiparasitic agents: new drugs on the horizon.

Curr Opin Pharmacol 2012 Oct 29;12(5):562-6. Epub 2012 May 29.

Swiss Tropical and Public Health Institute, 4003 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.coph.2012.05.001DOI Listing
October 2012

Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors.

Org Biomol Chem 2012 Aug 16;10(30):5764-8. Epub 2012 Feb 16.

Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1039/c2ob00034bDOI Listing
August 2012

Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula.

Phytochemistry 2011 Dec 6;72(18):2369-75. Epub 2011 Sep 6.

Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.phytochem.2011.08.019DOI Listing
December 2011

Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei.

ChemMedChem 2011 Feb 25;6(2):273-8. Epub 2010 Nov 25.

Laboratory of Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.1002/cmdc.201000449DOI Listing
February 2011

Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula.

J Nat Prod 2010 Nov 11;73(11):1810-4. Epub 2010 Oct 11.

Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Singapore.

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http://dx.doi.org/10.1021/np100442xDOI Listing
November 2010

Differential var gene expression in children with malaria and antidromic effects on host gene expression.

J Infect Dis 2010 Jul;202(2):313-7

Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1086/653586DOI Listing
July 2010

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker.

Bioorg Med Chem 2009 Dec 12;17(23):8048-59. Epub 2009 Oct 12.

Université de Lille 1, Unité de Catalyse et Chimie du Solide-UMR CNRS 8181, ENSCL, Bâtiment C7, B.P. 90108, 59652 Villeneuve d'Ascq Cedex, France.

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http://dx.doi.org/10.1016/j.bmc.2009.10.008DOI Listing
December 2009

Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

J Med Chem 2008 Feb 31;51(4):1035-42. Epub 2008 Jan 31.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm701168hDOI Listing
February 2008